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Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER)

National Toxicology Program. 2018. Data Release: Developmental NeuroToxicity Data Integration and Visualization Enabling Resource (DNT-DIVER). Last Updated: December 3, 2018.
DOI: https://doi.org/10.22427/NTP-DATA-002-00062-0001-0000-1

A Black Cohosh Extract Causes Hematologic and Biochemical Changes Consistent with a Functional Cobalamin Deficiency in Female B6C3F1/N Mice

Michelle C. Cora, William Gwinn, Ralph Wilson, Debra King, Suramya Waidyanatha, Grace E. Kissling, Sukhdev S. Brar, Dorian Olivera, Chad Blystone, and Greg Travlos.
Toxicologic Pathology (2017) DOI: https://doi.org/10.1177/0192623317714343 PMID: 28618975

A Hybrid Gene Selection Approach to Create the S1500+ Targeted Gene Sets for Use in High-Throughput Transcriptomics

Deepak Mav, Ruchir R. Shah, Brian E. Howard, Scott S. Auerbach, Pierre R. Bushel, Jennifer B. Collins, David L. Gerhold, Richard S. Judson, Agnes L. Karmaus, Elizabeth A. Maull, Donna L. Mendrick, B. Alex Merrick, Nisha S. Sipes, Daniel Svoboda, Richard S. Paules.
PLOS One. 2018 DOI: https://doi.org/10.1371/journal.pone.0191105 PMID: 29462216

A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro

Melanie Adler, Susanne Ramm, Marc Hafner, Jeremy L. Muhlich, Esther Maria Gottwald, Elijah Weber, Alenka Jaklic, Amrendra Kumar Ajay, Daniel Svoboda, Scott Auerbach, Edward J. Kelly, Jonathan Himmelfarb and Vishal S. Vaidya
JASN (2015) DOI: https://doi.org/10.1681/ASN.2015010060 PMID: 26260164

A Toxicogenomics Approach to Screen Chlorinated Flame Retardants Tris(2-Chloroethyl) Phosphate and Tris(2-Chloroisopropyl) Phosphate for Potential Health Effects

Boris V. Krivoshiev, Gerrit T.S. Beemster, Katrien Sprangers, Ronny Blust and Steven J. Husson
Journal of Applied Toxicology (2017) DOI: https://doi.org/10.1002/jat.3553 PMID: 29143341

Accelerating Adverse Outcome Pathway Development Using Publicly Available Data Sources

Noffisat O. Oki, Mark D. Nelms, Shannon M. Bell, Holly M. Mortensen, Stephen W. Edwards.
Current Environmental Health Reports. 2016 DOI: http://dx.doi.org/10.1007/s40572-016-0079-y PMID: 26809562

Advancing Alternative Analysis: Integration of Decision Science

Malloy TF, Zaunbrecher VM, Batteate CM, Blake A, Carroll WF, Jr., Corbett CJ, Hansen SF, Lempert RJ, Linkov I, McFadden R, Moran KD, Olivetti E, Ostrom NK, Romero M, Schoenung JM, Seager TP, Sinsheimer P, Thayer KA.
Environmental Health Perspectives (2017) DOI: https://doi.org/10.1289/ehp483 PMID: 28669940

Advancing Alternatives Analysis: The Role of Predictive Toxicology in Selecting Safer Chemical Products and Processes

Timothy Malloy, Virginia Zaunbrecher, Elizabeth Beryt, Richard Judson, Raymond Tice, Patrick Allard, Ann Blake, Ila Cote, Hilary Godwin, Lauren Heine, Patrick Kerzic, Jakub Kostal, Gary Marchant, Jennifer McPartland, Kelly Moran, Andre Nel, Oladele Ogunseitan, Mark Rossi, Kristina Thayer, Joel Tickner, Margaret Whittaker, Ken Zarker.
Integrated Environmental Assessment and Management (2017) DOI: https://doi.org/10.1002/ieam.1923 PMID: 28247928

Airway Injury in an in vitro Human Epithelium-Fibroblast Model of Diacetyl Vapor Exposure: Diacetyl-Induced Basal/Suprabasal Spongiosis

William M. Gwinn, Gordon P. Flake, Ronald W. Bousquet, Genie J. Taylor, and Daniel L. Morgan.
Inhalation Toxicology (2017) DOI: https://doi.org/10.1080/08958378.2017.1369604 PMID: 28984536

Alternative Approaches for Identifying Acute Systemic Toxicity: Moving from Research to Regulatory Testing

Jon Hamm, Kristie Sullivan, Amy J. Clippinger, Judy Strickland, Shannon Bell, Barun Bhhatarai, Bas Blaauboer, Warren Casey, David Dorman, Anna Forsby, Natàlia Garcia-Reyero, Sean Gehen, Rabea Graepel, Jon Hotchkiss, Anna Lowit, Joanna Matheson, Elissa Reaves, Louis Scarano, Catherine Sprankle, Jay Tunkel, Dan Wilson, Menghang Xia, Hao Zhu, David Allen.
Toxicology in Vitro (2017) DOI: https://doi.org/10.1016/j.tiv.2017.01.004 PMID: 28069485

An Evaluation of Neurotoxicity Following Fluoride Exposure from Gestational Through Adult Ages in Long-Evans Hooded Rats

Christopher A. McPherson, Guozhu Zhang, Richard Gilliam, Sukhdev S. Brar, Ralph Wilson, Amy Brix, Catherine Picut, and G. Jean Harry
Neurotoxicity Research (2018) DOI: https://doi.org/10.1007/s12640-018-9870-x PMID: 29404855

