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Organ Sites with Neoplasia

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  • Organ: Nasal Cavity
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-080 123-91-1 1,4-Dioxane Rats Female Dosed-Water Nasal Cavity Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
TR-080 123-91-1 1,4-Dioxane Rats Male Dosed-Water Nasal Cavity Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
TR-142 120-71-8 p-Cresidine Rats Female Dosed-Feed Nasal Cavity Positive (NEUROBLASTOMA) Neoplastic Lesions
TR-142 120-71-8 p-Cresidine Rats Male Dosed-Feed Nasal Cavity Positive (NEUROBLASTOMA) Neoplastic Lesions
TR-206 96-12-8 1,2-Dibromo-3-chloropropane Mice Female Inhalation Nasal Cavity Positive BENIGN AND MALIGNANT TUMORS 0/50 11/50 38/50 Neoplastic Lesions
TR-206 96-12-8 1,2-Dibromo-3-chloropropane Mice Male Inhalation Nasal Cavity Positive BENIGN AND MALIGNANT TUMORS 0/45 1/42 21/48 Neoplastic Lesions
TR-206 96-12-8 1,2-Dibromo-3-chloropropane Rats Female Inhalation Nasal Cavity Positive BENIGN AND MALIGNANT TUMORS 1/50 21/50 32/50 Neoplastic Lesions
TR-206 96-12-8 1,2-Dibromo-3-chloropropane Rats Male Inhalation Nasal Cavity Positive BENIGN AND MALIGNANT TUMORS 0/50 32/50 39/49 Neoplastic Lesions
TR-210 106-93-4 1,2-Dibromoethane Mice Female Inhalation Nasal Cavity Positive CARCINOMA 0/50 0/50 6/50 Neoplastic Lesions
TR-210 106-93-4 1,2-Dibromoethane Rats Female Inhalation Nasal Cavity Positive ADENOMA 0/50 11/50 3/50; ADENOCARCINOMA 0/50 20/50 29/50; CARCINOMA 0/50 0/50 25/50 Neoplastic Lesions
TR-210 106-93-4 1,2-Dibromoethane Rats Male Inhalation Nasal Cavity Positive ADENOMA 0/50 11/50 0/50; ADENOCARCINOMA 0/50 20/50 28/50; CARCINOMA 0/50 0/50 21/50 Neoplastic Lesions
TR-267 75-56-9 1,2-Propylene oxide Rats Female Inhalation Nasal Cavity Some Evidence ADENOMA 0/50 0/50 3/50 Neoplastic Lesions
TR-267 75-56-9 1,2-Propylene oxide Rats Male Inhalation Nasal Cavity Some Evidence ADENOMA 0/50 0/50 2/50 Neoplastic Lesions
TR-329 106-88-7 1,2-Epoxybutane Rats Male Inhalation Nasal Cavity Clear Evidence ADENOMA 0/50 0/50 7/50 Neoplastic Lesions
TR-316 513-37-1 Dimethylvinyl chloride (DMVC) Rats Female Gavage Nasal Cavity Clear Evidence ADENOCARCINOMA 0/50 3/49 6/41; CARCINOMA 0/50 11/49 28/41; SQUAMOUS CELL CARCINOMA 0/50 2/49 2/41 Neoplastic Lesions
TR-316 513-37-1 Dimethylvinyl chloride (DMVC) Rats Male Gavage Nasal Cavity Clear Evidence ADENOCARCINOMA 0/47 8/46 4/32; CARCINOMA 0/47 12/46 24/32; SQUAMOUS CELL CARCINOMA 0/47 3/46 0/32 Neoplastic Lesions
TR-278 87-62-7 2,6-Xylidine Rats Female Dosed-Feed Nasal Cavity Positive ADENOMA 0/56 0/56 1/56 6/56; CARCINOMA 0/56 0/56 1/56 24/56 Neoplastic Lesions
