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Organ Sites with Neoplasia

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  • Organ: Spleen
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-020 80-08-0 4,4'-Sulfonyldianiline (Dapsone) Rats Male Dosed-Feed Spleen Positive (FIBROMA, FIBROSARCOMA, SARCOMA) Neoplastic Lesions
TR-130 142-04-1 Aniline hydrochloride Rats Female Dosed-Feed Spleen Positive SARCOMA Neoplastic Lesions
TR-153 636-21-5 o-Toluidine hydrochloride Rats Female Dosed-Feed Spleen Positive (SARCOMA) Neoplastic Lesions
TR-153 636-21-5 o-Toluidine hydrochloride Rats Male Dosed-Feed Spleen Positive (SARCOMA) Neoplastic Lesions
TR-154 103-33-3 Azobenzene Rats Female Dosed-Feed Spleen Positive (FIBROSARCOMA) Neoplastic Lesions
TR-154 103-33-3 Azobenzene Rats Male Dosed-Feed Spleen Positive (SARCOMA, FIBROSARCOMA) Neoplastic Lesions
TR-225 5160-02-1 D & C red no. 9 Rats Male Dosed-Feed Spleen Positive SARCOMA 0/50 0/50 26/48 Neoplastic Lesions
TR-351 20265-96-7 p-Chloroaniline hydrochloride Rats Male Gavage Spleen Clear Evidence FIBROSARCOMA 0/49 1/50 2/50 17/50, HEMANGIOSARCOMA 0/49 0/50 0/50 4/50, OR OSTEOSARCOMA 0/49 0/50 1/50 19/50 COMBINED 0/49 1/50 3/50 38/50 Neoplastic Lesions
TR-360 121-69-7 N,N-Dimethylaniline Rats Male Gavage Spleen Some Evidence SARCOMA 0/49 0/49 3/50 OR OSTEOSARCOMA 0/49 0/49 1/50 COMBINED 0/49 0/49 4/50 Neoplastic Lesions
TR-510 51-79-6 Urethane Mice Female Dosed-Water Spleen Clear Evidence HEMANGIOSARCOMA 0/48 0/45 1/47 4/46 Neoplastic Lesions