An Integrated Chemical Environment to Support 21st-Century Toxicology

Bell SM, Phillips J, Sedykh A, Tandon A, Sprankle C, Morefield SQ, Shapiro A, Allen D, Shah R, Maull EA, Casey WM, Kleinstreuer NC.
Environmental Health Perspectives (2017) DOI: https://doi.org/10.1289/ehp1759 PMID: 28557712

An Intuitive Approach for Predicting Potential Human Health Risk with the Tox21 10k Library

Sipes NS, Wambaugh JF, Pearce R, Auerbach SS, Wetmore BA, Hsieh JH, Shapiro AJ, Svoboda D, DeVito MJ, Ferguson SS.
Environmental Science & Technology (2017) DOI: https://doi.org/10.1021/acs.est.7b00650 PMID: 27814246

Application of Adverse Outcome Pathways to U.S. EPA's Endocrine Disruptor Screening Program

Browne P, Noyes PD, Casey WM, Dix DJ
Environmental Health Perspectives (2017) DOI: https://doi.org/10.1289/ehp1304 PMID: 28934726

Assessment of Immunotoxicity in Female Fischer 344/N and Sprague Dawley Rats and Female B6C3F1 Mice Exposed to Hexavalent Chromium via the Drinking Water

Kelly A. Shipkowski, Christopher M. Sheth, Matthew J. Smith, Michelle J. Hooth, Kimber L. White Jr. and Dori R. Germolec.
Journal of Immunotoxicology (2017). DOI: https://doi.org/10.1080/1547691X.2017.1394932 PMID: 29141474

Assessment of the DNA Damaging Potential of Environmental Chemicals Using a Quantitative High-throughput Screening Approach to Measure p53 Activation

Witt KL, Hsieh JH, Smith-Roe SL, Xia M, Huang R, Zhao J, Auerbach SS, Hur J, Tice RR.
Environmental and Molecular Mutagenesis (2017) DOI: https://doi.org/10.1002/em.22112 PMID: 28714573

Benchmark Dose Modeling Estimates of the Concentrations of Inorganic Arsenic That Induce Changes to the Neonatal Transcriptome, Proteome, and Epigenome in a Pregnancy Cohort

Julia E. Rager, Scott S. Auerbach, Grace A. Chappell, Elizabeth Martin, Chad M. Thompson, and Rebecca C. Fry
Chemical Research in Toxicology (2017). DOI: https://doi.org/10.1021/acs.chemrestox.7b00221 PMID: 28927277

Beyond the RfD: Broad Application of a Probabilistic Approach to Improve Chemical Dose-Response Assessments for Noncancer Effects

Weihsueh A. Chiu, Daniel A. Axelrad, Chimeddulam Dalaijamts, Chris Dockins, Kan Shao, Andrew J. Shapiro, and Greg Paoli
Environ Health Perspect (2018) DOI: http://dx.doi.org/10.1289/ehp3368 PMID: 29968566

Bisphenol A Exposure, Ovarian Follicle Numbers, and Female Sex Steroid Hormone Levels: Results From a CLARITY-BPA Study

Shreya Patel, Emily Brehm, Liying Gao, Saniya Rattan, Ayelet Ziv-Gal, and Jodi A. Flaws.
Endocrinology (2017) DOI: https://doi.org/10.1210/en.2016-1887 PMID: 28324068

CEBS: A Comprehensive Annotated Database of Toxicological Data

Lea IA, Gong H, Paleja A, Rashid A, Fostel J.
Nucleic Acids Res (2017). DOI: https://doi.org/10.1093/nar/gkw1077 PMID: 27899660

CLARITY-BPA: Effects of Chronic Bisphenol A Exposure on the Immune System: Part 1 – Quantification of the Relative Number and Proportion of Leukocyte Populations in the Spleen and Thymus

Jinpeng Li, Anthony Bach, Robert B. Crawford, Ashwini S. Phadnis-Moghe, Weimin Chen, Shawna D’Ingillo, Natalia Kovalova, Jose E. Suarez-Martinez, Jiajun Zhou, Barbara L. F. Kaplan, and Norbert E. Kaminski.
Toxicology (2018) DOI: https://doi.org/10.1016/j.tox.2018.01.004 PMID: 29428349

CLARITY-BPA: Effects of Chronic Bisphenol A Exposure on the Immune System: Part 2 – Characterization of Lymphoproliferative and Immune Effector Responses by Splenic Leukocytes

Jinpeng Li, Anthony Bach, Robert B. Crawford, Ashwini S. Phadnis-Moghe, Weimin Chen, Shawna D’Ingillo, Natalia Kovalova, Jose E. Suarez-Martinez, Jiajun Zhou, Barbara L. F. Kaplan, and Norbert E. Kaminski.
Toxicology (2018) DOI: https://doi.org/10.1016/j.tox.2018.02.004 PMID: 29427786

Carcinogenic Activity of Pentabrominated Diphenyl Ether Mixture (DE-71) in Rats and Mice

J.K. Dunnick, A.R. Pandiri, B.A. Merrick, G.E. Kissling, H. Cunny, E. Mutlu, S. Waidyanatha, R. Sills, H.L. Hong, TV. Ton, T. Maynor, L. Recio, S.L. Phillips, M.J. Devito, and A. Brix.
Toxicology Reports (2018) DOI: https://doi.org/10.1016/j.toxrep.2018.05.010 PMID: 29868454

Characterization of Zinc Carbonate Basic as a Source of Zinc in a Rodent Study Investigating the Effects of Dietary Deficiency or Excess

Keith E. Levine, Bradley J. Collins, Matthew D. Stout, Michael Wyde, Scott E. Afton, Amal S. Essader, Todd J. Ennis, Kelly E. Amato, Andrea C. McWilliams, Brenda L. Fletcher, Reshan A. Fernando, James M. Harrington, Natasha Catlin, Veronica G. Robinson & Suramya Waidyanatha.
Analytical Letters (2017) DOI: https://doi.org/10.1080/00032719.2017.1293073 PMID: Currently Not Available

