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Organ Sites with Neoplasia

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  • Organ: Skin
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-084 39156-41-7 2,4-Diaminoanisole sulfate Rats Male Dosed-Feed Skin Positive (SQUAMOUS CELL CARCINOMA OR BASAL CELL CARCINOMA OR SEBACEOUS ADENOCARCINOMA) Neoplastic Lesions
TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Rats Male Dosed-Feed Skin Positive (PAPILLOMA OR CARCINOMA) Neoplastic Lesions
TR-054 121-14-2 2,4-Dinitrotoluene Rats Male Dosed-Feed Skin Positive (FIBROMA) Neoplastic Lesions
TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (thio-tepa) Mice Male Intraperitoneal Injection Skin Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (thio-tepa) Rats Female Intraperitoneal Injection Skin Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (thio-tepa) Rats Male Intraperitoneal Injection Skin Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
TR-127 99-59-2 5-Nitro-o-anisidine Rats Male Dosed-Feed Skin Positive (TRICHOEPITHELIOMA, SEBACEOUS ADENOMA, BASAL CELL CARCINOMA, SQUAMOUS CELL CARCINOMA, ADENOCARCINOMA) Neoplastic Lesions
TR-128 91-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate Rats Male Dosed-Feed Skin Positive (BASAL CELL ADENOMA, SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
TR-146 139-94-6 Nithiazide Rats Female Dosed-Feed Skin Positive (FIBROADENOMA OR CYSTADENOMA) Neoplastic Lesions
TR-289 71-43-2 Benzene Rats Male Gavage Skin Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 2/50 1/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 5/50 3/50 8/50 Neoplastic Lesions
TR-285 569-61-9 C.I. Basic red 9 monohydrochloride Rats Male Dosed-Feed Skin Clear Evidence TRICHOEPITHELIOMA 0/50 0/50 7/50; SEBACEOUS ADENOMA 0/50 0/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 10/50 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Male Dosed-Water Skin Clear Evidence BASAL CELL OR SEBACEOUS GLAND NEOPLASMS 2/60 33/45 56/75 41/60; SQUAMOUS CELL NEOPLASMS 0/60 13/45 28/75 22/60 Neoplastic Lesions
TR-374 556-52-5 Glycidol Mice Female Gavage Skin Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/50 1/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 2/50 Neoplastic Lesions
TR-374 556-52-5 Glycidol Mice Male Gavage Skin Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50 Neoplastic Lesions
TR-374 556-52-5 Glycidol Rats Male Gavage Skin Clear Evidence SEBACEOUS GLAND ADENOMA 0/50 0/50 1/50, BASAL CELL CARCINOMA 0/50 4/50 2/50, OR SEBACEOUS GLAND ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 5/50 4/50 Neoplastic Lesions
TR-362 106-87-6 4-Vinyl-1-cyclohexene diepoxide Mice Female Topical Application Skin Clear Evidence SQUAMOUS CELL CARCINOMA 0/50 6/50 37/50 43/50 Neoplastic Lesions
TR-362 106-87-6 4-Vinyl-1-cyclohexene diepoxide Mice Male Topical Application Skin Clear Evidence SQUAMOUS CELL CARCINOMA 0/50 14/50 40/50 43/50 Neoplastic Lesions
TR-362 106-87-6 4-Vinyl-1-cyclohexene diepoxide Rats Female Topical Application Skin Clear Evidence BASAL CELL CARCINOMA 2/50 5/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 16/50 34/50 Neoplastic Lesions
