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Organ Sites with Neoplasia

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  • Organ: Uterus/Cervix
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-019 366-70-1 Procarbazine hydrochloride Mice Female Intraperitoneal Injection Uterus/Cervix Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-032 3778-73-2 Isophosphamide Rats Female Intraperitoneal Injection Uterus/Cervix Positive (LEIOMYOSARCOMA) Neoplastic Lesions
TR-081 512-56-1 Trimethylphosphate Mice Female Gavage Uterus/Cervix Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-083 1596-84-5 Daminozide Rats Female Dosed-Feed Uterus/Cervix Positive (ADENOCARCINOMA, LEIOMYOSARCOMA) Neoplastic Lesions
TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Rats Female Dosed-Feed Uterus/Cervix Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-047 139-65-1 4,4'-Thiodianiline Rats Female Dosed-Feed Uterus/Cervix Positive ADENOCARCINOMA Neoplastic Lesions
TR-055 107-06-2 1,2-Dichloroethane Mice Female Gavage Uterus/Cervix Positive (POLYP, SARCOMA) Neoplastic Lesions
TR-078 21416-87-5 ICRF-159 Rats Female Intraperitoneal Injection Uterus/Cervix Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-128 91-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate Rats Female Dosed-Feed Uterus/Cervix Positive (POLYP) Neoplastic Lesions
TR-143 2243-62-1 1,5-Naphthalenediamine Rats Female Dosed-Feed Uterus/Cervix Positive (POLYP) Neoplastic Lesions
TR-326 75-21-8 Ethylene oxide Mice Female Inhalation Uterus/Cervix Clear Evidence ADENOCARCINOMA 0/49 1/47 5/49 Neoplastic Lesions
TR-374 556-52-5 Glycidol Mice Female Gavage Uterus/Cervix Clear Evidence CARCINOMA 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 3/50 2/50 COMBINED 0/50 3/50 3/50 Neoplastic Lesions
TR-384 96-18-4 1,2,3-Trichloropropane Mice Female Gavage Uterus/Cervix Clear Evidence ADENOMA 0/50 1/50 0/51 3/54; ADENOCARCINOMA 0/50 4/50 3/51 6/54; POLYP 0/50 2/50 1/51 6/54 Neoplastic Lesions
TR-346 75-00-3 Chloroethane Mice Female Inhalation Uterus/Cervix Clear Evidence ENDOMETRIAL CARCINOMA 0/49 43/50 Neoplastic Lesions
TR-363 74-96-4 Bromoethane (ethyl bromide) Mice Female Inhalation Uterus/Cervix Clear Evidence ADENOMA 0/50 1/50 1/47 6/48, ADENOCARCINOMA 0/50 2/50 3/47 19/48, OR SQUAMOUS CELL CARCINOMA 0/50 1/50 1/47 3/48 COMBINED 0/50 4/50 5/47 27/48 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Female Dosed-Water Uterus/Cervix Clear Evidence ADENOMA 0/60 3/45 1/75 2/59 OR CARCINOMA 0/60 1/45 1/75 0/59 COMBINED 0/60 4/45 2/75 2/59 Neoplastic Lesions
TR-397 2429-74-5 C.I. Direct blue 15 Rats Female Dosed-Water Uterus/Cervix Clear Evidence ADENOMA 0/50 0/35 1/65 1/50, ADENOCARCINOMA 1/50 0/35 0/65 3/50, COMBINED 1/50 0/35 1/65 4/50 Neoplastic Lesions
TR-510 51-79-6 Urethane Mice Female Dosed-Water Uterus/Cervix Clear Evidence HEMANGIOSARCOMA 0/48 0/47 0/48 2/46 Neoplastic Lesions
TR-521 1746-01-6 TEF evaluation (TCDD) Rats Female Gavage Uterus/Cervix Clear Evidence SQUAMOUS CELL CARCINOMA 0/53 0/54 0/53 0/53 5/53 0/53 2/50 Neoplastic Lesions