Combination of Multiple Neural Crest Migration Assays to Identify Environmental Toxicants from a Proof-of-Concept Chemical Library

Nyffeler J, Dolde X, Krebs A, Pinto-Gil K, Pastor M, Behl M, Waldmann T, Leist M.
Archives of Toxicology (2017) DOI: https://doi.org/10.1007/s00204-017-1977-y PMID: 28477266

Combined Analysis of Oligonucleotide Microarray Data from Transgenic and Knockout Mice Identifies Direct SREBP Target Genes

Jay D. Horton, Nila A. Shah, Janet A. Warrington, Norma N. Anderson, Sahng Wook Park, Michael S. Brown and Joseph L. Goldstein
PNAS (2003) DOI: https://doi.org/10.1073/pnas.1534923100 PMID: 14512514

Comparative Pulmonary Toxicity of Inhaled Metalworking Fluids in Rats and Mice

Ryan KR, Cesta MF, Herbert R, Brix A, Cora M, Witt K, Kissling G, Morgan DL.
Toxicol Ind Health. 2017 DOI: https://doi.org/10.1177/0748233716653912 PMID: 27343050

Cumulative Effects of Antiandrogenic Chemical Mixtures and Their Relevance to Human Health Risk Assessment

Kembra L. Howdeshell, Andrew K. Hotchkiss, L. Earl Gray Jr.
International Journal of Hygiene and Environmental Health (2017) DOI: https://doi.org/10.1016/j.ijheh.2016.11.007 PMID: 27923611

DNA Product Formation in Female Sprague-Dawley Rats Following Polyhalogenated Aromatic Hydrocarbon (PHAH) Exposure

Gao L, Mutlu E, Collins LB, Walker NJ, Hartwell HJ, Olson JR, Sun W, Gold A, Ball LM, Swenberg JA
Chemical Research in Toxicology (2017) DOI: https://doi.org/10.1021/acs.chemrestox.6b00368 PMID: 28207250

Development and Validation of a Computational Model for Androgen Receptor Activity

Kleinstreuer NC, Ceger P, Watt ED, Martin M, Houck K, Browne P, Thomas RS, Casey WM, Dix DJ, Allen D, Sakamuru S, Xia M, Huang R, Judson R.
Chemical Research in Toxicology (2017) DOI: https://doi.org/10.1021/acs.chemrestox.6b00347 PMID: 27933809

Development of Novel Cell Lines for High-Throughput Screening to Detect Estrogen-Related Receptor Alpha Modulators

Christina T. Teng, Jui-Hua Hsieh, Jinghua Zhao, Ruili Huang, Menghang Xia, Negin Martin, Xiaohua Gao, Darlene Dixon, Scott S. Auerbach, Kristine L. Witt, B. Alex Merrick.
SLAS Discovery (2017) DOI: https://doi.org/10.1177/2472555216689772 PMID: 28346099

Developmental Exposure to Low Concentrations of Organophosphate Flame Retardants Causes Life-Long Behavioral Alterations in Zebrafish

Lilah Glazer, Andrew B Hawkey, Corinne N Wells, Meghan Drastal, Kathryn-Ann Odamah, Mamta Behl, and Edward D Levin.
Toxicological Sciences (2018) DOI: http://dx.doi.org/10.1093/toxsci/kfy173 PMID: 29982741

Dose-Response Assessment of the Dermal Toxicity of Virginia Cedarwood Oil in F344/N Rats and B6C3F1/N Mice

Catlin NR, Herbert R, Janardhan K, Hejtmancik MR, Fomby LM, Vallant M, Kissling GE, DeVito MJ.
Food Chem Toxicol. (2016) DOI: http:/dx.doi.org/10.1016/j.fct.2016.10.016 PMID: 27769849

Dose–Response Analysis of RNA-Seq Profiles in Archival Formalin-Fixed Paraffin-Embedded Samples

Susan D. Hester, Virunya Bhat, Brian N. Chorley, Gleta Carswell, Wendell Jones, Leah C. Wehmas, Charles E. Wood
Toxicological Sciences (2016) DOI: https://doi.org/10.1093/toxsci/kfw161 PMID: 27562560

Effects of Continuous Bisphenol A Exposure from Early Gestation on 90 Day Old Rat Testes Function and Sperm Molecular Profiles: A CLARITY-BPA Consortium Study

Edward Dere, Linnea M. Anderson, Susan M. Huse, Daniel J. Spade, Elizabeth McDonnell-Clark, Samantha J. Madnick, Susan J. Hall, Luísa Camacho, Sherry M. Lewis, Michelle M. Vanlandingham, and Kim Boekelheide.
Toxicology and Applied Pharmacology (2018) DOI: https://doi.org/10.1016/j.taap.2018.03.021 PMID: 29596923

Effects of Developmental Exposure to Bisphenol A on Spatial Navigational Learning and Memory in Rats: A CLARITY-BPA Study

Sarah A. Johnson, Angela B. Javurek, Michele S. Painter, Mark R. Ellersieck, Thomas H. Welsh, Jr., Luísa Camacho, Sherry M. Lewis, Michelle M. Vanlandingham, Sherry A. Ferguson, and Cheryl S. Rosenfeld.
Hormones and Behavior (2016) DOI: https://doi.org/10.1016/j.yhbeh.2015.09.005 PMID: 26436835

Effects of Perfluorinated Chemicals on Thyroid Function, Markers of Ovarian Reserve, and Natural Fertility

Natalie M. Crawford, Suzanne E. Fenton, Mark Strynar, Erin P. Hines, David A. Pritchard, and Anne Z. Steiner.
Reproductive Toxicology (2017) DOI: https://doi.org/10.1016/j.reprotox.2017.01.006 PMID: 28111093

