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Organ Sites with Neoplasia

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  • Organ: Oral Cavity
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-206 96-12-8 1,2-Dibromo-3-chloropropane Rats Female Inhalation Oral Cavity Positive SQUAMOUS CELL PAPILLOMA 0/50 3/50 11/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 5/50 Neoplastic Lesions
TR-206 96-12-8 1,2-Dibromo-3-chloropropane Rats Male Inhalation Oral Cavity Positive SQUAMOUS CELL PAPILLOMA 0/50 1/50 8/49; SQUAMOUS CELL CARCINOMA 0/50 0/50 3/49 Neoplastic Lesions
TR-289 71-43-2 Benzene Rats Female Gavage Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 4/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 4/50 5/50 COMBINED 1/50 5/50 12/50 9/50 Neoplastic Lesions
TR-289 71-43-2 Benzene Rats Male Gavage Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 6/50 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 3/50 5/50 7/50 COMBINED 1/50 9/50 16/50 19/50 Neoplastic Lesions
TR-316 513-37-1 Dimethylvinyl chloride (DMVC) Rats Female Gavage Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/50 COMBINED 0/50 2/50 5/50 Neoplastic Lesions
TR-316 513-37-1 Dimethylvinyl chloride (DMVC) Rats Male Gavage Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 2/50 COMBINED 0/50 5/50 4/50 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Female Dosed-Water Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 2/60 2/45 3/75 3/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 3/75 2/60 COMBINED 2/60 2/45 6/75 5/60 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Male Dosed-Water Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 1/60 7/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/60 1/45 0/75 2/60 COMBINED 1/60 8/45 10/75 11/60 Neoplastic Lesions
TR-374 556-52-5 Glycidol Rats Female Gavage Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 3/50 6/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 1/50 3/50 7/50 Neoplastic Lesions
TR-384 96-18-4 1,2,3-Trichloropropane Mice Female Gavage Oral Cavity Clear Evidence SQUAMOUS CELL CARCINOMA 0/50 0/50 1/51 5/55 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Female Dosed-Water Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 0/60 3/45 7/75 9/60 OR SQUAMOUS CELL CARCINOMA 0/60 1/45 2/75 4/60 COMBINED 0/60 3/45 9/75 13/60 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Male Dosed-Water Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 2/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 1/75 3/60 COMBINED 0/60 0/45 4/75 5/60 Neoplastic Lesions
TR-397 2429-74-5 C.I. Direct blue 15 Rats Female Dosed-Water Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 2/50 3/35 12/65 9/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 8/65 6/50, COMBINED 2/50 4/35 19/65 15/50 Neoplastic Lesions
TR-397 2429-74-5 C.I. Direct blue 15 Rats Male Dosed-Water Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 9/35 18/65 15/50, SQUAMOUS CELL CARCINOMA 1/50 1/35 6/65 2/50, COMBINED 1/50 10/35 24/65 17/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Female Topical Application Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 27/50 41/50 OR SQUAMOUS CELL CARCINOMA 0/50 15/50 27/50 COMBINED 0/50 39/50 49/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Male Topical Application Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 40/50 33/50 OR SQUAMOUS CELL CARCINOMA 0/50 16/50 25/50 COMBINED 0/50 47/50 48/50 Neoplastic Lesions
TR-405 6459-94-5 C.I. Acid red 114 Rats Female Dosed-Water Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 3/35 6/65 4/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 3/65 2/50, COMBINED 0/50 3/35 9/65 6/50 Neoplastic Lesions
TR-384 96-18-4 1,2,3-Trichloropropane Rats Female Gavage Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 5/49 10/52 18/52 ; SQUAMOUS CELL CARCINOMA 0/50 1/49 21/52 21/52 Neoplastic Lesions
TR-384 96-18-4 1,2,3-Trichloropropane Rats Male Gavage Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 4/50 9/49 19/52; SQUAMOUS CELL CARCINOMA 1/50 0/50 11/49 25/52 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Rats Female Inhalation Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 1/49 2/50 2/50 7/50 OR SQUAMOUS CELL CARCINOMA 0/49 1/50 3/50 4/50 COMBINED 1/49 3/50 5/50 11/50 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Male Dosed-Feed Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 0/51 4/53 8/51 10/55 12/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 1/51 0/55 2/60 COMBINED 0/51 4/53 9/51 10/55 13/60 Neoplastic Lesions
