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Organ Sites with Neoplasia

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  • Organ: Mammary Gland
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-019 366-70-1 Procarbazine hydrochloride Rats Female Intraperitoneal Injection Mammary Gland Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-019 366-70-1 Procarbazine hydrochloride Rats Male Intraperitoneal Injection Mammary Gland Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-028 96-12-8 1,2-Dibromo-3-chloropropane Rats Female Gavage Mammary Gland Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-032 3778-73-2 Isophosphamide Rats Female Intraperitoneal Injection Mammary Gland Positive (FIBROADENOMA) Neoplastic Lesions
TR-092 122-66-7 Hydrazobenzene Rats Female Dosed-Feed Mammary Gland Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-049 7008-42-6 Acronycine Rats Female Intraperitoneal Injection Mammary Gland Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-054 121-14-2 2,4-Dinitrotoluene Rats Female Dosed-Feed Mammary Gland Positive (FIBROADENOMA) Neoplastic Lesions
TR-055 107-06-2 1,2-Dichloroethane Mice Female Gavage Mammary Gland Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-055 107-06-2 1,2-Dichloroethane Rats Female Gavage Mammary Gland Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-060 3546-10-9 Phenesterin Rats Female Gavage Mammary Gland Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-115 95-06-7 Sulfallate Mice Female Dosed-Feed Mammary Gland Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-115 95-06-7 Sulfallate Rats Female Dosed-Feed Mammary Gland Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-118 602-87-9 5-Nitroacenaphthene Rats Female Dosed-Feed Mammary Gland Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-146 139-94-6 Nithiazide Rats Female Dosed-Feed Mammary Gland Positive (FIBROADENOMA OR CYSTADENOMA) Neoplastic Lesions
TR-153 636-21-5 o-Toluidine hydrochloride Rats Female Dosed-Feed Mammary Gland Positive (ADENOMA OR FIBROADENOMA) Neoplastic Lesions
TR-162 95-80-7 2,4-Diaminotoluene (2,4-toluene diamine) Rats Female Dosed-Feed Mammary Gland Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
TR-207 21739-91-3 Cytembena Rats Female Intraperitoneal Injection Mammary Gland Positive FIBROADENOMA 13/49 22/50 36/50 Neoplastic Lesions
TR-210 106-93-4 1,2-Dibromoethane Mice Female Inhalation Mammary Gland Positive ADENOCARCINOMA 2/50 14/50 8/50 Neoplastic Lesions
TR-210 106-93-4 1,2-Dibromoethane Rats Female Inhalation Mammary Gland Positive FIBROADENOMA 4/50 29/50 24/50 Neoplastic Lesions
TR-251 26471-62-5 2,4- & 2,6-Toluene diisocyanate Rats Female Gavage Mammary Gland Positive FIBROADENOMA 15/50 21/50 18/50 Neoplastic Lesions
TR-193 50-55-5 Reserpine Mice Female Dosed-Feed Mammary Gland Positive (FIBROADENOMA, ADENOCARCINOMA, ADENOSQUAMOUS CARCINOMA) Neoplastic Lesions
TR-288 106-99-0 1,3-Butadiene Mice Female Inhalation Mammary Gland Clear Evidence ACINAR CELL CARCINOMA 0/50 2/49 6/49 Neoplastic Lesions
TR-289 71-43-2 Benzene Mice Female Gavage Mammary Gland Clear Evidence CARCINOMA 0/49 2/45 5/50 10/49; CARCINOSARCOMA 0/49 0/45 1/50 4/49 Neoplastic Lesions
TR-306 75-09-2 Methylene chloride Rats Female Inhalation Mammary Gland Clear Evidence ADENOMA 0/50 0/50 0/50 1/50 OR FIBROADENOMA 5/50 11/50 13/50 22/50 COMBINED 5/50 11/50 13/50 23/50 Neoplastic Lesions
TR-306 75-09-2 Methylene chloride Rats Male Inhalation Mammary Gland Some Evidence ADENOMA 0/50 0/50 0/50 1/50 OR FIBROADENOMA 0/50 0/50 2/50 4/50 COMBINED 0/50 0/50 2/50 5/50 Neoplastic Lesions
TR-326 75-21-8 Ethylene oxide Mice Female Inhalation Mammary Gland Clear Evidence ADENOCARCINOMA 1/49 6/48 4/49; ADENOSQUAMOUS CARCINOMA 0/49 2/48 2/49 Neoplastic Lesions
TR-374 556-52-5 Glycidol Mice Female Gavage Mammary Gland Clear Evidence ADENOMA 0/50 1/50 0/50, FIBROADENOMA 1/50 0/50 0/50, OR ADENOCARCINOMA 1/50 5/50 15/50 COMBINED 2/50 6/50 15/50 Neoplastic Lesions
TR-374 556-52-5 Glycidol Rats Female Gavage Mammary Gland Clear Evidence FIBROADENOMA 14/50 32/50 29/50; ADENOCARCINOMA 1/50 11/50 16/50 Neoplastic Lesions