Embryo-Fetal Development Studies with The Dietary Supplement Vinpocetine in The Rat and Rabbit

Natasha Catlin, Suramya Waidyanatha, Eve Mylchreest, Lutfiya Miller-Pinsler, Helen Cunny, Paul Foster, Vicki Sutherland, Barry McIntyre
Birth Defects Research (2018) DOI: https://doi.org/10.1002/bdr2.1207 PMID: 29460393

Embryonic Vascular Disruption Adverse Outcomes: Linking High Throughput Signaling Signatures with Functional Consequences

Ellis-Hutchings RG, Settivari RS, McCoy AT, Kleinstreuer N, Franzosa J, Knudsen TB, Carney EW.
Reproductive Toxicology (2017) DOI: https://doi.org/10.1016/j.reprotox.2017.05.005 PMID: 28527947

Evaluation of 4-methylcyclohexanemethanol (MCHM) in a Combined Irritancy and Local Lymph Node Assay (LLNA) in Mice

Johnson VJ, Auerbach SS, Luster MI, Waidyanatha S, Masten SA, Wolfe MS, Burleson FG, Burleson GR, Germolec DR.
Food and Chemical Toxicology (2017) DOI: https://doi.org/10.1016/j.fct.2017.03.034 PMID: 28343035

Evaluation of the Respiratory Tract Toxicity of ortho-Phthalaldehyde, a Proposed Alternative for the Chemical Disinfectant Glutaraldehyde

Natasha R. Catlin, Cynthia J. Willson, Matthew Stout, Grace E. Kissling, Suramya Waidyanatha, Gregory L. Baker, Barry K. Hayden, Michael Wyde.
Inhalation Toxicology (2017). DOI: https://doi.org/10.1080/08958378.2017.1390015 PMID: 29039228

Gene Ontology Mapping as an Unbiased Method for Identifying Molecular Pathways and Processes Affected by Toxicant Exposure: Application to Acute Effects Caused by the Rodent Non-Genotoxic Carcinogen Diethylhexylphthalate

Richard A. Currie, Vincent Bombail, Jason D. Oliver, David J. Moore, Fei Ling Lim, Victoria Gwilliam, Ian Kimber, Kevin Chipman, Jonathan G. Moggs, George Orphanides
Toxicological Sciences (2005) DOI: https://doi.org/10.1093/toxsci/kfi207 PMID: 15901911

Genetic versus Chemoprotective Activation of Nrf2 Signaling: Overlapping yet Distinct Gene Expression Profiles between Keap1 Knockout and Triterpenoid-treated Mice

Melinda S. Yates, Quynh T. Tran, Patrick M. Dolan, William O. Osburn, Soona Shin, Colin C. McCulloch, Jay B. Silkworth, Keiko Taguchi, Masayuki Yamamoto, Charlotte R. Williams, Karen T. Liby, Michael B. Sporn, Thomas R. Sutter, Thomas W. Kensler
Carcinogenesis (2009). DOI: https://doi.org/10.1093/carcin/bgp100 PMID: 19386581

Genome-Wide Binding and Transcriptome Analysis of Human Farnesoid X Receptor in Primary Human Hepatocytes

Le Zhan, Hui-Xin Liu, Yaping Fang, Bo Kong, Yuqi He, Xiao-bo Zhong, Jianwen Fang, Yu-Jui Yvonne Wan, Grace L. Guo
PLoS ONE (2014) DOI: https://doi.org/10.1371/journal.pone.0105930 PMID: 25198545

Gestational Exposure to Perfluorooctanoic Acid (PFOA): Alterations in Motor Related Behaviors

David R. Goulding, Sally S. White, Sandra J. McBride, Suzanne E. Fenton, and G. Jean Harry.
Neurotoxicology (2017) DOI: https://doi.org/10.1016/j.neuro.2016.11.008 PMID: 27888120

Histology Atlas of the Developing Prenatal and Postnatal Mouse Central Nervous System, with Emphasis on Prenatal Days E7.5 to E18.5

Vivian S. Chen, James P. Morrison, Myra F. Southwell, Julie F. Foley, Brad Bolon, and Susan A. Elmore.
Toxicologic Pathology (2017) DOI: https://doi.org/10.1177/0192623317728134 PMID: 28891434

House Dust Endotoxin and Peripheral Leukocyte Counts: Results from Two Large Epidemiologic Studies

Michael B. Fessler, Megan U. Carnes, Päivi M. Salo, Jesse Wilkerson, Richard D. Cohn, Debra King, Jane A. Hoppin, Dale P. Sandler, Greg Travlos, Stephanie J. London, Peter S. Thorne, and Darryl C. Zeldin.
Environmental Health Perspectives (2017). DOI: https://doi.org/10.1289/EHP661 PMID: 28599265

Identification of Estrogen-Related Receptor Alpha Agonists in the Tox21 Compound Library

Caitlin Lynch, Jinghua Zhao, Ruili Huang, Noriko Kanaya, Lauren Bernal, Jui-Hua Hsieh, Scott S Auerbach, Kristine L Witt, B Alex Merrick, Shiuan Chen, Christina T Teng, and Menghang Xia.
Endocrinology (2018). DOI: https://doi.org/10.1210/en.2017-00658 PMID: 29216352

Identification of Novel NRF2-regulated Genes by ChIP-Seq: Influence on Retinoid X Receptor alpha

Brian N. Chorley, Michelle R. Campbell, Xuting Wang, Mehmet Karaca, Deepa Sambandan, Fatu Bangura, Peng Xue, Jingbo Pi, Steven R. Kleeberger, Douglas A. Bell
Nucleic Acids Research (2012). DOI: https://doi.org/10.1093/nar/gks409 PMID: 22581777

