Share This:

Organ Sites with Neoplasia

View results
  • Organ: Preputial Gland
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-084 39156-41-7 2,4-Diaminoanisole sulfate Rats Male Dosed-Feed Preputial Gland Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (thio-tepa) Mice Male Intraperitoneal Injection Preputial Gland Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
TR-289 71-43-2 Benzene Mice Male Gavage Preputial Gland Clear Evidence SQUAMOUS CELL CARCINOMA 0/21 3/28 18/29 28/35 Neoplastic Lesions
TR-291 78-59-1 Isophorone Rats Male Gavage Preputial Gland Some Evidence CARCINOMA 0/50 0/50 5/50 Neoplastic Lesions
TR-332 149-30-4 2-Mercaptobenzothiazole Rats Male Gavage Preputial Gland Some Evidence ADENOMA 0/50 4/50 4/50 OR CARCINOMA 1/50 2/50 1/50 COMBINED 1/50 6/50 5/50 Neoplastic Lesions
TR-316 513-37-1 Dimethylvinyl chloride (DMVC) Mice Male Gavage Preputial Gland Clear Evidence SQUAMOUS CELL CARCINOMA 1/48 3/47 16/44 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Male Dosed-Water Preputial Gland Clear Evidence ADENOMA 14/60 6/43 19/73 12/59 OR CARCINOMA 2/60 6/43 15/73 19/59 COMBINED 16/60 12/43 33/73 29/59 Neoplastic Lesions
TR-368 389-08-2 Nalidixic acid Rats Male Dosed-Feed Preputial Gland Clear Evidence ADENOMA 2/49 10/49 10/47, PAPILLOMA 1/49 0/49 0/47, OR CARCINOMA 0/49 10/49 12/47 COMBINED 3/49 19/49 20/47 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Male Dosed-Water Preputial Gland Clear Evidence ADENOMA 2/60 4/45 4/75 8/60 OR CARCINOMA 0/60 0/45 2/75 1/60 COMBINED 2/60 4/45 6/75 9/60 Neoplastic Lesions
TR-397 2429-74-5 C.I. Direct blue 15 Rats Male Dosed-Water Preputial Gland Clear Evidence ADENOMA 6/49 2/35 12/64 8/48, CARCINOMA 2/49 3/35 11/64 1/48, COMBINED 8/49 5/35 23/64 9/48 Neoplastic Lesions
TR-384 96-18-4 1,2,3-Trichloropropane Rats Male Gavage Preputial Gland Clear Evidence ADENOMA 5/49 3/47 5/49 11/50 OR CARCINOMA 0/49 3/47 3/49 5/50 COMBINED 5/49 6/47 8/49 16/50 Neoplastic Lesions
TR-434 106-99-0 1,3-Butadiene Mice Male Inhalation Preputial Gland Clear Evidence CARCINOMA 0/50 0/50 0/50 0/50 5/50 0/73, STOP STUDY 1/50 4/50 4/50 3/50 Neoplastic Lesions
TR-570 76231-76-0 alpha/beta Thujone mixture Rats Male Gavage Preputial Gland Some Evidence Carcinoma 1/49 0/49 5/50; adenoma or carcinoma 3/49 1/49 9/50 Neoplastic Lesions