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Organ Sites with Neoplasia

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  • Organ: Thyroid Gland Follicular Cell
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-084 39156-41-7 2,4-Diaminoanisole sulfate Mice Female Dosed-Feed Thyroid Gland Follicular Cell Positive ADENOMA OR CARCINOMA Neoplastic Lesions
TR-084 39156-41-7 2,4-Diaminoanisole sulfate Mice Male Dosed-Feed Thyroid Gland Follicular Cell Positive ADENOMA Neoplastic Lesions
TR-084 39156-41-7 2,4-Diaminoanisole sulfate Rats Female Dosed-Feed Thyroid Gland Follicular Cell Positive ADENOMA OR CARCINOMA Neoplastic Lesions
TR-084 39156-41-7 2,4-Diaminoanisole sulfate Rats Male Dosed-Feed Thyroid Gland Follicular Cell Positive ADENOMA OR CARCINOMA Neoplastic Lesions
TR-089 134-29-2 o-Anisidine hydrochloride Rats Male Dosed-Feed Thyroid Gland Follicular Cell Positive ADENOMA OR CARCINOMA Neoplastic Lesions
TR-047 139-65-1 4,4'-Thiodianiline Mice Female Dosed-Feed Thyroid Gland Follicular Cell Positive ADENOMA, CARCINOMA, ADENOMA OR CARCINOMA Neoplastic Lesions
TR-047 139-65-1 4,4'-Thiodianiline Mice Male Dosed-Feed Thyroid Gland Follicular Cell Positive CARCINOMA Neoplastic Lesions
TR-047 139-65-1 4,4'-Thiodianiline Rats Female Dosed-Feed Thyroid Gland Follicular Cell Positive CARCINOMA Neoplastic Lesions
TR-047 139-65-1 4,4'-Thiodianiline Rats Male Dosed-Feed Thyroid Gland Follicular Cell Positive CARCINOMA Neoplastic Lesions
TR-129 2489-77-2 Trimethylthiourea Rats Female Dosed-Feed Thyroid Gland Follicular Cell Positive CARCINOMA Neoplastic Lesions
TR-143 2243-62-1 1,5-Naphthalenediamine Mice Male Dosed-Feed Thyroid Gland Follicular Cell Positive ADENOMA Neoplastic Lesions
TR-149 105-55-5 N,N'-Diethylthiourea Rats Female Dosed-Feed Thyroid Gland Follicular Cell Positive ADENOMA OR CARCINOMA Neoplastic Lesions
TR-149 105-55-5 N,N'-Diethylthiourea Rats Male Dosed-Feed Thyroid Gland Follicular Cell Positive CARCINOMA Neoplastic Lesions
TR-186 101-61-1 4,4'-Methylenebis(N,N-dimethyl)benzenamine Rats Female Dosed-Feed Thyroid Gland Follicular Cell Positive CARCINOMA Neoplastic Lesions
TR-186 101-61-1 4,4'-Methylenebis(N,N-dimethyl)benzenamine Rats Male Dosed-Feed Thyroid Gland Follicular Cell Positive CARCINOMA Neoplastic Lesions
TR-112 17026-81-2 3-Amino-4-ethoxyacetanilide Mice Male Dosed-Feed Thyroid Gland Follicular Cell Positive CARCINOMA Neoplastic Lesions
TR-205 101-80-4 4,4'-Oxydianiline Mice Female Dosed-Feed Thyroid Gland Follicular Cell Positive ADENOMA Neoplastic Lesions
TR-205 101-80-4 4,4'-Oxydianiline Rats Female Dosed-Feed Thyroid Gland Follicular Cell Positive ADENOMA OR CARCINOMA Neoplastic Lesions
TR-205 101-80-4 4,4'-Oxydianiline Rats Male Dosed-Feed Thyroid Gland Follicular Cell Positive ADENOMA OR CARCINOMA Neoplastic Lesions
TR-209 1746-01-6 2,3,7,8-Tetrachlorodibenzo-p-dioxin Mice Female Gavage Thyroid Gland Follicular Cell Positive ADENOMA 0/69 3/50 1/47 5/46 Neoplastic Lesions
TR-209 1746-01-6 2,3,7,8-Tetrachlorodibenzo-p-dioxin Rats Male Gavage Thyroid Gland Follicular Cell Positive ADENOMA 1/69 5/48 6/50 10/50 Neoplastic Lesions
TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Mice Female Dosed-Water Thyroid Gland Follicular Cell Positive ADENOMA 0/50 1/47 13/50 Neoplastic Lesions
TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Mice Male Dosed-Water Thyroid Gland Follicular Cell Positive ADENOMA 0/47 3/49 16/49 Neoplastic Lesions
TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Rats Female Dosed-Water Thyroid Gland Follicular Cell Positive ADENOMA 0/47 2/47 17/48 Neoplastic Lesions
TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Rats Male Dosed-Water Thyroid Gland Follicular Cell Positive CARCINOMA 0/49 0/47 7/48 Neoplastic Lesions
TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Mice Female Gavage Thyroid Gland Follicular Cell Clear Evidence ADENOMA 8/50 12/49 18/49 OR CARCINOMA 0/50 0/49 2/49 COMBINED 8/50 12/49 15/49 Neoplastic Lesions
TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Rats Female Gavage Thyroid Gland Follicular Cell Clear Evidence ADENOMA 0/50 6/50 3/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 6/50 6/50 Neoplastic Lesions
TR-331 24382-04-5 Malonaldehyde, sodium salt Rats Female Gavage Thyroid Gland Follicular Cell Clear Evidence ADENOMA 2/50 0/50 5/50 OR CARCINOMA 0/50 1/50 2/50 COMBINED 2/50 1/50 7/50 Neoplastic Lesions
TR-331 24382-04-5 Malonaldehyde, sodium salt Rats Male Gavage Thyroid Gland Follicular Cell Clear Evidence ADENOMA 3/50 3/49 9/50 OR CARCINOMA 1/50 5/49 5/50 COMBINED 4/50 8/49 13/50 Neoplastic Lesions
TR-285 569-61-9 C.I. Basic red 9 monohydrochloride Rats Female Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence ADENOMA 0/47 0/48 4/50 OR CARCINOMA 0/47 2/48 2/50 COMBINED 0/47 2/48 6/50 Neoplastic Lesions
TR-285 569-61-9 C.I. Basic red 9 monohydrochloride Rats Male Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence ADENOMA 0/49 0/46 9/44 OR CARCINOMA 0/49 5/46 18/44 Neoplastic Lesions
TR-374 556-52-5 Glycidol Rats Female Gavage Thyroid Gland Follicular Cell Clear Evidence ADENOMA 0/50 1/50 0/49 OR CARCINOMA 0/50 0/50 3/49 COMBINED 0/50 1/50 3/49 Neoplastic Lesions
TR-374 556-52-5 Glycidol Rats Male Gavage Thyroid Gland Follicular Cell Clear Evidence ADENOMA 0/50 2/50 2/50 OR CARCINOMA 1/50 2/50 5/50 COMBINED 1/50 4/50 6/50 Neoplastic Lesions
TR-340 5634-39-9 Iodinated glycerol Rats Male Gavage Thyroid Gland Follicular Cell Some Evidence CARCINOMA 0/49 5/49 1/49 Neoplastic Lesions
TR-388 96-45-7 Ethylene thiourea (ETU) Rats Female Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence ADENOMA 1/50 6/44 28/49 CARCINOMA 2/50 1/44 8/49 Neoplastic Lesions
TR-388 96-45-7 Ethylene thiourea (ETU) Rats Male Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence ADENOMA 0/49 9/46 23/50 CARCINOMA 1/49 3/46 26/50 Neoplastic Lesions
TR-407 2425-85-6 C.I. Pigment red 3 Mice Male Dosed-Feed Thyroid Gland Follicular Cell Some Evidence ADENOMA 0/50 0/49 1/50 5/50 Neoplastic Lesions
TR-388 96-45-7 Ethylene thiourea (ETU) Mice Female Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence ADENOMA 0/50 2/50 35/50 CARCINOMA 0/50 0/50 8/50 Neoplastic Lesions