Identification of Vascular Disruptor Compounds by Analysis in Zebrafish Embryos and Mouse Embryonic Endothelial Cells

McCollum CW, Conde-Vancells J, Hans C, Vazquez-Chantada M, Kleinstreuer N, Tal T, Knudsen T, Shah SS, Merchant FA, Finnell RH, Gustafsson JÅ, Cabrera R, Bondesson M.
Reproductive Toxicology (2017) DOI: https://doi.org/10.1016/j.reprotox.2016.11.005 PMID: 27838387

Identifying Environmental Chemicals as Agonists of the Androgen Receptor by using a Quantitative High-Throughput Screening Platform

Lynch C, Sakamuru S, Huang R, Stavreva DA, Varticovski L, Hager GL, Judson RS, Houck KA, Kleinstreuer NC, Casey W, Paules RS, Simeonov A, Xia M.
Toxicology (2017) DOI: https://doi.org/10.1016/j.tox.2017.05.001 PMID: 28478275

Immunotoxic Effects of Sodium Tungstate Dihydrate on Female B6C3F1/N Mice When Administered in Drinking Water

Frawley RP, Smith MJ, White KL Jr, Elmore SA, Herbert R, Moore R, Staska LM, Behl M, Hooth MJ, Kissling GE, Germolec DR.
J Immunotoxicol. (2016). DOI: https://doi.org/10.3109/1547691X.2016.1154118 PMID: 27223060

Immunotoxic and Hepatotoxic Effects of Perfluoro-n-decanoic Acid (PFDA) on Female Harlan Sprague–Dawley Rats and B6C3F1/N Mice when Administered by Oral Gavage for 28 Days

Rachel P. Frawley, Matthew Smith, Mark F. Cesta, Schantel Hayes-Bouknight, Chad Blystone, Grace E. Kissling, Shawn Harris & Dori Germolec.
Journal of Immunotoxicology (2018) DOI: https://doi.org/10.1080/1547691X.2018.1445145 PMID: 29514525

Immunotoxicology: a Brief History, Current Status and Strategies for Future Immunotoxicity Assessment

Dori Germolec, Robert Luebke, Andrew Rooney, Kelly Shipkowski, Rob Vandebriel, Henk van Loveren.
Current Opinion in Toxicology (2017). DOI: https://doi.org/10.1016/j.cotox.2017.08.002 PMID: 28989989

Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on the Neonatal Rat Hypothalamic and Hippocampal Transcriptome: A CLARITY-BPA Consortium Study

Sheryl E. Arambula, Scott M. Belcher, Antonio Planchart, Stephen D. Turner, and Heather B. Patisaul.
Endocrinology (2016). DOI: https://doi.org/10.1210/en.2016-1339 PMID: 27571134

Impact of Low-Dose Oral Exposure to Bisphenol A (BPA) on Juvenile and Adult Rat Exploratory and Anxiety Behavior: A CLARITY-BPA Consortium Study

Meghan E. Rebuli, Luísa Camacho, Maria E. Adonay, David M. Reif, David L. Aylor, and Heather B. Patisaul.
Toxicological Sciences (2015) DOI: https://doi.org/10.1093/toxsci/kfv163 PMID: 26209558

In Silico Prediction of Physicochemical Properties of Environmental Chemicals Using Molecular Fingerprints and Machine Learning

Zang Q, Mansouri K, Williams AJ, Judson RS, Allen DG, Casey WM, Kleinstreuer NC.
Journal of Chemical Information and Modeling (2017) DOI: https://doi.org/10.1021/acs.jcim.6b00625 PMID: 28006899

In vitro Cardiotoxicity Assessment of Environmental Chemicals Using an Organotypic Human Induced Pluripotent Stem Cell-Derived Model

Oksana Sirenko, Fabian A. Grimm, Kristen R. Ryan, Yasuhiro Iwata, Weihsueh A. Chiu, Frederick Parham, Jessica A. Wignall, Blake Anson, Evan F. Cromwell, Mamta Behl, Ivan Rusyn, and Raymond R. Tice.
Toxicology and Applied Pharmacology (2017) DOI: https://doi.org/10.1016/j.taap.2017.02.020 PMID: 28259702

Insecticide Use and Breast Cancer Risk among Farmers’ Wives in the Agricultural Health Study

Lawrence S. Engel, Emily Werder, Jaya Satagopan, Aaron Blair, Jane A. Hoppin, Stella Koutros, Catherine C. Lerro, Dale P. Sandler, Michael C. Alavanja, and Laura E. Beane Freeman
Environmental Health Perspectives (2017) DOI: https://doi.org/10.1289/EHP1295 PMID: 28934092

Integrating Drug's Mode of Action into Quantitative Structure-Activity Relationships for Improved Prediction of Drug-Induced Liver Injury

Leihong Wu, Zhichao Liu, Scott Auerbach, Ruili Huang, Minjun Chen, Kristin McEuen, Joshua Xu, Hong Fang, and Weida Tong.
Journal of Chemical Information and Modeling (2017) DOI: https://doi.org/10.1021/acs.jcim.6b00719 PMID: 28350954

Is It Adverse, Nonadverse, Adaptive, or Artifact?

