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Organ Sites with Neoplasia

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  • Organ: Urinary Bladder
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-006 139-13-9 Nitrilotriacetic acid (NTA) Rats Female Dosed-Feed Urinary Bladder Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
TR-006 18662-53-8 Nitrilotriacetic acid trisodium monohydrate Rats Female Dosed-Feed Urinary Bladder Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
TR-094 119-34-6 4-Amino-2-nitrophenol Rats Male Dosed-Feed Urinary Bladder Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
TR-089 134-29-2 o-Anisidine hydrochloride Mice Female Dosed-Feed Urinary Bladder Positive (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
TR-089 134-29-2 o-Anisidine hydrochloride Mice Male Dosed-Feed Urinary Bladder Positive (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
TR-089 134-29-2 o-Anisidine hydrochloride Rats Female Dosed-Feed Urinary Bladder Positive (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
TR-089 134-29-2 o-Anisidine hydrochloride Rats Male Dosed-Feed Urinary Bladder Positive (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
TR-063 95-83-0 4-Chloro-o-phenylenediamine Rats Female Dosed-Feed Urinary Bladder Positive (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
TR-063 95-83-0 4-Chloro-o-phenylenediamine Rats Male Dosed-Feed Urinary Bladder Positive (TRANSITIONAL CELL PAPILLOMA, TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
TR-142 120-71-8 p-Cresidine Mice Female Dosed-Feed Urinary Bladder Positive (CARCINOMA) Neoplastic Lesions
TR-142 120-71-8 p-Cresidine Mice Male Dosed-Feed Urinary Bladder Positive (CARCINOMA) Neoplastic Lesions
TR-142 120-71-8 p-Cresidine Rats Female Dosed-Feed Urinary Bladder Positive (PAPILLOMA, CARCINOMA) Neoplastic Lesions
TR-142 120-71-8 p-Cresidine Rats Male Dosed-Feed Urinary Bladder Positive (PAPILLOMA, CARCINOMA) Neoplastic Lesions
TR-153 636-21-5 o-Toluidine hydrochloride Rats Female Dosed-Feed Urinary Bladder Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
TR-164 86-30-6 N-Nitrosodiphenylamine Rats Female Dosed-Feed Urinary Bladder Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
TR-164 86-30-6 N-Nitrosodiphenylamine Rats Male Dosed-Feed Urinary Bladder Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
TR-179 105-11-3 p-Benzoquinone dioxime Rats Female Dosed-Feed Urinary Bladder Positive (TRANSITIONAL CELL PAPILLOMA OR CARCINOMA OR SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
TR-105 102-50-1 m-Cresidine Rats Female Gavage Urinary Bladder Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
TR-105 102-50-1 m-Cresidine Rats Male Gavage Urinary Bladder Positive (TRANSITIONAL CELL CARCINOMA) Neoplastic Lesions
TR-216 2432-99-7 11-Aminoundecanoic acid Rats Male Dosed-Feed Urinary Bladder Positive TRANSITIONAL CELL CARCINOMA 0/48 0/48 7/49 Neoplastic Lesions
TR-234 57-06-7 Allyl isothiocyanate Rats Male Gavage Urinary Bladder Positive TRANSITIONAL CELL PAPILLOMA 0/49 2/49 4/49 Neoplastic Lesions
TR-245 108-78-1 Melamine Rats Male Dosed-Feed Urinary Bladder Positive TRANSITIONAL CELL CARCINOMA 0/45 0/50 8/49 Neoplastic Lesions
TR-269 542-75-6 1,3-Dichloropropene (Telone II) Mice Female Gavage Urinary Bladder Clear Evidence TRANSITIONAL CELL CARCINOMA 0/50 8/50 21/48 Neoplastic Lesions
