COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

Search Results

One moment please while the data are loaded...
View results
  • Organ: Lung
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
Yes TR-019 366-70-1 Procarbazine hydrochloride Mice Female Intraperitoneal Injection Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
Yes TR-019 366-70-1 Procarbazine hydrochloride Mice Male Intraperitoneal Injection Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
Yes TR-086 106-93-4 1,2-Dibromoethane Mice Female Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
Yes TR-086 106-93-4 1,2-Dibromoethane Mice Male Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
Yes TR-034 1582-09-8 Trifluralin Mice Female Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
Yes TR-055 107-06-2 1,2-Dichloroethane Mice Female Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
Yes TR-055 107-06-2 1,2-Dichloroethane Mice Male Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
Yes TR-059 22966-79-6 Estradiol mustard Mice Female Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-059 22966-79-6 Estradiol mustard Mice Male Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
Yes TR-060 3546-10-9 Phenesterin Mice Female Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
Yes TR-060 3546-10-9 Phenesterin Mice Male Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
Yes TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Mice Female Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Mice Male Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
Yes TR-115 95-06-7 Sulfallate Mice Male Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, CARCINOMA) Neoplastic Lesions
Yes TR-118 602-87-9 5-Nitroacenaphthene Rats Female Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-118 602-87-9 5-Nitroacenaphthene Rats Male Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-143 2243-62-1 1,5-Naphthalenediamine Mice Female Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-160 137-17-7 2,4,5-Trimethylaniline Rats Female Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
Yes TR-206 96-12-8 1,2-Dibromo-3-chloropropane Mice Female Inhalation Lung Positive ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 3/49 10/47; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/49 2/49 4/47 Neoplastic Lesions
Yes TR-206 96-12-8 1,2-Dibromo-3-chloropropane Mice Male Inhalation Lung Positive ALVEOLAR/BRONCHIOLAR ADENOMA 0/41 1/40 6/45; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/41 2/40 1/45 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Mice Female Inhalation Lung Positive ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 7/49 13/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/49 5/49 37/50 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Mice Male Inhalation Lung Positive ALVEOLAR/BRONCHIOLAR ADENOMA 0/41 0/48 11/46; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/41 3/48 19/46 Neoplastic Lesions
Yes TR-210 106-93-4 1,2-Dibromoethane Rats Female Inhalation Lung Positive ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/48 1/47 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/48 4/47 COMBINED 0/50 0/48 5/47 Neoplastic Lesions
Yes TR-239 108-60-1 bis(2-Chloro-1-methylethyl) ether Mice Female Gavage Lung Positive ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 4/50 8/50 Neoplastic Lesions
Yes TR-239 108-60-1 bis(2-Chloro-1-methylethyl) ether Mice Male Gavage Lung Positive ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 13/50 11/50 Neoplastic Lesions
Yes TR-269 542-75-6 1,3-Dichloropropene (Telone II) Mice Female Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 8/50 Neoplastic Lesions
Yes TR-271 2784-94-3 HC blue 1 Rats Female Dosed-Feed Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/49 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/49 4/50 COMBINED 1/50 3/49 7/50 Neoplastic Lesions
Yes TR-194 7446-34-6 Selenium sulfide Mice Female Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
Yes TR-288 106-99-0 1,3-Butadiene Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 9/48 20/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 6/48 8/49 Neoplastic Lesions
