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Organ Sites with Neoplasia

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  • Organ: Ovary
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-118 602-87-9 5-Nitroacenaphthene Mice Female Dosed-Feed Ovary Positive (TUBULAR CELL ADENOMA OR GRANULOSA CELL TUMOR OR LUTEOMA) Neoplastic Lesions
TR-288 106-99-0 1,3-Butadiene Mice Female Inhalation Ovary Clear Evidence GRANULOSA CELL TUMOR 0/49 6/45 12/48 Neoplastic Lesions
TR-289 71-43-2 Benzene Mice Female Gavage Ovary Clear Evidence BENIGN MIXED TUMORS 0/47 1/44 12/49 7/48; GRANULOSA CELL TUMOR 1/47 1/44 6/49 7/48 Neoplastic Lesions
TR-303 100-40-3 4-Vinylcyclohexene Mice Female Gavage Ovary Clear Evidence GRANULOSA CELL TUMOR 1/49 9/48 11/47 OR CARCINOMA 0/49 1/48 2/47 COMBINED 1/49 10/48 13/47 Neoplastic Lesions
TR-337 59-87-0 Nitrofurazone Mice Female Dosed-Feed Ovary Clear Evidence GRANULOSA CELL TUMOR 1/47 4/50 9/50; BENIGN MIXED TUMORS 0/47 17/50 20/50 Neoplastic Lesions
TR-341 67-20-9 Nitrofurantoin Mice Female Dosed-Feed Ovary Clear Evidence TUBULAR CELL ADENOMA 0/50 0/50 5/50; BENIGN MIXED TUMORS 0/50 0/50 4/50; GRANULOSA CELL TUMOR 0/50 3/50 2/50 Neoplastic Lesions
TR-352 924-42-5 N-Methylolacrylamide Mice Female Gavage Ovary Clear Evidence GRANULOSA CELL TUMOR 0/50 5/45 5/47 Neoplastic Lesions
TR-362 106-87-6 4-Vinyl-1-cyclohexene diepoxide Mice Female Topical Application Ovary Clear Evidence BENIGN MIXED TUMORS 0/50 0/49 11/49 6/50, GRANULOSA CELL TUMOR 0/50 0/49 5/49 10/50, LUTEOMA 1/50 0/49 0/49 0/50, OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/49 2/49 2/50 COMBINED 1/50 0/49 17/49 18/50 Neoplastic Lesions
TR-465 77-09-8 Phenolphthalein Mice Female Dosed-Feed Ovary Clear Evidence BENIGN SEX-CORD STROMAL TUMOR 0/50 7/49 6/50 5/50 Neoplastic Lesions
TR-434 106-99-0 1,3-Butadiene Mice Female Inhalation Ovary Clear Evidence BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 1/49 0/49 1/48 9/50 8/50 6/79; ADENOMA OR BENIGN MIXED TUMOR 2/49 4/49 1/48 4/50 6/50 2/79 Neoplastic Lesions
TR-510 51-79-6 Urethane Mice Female Dosed-Water Ovary Clear Evidence BENIGN GRANULOSA CELL TUMOR 0/48 0/46 2/46 3/39 MALIGNANT GRANULOSA CELL TUMOR 0/48 0/46 0/46 3/39 COMBINED 0/48 0/46 2/46 5/39 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Mice Female Dosed-Water Ovary Clear Evidence granulosa cell tumor – benign or malignant 0/45 0/47 0/47 3/46 3/44 May Have Been Related
TR-575 79-06-1 Acrylamide Mice Female Dosed-Water Ovary Clear Evidence benign granulose cell tumor 0/46 1/45 0/48 1/45 5/42 Neoplastic Lesions