TR-278 87-62-7 2,6-Xylidine Rats Male Dosed-Feed Nasal Cavity Positive ADENOMA 0/56 0/56 2/56 10/56; CARCINOMA 0/56 0/56 0/56 26/56 Neoplastic Lesions
TR-376 106-92-3 Allyl glycidyl ether Mice Male Inhalation Nasal Cavity Some Evidence ADENOMA 0/50 0/50 3/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Female Topical Application Nasal Cavity Clear Evidence ADENOMA 0/50 44/50 49/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Male Topical Application Nasal Cavity Clear Evidence ADENOMA 0/50 48/50 48/50 Neoplastic Lesions
TR-482 98-00-0 Furfuryl alcohol Rats Male Inhalation Nasal Cavity Some Evidence ADENOMA, CARCINOMA, OR SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 4/50 Neoplastic Lesions
TR-483 87-86-5 Pentachlorophenol, purified Rats Male Dosed-Feed Nasal Cavity Some Evidence CARCINOMA 1/50 3/50 1/50 0/50 5/50 (STOP STUDY) Neoplastic Lesions
TR-500 91-20-3 Naphthalene Rats Female Inhalation Nasal Cavity Clear Evidence (RESPIRATORY EPITHELIUM) ADENOMA 0/49 0/49 4/49 2/49 (OLFACTORY EPITHELIUM) NEUROBLASTOMA 0/49 2/49 3/49 12/49 Neoplastic Lesions
TR-500 91-20-3 Naphthalene Rats Male Inhalation Nasal Cavity Clear Evidence (RESPIRATORY EPITHELIUM) ADENOMA 0/49 6/49 8/48 15/48 (OLFACTORY EPITHELIUM) NEUROBLASTOMA 0/49 0/49 4/48 3/48 Neoplastic Lesions
TR-552 107-19-7 Propargyl alcohol Mice Female Inhalation Nasal Cavity Some Evidence adenoma, respiratory epithelium (0/50, 2/50, 4/50, 6/50) Neoplastic Lesions
TR-552 107-19-7 Propargyl alcohol Mice Male Inhalation Nasal Cavity Some Evidence adenoma, respiratory epithelium (0/49, 1/50, 4/50, 7/50) Neoplastic Lesions
TR-552 107-19-7 Propargyl alcohol Rats Male Inhalation Nasal Cavity Some Evidence adenoma, respiratory epithelium (0/49, 0/49, 0/50, 3/49) Neoplastic Lesions
TR-542 98-82-8 Cumene Rats Female Inhalation Nasal Cavity Some Evidence respiratory epithelium, adenoma (0/50, 5/48, 4/50, 3/50) Neoplastic Lesions
TR-542 98-82-8 Cumene Rats Male Inhalation Nasal Cavity Clear Evidence respiratory epithelium, adenoma (0/50, 7/50, 18/49, 10/50) Neoplastic Lesions
TR-593 431-03-8 2,3-Butanedione Rats Male Inhalation Nasal Cavity Some Evidence squamous cell carcinoma (0/50, 0/50, 0/50, 3/50); squamous cell papilloma or carcinoma (0/50, 0/50, 0/50, 4/50) Neoplastic Lesions
TR-593 431-03-8 2,3-Butanedione Rats Female Inhalation Nasal Cavity Some Evidence squamous cell carcinoma (0/50, 0/50, 0/50, 3/50) Neoplastic Lesions
TR-579 99-97-8 N,N-Dimethyl-p-toluidine Rats Female Gavage Nasal Cavity Clear Evidence transitional epithelium, adenoma 0/50, 1/49, 0/50, 2/49 Neoplastic Lesions
TR-579 99-97-8 N,N-Dimethyl-p-toluidine Rats Male Gavage Nasal Cavity Clear Evidence transitional epithelium, adenoma 0/50, 3/49, 2/50, 11/49; transitional epithelium, adenoma or carcinoma 0/50, 3/49, 2/50, 13/49 Neoplastic Lesions