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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:
- Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
- Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
- Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
| Exact Match | Publication No. | CASRN | Test Article Name | Species | Strain | Sex | Route | Organ | Level of Evidence | Organ Site Call | Tumor Type/Incidence | Finding Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Yes | TR-020 | 80-08-0 | 4,4'-Sulfonyldianiline (Dapsone) | Rats | F344/N | Male | Dosed-Feed | Spleen | Positive | Positive | (FIBROMA, FIBROSARCOMA, SARCOMA) | Neoplastic Lesions |
| Yes | TR-130 | 142-04-1 | Aniline hydrochloride | Rats | F344/N | Female | Dosed-Feed | Spleen | Positive | Positive | SARCOMA | Neoplastic Lesions |
| Yes | TR-153 | 636-21-5 | o-Toluidine hydrochloride | Rats | F344/N | Female | Dosed-Feed | Spleen | Positive | Positive | (SARCOMA) | Neoplastic Lesions |
| Yes | TR-153 | 636-21-5 | o-Toluidine hydrochloride | Rats | F344/N | Male | Dosed-Feed | Spleen | Positive | Positive | (SARCOMA) | Neoplastic Lesions |
| Yes | TR-154 | 103-33-3 | Azobenzene | Rats | F344/N | Female | Dosed-Feed | Spleen | Positive | Positive | (FIBROSARCOMA) | Neoplastic Lesions |
| Yes | TR-154 | 103-33-3 | Azobenzene | Rats | F344/N | Male | Dosed-Feed | Spleen | Positive | Positive | (SARCOMA, FIBROSARCOMA) | Neoplastic Lesions |
| Yes | TR-225 | 5160-02-1 | D&C Red No. 9 | Rats | F344/N | Male | Dosed-Feed | Spleen | Positive | Positive | SARCOMA 0/50 0/50 26/48 | Neoplastic Lesions |
| Yes | TR-360 | 121-69-7 | N,N-Dimethylaniline | Rats | F344/N | Male | Gavage | Spleen | Some Evidence | Some Evidence | SARCOMA 0/49 0/49 3/50 OR OSTEOSARCOMA 0/49 0/49 1/50 COMBINED 0/49 0/49 4/50 | Neoplastic Lesions |
| Yes | TR-351 | 20265-96-7 | p-Chloroaniline hydrochloride | Rats | F344/N | Male | Gavage | Spleen | Clear Evidence | Clear Evidence | FIBROSARCOMA 0/49 1/50 2/50 17/50, HEMANGIOSARCOMA 0/49 0/50 0/50 4/50, OR OSTEOSARCOMA 0/49 0/50 1/50 19/50 COMBINED 0/49 1/50 3/50 38/50 | Neoplastic Lesions |
| Yes | TR-542 | 98-82-8 | Cumene | Mice | B6C3F1/N | Male | Inhalation | Spleen | Clear Evidence | Equivocal Evidence | hemangioscaroma | May Have Been Related |
| Yes | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Spleen | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/48 0/45 1/47 4/46 | Neoplastic Lesions |
| Yes | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Spleen | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/46 0/46 1/46 3/46 | Neoplastic Lesions |
| Yes | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Spleen | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/46 0/46 3/46 | Neoplastic Lesions |
| Exact Match | Publication No. | CASRN | Test Article Name | Species | Strain | Sex | Route | Organ | Level of Evidence | Organ Site Call | Tumor Type/Incidence | Finding Type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No | TR-020 | 80-08-0 | 4,4'-Sulfonyldianiline (Dapsone) | Mice | B6C3F1 | Female | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
| No | TR-020 | 80-08-0 | 4,4'-Sulfonyldianiline (Dapsone) | Mice | B6C3F1 | Male | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
| No | TR-020 | 80-08-0 | 4,4'-Sulfonyldianiline (Dapsone) | Rats | F344/N | Female | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
| Yes | TR-020 | 80-08-0 | 4,4'-Sulfonyldianiline (Dapsone) | Rats | F344/N | Male | Dosed-Feed | Spleen | Positive | Positive | (FIBROMA, FIBROSARCOMA, SARCOMA) | Neoplastic Lesions |
| No | TR-130 | 142-04-1 | Aniline hydrochloride | Mice | B6C3F1 | Female | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
