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Organ Sites with Neoplasia

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  • Organ: Mesothelium
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-049 7008-42-6 Acronycine Rats Female Intraperitoneal Injection Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive MESOTHELIOMA; SARCOMA Neoplastic Lesions
TR-049 7008-42-6 Acronycine Rats Male Intraperitoneal Injection Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive MESOTHELIOMA; SARCOMA Neoplastic Lesions
TR-072 63-92-3 Phenoxybenzamine hydrochloride Mice Female Intraperitoneal Injection Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive SARCOMA Neoplastic Lesions
TR-072 63-92-3 Phenoxybenzamine hydrochloride Mice Male Intraperitoneal Injection Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive SARCOMA Neoplastic Lesions
TR-072 63-92-3 Phenoxybenzamine hydrochloride Rats Female Intraperitoneal Injection Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive SARCOMA Neoplastic Lesions
TR-072 63-92-3 Phenoxybenzamine hydrochloride Rats Male Intraperitoneal Injection Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive SARCOMA Neoplastic Lesions
TR-153 636-21-5 o-Toluidine hydrochloride Rats Male Dosed-Feed Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive MESOTHELIOMA Neoplastic Lesions
TR-207 21739-91-3 Cytembena Rats Male Intraperitoneal Injection Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive MESOTHELIOMA 0/50 37/50 36/50 Neoplastic Lesions
TR-210 106-93-4 1,2-Dibromoethane Rats Male Inhalation Mesothelium (Abdominal Cavity/Tunica Vaginalis) Positive MESOTHELIOMA 0/50 7/50 25/50 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Male Dosed-Water Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence MESOTHELIOMA 2/60 1/45 7/75 6/60 Neoplastic Lesions
TR-374 556-52-5 Glycidol Rats Male Gavage Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence MESOTHELIOMA 3/50 34/50 39/50 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Male Dosed-Water Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence MESOTHELIOMA 0/60 0/45 3/75 4/60 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Male Topical Application Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence 0/50 1/50 4/50 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Mice Female Inhalation Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence SARCOMA 0/50 4/50 8/50 3/50 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Male Dosed-Feed Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence MESOTHELIOMA 0/51 3/53 8/51 9/55 26/60 Neoplastic Lesions
TR-483 87-86-5 Pentachlorophenol, purified Rats Male Dosed-Feed Mesothelium (Abdominal Cavity/Tunica Vaginalis) Some Evidence MESOTHELIOMA 1/50 0/50 2/50 0/50 9/50 (STOP STUDY) Neoplastic Lesions
TR-491 93-15-2 Methyleugenol Rats Male Gavage Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence MESOTHELIOMA 1/50 3/50 5/50 12/50 5/50 Neoplastic Lesions
TR-504 88-72-2 o-Nitrotoluene Rats Male Dosed-Feed Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence MALIGNANT MESOTHELIOMA 2/60 20/60 29/60 44/60 44/60 54/60 Neoplastic Lesions
TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Rats Male Dosed-Water Mesothelium (Abdominal Cavity/Tunica Vaginalis) Clear Evidence Malignant Mesothelioma 1/50 5/50 10/50 6/50 Neoplastic Lesions