TR-362 106-87-6 4-Vinyl-1-cyclohexene diepoxide Rats Male Topical Application Skin Clear Evidence BASAL CELL CARCINOMA 2/50 4/50 8/50; SQUAMOUS CELL CARCINOMA 0/50 33/50 36/50 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Female Dosed-Water Skin Clear Evidence SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 0/60; BASAL CELL NEOPLASMS 0/60 4/45 3/75 2/60 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Female Dosed-Water Skin Clear Evidence BASAL CELL ADENOMA 0/60 3/45 5/75 5/60 OR BASAL CELL CARCINOMA 0/60 0/45 5/75 4/60 COMBINED 0/60 3/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA 0/60 1/45 6/75 5/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 4/75 7/60 COMBINED 0/60 3/45 9/75 12/60 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Male Dosed-Water Skin Clear Evidence BASAL CELL ADENOMA 0/60 10/45 52/75 29/60 OR BASAL CELL CARCINOMA 0/60 1/45 4/75 2/60 COMBINED 0/60 11/45 54/75 30/60; SEBACEOUS GLAND ADENOMA 0/60 0/45 7/75 5/60; KERATOACANTHOMA 1/60 1/45 8/75 5/60; SQUAMOUS CELL PAPILLOMA 0/60 0/45 8/75 15/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 10/75 13/60 COMBINED 0/60 2/45 17/75 27/60 Neoplastic Lesions
TR-397 2429-74-5 C.I. Direct blue 15 Rats Female Dosed-Water Skin Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 2/35 5/65 5/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 0/50 2/35 6/65 5/50 Neoplastic Lesions
TR-397 2429-74-5 C.I. Direct blue 15 Rats Male Dosed-Water Skin Clear Evidence BASAL CELL ADENOMA 2/50 8/35 23/65 26/50, BASAL CELL CARCINOMA 0/50 2/35 4/65 10/50, COMBINED 2/50 9/35 27/65 28/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 7/65 3/50; SQUAMOUS CELL PAPILLOMA 2/50 3/35 5/65 8/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 7/65 13/50, COMBINED 2/50 4/35 11/65 19/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Mice Female Topical Application Skin Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 6/50; SEBACEOUS GLAND ADENOMA 0/50 3/50 2/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Mice Male Topical Application Skin Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 3/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 3/50 11/50; SEBACEOUS GLAND ADENOMA 0/50 1/50 8/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Female Topical Application Skin Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA OR KERATOACANTHOMA 0/50 3/50 18/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Male Topical Application Skin Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 3/50 0/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 8/50 COMBINED 1/50 8/50 8/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA, OR KERATOACANTHOMA 0/50 20/50 31/50 Neoplastic Lesions
TR-405 6459-94-5 C.I. Acid red 114 Rats Female Dosed-Water Skin Clear Evidence BASAL CELL ADENOMA 0/50 3/35 5/65 3/50, BASAL CELL CARCINOMA 0/50 1/35 2/65 2/50, COMBINED 0/50 4/35 7/65 5/50 Neoplastic Lesions
TR-405 6459-94-5 C.I. Acid red 114 Rats Male Dosed-Water Skin Clear Evidence BASAL CELL ADENOMA 1/50 4/35 26/65 30/50, BASAL CELL CARCINOMA 0/50 1/35 5/65 6/50, COMBINED 1/50 5/35 28/65 32/50; KERATOACANTHOMA 1/50 1/35 4/65 7/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 5/65 5/50, SEBACEOUS GLAND CARCINOMA 1/50 0/35 0/65 1/50, COMBINED 1/50 1/35 5/65 6/50; SQUAMOUS CELL PAPILLOMA 1/50 0/35 3/65 2/50, SQUAMOUS CELL CARCINOMA 0/50 2/35 8/65 7/50, COMBINED 1/50 2/35 11/65 9/50 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Male Dosed-Feed Skin Clear Evidence SQUAMOUS CELL PAPILLOMA 1/51 0/53 2/51 5/55 11/60 OR KERATOACANTHOMA 3/51 5/53 11/51 16/55 10/60 OR TRICHOEPITHELIOMA 0/51 0/53 0/51 1/55 1/60 OR BASAL CELL ADENOMA 0/51 1/53 0/51 3/55 6/60 OR BASAL CELL CARCINOMA 0/51 0/53 2/51 2/55 0/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 0/51 0/55 1/60 COMBINED 4/51 6/53 14/51 24/55 21/60 Neoplastic Lesions