| No | TR-130 | 142-04-1 | Aniline hydrochloride | Mice | B6C3F1 | Male | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
| Yes | TR-130 | 142-04-1 | Aniline hydrochloride | Rats | F344/N | Female | Dosed-Feed | Spleen | Positive | Positive | SARCOMA | Neoplastic Lesions |
| No | TR-130 | 142-04-1 | Aniline hydrochloride | Rats | F344/N | Male | Dosed-Feed | Vascular System (Spleen) | Positive | Positive | HEMANGIOSARCOMA; SARCOMA OR FIBROSARCOMA | Neoplastic Lesions |
| No | TR-154 | 103-33-3 | Azobenzene | Mice | B6C3F1 | Female | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
| No | TR-154 | 103-33-3 | Azobenzene | Mice | B6C3F1 | Male | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
| Yes | TR-154 | 103-33-3 | Azobenzene | Rats | F344/N | Female | Dosed-Feed | Spleen | Positive | Positive | (FIBROSARCOMA) | Neoplastic Lesions |
| Yes | TR-154 | 103-33-3 | Azobenzene | Rats | F344/N | Male | Dosed-Feed | Spleen | Positive | Positive | (SARCOMA, FIBROSARCOMA) | Neoplastic Lesions |
| No | TR-542 | 98-82-8 | Cumene | Rats | F344/N | Male | Inhalation | Kidney Tubular Cell | Clear Evidence | Clear Evidence | renal tubule, adenoma or carcinoma (2/50, 5/50, 8/50, 7/50) | Neoplastic Lesions |
| No | TR-542 | 98-82-8 | Cumene | Mice | B6C3F1/N | Female | Inhalation | Liver | Clear Evidence | Clear Evidence | adenoma (18/50, 23/50, 27/50, 29/50); adenoma or carcinoma (25/50, 26/50, 29/50, 36/50) | Neoplastic Lesions |
| No | TR-542 | 98-82-8 | Cumene | Mice | B6C3F1/N | Female | Inhalation | Lung | Clear Evidence | Clear Evidence | alveolar/bronchiolar adenoma (1/50, 26/50, 36/50, 38/50); alveolar/bronchiolar carcinoma (3/50, 16/50, 20/50, 34/50); alveolar/bronchiolar adenoma or carcinoma (4/50, 31/50, 42/50, 46/50) | Neoplastic Lesions |
| No | TR-542 | 98-82-8 | Cumene | Mice | B6C3F1/N | Male | Inhalation | Lung | Clear Evidence | Clear Evidence | alveolar/bronchiolar adenoma (13/50, 31/50, 31/50, 29/50); alveolar/bronchiolar carcinoma (9/50, 19/50, 32/50, 33/50); alveolar/bronchiolar adenoma or carcinoma (19/50, 38/50, 42/50, 43/50) | Neoplastic Lesions |
| No | TR-542 | 98-82-8 | Cumene | Rats | F344/N | Male | Inhalation | Nasal Cavity | Clear Evidence | Clear Evidence | respiratory epithelium, adenoma (0/50, 7/50, 18/49, 10/50) | Neoplastic Lesions |
| No | TR-542 | 98-82-8 | Cumene | Rats | F344/N | Female | Inhalation | Nasal Cavity | Some Evidence | Some Evidence | respiratory epithelium, adenoma (0/50, 5/48, 4/50, 3/50) | Neoplastic Lesions |
| Yes | TR-542 | 98-82-8 | Cumene | Mice | B6C3F1/N | Male | Inhalation | Spleen | Clear Evidence | Equivocal Evidence | hemangioscaroma | May Have Been Related |
| No | TR-542 | 98-82-8 | Cumene | Rats | F344/N | Male | Inhalation | Testis | Clear Evidence | Equivocal Evidence | interstitial cell adenoma | May Have Been Related |
| No | TR-542 | 98-82-8 | Cumene | Mice | B6C3F1/N | Male | Inhalation | Thyroid Gland Follicular Cell | Clear Evidence | Equivocal Evidence | adenoma | May Have Been Related |
| No | TR-225 | 5160-02-1 | D&C Red No. 9 | Mice | B6C3F1 | Female | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
| No | TR-225 | 5160-02-1 | D&C Red No. 9 | Mice | B6C3F1 | Male | Dosed-Feed | Unspecified | Negative | Not applicable | Not applicable | |
| No | TR-225 | 5160-02-1 | D&C Red No. 9 | Rats | F344/N | Female | Dosed-Feed | Liver | Equivocal Evidence | Equivocal | NEOPLASTIC NODULE 1/50 1/50 5/50 | Neoplastic Lesions |
| No | TR-225 | 5160-02-1 | D&C Red No. 9 | Rats | F344/N | Male | Dosed-Feed | Liver | Positive | Positive | NEOPLASTIC NODULE 0/50 6/50 7/49 | Neoplastic Lesions |
| Yes | TR-225 | 5160-02-1 | D&C Red No. 9 | Rats | F344/N | Male | Dosed-Feed | Spleen | Positive | Positive | SARCOMA 0/50 0/50 26/48 | Neoplastic Lesions |
