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Organ Sites with Neoplasia

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  • Organ: Zymbal Gland
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-084 39156-41-7 2,4-Diaminoanisole sulfate Rats Female Dosed-Feed Zymbal Gland Positive (SEBACEOUS ADENOCARCINOMA) Neoplastic Lesions
TR-084 39156-41-7 2,4-Diaminoanisole sulfate Rats Male Dosed-Feed Zymbal Gland Positive (SQUAMOUS CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA) Neoplastic Lesions
TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Rats Male Dosed-Feed Zymbal Gland Positive (CARCINOMA) Neoplastic Lesions
TR-100 135-20-6 Cupferron Mice Female Dosed-Feed Zymbal Gland Positive CARCINOMA Neoplastic Lesions
TR-100 135-20-6 Cupferron Rats Female Dosed-Feed Zymbal Gland Positive CARCINOMA Neoplastic Lesions
TR-092 122-66-7 Hydrazobenzene Rats Male Dosed-Feed Zymbal Gland Positive (SQUAMOUS CELL PAPILLOMA OR CARCINOMA) Neoplastic Lesions
TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Rats Female Dosed-Feed Zymbal Gland Positive (CARCINOMA) Neoplastic Lesions
TR-047 139-65-1 4,4'-Thiodianiline Rats Female Dosed-Feed Zymbal Gland Positive SQUAMOUS CELL PAPILLOMA OR CARCINOMA Neoplastic Lesions
TR-047 139-65-1 4,4'-Thiodianiline Rats Male Dosed-Feed Zymbal Gland Positive SQUAMOUS CELL PAPILLOMA OR CARCINOMA Neoplastic Lesions
TR-057 789-61-7 beta-Thioguanidine deoxyriboside Rats Female Intraperitoneal Injection Zymbal Gland Positive (CARCINOMA) Neoplastic Lesions
TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (thio-tepa) Rats Female Intraperitoneal Injection Zymbal Gland Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (thio-tepa) Rats Male Intraperitoneal Injection Zymbal Gland Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
TR-118 602-87-9 5-Nitroacenaphthene Rats Female Dosed-Feed Zymbal Gland Positive (CARCINOMA) Neoplastic Lesions
TR-118 602-87-9 5-Nitroacenaphthene Rats Male Dosed-Feed Zymbal Gland Positive (CARCINOMA) Neoplastic Lesions
TR-127 99-59-2 5-Nitro-o-anisidine Rats Female Dosed-Feed Zymbal Gland Positive (CARCINOMA) Neoplastic Lesions
TR-127 99-59-2 5-Nitro-o-anisidine Rats Male Dosed-Feed Zymbal Gland Positive (CARCINOMA) Neoplastic Lesions
TR-128 91-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate Rats Female Dosed-Feed Zymbal Gland Positive (CARCINOMA) Neoplastic Lesions
TR-128 91-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate Rats Male Dosed-Feed Zymbal Gland Positive (CARCINOMA) Neoplastic Lesions
TR-289 71-43-2 Benzene Mice Female Gavage Zymbal Gland Clear Evidence SQUAMOUS CELL CARCINOMA 0/43 0/32 1/37 3/31 Neoplastic Lesions
TR-289 71-43-2 Benzene Mice Male Gavage Zymbal Gland Clear Evidence SQUAMOUS CELL CARCINOMA 0/43 1/34 4/40 21/39 Neoplastic Lesions
TR-289 71-43-2 Benzene Rats Female Gavage Zymbal Gland Clear Evidence CARCINOMA 0/45 5/40 5/44 14/46 Neoplastic Lesions
TR-289 71-43-2 Benzene Rats Male Gavage Zymbal Gland Clear Evidence CARCINOMA 2/32 6/46 10/42 Neoplastic Lesions