TR-299 2475-45-8 C.I. Disperse blue 1 Rats Female Dosed-Feed Urinary Bladder Clear Evidence TRANSITIONAL CELL PAPILLOMA 0/48 0/50 9/50 15/48 OR TRANSITIONAL CELL CARCINOMA 0/48 0/50 10/50 13/48 COMBINED 0/48 0/50 15/50 21/48; LEIOMYOMA 0/48 0/50 1/50 4/48 OR LEIOMYOSARCOMA 0/48 0/50 2/50 23/48 COMBINED 0/48 0/50 3/50 26/48; SQUAMOUS CELL PAPILLOMA 0/48 0/50 1/50 7/48 OR SQUAMOUS CELL CARCINOMA 0/48 0/50 1/50 4/48 COMBINED 0/48 0/50 1/50 11/48 Neoplastic Lesions
TR-299 2475-45-8 C.I. Disperse blue 1 Rats Male Dosed-Feed Urinary Bladder Clear Evidence TRANSITIONAL CELL PAPILLOMA 0/49 0/50 8/50 4/49 OR TRANSITIONAL CELL CARCINOMA 0/49 0/50 4/50 8/49 COMBINED 0/49 0/50 10/50 11/49; LEIOMYOMA 0/49 0/50 7/50 41/49 OR LEIOMYOSARCOMA 0/49 0/50 6/50 41/49 COMBINED 0/49 0/50 7/50 41/49; SQUAMOUS CELL PAPILLOMA 0/49 0/50 1/50 3/49 OR SQUAMOUS CELL CARCINOMA 0/49 0/50 1/50 1/49 COMBINED 0/49 0/50 2/50 4/49 Neoplastic Lesions
TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats Female Dosed-Feed Urinary Bladder Clear Evidence TRANSITIONAL CELL PAPILLOMA 0/50 2/40 7/60 9/46; TRANSITIONAL CELL CARCINOMA 0/50 0/40 8/60 16/46 Neoplastic Lesions
TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats Male Dosed-Feed Urinary Bladder Clear Evidence TRANSITIONAL CELL PAPILLOMA 0/50 1/38 2/58 8/50; TRANSITIONAL CELL CARCINOMA 0/50 0/38 1/58 4/50 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Male Dosed-Feed Urinary Bladder Clear Evidence TRANSITIONAL CELL PAPILLOMA 0/51 0/53 1/51 2/55 1/59 OR TRANSITIONAL CELL CARCINOMA 0/51 0/53 0/51 1/55 1/59 COMBINED 0/51 0/53 1/51 3/55 2/59 Neoplastic Lesions
TR-457 599-79-1 Salicylazosulfapyridine Rats Female Gavage Urinary Bladder Some Evidence TRANSITIONAL CELL PAPILLOMA 0/49 0/50 2/50 0/50 Neoplastic Lesions
TR-457 599-79-1 Salicylazosulfapyridine Rats Female Gavage Urinary Bladder Some Evidence TRANSITIONAL CELL PAPILLOMA 0/49 0/50 2/50 0/50 Neoplastic Lesions
TR-457 599-79-1 Salicylazosulfapyridine Rats Male Gavage Urinary Bladder Some Evidence (CORE STUDY) TRANSITIONAL CELL PAPILLOMA 0/50 0/49 2/50 6/50 Neoplastic Lesions
TR-457 599-79-1 Salicylazosulfapyridine Rats Male Gavage Urinary Bladder Some Evidence (CORE STUDY) TRANSITIONAL CELL PAPILLOMA 0/50 0/49 2/50 6/50 Neoplastic Lesions
TR-416 91-23-6 o-Nitroanisole Rats Female Dosed-Feed Urinary Bladder Clear Evidence (STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/58 2/59 1/60, TRANSITIONAL CELL CARCINOMA 0/58 28/59 48/60 Neoplastic Lesions
TR-416 91-23-6 o-Nitroanisole Rats Male Dosed-Feed Urinary Bladder Clear Evidence (STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/59 9/59 1/60, TRANSITIONAL CELL CARCINOMA 0/59 27/59 50/60, SQUAMOUS CELL PAPILLOMA 0/59 0/59 4/60, SQUAMOUS CELL CARCINOMA 0/59 0/59 6/60, SARCOMA 0/59 2/59 9/60 Neoplastic Lesions
TR-494 84-65-1 Anthraquinone Rats Female Dosed-Feed Urinary Bladder Clear Evidence TRANSITIONAL EPITHELIAL PAPILLOMA OR CARCINOMA 0/49 0/49 0/49 1/50 2/49 Neoplastic Lesions
TR-494 84-65-1 Anthraquinone Rats Male Dosed-Feed Urinary Bladder Some Evidence TRANSITIONAL EPITHELIAL PAPILLOMA 0/50 1/50 3/50 7/50 3/49 Neoplastic Lesions
TR-563 89-82-7 Pulegone Rats Female Gavage Urinary Bladder Some Evidence Papilloma 0/50 0/49 1/50 3/47 papilloma or carcinoma 0/50 0/49 1/50 5/47 Neoplastic Lesions