Yes TR-288 106-99-0 1,3-Butadiene Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 12/49 11/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/49 5/49 Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Mice Female Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 2/42 5/50 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 3/42 6/50 6/49 COMBINED 4/49 5/42 10/50 13/49 Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Mice Male Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 6/49 6/48 8/50 12/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 5/49 11/48 12/50 14/49 COMBINED 10/49 16/48 19/50 21/49 Neoplastic Lesions
Yes TR-306 75-09-2 Methylene chloride Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 23/48 28/48; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 13/48 29/48 Neoplastic Lesions
Yes TR-306 75-09-2 Methylene chloride Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 19/50 24/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 10/50 28/50 Neoplastic Lesions
Yes TR-326 75-21-8 Ethylene oxide Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/49 4/48 17/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 1/48 7/49 Neoplastic Lesions
Yes TR-326 75-21-8 Ethylene oxide Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 11/50 11/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 10/50 16/50 Neoplastic Lesions
Yes TR-329 106-88-7 1,2-Epoxybutane Rats Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 1/50 1/49 OR ALVEOLAR/BRONCHIOLR CARCINOMA 0/50 1/50 4/49 COMBINED 0/50 2/50 5/49 Neoplastic Lesions
Yes TR-287 868-85-9 Dimethyl hydrogen phosphite Rats Male Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/50 5/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/50 20/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 5/50 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Mice Male Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 6/50 6/50 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/50 5/50 14/50 COMBINED 13/50 11/50 21/50 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Mice Female Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 17/50 13/49 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Mice Male Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 26/51 24/50 Neoplastic Lesions
Yes TR-352 924-42-5 N-Methylolacrylamide Mice Female Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 4/50 7/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 5/50 7/49 COMBINED 6/50 8/50 13/49 Neoplastic Lesions
Yes TR-352 924-42-5 N-Methylolacrylamide Mice Male Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 6/50 11/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/49 4/50 10/50 COMBINED 5/49 10/50 18/50 Neoplastic Lesions
Yes TR-370 271-89-6 Benzofuran Mice Female Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 5/48 13/47 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/48 3/47 COMBINED 2/50 9/48 14/47 Neoplastic Lesions
Yes TR-370 271-89-6 Benzofuran Mice Male Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 7/39 15/48 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/49 3/39 5/48 COMBINED 10/49 9/39 19/48 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Female Dosed-Water Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 1/45 3/74 3/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 0/74 1/60 COMBINED 1/60 1/45 3/74 4/60 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Male Dosed-Water Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 0/45 7/75 6/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 1/75 0/60 COMBINED 1/60 0/45 8/75 6/60 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Mice Male Topical Application Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 1/50 6/50 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid red 114 Rats Female Dosed-Water Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/35 8/65 4/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 1/50 2/35 9/65 4/50 Neoplastic Lesions
Yes TR-410 91-20-3 Naphthalene Mice Female Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 5/68 2/64 28/134 Neoplastic Lesions