| No | TR-510 | 64-17-5 | Ethanol | Mice | MV | Female | Dosed-Water | Unspecified | Inadequate Study | Not applicable | Not applicable | |
| No | TR-510 | 64-17-5 | Ethanol | Mice | MV | Male | Dosed-Water | Unspecified | Inadequate Study | Not applicable | Not applicable | |
| No | TR-360 | 121-69-7 | N,N-Dimethylaniline | Mice | B6C3F1 | Male | Gavage | Unspecified | No Evidence | Not applicable | Not applicable | |
| No | TR-360 | 121-69-7 | N,N-Dimethylaniline | Rats | F344/N | Female | Gavage | Unspecified | No Evidence | Not applicable | Not applicable | |
| No | TR-360 | 121-69-7 | N,N-Dimethylaniline | Mice | B6C3F1 | Female | Gavage | Forestomach | Equivocal Evidence | Equivocal Evidence | SQUAMOUS CELL PAPILLOMA 2/50 2/50 8/50 | Neoplastic Lesions |
| Yes | TR-360 | 121-69-7 | N,N-Dimethylaniline | Rats | F344/N | Male | Gavage | Spleen | Some Evidence | Some Evidence | SARCOMA 0/49 0/49 3/50 OR OSTEOSARCOMA 0/49 0/49 1/50 COMBINED 0/49 0/49 4/50 | Neoplastic Lesions |
| No | TR-153 | 636-21-5 | o-Toluidine hydrochloride | Mice | B6C3F1 | Female | Dosed-Feed | Liver | Positive | Positive | (ADENOMA OR CARCINOMA) | Neoplastic Lesions |
| No | TR-153 | 636-21-5 | o-Toluidine hydrochloride | Rats | F344/N | Female | Dosed-Feed | Mammary Gland | Positive | Positive | (ADENOMA OR FIBROADENOMA) | Neoplastic Lesions |
| No | TR-153 | 636-21-5 | o-Toluidine hydrochloride | Rats | F344/N | Male | Dosed-Feed | Mesothelium (Abdominal Cavity/Tunica Vaginalis) | Positive | Positive | MESOTHELIOMA | Neoplastic Lesions |
| Yes | TR-153 | 636-21-5 | o-Toluidine hydrochloride | Rats | F344/N | Female | Dosed-Feed | Spleen | Positive | Positive | (SARCOMA) | Neoplastic Lesions |
| Yes | TR-153 | 636-21-5 | o-Toluidine hydrochloride | Rats | F344/N | Male | Dosed-Feed | Spleen | Positive | Positive | (SARCOMA) | Neoplastic Lesions |
| No | TR-153 | 636-21-5 | o-Toluidine hydrochloride | Rats | F344/N | Male | Dosed-Feed | Subcutaneous Tissue | Positive | Positive | (FIBROMA) | Neoplastic Lesions |
| No | TR-153 | 636-21-5 | o-Toluidine hydrochloride | Rats | F344/N | Female | Dosed-Feed | Urinary Bladder | Positive | Positive | (TRANSITIONAL CELL CARCINOMA) | Neoplastic Lesions |
| No | TR-153 | 636-21-5 | o-Toluidine hydrochloride | Mice | B6C3F1 | Male | Dosed-Feed | Vascular System (Unspecified) | Positive | Positive | HEMANGIOSARCOMA | Neoplastic Lesions |
| No | TR-351 | 20265-96-7 | p-Chloroaniline hydrochloride | Mice | B6C3F1 | Female | Gavage | Unspecified | No Evidence | Not applicable | Not applicable | |
| No | TR-351 | 20265-96-7 | p-Chloroaniline hydrochloride | Rats | F344/N | Male | Gavage | Adrenal Gland Medulla | Clear Evidence | Equivocal Evidence | PHEOCHROMOCYTOMA 13/49 14/48 15/48 26/49 | May Have Been Related |
| No | TR-351 | 20265-96-7 | p-Chloroaniline hydrochloride | Rats | F344/N | Female | Gavage | Adrenal Gland Medulla | Equivocal Evidence | Equivocal Evidence | PHEOCHROMOCYTOMA 2/50 3/50 1/50 6/50 | Neoplastic Lesions |
| No | TR-351 | 20265-96-7 | p-Chloroaniline hydrochloride | Mice | B6C3F1 | Male | Gavage | Liver | Some Evidence | Some Evidence | ADENOMA 9/50 15/49 10/50 44/50 OR CARCINOMA 3/50 7/49 11/50 17/50 COMBINED 11/50 21/49 20/50 21/50 | Neoplastic Lesions |
| Yes | TR-351 | 20265-96-7 | p-Chloroaniline hydrochloride | Rats | F344/N | Male | Gavage | Spleen | Clear Evidence | Clear Evidence | FIBROSARCOMA 0/49 1/50 2/50 17/50, HEMANGIOSARCOMA 0/49 0/50 0/50 4/50, OR OSTEOSARCOMA 0/49 0/50 1/50 19/50 COMBINED 0/49 1/50 3/50 38/50 | Neoplastic Lesions |
| No | TR-351 | 20265-96-7 | p-Chloroaniline hydrochloride | Rats | F344/N | Female | Gavage | Spleen | Equivocal Evidence | Equivocal Evidence | FIBROSARCOMA 0/50 0/50 1/50 0/50 OR OSTEOSARCOMA 0/50 0/50 0/50 1/50 COMBINED 0/50 0/50 1/50 1/50 | Neoplastic Lesions |
