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Organ Sites with Neoplasia

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  • Organ: Vascular System (Spleen)
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-130 142-04-1 Aniline hydrochloride Rats Male Dosed-Feed Vascular System (Spleen) Positive HEMANGIOSARCOMA; SARCOMA OR FIBROSARCOMA Neoplastic Lesions
TR-349 87-86-5 Pentachlorophenol, Dowicide EC-7 Mice Female Dosed-Feed Vascular System (Spleen) Clear Evidence HEMANGIOSARCOMA 0/34 0/50 2/50 2/47 Neoplastic Lesions
TR-349 87-86-5 Pentachlorophenol, technical Mice Female Dosed-Feed Vascular System (Spleen) Some Evidence HEMANGIOSARCOMA 0/33 1/50 3/47 Neoplastic Lesions
TR-351 20265-96-7 p-Chloroaniline hydrochloride Mice Male Gavage Vascular System (Spleen) Some Evidence HEMANGIOSARCOMA 3/50 2/47 0/49 5/49 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Male Topical Application Vascular System (Spleen) Clear Evidence HEMANGIOMA 0/50 0/50 3/50 OR HEMANGIOSARCOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 4/50 Neoplastic Lesions