TR-463 8003-22-3 D & C yellow no. 11 Rats Male Dosed-Feed Oral Cavity Some Evidence SQUAMOUS CELL PAPILLOMA 1/50 1/51 2/51 4/54 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/51 1/54 COMBINED 1/50 2/51 3/51 5/54 Neoplastic Lesions
TR-430 28407-37-6 C.I. Direct blue 218 Rats Male Dosed-Feed Oral Cavity Some Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/50 0/50 5/51; SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 1/51; BASOSQUAMOUS TUMOR BENIGN 0/50 0/50 0/50 1/51 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Female Dosed-Feed Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 2/50 2/51 4/53 5/52 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/53 1/52 COMBINED 2/50 3/51 5/53 6/52 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Rats Male Inhalation Oral Cavity Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 2/50 4/50 10/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 2/50 COMBINED 0/50 2/50 5/50 12/50 Neoplastic Lesions
TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Female Gavage Oral Cavity Clear Evidence Mucosa: Gingival squamous cell carcinoma 0/50 0/50 4/50 6/50 Neoplastic Lesions
TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Male Gavage Oral Cavity Clear Evidence Mucosa: Gingival squamous cell carcinoma 1/50 5/50 4/50 5/50 Neoplastic Lesions
TR-520 57465-28-8 Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) Rats Female Gavage Oral Cavity Clear Evidence GINGIVAL SQUAMOUS CELL CARINOMA (ORAL MUCOSA) 0/53 1/55 1/53 1/53 2/53 2/53 7/53 2/50 Neoplastic Lesions
TR-521 1746-01-6 TEF evaluation (TCDD) Rats Female Gavage Oral Cavity Clear Evidence GINGIVAL SQAMOUS CELL CARCINOMA (ORAL MUCOSA) 1/53 2/54 1/53 0/53 4/53 10/53 5/50 Neoplastic Lesions
TR-525 57117-31-4 TEF evaluation (PECDF (Pentachlorodibenzofuran)) Rats Female Gavage Oral Cavity Some Evidence (ORAL MUCOSA) GINGIVAL SQUAMOUS CELL CARCINOMA 1/53 2/53 1/53 0/53 1/53 3/53 3/50 Neoplastic Lesions
TR-530 TEFBINARYMIX TEF evaluation (Binary mixture; PCB 126/PCB 153) Rats Female Gavage Oral Cavity Clear Evidence SQUAMOUS CELL CARCINOMA (GINGIVAL) 0/53 0/53 2/53 5/53 9/53 Neoplastic Lesions
TR-531 TEFPCBMIX TEF Evaluation (PCB Mixture; PCB 126/PCB 118) Rats Female Gavage Oral Cavity Clear Evidence GINGIVAL SQUAMOUS CELL CARCINOMA 1/53 1/51 2/53 4/53 0/53 1/66 1/50 Neoplastic Lesions
TR-544 3252-43-5 Water disinfection byproducts (Dibromoacetonitrile) Rats Female Dosed-Water Oral Cavity Some Evidence Squamous cell papilloma 1/50 0/50 4/50 0/50 Neoplastic Lesions
TR-544 3252-43-5 Water disinfection byproducts (Dibromoacetonitrile) Rats Male Dosed-Water Oral Cavity Clear Evidence Squamous cell papilloma or carcinoma 0/50 0/50 2/50 5/50 Neoplastic Lesions
TR-546 7789-12-0 Sodium dichromate dihydrate (VI) Rats Female Dosed-Water Oral Cavity Clear Evidence squamous cell carcinoma (0/50, 0/50, 0/50, 2/50, 11/50); squamous cell papilloma, or carcinoma (1/50, 1/50, 0/50, 2/50, 11/50) Neoplastic Lesions
TR-546 7789-12-0 Sodium dichromate dihydrate (VI) Rats Male Dosed-Water Oral Cavity Clear Evidence squamous cell carcinoma (0/50, 1/50, 0/49, 0/50, 6/49); squamous cell papilloma or carcinoma (0/50, 1/50, 0/49, 0/50, 7/49) Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Rats Female Dosed-Water Oral Cavity Clear Evidence Oral mucosa: squamous cell papilloma 1/48 1/48 2/48 0/48 4/48 squamous cell carcinoma 0/48 0/48 0/48 1/48 2/48 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Rats Female Dosed-Water Oral Cavity Clear Evidence Tongue: squamous cell papilloma 0/48 1/48 0/48 1/48 0/48 squamous cell carcinoma 0/48 0/48 0/48 0/48 1/48 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Rats Male Dosed-Water Oral Cavity Clear Evidence Oral mucosa: squamous cell papilloma 1/48 1/48 0/48 2/47 3/48 squamous cell carcinoma 1/48 0/48 1/48 1/47 0/48 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Rats Female Dosed-Water Oral Cavity Clear Evidence Oral mucosa or tongue: squamous cell papilloma or carcinoma 1/48 2/48 2/48 2/48 7/48 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Rats Male Dosed-Water Oral Cavity Clear Evidence Tongue: squamous cell papilloma 0/48 1/48 0/48 1/47 4/48 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Rats Male Dosed-Water Oral Cavity Clear Evidence Oral mucosa or tongue: squamous cell papilloma or carcinoma 2/48 2/48 2/48 3/47 7/48 Neoplastic Lesions
TR-575 79-06-1 Acrylamide Rats Female Dosed-Water Oral Cavity Clear Evidence squamous cell papilloma or carcinoma 0/48 2/48 1/48 3/48 5/48 Neoplastic Lesions