Yes TR-386 509-14-8 Tetranitromethane Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 19/50 41/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 11/50 45/50 Neoplastic Lesions
Yes TR-386 509-14-8 Tetranitromethane Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 17/50 34/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 16/50 46/50 Neoplastic Lesions
Yes TR-386 509-14-8 Tetranitromethane Rats Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 6/50 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 19/50 50/50 COMBINED 0/50 22/50 50/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 12/50; MALIGNANT MIXED TUMORS 0/50 0/50 1/50; SARCOMA 0/50 0/50 1/50 Neoplastic Lesions
Yes TR-386 509-14-8 Tetranitromethane Rats Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 13/50 11/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/50 19/50, COMBINED 0/50 26/50 46/50; SQUAMOUS CELL CARCINOMA 1/50 1/50 19/50; SARCOMA 0/50 0/50 1/50 Neoplastic Lesions
Yes TR-466 100-41-4 Ethylbenzene Mice Male Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 9/50 10/50 16/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 1/50 5/50 3/50 COMBINED 7/50 10/50 15/50 19/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Mice Female Inhalation Lung Clear Evidence Alveolar/Bronchiolar Adenoma 2/50 16/49 29/50 26/50 or Alveolar/Bronchiolar Carcinoma 2/50 14/49 16/50 28/50 Combined 4/50 28/49 34/50 42/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Mice Male Inhalation Lung Clear Evidence Alveolar/Bronchiolar Adenoma 8/50 18/50 22/50 28/50 or Alveolar/Bronchiolar Carcinoma 6/50 12/50 23/50 28/50 Combined 13/50 28/50 36/50 43/50 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Male Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/51 0/53 3/51 1/55 4/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 1/53 0/51 3/55 3/60 COMBINED 1/51 1/53 3/51 4/55 7/60 Neoplastic Lesions
Yes TR-453 12035-72-2 Nickel subsulfide Rats Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/53 5/53 5/53 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 3/53 6/53 OR SQUAMOUS CELL CARCINOMA 0/53 1/53 0/53 COMBINED 2/53 6/53 9/53 Neoplastic Lesions
Yes TR-453 12035-72-2 Nickel subsulfide Rats Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/53 3/53 6/53; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 3/53 6/53; ALVEOLAR/BRONCHIOLAR ADENOMA OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 6/53 11/53 Neoplastic Lesions
Yes TR-461 75-52-5 Nitromethane Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 3/50 2/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 3/50 5/50 3/50 COMBINED 3/50 6/50 6/50 12/50 Neoplastic Lesions
Yes TR-461 75-52-5 Nitromethane Mice Male Inhalation Lung Clear Evidence ALVEOLAR ADENOMA 11/50 10/50 9/50 12/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 3/50 3/50 11/50 COMBINED 13/50 13/50 12/50 20/50 Neoplastic Lesions
Yes TR-462 1313-27-5 Molybdenum trioxide Mice Female Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 4/50 8/49 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 2/50 0/49 6/50 COMBINED 3/50 6/50 8/49 15/49 Neoplastic Lesions
Yes TR-462 1313-27-5 Molybdenum trioxide Mice Male Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 9/50 14/50 10/49 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 16/50 14/49 10/50 COMBINED 11/50 27/50 21/49 18/50 Neoplastic Lesions
Yes TR-421 14807-96-6 Talc Rats Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 0/48 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/48 5/50 COMBINED 1/50 0/48 13/50 Neoplastic Lesions
Yes TR-422 91-64-5 Coumarin Mice Female Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/51 5/49 7/49 20/51 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 0/49 0/49 7/51 COMBINED 2/51 5/49 7/49 27/51 Neoplastic Lesions
Yes TR-422 91-64-5 Coumarin Mice Male Gavage Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 14/50 8/50 14/50 24/51 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 1/50 2/50 1/51 COMBINED 14/50 9/50 15/50 25/51 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 4/50 15/50 19/50 24/50 25/50 22/78 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 21/50 23/50 19/50 31/49 35/50 3/73, STOP STUDY 36/50 28/50 32/50 17/50 Neoplastic Lesions
