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Organ Sites with Neoplasia

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  • Organ: Thyroid Gland
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Male Gavage Thyroid Gland Clear Evidence Follicular cell adenoma 0/50 3/50 4/50 4/50 Neoplastic Lesions
TR-594 98-56-6 p-Chloro-a,a,a-trifluorotoluene Rats Male Inhalation Thyroid Gland Some Evidence C-cell adenoma (2/50, 5/49, 3/49, 12/50) Neoplastic Lesions
TR-594 98-56-6 p-Chloro-a,a,a-trifluorotoluene Rats Female Inhalation Thyroid Gland Some Evidence C-cell adenoma (2/50, 8/50, 8/50, 14/50) Neoplastic Lesions
TR-575 79-06-1 Acrylamide Rats Female Dosed-Water Thyroid Gland Clear Evidence follicular cell adenoma 0/48 0/48 1/48 0/48 2/47 follicular cell carcinoma 0/48 0/48 1/48 3/48 2/47 follicular cell adenoma or carcinoma 0/48 0/48 2/48 3/48 4/47 Neoplastic Lesions
TR-575 79-06-1 Acrylamide Rats Male Dosed-Water Thyroid Gland Clear Evidence follicular cell adenoma 0/47 1/48 1/47 1/48 3/48 follicular cell carcinoma 1/47 2/48 3/47 6/48 6/48 follicular cell adenoma or carcinoma 1/47 3/48 4/47 6/48 9/48 Neoplastic Lesions
TR-578 90045-36-6 Ginkgo biloba extract Mice Male Gavage Thyroid Gland Clear Evidence follicular cell, adenoma 0/50, 0/50, 2/50, 2/50 Neoplastic Lesions
TR-578 90045-36-6 Ginkgo biloba extract Rats Female Gavage Thyroid Gland Some Evidence follicular cell, adenoma 1/49, 0/50, 3/49, 1/49; follicular cell, carcinoma 0/49, 0/50, 1/49, 1/49 Neoplastic Lesions
TR-578 90045-36-6 Ginkgo biloba extract Rats Male Gavage Thyroid Gland Some Evidence follicular cell, adenoma 2/50, 1/50, 3/49, 5/45 Neoplastic Lesions