| No | TR-351 | 20265-96-7 | p-Chloroaniline hydrochloride | Mice | B6C3F1 | Male | Gavage | Vascular System (Liver) | Some Evidence | Some Evidence | HEMANGIOSARCOMA 2/50 2/50 1/49 6/50 | Neoplastic Lesions |
| No | TR-351 | 20265-96-7 | p-Chloroaniline hydrochloride | Mice | B6C3F1 | Male | Gavage | Vascular System (Spleen) | Some Evidence | Some Evidence | HEMANGIOSARCOMA 3/50 2/47 0/49 5/49 | Neoplastic Lesions |
| No | TR-510 | 51-79-6 | Urethane | Mice | MV | Male | Dosed-Water | Forestomach | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/46 2/47 3/44 5/45 | Neoplastic Lesions |
| No | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | ADENOMA 3/48 10/48 8/48 21/48 CARCINOMA 0/48 1/48 11/48 11/48 COMBINED 3/48 11/48 19/48 30/48 | Neoplastic Lesions |
| No | TR-510 | 51-79-6 | Urethane | Mice | MV | Male | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | ADENOMA 3/47 11/47 25/47 28/47 CARCINOMA 0/47 1/47 7/47 16/47 COMBINED 3/47 12/47 30/47 38/47 | Neoplastic Lesions |
| No | TR-510 | 51-79-6 | Urethane | Mice | MV | Male | Dosed-Water | Heart | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/48 0/48 1/47 5/48 | Neoplastic Lesions |
| No | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/48 0/47 1/47 7/47 ADENOMA 5/48 10/47 19/47 18/47 ADENOMA OR CARCINOMA 5/48 11/47 20/47 19/47 | Neoplastic Lesions |
| No | TR-510 | 51-79-6 | Urethane | Mice | MV | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 1/46 2/47 5/46 13/44 ADENOMA 7/46 13/47 17/46 17/44 ADENOMA OR CARCINOMA 12/46 18/47 24/46 23/44 | Neoplastic Lesions |
| No | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 6/48 17/48 29/47 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 4/48 13/48 19/47 COMBINED 6/48 8/48 28/48 39/47 | Neoplastic Lesions |
| No | TR-510 | 51-79-6 | Urethane | Mice | MV | Male | Dosed-Water | Lung | Clear Evidence | Clear Evidence | ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 17/48 22/47 34/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 1/48 9/47 9/48 COMBINED 5/48 18/48 29/47 37/48 | Neoplastic Lesions |
| No | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | ADENOACANTHOMA 0/47 1/46 1/46 11/48 ADENOCARCINOMA 4/47 3/46 3/46 11/48 COMBINED 4/47 4/46 4/46 22/48 | Neoplastic Lesions |
| No | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Ovary | Clear Evidence | Clear Evidence | BENIGN GRANULOSA CELL TUMOR 0/48 0/46 2/46 3/39 MALIGNANT GRANULOSA CELL TUMOR 0/48 0/46 0/46 3/39 COMBINED 0/48 0/46 2/46 5/39 | Neoplastic Lesions |
| No | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/48 0/48 0/46 2/48 | Neoplastic Lesions |
| No | TR-510 | 51-79-6 | Urethane | Mice | MV | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/47, 1/48, 5/47, 8/48) | Neoplastic Lesions |
| Yes | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Spleen | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/48 0/45 1/47 4/46 | Neoplastic Lesions |
| No | TR-510 | 51-79-6 | Urethane | Mice | MV | Female | Dosed-Water | Uterus/Cervix | Clear Evidence | Clear Evidence | HEMANGIOSARCOMA 0/48 0/47 0/48 2/46 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) ADENOMA 4/48 7/48 6/46 20/46 CARCINOMA 1/48 11/48 7/46 10/46 COMBINED 5/48 18/48 13/46 29/46 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) ADENOMA 2/47 3/47 9/46 19/47 CARCINOMA 1/47 3/47 6/46 16/47 COMBINED 3/47 5/47 15/46 35/47 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) ADENOMA 6/48 14/48 21/47 27/48 CARCINOMA 0/48 0/48 1/47 16/48 COMBINED 6/48 14/48 21/47 38/48 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Harderian Gland | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) ADENOMA 5/47 12/48 15/48 26/45 CARCINOMA 0/47 2/48 2/48 10/45 COMBINED 5/47 14/48 17/48 35/45 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Heart | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 3/48 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Heart | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 0/48 6/47 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Heart | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 1/48 4/48 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Heart | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/48 0/48 2/47 4/48 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 1/47 2/47 0/47 7/46 ADENOMA 6/47 5/47 15/47 23/46 ADENOMA OR CARCINOMA 7/47 5/47 16/47 23/46 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Liver | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/48 0/47 0/48 6/48 ADENOMA 3/48 6/47 16/48 16/48 ADENOMA OR CARCINOMA 3/48 7/47 16/48 17/48 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 2/48 2/46 4/48 13/48 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Liver | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 3/47 4/48 3/46 11/48 ADENOMA 12/47 15/48 16/46 24/48 ADENOMA OR CARCINOMA 16/47 19/48 17/46 24/48 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Lung | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADEMONA 5/48 10/48 18/48 30/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 7/48 9/48 23/48 COMBINED 5/48 17/48 24/48 37/48 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Lung | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADENOMA 5/47 10/47 16/48 28/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 0/47 2/47 6/48 23/48 COMBINED 5/47 11/47 21/48 38/48 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Lung | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADEMONA 6/48 8/48 9/48 33/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 5/48 4/48 5/48 17/48 COMBINED 11/48 11/48 14/48 40/48 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Lung | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADENOMA 10/48 16/48 19/47 35/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 3/48 8/47 24/48 COMBINED 11/48 19/48 24/47 43/48 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) ADENOACANTHOMA 0/47 0/48 1/48 9/45 ADENOCARCINOMA 3/47 4/48 6/48 15/45 COMBINED 3/47 4/48 7/48 23/45 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Mammary Gland | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) ADENOACANTHOMA 0/47 0/45 2/48 3/47 ADENOCARCINOMA 4/47 3/45 11/48 14/47 COMBINED 4/47 3/45 12/48 16/47 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Ovary | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) BENIGN GRANULOSA CELL TUMOR 0/46 0/47 5/46 3/45 BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/46 0/47 6/46 3/45 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Skin | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 2/47 | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | (URETHANE AND 5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 2/47, 0/48, 7/48) | Neoplastic Lesions |
| No | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Skin | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 1/48, 4/46, 7/47) | Neoplastic Lesions |
| Yes | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Female | Dosed-Water | Spleen | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/46 0/46 3/46 | Neoplastic Lesions |
| Yes | TR-510 | URETHCOMB | Urethane + ethanol (combination) | Mice | MV | Male | Dosed-Water | Spleen | Clear Evidence | Clear Evidence | (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/46 0/46 1/46 3/46 | Neoplastic Lesions |