Yes TR-440 10028-15-6 Ozone Mice Female Inhalation Lung Some Evidence (2 YR. STUDY) ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 5/50 5/49 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 2/50 5/49 8/50 COMBINED 6/50 7/50 9/49 16/50 Neoplastic Lesions
Yes TR-440 10028-15-6 Ozone Mice Female Inhalation Lung Some Evidence (LIFETIME STUDY) ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 3/49 11/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 5/49 2/50 COMBINED 6/50 8/49 12/50 Neoplastic Lesions
Yes TR-448 542-56-3 Isobutyl nitrite Mice Female Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/51 14/51 7/50 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/51 2/51 2/50 2/50 COMBINED 6/51 15/51 9/50 19/50 Neoplastic Lesions
Yes TR-448 542-56-3 Isobutyl nitrite Mice Male Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 12/50 13/49 17/53 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/49 4/53 COMBINED 8/50 16/50 16/49 19/53 Neoplastic Lesions
Yes TR-448 542-56-3 Isobutyl nitrite Rats Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/46 2/45 2/46 10/46 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/46 1/45 0/46 1/46 COMBINED 0/46 3/45 2/46 11/46 Neoplastic Lesions
Yes TR-448 542-56-3 Isobutyl nitrite Rats Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/46 3/46 12/46 13/46 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/46 2/46 1/46 6/46 COMBINED 1/46 5/46 13/46 15/46 Neoplastic Lesions
Yes TR-451 1313-99-1 Nickel (II) oxide Rats Female Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/53 0/53 1/53 4/54 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 0/53 5/53 1/54 COMBINED 1/53 0/53 6/53 5/54 Neoplastic Lesions
Yes TR-451 1313-99-1 Nickel (II) oxide Rats Male Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/54 1/53 3/53 2/52 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/54 0/53 3/53 2/52 OR SQUAMOUS CELL CARCINOMA 1/54 0/53 0/53 0/52 COMBINED 1/54 1/53 6/53 4/52 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice Female Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/52 3/50 9/51 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/52 2/50 6/51 5/50 COMBINED 5/52 5/50 15/51 19/50 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice Male Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 12/50 4/51 12/50 21/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 7/51 8/50 11/49 COMBINED 15/50 11/51 16/50 25/49 Neoplastic Lesions
Yes TR-485 434-07-1 Oxymetholone Rats Female Gavage Lung Clear Evidence ADEMONA 0/50 0/50 6/50 1/49 COMBINED 0/50 0/50 7/50 1/49 Neoplastic Lesions
Yes TR-492 1303-00-0 Gallium arsenide Rats Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/50 2/50 7/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/50 2/50 3/50 COMBINED 0/50 0/50 4/50 9/50 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADEMONA 3/50 6/50 10/50 7/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/50 7/50; COMBINED 4/50 11/50 15/50 14/50 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 15/50 22/50 13/50 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Rats Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADEMONA 0/50 7/50 5/50 19/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 3/50 1/50 11/50; COMBINED 1/50 10/50 6/50 26/50 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Rats Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADEMONA 6/50 13/50 27/50 30/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 10/50 8/50 16/50; COMBINED 7/50 22/50 30/50 35/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 4/50 Neoplastic Lesions
Yes TR-504 88-72-2 o-Nitrotoluene Rats Male Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 5/60 1/60 2/60 3/60 8/60 OR ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 2/60 5/60 1/60 2/60 3/60 11/60 Neoplastic Lesions
Yes TR-507 1314-62-1 Vanadium pentoxide Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 17/50 23/50 19/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 23/50 18/50 22/50 COMBINED 1/50 32/50 35/50 32/50 Neoplastic Lesions