Pandiri AR, Kerlin RL, Mann PC, Everds NE, Sharma AK, Myers LP, Steinbach TJ.
Toxicol Pathol. (2016) DOI: http://dx.doi.org/10.1177/0192623316672352 PMID: 27770107

Low Dose Assessment of the Carcinogenicity of Furan in Male F344/N Nctr Rats in a 2-Year Gavage Study

Von Tungeln LS, Walker NJ, Olson GR, Mendoza MC, Felton RP, Thorn BT, Marques MM, Pogribny IP, Doerge DR, Beland FA.
Food Chem Toxicol. (2016), DOI: http://dx.doi.org/10.1016/j.fct.2016.11.015 PMID: 27871980

Lung Deposition and Clearance of Microparticle and Nanoparticle C60 Fullerene Aggregates in B6C3F1 Mice and Wistar Han Rats Following Nose-Only Inhalation for 13 Weeks

Sayers BC, Walker NJ, Roycroft JH, Germolec DR, Baker GL, Clark ML, Hayden BK, DeFord H, Dill JA, Gupta A, Stout MD.
Toxicology (2016). DOI: https://doi.org/10.1016/j.tox.2015.11.003 PMID: 26612504

Mammary Gland Evaluation in Juvenile Toxicity Studies: Temporal Developmental Patterns in the Male and Female Harlan Sprague-Dawley Rat

Filgo AJ, Foley JF, Puvanesarajah S, Borde AR, Midkiff BR, Reed CE, Chappell VA, Alexander LB, Borde PR, Troester MA, Hayes Bouknight SA, Fenton SE.
Toxicol Pathol (2016), DOI: https://doi.org/10.1177/0192623316663864 PMID: 27613106

Metabolic Disruption Early in Life is Associated With Latent Carcinogenic Activity of Dichloroacetic Acid in Mice

Leah C. Wehmas, Anthony B. DeAngelo, Susan D. Hester, Brian N. Chorley, Gleta Carswell, Greg R. Olson, Michael H. George, Julia H. Carter, Sandra R. Eldridge, Anna Fisher, Beena Vallanat, Charles E. Wood
Toxicological Sciences (2017) DOI: https://doi.org/10.1093/toxsci/kfx146 PMID: 28962523

Metabolism and Disposition of 2-ethylhexyl-p-methoxycinnamate following Oral Gavage and Dermal Exposure in Harlan Sprague Dawley Rats and B6C3F1/N Mice and in Hepatocytes in vitro

Timothy R. Fennell, James M. Mathews, Rodney W. Snyder, Yan Hong, Scott L. Watson, Sherry R. Black, Barry S. McIntyre, and Suramya Waidyanatha.
Xenobiotica (2017). DOI: https://doi.org/10.1080/00498254.2017.1400129 PMID: 29111853

Molecular Effects of 1-Naphthyl-Methylcarbamate and Solar Radiation Exposures on Human Melanocytes

Bianca Ferrucio, Manoela Tiago, Richard D. Fannin, Liwen Liu, Kevin Gerrish, Silvya Stuchi Maria-Engler, Richard S. Paules, and Silvia Berlanga de Moraes Barros.
Toxicology in Vitro (2017) DOI: https://doi.org/10.1016/j.tiv.2016.11.005 PMID: 27829164

Multivariate Models for Prediction of Human Skin Sensitization Hazard

Judy Strickland, Qingda Zang, Michael Paris, David M. Lehmann, David Allen, Neepa Choksi, Joanna Matheson, Abigail Jacobs, Warren Casey, Nicole Kleinstreuer.
Journal of Applied Toxicology (2017) DOI: https://doi.org/10.1002/jat.3366 PMID: 27480324

NIEHS/FDA CLARITY-BPA research program update

Heindel JJ, Newbold RR, Bucher JR, Camacho L, Delclos KB, Lewis SM, Vanlandingham M, Churchwell MI, Twaddle NC, McLellen M, Chidambaram M, Bryant M, Woodling K, Gamboa da Costa G, Ferguson SA, Flaws J, Howard PC, Walker NJ, Zoeller RT, Fostel J, Favaro C, Schug TT.
Reprod Toxicol. (2015) DOI: https://doi.org/10.1016/j.reprotox.2015.07.075 PMID: 26232693

Non-Animal Methods to Predict Skin Sensitization (I): The Cosmetics Europe Database

Sebastian Hoffmann, Nicole Kleinstreuer, Nathalie Alépée, David Allen, Anne Marie Api, Takao Ashikaga, Elodie Clouet, Magalie Cluzel, Bertrand Desprez, Nichola Gellatly, Carsten Goebel, Petra S. Kern, Martina Klaric, Jochen Kühnl, Jon F. Lalko, Silvia Martinozzi-Teissier, Karsten Mewes, Masaaki Miyazawa, Rahul Parakhia, Erwin van Vliet, Qingda Zang, Dirk Petersohn
Critical Reviews in Toxicology (2018) DOI: https://doi.org/10.1080/10408444.2018.1429385 PMID: 29474128

Non-Animal Methods to Predict Skin Sensitization (II): An Assessment of Defined Approaches

Nicole C. Kleinstreuer, Sebastian Hoffmann, Nathalie Alépée, David Allen, Takao Ashikaga, Warren Casey, Elodie Clouet, Magalie Cluzel, Bertrand Desprez, Nichola Gellatly, Carsten Göbel, Petra S. Kern, Martina Klaric, Jochen Kühnl, Silvia Martinozzi-Teissier, Karsten Mewes, Masaaki Miyazawa, Judy Strickland, Erwin van Vliet, Qingda Zang, Dirk Petersohn.
Critical Reviews in Toxicology (2018) DOI: https://doi.org/10.1080/10408444.2018.1429386 PMID: 29474122

ORIO (Online Resource for Integrative Omics): A Web-Based Platform for Rapid Integration of Next Generation Sequencing Data

Lavender CA, Shapiro AJ, Burkholder AB, Bennett BD, Adelman K, Fargo DC.
Nucleic Acids Research (2017) DOI: https://doi.org/10.1093/nar/gkx270 PMID: 27933809

Pred-Skin: A Fast and Reliable Web Application to Assess Skin Sensitization Effect of Chemicals

