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Organ Sites with Neoplasia

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  • Organ: Pancreas Islet Cell
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-251 26471-62-5 2,4- & 2,6-Toluene diisocyanate Rats Female Gavage Pancreas Islet Cell Positive ADENOMA 0/50 6/49 2/47 CARCINOMA 0/50 1/49 0/47 COMBINED 0/50 7/49 2/47 Neoplastic Lesions
TR-560 63-05-8 Androstenedione Mice Female Gavage Pancreas Islet Cell Clear Evidence Adenoma 0/49 2/50 4/49 4/48 Neoplastic Lesions
TR-560 63-05-8 Androstenedione Mice Male Gavage Pancreas Islet Cell Clear Evidence Adenoma (includes multiples) 2/50 2/50 2/50 5/49 Neoplastic Lesions
TR-581 7440-48-4 Cobalt Rats Male Inhalation Pancreas Islet Cell Clear Evidence adenoma or carcinoma 2/50 2/50 10/48 9/49 Neoplastic Lesions
TR-540 7220-79-3 Methylene blue trihydrate Rats Male Gavage Pancreas Islet Cell Some Evidence ADENOMA 4/50 9/50 12/50 8/50 ADENOMA OR CARCINOMA 4/50 9/50 14/50 8/50 Neoplastic Lesions
TR-581 7440-48-4 Cobalt Rats Female Inhalation Pancreas Islet Cell Clear Evidence carcinoma 1/50 0/50 0/50 3/50 May Have Been Related
TR-595 CELLPRADGSM Cell Phone Radiation: GSM Rats Male Whole Body Exposure Pancreas Islet Cell Clear Evidence adenoma or carcinoma (13/90, 27/89, 19/86, 16/85) May Have Been Related
TR-575 79-06-1 Acrylamide Rats Male Dosed-Water Pancreas Islet Cell Clear Evidence adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48 Neoplastic Lesions