TR-285 569-61-9 C.I. Basic red 9 monohydrochloride Rats Female Dosed-Feed Zymbal Gland Clear Evidence CARCINOMA 0/50 2/50 7/50 Neoplastic Lesions
TR-285 569-61-9 C.I. Basic red 9 monohydrochloride Rats Male Dosed-Feed Zymbal Gland Clear Evidence CARCINOMA 1/50 1/50 13/50 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Male Dosed-Water Zymbal Gland Clear Evidence ADENOMA 0/59 4/45 11/75 9/60; CARCINOMA 0/59 7/45 14/75 21/60 Neoplastic Lesions
TR-374 556-52-5 Glycidol Rats Male Gavage Zymbal Gland Clear Evidence CARCINOMA 1/50 3/50 6/50 Neoplastic Lesions
TR-359 298-81-7 8-Methoxypsoralen Rats Male Gavage Zymbal Gland Clear Evidence CARCINOMA 1/50 7/50 4/49 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Female Dosed-Water Zymbal Gland Clear Evidence ADENOMA 0/60 3/45 4/75 3/60 OR CARCINOMA 1/60 10/45 17/75 13/60 COMBINED 1/60 12/45 21/75 16/60 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Female Dosed-Water Zymbal Gland Clear Evidence ADENOMA 0/60 4/45 11/75 12/60 OR CARCINOMA 0/60 2/45 22/75 35/60 COMBINED 0/57 6/45 32/75 42/60 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Male Dosed-Water Zymbal Gland Clear Evidence ADENOMA 1/60 1/45 13/75 16/60 OR CARCINOMA 0/60 2/45 21/75 23/60 COMBINED 1/60 3/45 32/75 36/60 Neoplastic Lesions
TR-397 2429-74-5 C.I. Direct blue 15 Rats Female Dosed-Water Zymbal Gland Clear Evidence ADENOMA 0/50 1/35 5/65 3/50, CARCINOMA 0/50 4/35 7/65 14/50, COMBINED 0/50 4/35 11/65 17/50 Neoplastic Lesions
TR-397 2429-74-5 C.I. Direct blue 15 Rats Male Dosed-Water Zymbal Gland Clear Evidence ADENOMA 0/50 2/35 2/65 4/50, CARCINOMA 1/50 3/35 8/65 17/50, COMBINED 1/50 5/35 10/65 20/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Female Topical Application Zymbal Gland Clear Evidence ADENOMA 0/50 7/50 3/50 OR ADENOCARCINOMA 1/50 2/50 19/50 COMBINED 1/50 9/50 22/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Male Topical Application Zymbal Gland Clear Evidence ADENOMA 0/50 1/50 7/50 OR ADENOCARCINOMA 0/50 8/50 29/50 COMBINED 0/50 9/50 35/50 Neoplastic Lesions
TR-405 6459-94-5 C.I. Acid red 114 Rats Female Dosed-Water Zymbal Gland Clear Evidence ADENOMA 0/50 0/35 2/65 6/50, CARCINOMA 0/50 3/35 17/65 13/50, COMBINED 0/50 3/35 18/65 19/50 Neoplastic Lesions
TR-405 6459-94-5 C.I. Acid red 114 Rats Male Dosed-Water Zymbal Gland Clear Evidence ADENOMA 0/50 0/35 1/65 1/50, CARCINOMA 0/50 0/35 7/65 6/50, COMBINED 0/50 0/35 8/65 7/50 Neoplastic Lesions
TR-384 96-18-4 1,2,3-Trichloropropane Rats Female Gavage Zymbal Gland Clear Evidence CARCINOMA 0/60 1/59 0/60 4/60 Neoplastic Lesions
TR-384 96-18-4 1,2,3-Trichloropropane Rats Male Gavage Zymbal Gland Clear Evidence CARCINOMA 0/60 0/60 0/59 3/60 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Mice Female Inhalation Zymbal Gland Clear Evidence CARCINOMA 0/50 0/50 0/50 3/50 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Male Dosed-Feed Zymbal Gland Clear Evidence ADENOMA 0/51 0/53 1/51 3/55 2/60 OR CARCINOMA 2/51 1/53 3/51 2/55 15/60 COMBINED 2/51 1/53 4/51 5/55 15/60 Neoplastic Lesions