TR-388 96-45-7 Ethylene thiourea (ETU) Mice Male Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence ADENOMA 0/50 1/49 26/50 CARCINOMA 1/50 0/49 5/50 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Rats Female Inhalation Thyroid Gland Follicular Cell Clear Evidence ADENOMA 1/49 1/50 0/50 3/50 OR CARCINOMA 0/49 0/50 1/50 2/50 COMBINED 1/49 1/50 1/50 5/50 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Rats Male Inhalation Thyroid Gland Follicular Cell Clear Evidence ADENOMA 0/50 2/50 2/49 4/50 OR CARCINOMA 0/50 0/50 2/49 1/50 COMBINED 0/50 2/50 4/49 5/50 Neoplastic Lesions
TR-436 75-65-0 tert-Butyl alcohol Mice Female Dosed-Water Thyroid Gland Follicular Cell Some Evidence ADENOMA 2/58 3/60 2/59 9/59 Neoplastic Lesions
TR-443 604-75-1 Oxazepam Mice Female Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence ADENOMA 0/50 4/50 5/50 6/50 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Female Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence ADENOMA 0/50 0/51 2/53 3/52 OR CARCINOMA 0/50 0/51 0/53 1/52 COMBINED 0/50 0/51 2/53 4/52 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Male Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence ADENOMA 0/51 1/53 2/51 2/55 7/59 OR CARCINOMA 0/51 1/53 4/51 1/55 2/59 COMBINED 0/51 2/53 6/51 3/55 9/59 Neoplastic Lesions
TR-487 115-11-7 Isobutene Rats Male Inhalation Thyroid Gland Follicular Cell Some Evidence CARCINOMA 1/48 0/48 0/48 5/50 Neoplastic Lesions
TR-516 693-98-1 2-Methylimidazole Mice Male Dosed-Feed Thyroid Gland Follicular Cell Some Evidence ADENOMA 0/50 1/50 0/50 7/50 Neoplastic Lesions
TR-476 125-33-7 Primidone (primaclone) Mice Male Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence ADENOMA 0/49 3/48 3/50 6/50 Neoplastic Lesions
TR-516 693-98-1 2-Methylimidazole Rats Female Dosed-Feed Thyroid Gland Follicular Cell Clear Evidence ADENOMA 0/49 0/48 0/42 5/48 CARCINOMA 1/49 1/48 1/42 7/48 COMBINED 1/49 1/48 1/42 11/48 Neoplastic Lesions
TR-516 693-98-1 2-Methylimidazole Rats Male Dosed-Feed Thyroid Gland Follicular Cell Some Evidence ADENOMA OR CARCINOMA 1/48 2/46 1/43 5/50 Neoplastic Lesions
TR-517 7775-09-9 Water disinfection byproducts (Sodium chlorate) Rats Female Dosed-Water Thyroid Gland Follicular Cell Some Evidence ADENOMA OR CARCINOMA 1/47 0/47 1/43 4/46 Neoplastic Lesions
TR-517 7775-09-9 Water disinfection byproducts (Sodium chlorate) Rats Male Dosed-Water Thyroid Gland Follicular Cell Some Evidence CARCINOMA 0/47 0/44 0/43 4/47 ADENOMA OR CARCINOMA 1/47 0/44 0/43 6/47 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Rats Female Dosed-Water Thyroid Gland Follicular Cell Clear Evidence adenoma 0/48 3/48 3/46 1/46 5/47 follicular cell carcinoma 0/48 0/48 2/46 3/46 3/47 follicular cell adenoma or carcinoma 0/48 3/48 5/46 4/46 8/47 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Rats Male Dosed-Water Thyroid Gland Follicular Cell Clear Evidence adenoma 2/47 1/42 3/48 3/47 8/46 follicular cell carcinoma 0/47 2/42 3/48 1/47 5/46 follicular cell adenoma or carcinoma 2/47 3/42 6/48 4/47 13/46 Neoplastic Lesions
TR-589 32534-81-9 Pentabromodiphenyl Oxide (Technical) (DE 71) Rats Male Gavage Thyroid Gland Follicular Cell Clear Evidence adenoma 1/45 3/45 2/48 6/46 Neoplastic Lesions