Yes TR-507 1314-62-1 Vanadium pentoxide Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 13/50 16/50 26/50 15/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 12/50 29/50 30/50 35/50 COMBINED 22/50 42/50 43/50 43/50 Neoplastic Lesions
Yes TR-507 1314-62-1 Vanadium pentoxide Rats Male Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 8/49 5/48 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 3/49 1/48 3/50 COMBINED 4/50 10/49 6/48 9/50 Neoplastic Lesions
Yes TR-508 23246-96-0 Riddelliine Mice Female Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/50 COMBINED 2/50 13/50 Neoplastic Lesions
Yes TR-510 51-79-6 Urethane Mice Female Dosed-Water Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 6/48 17/48 29/47 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 4/48 13/48 19/47 COMBINED 6/48 8/48 28/48 39/47 Neoplastic Lesions
Yes TR-510 51-79-6 Urethane Mice Male Dosed-Water Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 17/48 22/47 34/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 1/48 9/47 9/48 COMBINED 5/48 18/48 29/47 37/48 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Rats Male Inhalation Lung Clear Evidence Alveolar/Bronchiolar Adenoma 2/50 0/50 3/49 3/50 or Alveolar/Bronchiolar Carcinoma 0/50 2/50 1/49 4/50 Combined 2/50 2/50 4/49 6/50 Neoplastic Lesions
Yes TR-471 10026-24-1 Cobalt sulfate heptahydrate Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 6/50 9/50 10/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 1/50 4/50 9/50 COMBINED 4/50 7/50 13/50 18/50 Neoplastic Lesions
Yes TR-471 10026-24-1 Cobalt sulfate heptahydrate Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 9/50 12/50 13/50 18/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 4/50 5/50 7/50 11/50 COMBINED 11/50 14/50 19/50 28/50 Neoplastic Lesions
Yes TR-471 10026-24-1 Cobalt sulfate heptahydrate Rats Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 1/49 10/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/49 6/50 6/50 COMBINED 0/50 3/49 16/50 16/50 Neoplastic Lesions
Yes TR-471 10026-24-1 Cobalt sulfate heptahydrate Rats Male Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 4/50 1/48 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/50 3/48 1/50 COMBINED 1/50 4/50 4/48 7/50 Neoplastic Lesions
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Mice Female Gavage Lung Clear Evidence Alveolar/bronchiolar adenoma or carcinoma 0/49 2/50 1/50 4/50 alveolar/bronchiolar adenoma or carcinoma 3/49 8/50 5/50 10/50 cystic keratinizing epithelioma 0/49 0/50 0/50 2/50 Neoplastic Lesions
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Mice Male Gavage Lung Clear Evidence Alveolar/bronchiolar adenoma 5/50 16/50 12/49 6/50 alveolar/bronchiolar adenoma or carcinoma 7/50 17/50 15/49 6/50 Neoplastic Lesions
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Female Gavage Lung Clear Evidence Cystic keratinizing epithelioma 0/50 6/50 26/49 39/49 Neoplastic Lesions
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Male Gavage Lung Clear Evidence Cystic keratinizing epithelioma 0/50 14/50 31/50 37/50 Neoplastic Lesions
Yes TR-559 31508-00-6 TEF evaluation (PCB 118) Rats Female Gavage Lung Clear Evidence Cystic keratinizing epithelioma 0/51 0/52 0/52 0/52 0/52 20/50 0/50 Neoplastic Lesions
Yes TR-564 106-94-5 1-Bromopropane Mice Female Inhalation Lung Clear Evidence Alveolar/bronchiolar adenoma 1/50 6/50 4/50 10/50 alveolar/bronchiolar carcinoma 0/50 7/50 5/50 4/50 alveolar/bronchiolar adenoma or carcinoma 1/50 9/50 8/50 14/50 Neoplastic Lesions
Yes TR-520 57465-28-8 Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) Rats Female Gavage Lung Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/55 0/53 0/53 1/53 11/51 35/51 0/50 OR SQUAMOUS CELL CARCINOMA 0/53 0/55 0/53 0/53 0/53 1/51 2/51 0/50 Neoplastic Lesions
Yes TR-521 1746-01-6 TEF evaluation (TCDD) Rats Female Gavage Lung Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/54 0/53 0/52 0/53 9/52 0/50 Neoplastic Lesions
Yes TR-522 30516-87-1 AZT transplacental carcinogenesis study Mice Male In Utero Lung Clear Evidence ALVEOLAR/BRONCHIOLAR CARCINOMA 5/50 11/50 6/50 11/37 8/32 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 14/50 20/50 13/50 18/37 18/32 Neoplastic Lesions
