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Organ Sites with Neoplasia

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  • Organ: Subcutaneous Tissue
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-029 129-15-7 2-Methyl-1-nitroanthraquinone Rats Female Dosed-Feed Subcutaneous Tissue Positive (FIBROMA) Neoplastic Lesions
TR-029 129-15-7 2-Methyl-1-nitroanthraquinone Rats Male Dosed-Feed Subcutaneous Tissue Positive (FIBROMA) Neoplastic Lesions
TR-081 512-56-1 Trimethylphosphate Rats Male Gavage Subcutaneous Tissue Positive (FIBROMA) Neoplastic Lesions
TR-055 107-06-2 1,2-Dichloroethane Rats Male Gavage Subcutaneous Tissue Positive (FIBROMA) Neoplastic Lesions
TR-153 636-21-5 o-Toluidine hydrochloride Rats Male Dosed-Feed Subcutaneous Tissue Positive (FIBROMA) Neoplastic Lesions
TR-201 1746-01-6 2,3,7,8-Tetrachlorodibenzo-p-dioxin Mice Female Topical Application Subcutaneous Tissue Positive FIBROSARCOMA 2/41 8/27 Neoplastic Lesions
TR-210 106-93-4 1,2-Dibromoethane Mice Female Inhalation Subcutaneous Tissue Positive FIBROSARCOMA 0/50 5/50 11/50 Neoplastic Lesions
TR-251 26471-62-5 2,4- & 2,6-Toluene diisocyanate Rats Female Gavage Subcutaneous Tissue Positive FIBROMA 0/50 1/50 3/50 OR FIBROSARCOMA 2/50 0/50 2/50 COMBINED 2/50 1/50 5/50 Neoplastic Lesions
TR-251 26471-62-5 2,4- & 2,6-Toluene diisocyanate Rats Male Gavage Subcutaneous Tissue Positive FIBROMA 3/50 3/50 9/50 OR FIBROSARCOMA 0/50 3/50 3/50 COMBINED 3/50 6/50 12/50 Neoplastic Lesions
TR-285 569-61-9 C.I. Basic red 9 monohydrochloride Rats Female Dosed-Feed Subcutaneous Tissue Clear Evidence FIBROMA 0/50 15/50 10/50 Neoplastic Lesions
TR-285 569-61-9 C.I. Basic red 9 monohydrochloride Rats Male Dosed-Feed Subcutaneous Tissue Clear Evidence FIBROMA 2/50 20/50 16/50 Neoplastic Lesions
TR-374 556-52-5 Glycidol Mice Female Gavage Subcutaneous Tissue Clear Evidence SARCOMA 0/50 1/50 6/50 OR FIBROSARCOMA 0/50 2/50 3/50 COMBINED 0/50 3/50 9/50 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Mice Female Inhalation Subcutaneous Tissue Clear Evidence SARCOMA 0/50 11/50 11/50 18/50 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Male Dosed-Feed Subcutaneous Tissue Clear Evidence FIBROMA 2/51 8/53 11/51 15/55 7/60 OR FIBROSARCOMA 0/51 1/53 0/51 0/55 1/60 OR SARCOMA 0/51 0/53 2/51 3/55 2/60 COMBINED 2/51 9/53 13/51 16/55 10/60 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice Female Dosed-Feed Subcutaneous Tissue Clear Evidence SARCOMA 0/52 1/50 4/51 11/50 Neoplastic Lesions