TR-485 434-07-1 Oxymetholone Rats Female Gavage Skin Clear Evidence COMBINED 0/50 0/50 4/50 5/50 Neoplastic Lesions
TR-491 93-15-2 Methyleugenol Rats Male Gavage Skin Clear Evidence FIBROMA 1/50 9/50 8/50 5/50 4/50 OR FIBROMA OR FIBROSARCOMA 1/50 12/50 8/50 8/50 4/50 Neoplastic Lesions
TR-504 88-72-2 o-Nitrotoluene Rats Female Dosed-Feed Skin Clear Evidence (SUBCUTANEOUS) FIBROMA 3/60 3/60 18/60 20/60 FIBROMA OR FIBROSARCOMA 3/60 3/60 21/60 22/60 Neoplastic Lesions
TR-504 88-72-2 o-Nitrotoluene Rats Male Dosed-Feed Skin Clear Evidence (SUBCUTANEOUS) LIPOMA 0/60 4/60 13/60 13/60 10/60 12/60 FIBROMA 5/60 46/60 52/60 59/60 45/60 52/60 FIBROSARCOMA 0/60 7/60 17/60 20/60 8/60 12/60 COMBINED 5/60 47/60 55/60 59/60 47/60 53/60 Neoplastic Lesions
TR-510 51-79-6 Urethane Mice Female Dosed-Water Skin Clear Evidence HEMANGIOSARCOMA 0/48 0/48 0/46 2/48 Neoplastic Lesions
TR-510 51-79-6 Urethane Mice Male Dosed-Water Skin Clear Evidence SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/47, 1/48, 5/47, 8/48) Neoplastic Lesions
TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Mice Female Gavage Skin Clear Evidence Fibrosarcoma 1/50 6/50 5/50 8/50 fibrosarcoma or malignant schwannoma 2/50 8/50 7/50 12/50 Neoplastic Lesions
TR-564 106-94-5 1-Bromopropane Rats Male Inhalation Skin Some Evidence Keratoacanthoma 0/50 3/50 6/50 6/50 keratoacanthoma or squamous cell carcinoma 1/50 4/50 6/50 8/50 keratoacanthoma, basal cell adenoma or carcinoma or squamous cell carcinoma 1/50 7/50 9/50 10/50 Neoplastic Lesions
TR-569 30516-87-1 3'-Azido-3'-deoxythymidine (AIDS) Mice Male Gavage Skin Some Evidence (subcutaneous tissue): fibroma, fibrous, histiocytoma, or fibrosarcoma 2/65 2/47 7/48 12/48 -- AZT/3TC/NVP Neoplastic Lesions
TR-569 134678-17-4 Lamivudine (3TC) Mice Male Gavage Skin Some Evidence (subcutaneous tissue): fibroma, fibrous, histiocytoma, or fibrosarcoma 2/65 2/47 7/48 12/48 -- AZT/3TC/NVP Neoplastic Lesions
TR-569 129618-40-2 Nevirapine (NVP)  Mice Male Gavage Skin Some Evidence (subcutaneous tissue): fibroma, fibrous, histiocytoma, or fibrosarcoma 2/65 2/47 7/48 12/48 -- AZT/3TC/NVP Neoplastic Lesions
TR-574 87-66-1 Pyrogallol Mice Female Topical Application Skin Some Evidence (site of application): squamous cell carcinoma 0/50, 0/50, 0/50, 4/50 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Mice Male Dosed-Water Skin Clear Evidence squamous cell papilloma 0/47 1/48 2/47 1/47 8/46 squamous cell carcinoma 0/47 0/48 0/47 0/47 2/46 squamous cell papilloma or carcinoma 0/47 1/48 2/47 1/47 9/46 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Mice Female Dosed-Water Skin Clear Evidence fibrosarcoma 0/45 1/48 2/47 2/47 9/45 sarcoma 0/45 0/48 1/47 3/47 3/45 fibrosarcoma or sarcoma 0/45 1/48 3/47 5/47 12/45 Neoplastic Lesions
TR-590 1309-64-4 Antimony Trioxide Mice Male Inhalation Skin Clear Evidence fibrous histiocytoma (0/50, 1/50, 1/50, 4/50); fibrous histiocytoma or fibrosarcoma (0/50, 1/50, 3/50, 4/50) Neoplastic Lesions
TR-590 1309-64-4 Antimony Trioxide Mice Female Inhalation Skin Clear Evidence squamous cell carcinoma (0/50, 0/50, 0/50, 2/50) May Have Been Related
TR-575 79-06-1 Acrylamide Mice Female Dosed-Water Skin Clear Evidence fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43 Neoplastic Lesions
TR-575 79-06-1 Acrylamide Rats Female Dosed-Water Skin Clear Evidence subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48 Neoplastic Lesions