Rodolpho C. Braga, Vinicius M. Alves, Eugene N. Muratov, Judy Strickland∥, Nicole Kleinstreuer, Alexander Trospsha, and Carolina Horta Andrade.
Journal of Chemical Information and Modeling (2017) DOI: https://doi.org/10.1021/acs.jcim.7b00194 PMID: 28459556

Prediction of Skin Sensitization Potency Using Machine Learning Approaches

Zang Q, Paris M, Lehmann DM, Bell S, Kleinstreuer N, Allen D, Matheson J, Jacobs A, Casey W, Strickland J.
Journal of Applied Toxicology (2017) DOI: https://doi.org/10.1002/jat.3424 PMID: 28074598

Prenatal Arsenic Exposure and the Epigenome: Altered microRNAs Associated With Innate and Adaptive Immune Signaling in Newborn Cord Blood

Julia E. Rager, Kathryn A. Bailey, Lisa Smeester, Sloane K. Miller, Joel S. Parker, Jessica E. Laine, Zuzana Drobná, Jenna Currier, Christelle Douillet, Andrew F. Olshan, Marisela Rubio-Andrade, Miroslav Stýblo, Gonzalo García-Vargas, Rebecca C. Fry
Environmental and Molecular Mutagenesis (2014) DOI: https://doi.org/10.1002/em.21842 PMID: 24327377

Proteomic Analysis of Primary Human Airway Epithelial Cells Exposed to the Respiratory Toxicant Diacetyl

Foster MW, Gwinn WM, Kelly FL, Brass DM, Valente AM, Moseley MA, Thompson JW, Morgan DL, Palmer SM.
Journal of Proteome Research (2017) DOI: https://doi.org/10.1021/acs.jproteome.6b00672 PMID: 27966365

QSAR Models of Human Data can Enrich or Replace LLNA Testing for Human Skin Sensitization

Vinicius M. Alves, Stephen J. Capuzzi, Eugene N. Muratov, Rodolpho C. Braga, Thomas E. Thornton, Denis Fourches, Judy Strickland, Nicole Kleinstreuer, Carolina H. Andrade and Alexander Tropsha.
Green Chemistry (2016) DOI: https://doi.org/10.1039/c6gc01836j PMID: 28630595

RNA-Seq Profiling Reveals Novel Hepatic Gene Expression Pattern in Aflatoxin B1 Treated Rats

Merrick BA, Phadke DP, Auerbach SS, Mav D, Stiegelmeyer SM, Shah RR, Tice RR.
PLoS One (2013) DOI: https://doi.org/10.1371/journal.pone.0061768 PMID: 23630614

Real-time Cell Toxicity Profiling of Tox21 10K Compounds Reveals Cytotoxicity Dependent Toxicity Pathway Linkage

Hsieh JH, Huang R, Lin JA, Sedykh A, Zhao J, Tice RR, Paules RS, Xia M, Auerbach SS.
PLoS One (2017) DOI: https://doi.org/10.1371/journal.pone.0177902 PMID: 28531190

Respiratory, Dermal, and Eye Irritation Symptoms Associated with Corexit™ EC9527A/EC9500A following the Deepwater Horizon Oil Spill: Findings from the GuLF STUDY

Craig J. McGowan, Richard K. Kwok, Lawrence S. Engel, Mark R. Stenzel, Patricia A. Stewart, and Dale P. Sandler
Environmental Health Perspectives (2017). DOI: https://doi.org/10.1289/EHP1677 PMID: 28934097

Screening a Mouse Liver Gene Expression Compendium Identifies Modulators of the Aryl hydrocarbon Receptor (AhR)

Keiyu Oshida, Naresh Vasani, Russell S. Thomas, Dawn Applegate, Frank J. Gonzalez, Lauren M. Aleksunes, Curtis D. Klaassen and J. Christopher Corton
Toxicology (2015) DOI: https://doi.org/10.1016/j.tox.2015.07.005 PMID: 26215100

Screening for Angiogenic Inhibitors in Zebrafish to Evaluate A Predictive Model for Developmental Vascular Toxicity

Tamara Tal, Claire Kilty, Andrew Smith, Carlie LaLone, Brendán Kennedy, AlanTennant, Catherine W. McCollum, Maria Bondesson, Thomas Knudsen, Stephanie Padilla, and Nicole Kleinstreuer.
Reproductive Toxicology (2017) DOI: https://doi.org/10.1016/j.reprotox.2016.12.004 PMID: 28007540

Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon

Tao Yang, Niousha Ahmari, Jordan T. Schmidt, Ty Redler, Rebeca Arocha, Kevin Pacholec, Kacy L. Magee, Wendi Malphurs, Jennifer L. Owen, Gregory A. Krane, Eric Li, Gary P. Wang, Thomas W. Vickroy, Mohan K. Raizada, Christopher J. Martyniuk, and Jasenka Zubcevic.
Frontiers in Physiology (2017) DOI: https://doi.org/10.3389/fphys.2017.00220 PMID: 28446880

Standardisation of Defined Approaches for Skin Sensitisation Testing to Support Regulatory Use and International Adoption: Position of the International Cooperation on Alternative Test Methods

Casati S, Aschberger K, Barroso J, Casey W, Delgado I, Kim TS, Kleinstreuer N, Kojima H, Lee JK, Lowit A, Park HK, Régimbald-Krnel MJ, Strickland J, Whelan M, Yang Y, Zuang V.
Archives of Toxicology (2017). DOI: https://doi.org/10.1007/s00204-017-2097-4 PMID: 29127450

Statistical Guidance for Reviewers of Toxicologic Pathology

Keith R. Shockley and Grace E. Kissling
Toxicologic Pathology (2018) DOI: http://dx.doi.org/10.1177/0192623318785097 PMID: 29966505

Supplemental Material for NTP Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives.