TR-374 556-52-5 Glycidol Rats Male Gavage Mammary Gland Clear Evidence FIBROADENOMA 3/50 8/50 7/50 Neoplastic Lesions
TR-337 59-87-0 Nitrofurazone Rats Female Dosed-Feed Mammary Gland Clear Evidence FIBROADENOMA 8/49 36/50 36/50 Neoplastic Lesions
TR-356 54-31-9 Furosemide Mice Female Dosed-Feed Mammary Gland Some Evidence ADENOCARCINOMA 0/50 2/50 5/48 Neoplastic Lesions
TR-358 303-47-9 Ochratoxin A Rats Female Gavage Mammary Gland Clear Evidence FIBROADENOMA 17/50 23/51 22/50 28/50 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Female Dosed-Water Mammary Gland Clear Evidence ADENOCARCINOMA 1/60 2/45 14/75 20/60 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Female Dosed-Water Mammary Gland Clear Evidence ADENOCARCINOMA 0/60 1/45 3/75 6/60 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Female Topical Application Mammary Gland Clear Evidence ADENOCARCINOMA 0/50 0/50 5/50 Neoplastic Lesions
TR-384 96-18-4 1,2,3-Trichloropropane Rats Female Gavage Mammary Gland Clear Evidence ADENOCARCINOMA 1/50 6/49 12/52 21/52 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Mice Female Inhalation Mammary Gland Clear Evidence CARCINOMA 3/50 4/50 7/50 12/50 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Rats Female Inhalation Mammary Gland Clear Evidence FIBROADENOMA 24/49 32/50 36/50 36/50 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Male Dosed-Feed Mammary Gland Clear Evidence FIBROADENOMA 0/51 4/53 6/51 6/55 5/60 OR ADENOMA 0/51 0/53 1/51 1/55 0/60 COMBINED 0/51 4/53 7/51 7/55 5/60 Neoplastic Lesions
TR-461 75-52-5 Nitromethane Rats Female Inhalation Mammary Gland Clear Evidence FIBROADENOMA 19/50 21/50 33/50 36/50 OR CARCINOMA 2/50 7/50 1/50 11/50 COMBINED 9/50 25/50 34/50 39/50 Neoplastic Lesions
TR-434 106-99-0 1,3-Butadiene Mice Female Inhalation Mammary Gland Clear Evidence ADENOACANTHOMA, ADENOCARCINOMA, OR MALIGNANT MIXED TUMOR 0/50 2/50 4/50 12/50 15/50 16/80 Neoplastic Lesions
TR-486 78-79-5 Isoprene Rats Female Inhalation Mammary Gland Some Evidence FIBROADENOMA 19/50 35/50 32/50 32/50 MULTIPLE FIBROADENOMA 7/50 12/50 19/50 17/50 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Female Dosed-Feed Mammary Gland Clear Evidence FIBROADENOMA 25/50 45/51 46/53 45/52 Neoplastic Lesions
TR-486 78-79-5 Isoprene Rats Male Inhalation Mammary Gland Clear Evidence FIBROADENOMA 2/50 4/50 6/50 21/50 FIBROADENOMA OR CARCINOMA COMBINED 2/50 5/50 7/50 21/50 Neoplastic Lesions
TR-491 93-15-2 Methyleugenol Rats Male Gavage Mammary Gland Clear Evidence FIBROADENOMA 5/50 5/50 15/50 13/50 6/50 Neoplastic Lesions
TR-504 88-72-2 o-Nitrotoluene Rats Female Dosed-Feed Mammary Gland Clear Evidence FIBROADENOMA 23/60 47/60 52/60 56/60 Neoplastic Lesions
TR-504 88-72-2 o-Nitrotoluene Rats Male Dosed-Feed Mammary Gland Clear Evidence FIBROADENOMA 0/60 7/60 10/60 2/60 13/60 20/60 Neoplastic Lesions
TR-510 51-79-6 Urethane Mice Female Dosed-Water Mammary Gland Clear Evidence ADENOACANTHOMA 0/47 1/46 1/46 11/48 ADENOCARCINOMA 4/47 3/46 3/46 11/48 COMBINED 4/47 4/46 4/46 22/48 Neoplastic Lesions
TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Rats Female Dosed-Water Mammary Gland Clear Evidence Fibroadenoma, multiple 22/50 24/50 43/50 38/50 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Rats Female Dosed-Water Mammary Gland Clear Evidence fibroadenoma 16/48 26/48 35/48 33/48 36/48 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Mice Female Dosed-Water Mammary Gland Clear Evidence adenoacanthoma 0/45 0/48 0/47 1/47 8/45 adenocarcinoma 1/45 1/48 2/47 9/47 11/45 adenoacanthoma or adenocarcinoma 1/45 1/48 2/47 9/47 18/45 Neoplastic Lesions
TR-575 79-06-1 Acrylamide Mice Female Dosed-Water Mammary Gland Clear Evidence adenoacanthoma 0/47 1/46 1/48 2/45 4/42 adenocarcinoma 0/47 4/46 6/48 2/45 13/42 adenoacanthoma or adenocarcinoma 0/47 4/46 7/48 4/45 17/42 Neoplastic Lesions
TR-575 79-06-1 Acrylamide Rats Female Dosed-Water Mammary Gland Clear Evidence fibroadenoma 16/48 18/48 24/46 22/47 31/48 Neoplastic Lesions