Pelch KE, Wignall JA, Goldstone AE, Ross PK, Blain RB, Shapiro AJ, Holmgren SD, Hsieh J-H, Svoboda D, Auerbach SS, Parham FM, Masten SA, Thayer KA.
2017 NTP Research Report on Biological Activity of Bisphenol A (BPA) Structural Analogues and Functional Alternatives. NTP RR 4. Research Triangle Park, NC: National Toxicology Program. (4): 1-78. https://doi.org/10.22427/NTP-RR-4

Systems Biology for Organotypic Cell Cultures

Grego S, Dougherty ER, Alexander FJ, Auerbach SS, Berridge BR, Bittner ML, Casey W, Cooley PC, Dash A, Ferguson SS, Fennell TR, Hawkins BT, Hickey AJ, Kleensang A, Liebman MNJ, Martin F, Maull EA, Paragas J, Qiao GG, Ramaiahgari S, Sumner SJ, Yoon M.
ALTEX (2017) DOI: https://doi.org/10.14573/altex.1608221 PMID: 27846345

Tetrabromobisphenol A Activates the Hepatic Interferon Pathway in Rats

Dunnick JK, Morgan DL, Elmore SA, Gerrish K, Pandiri A, Ton TV, Shockley KR, Merrick BA.
Toxicology Letters (2017) DOI: https://doi.org/10.1016/j.toxlet.2016.11.019 PMID: 27914987

The Association of Arsenic Exposure and Metabolism With Type 1 and Type 2 Diabetes in Youth: The SEARCH Case-Control Study

Grau-Perez M, Kuo CC, Spratlen M, Thayer KA, Mendez MA, Hamman RF, Dabelea D, Adgate JL, Knowler WC, Bell RA, Miller FW, Liese AD, Zhang C, Douillet C, Drobná Z, Mayer-Davis EJ, Styblo M, Navas-Acien A.
Diabetes Care (2017) DOI: https://doi.org/10.2337/dc16-0810 PMID: 27810988

The Concordance between RNA-seq and Microarray Data Depends on Chemical Treatment And Transcript Abundance

Charles Wang, Binsheng Gong, Pierre R Bushel, Jean Thierry-Mieg, Danielle Thierry-Mieg, Joshua Xu, Hong Fang, Huixiao Hong, Jie Shen, Zhenqiang Su, Joe Meehan, Xiaojin Li, Lu Yang, Haiqing Li, Paweł P Łabaj, David P Kreil, Dalila Megherbi, Stan Gaj, Florian Caiment, Joost van Delft, Jos Kleinjans, Andreas Scherer, Viswanath Devanarayan, Jian Wang, Yong Yang, Hui-Rong Qian, Lee J Lancashire, Marina Bessarabova, Yuri Nikolsky, Cesare Furlanello, Marco Chierici, Davide Albanese, Giuseppe Jurman, Samantha Riccadonna, Michele Filosi, Roberto Visintainer, Ke K Zhang, Jianying Li, Jui-Hua Hsieh, Daniel L Svoboda, James C Fuscoe, Youping Deng, Leming Shi, Richard S Paules, Scott S Auerbach, and Weida Tong.
Nature Biotechnology (2014) DOI: https://doi.org/10.1038/nbt.3001 PMID: 25150839

The Diacetyl-Exposed Human Airway Epithelial Secretome: New Insights into Flavoring-Induced Airways Disease

Brass DM, Gwinn WM, Valente AM, Kelly FL, Brinkley CD, Nagler AE, Moseley MA, Morgan DL, Palmer SM, Foster MW.
American Journal of Respiratory Cell and Molecular Biology (2017) DOI: https://doi.org/10.1165/rcmb.2016-0372OC PMID: 28248570

The Genomic Analysis of the Impact of Steroid Receptor Coactivators Ablation on Hepatic Metabolism

Jae-Wook Jeong, Inseok Kwak, Kevin Y. Lee, Lisa D. White, Xiao-Ping Wang, F. C. Brunicardi, Bert W. O’Malley, Francesco J. DeMayo
Molecular Endocrinology (2006) DOI: https://doi.org/10.1210/me.2005-0407 PMID: 16423883

Three-Dimensional (3D) HepaRG Spheroid Model with Physiologically Relevant Xenobiotic Metabolism Competence and Hepatocyte Functionality for Liver Toxicity Screening

Sreenivasa C. Ramaiahgari, Suramya Waidyanatha, Darlene Dixon, Michael J. DeVito, Richard S. Paules, Stephen S. Ferguson.
Toxicological Sciences (2017) DOI: https://doi.org/10.1093/toxsci/kfx122 PMID: 28633424

Toxicogenomics of the Flame Retardant tris(2-butoxyethyl)Phosphate in HepG2 Cells using RNA-seq

Boris V. Krivoshiev, Gerrit T.S. Beemster, Katrien Sprangers, Bart Cuypers, Kris Laukens, Ronny Blust and Steven J. Husson.
Toxicology in Vitro (2018) DOI: https://doi.org/10.1016/j.tiv.2017.10.011 PMID: 29024780

Transcriptomic Profiling of Rat Liver Samples in A Comprehensive Study Design by RNA-Seq

Binsheng Gong, Charles Wang, Zhenqiang Su, Huixiao Hong, Jean Thierry-Mieg, Danielle Thierry-Mieg, Leming Shi, Scott S. Auerbach, Weida Tong, and Joshua Xu
Scientific Data (2014) DOI: https://doi.org/10.1038/sdata.2014.21 PMID: 25977778

httk: R Package for High-Throughput Toxicokinetics

Robert G. Pearce, R. Woodrow Setzer, Cory L. Strope, Nisha S. Sipes, John F. Wambaugh.
Journal of Statistical Software (2017) DOI: https://doi.org/10.18637/jss.v079.i04 PMID: Not available