Yes TR-526 TEFDIOXINMIX TEF evaluation (Dioxin mixture) Rats Female Gavage Lung Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/53 0/53 2/53 20/53 Neoplastic Lesions
Yes TR-530 TEFBINARYMIX TEF evaluation (Binary mixture; PCB 126/PCB 153) Rats Female Gavage Lung Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/53 0/52 1/53 11/52 Neoplastic Lesions
Yes TR-531 TEFPCBMIX TEF Evaluation (PCB Mixture; PCB 126/PCB 118) Rats Female Gavage Lung Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/51 0/53 20/53 49/53 41/66 12/50 Neoplastic Lesions
Yes TR-535 822-36-6 4-Methylimidazole Mice Female Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 8/50 16/50 8/50 ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 0/50 2/50 7/50 COMBINED 3/50 8/50 17/50 14/50 Neoplastic Lesions
Yes TR-535 822-36-6 4-Methylimidazole Mice Male Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 4/50 4/50 8/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA (COMBINED) 9/50 13/50 16/50 22/50 Neoplastic Lesions
Yes TR-537 631-64-1 Water disinfection byproducts (Dibromoacetic acid) Mice Male Dosed-Water Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 7/49 5/50 17/50 12/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 12/49 12/50 22/50 17/50 Neoplastic Lesions
Yes TR-542 98-82-8 Cumene Mice Female Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma (1/50, 26/50, 36/50, 38/50); alveolar/bronchiolar carcinoma (3/50, 16/50, 20/50, 34/50); alveolar/bronchiolar adenoma or carcinoma (4/50, 31/50, 42/50, 46/50) Neoplastic Lesions
Yes TR-542 98-82-8 Cumene Mice Male Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma (13/50, 31/50, 31/50, 29/50); alveolar/bronchiolar carcinoma (9/50, 19/50, 32/50, 33/50); alveolar/bronchiolar adenoma or carcinoma (19/50, 38/50, 42/50, 43/50) Neoplastic Lesions
Yes TR-581 7440-48-4 Cobalt Rats Male Inhalation Lung Clear Evidence cystic keratinizing epithelioma 0/50 1/50 0/50 1/50 May Have Been Related
Yes TR-581 7440-48-4 Cobalt Mice Female Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma 3/49 9/50 8/50 10/50 alveolar/bronchiolar carcinoma 5/49 25/50 38/50 43/50 alveolar/bronchiolar adenoma or carcinoma 8/49 30/50 41/50 45/50 May Have Been Related
Yes TR-588 5694-00-8 Glycidamide Mice Male Dosed-Water Lung Clear Evidence alveolar/bronchiolar adenoma 0/47 7/46 7/47 13/47 17/47 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Mice Female Dosed-Water Lung Clear Evidence alveolar/bronchiolar adenoma 3/46 5/48 3/47 7/47 9/44 Neoplastic Lesions
Yes TR-580 108-99-6 beta-Picoline Rats Female Dosed-Water Lung Some Evidence alveolar/bronchiolar adenoma 0/50 3/50 2/50 5/50 alveolar/bronchiolar adenoma or carcinoma 0/50 4/50 2/50 5/50 Neoplastic Lesions
Yes TR-580 108-99-6 beta-Picoline Mice Female Dosed-Water Lung Clear Evidence alveolar/bronchiolar adenoma 5/50 6/50 4/49 11/50 carcinoma 7/50 8/50 10/49 13/50 alveolar/bronchiolar adenoma or carcinoma 11/50 13/50 13/49 21/50 Neoplastic Lesions
Yes TR-591 TRIMVX Metal Working Fluids: TRIM® VX Mice Male Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma or carcinoma 14/50 14/50 11/49 23/50 Neoplastic Lesions
Yes TR-591 TRIMVX Metal Working Fluids: TRIM® VX Mice Female Inhalation Lung Clear Evidence alveolar/bronchiolar carcinoma 5/50 3/50 6/50 14/50 alveolar/bronchiolar adenoma or carcinoma 9/50 8/50 8/50 20/50 Neoplastic Lesions
Yes TR-590 1309-64-4 Antimony Trioxide Rats Male Inhalation Lung Some Evidence alveolar/bronchiolar adenoma (3/50, 4/50, 6/50, 8/50); alveolar/bronchiolar adenoma or carcinoma (3/50, 4/50, 8/50, 8/50) Neoplastic Lesions
Yes TR-590 1309-64-4 Antimony Trioxide Rats Female Inhalation Lung Some Evidence alveolar/bronchiolar adenoma (0/50, 2/50, 6/50, 5/50) Neoplastic Lesions
Yes TR-590 1309-64-4 Antimony Trioxide Mice Male Inhalation Lung Clear Evidence alveolar/bronchiolar carcinoma (4/50, 18/50, 20/50, 27/50) Neoplastic Lesions
Yes TR-590 1309-64-4 Antimony Trioxide Mice Female Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma (1/50, 10/50, 19/50, 8/50); alveolar/bronchiolar carcinoma (2/50, 14/50, 11/50, 11/50); alveolar/bronchiolar adenoma or carcinoma (3/50, 22/50, 27/50, 18/50) Neoplastic Lesions
Yes TR-590 1309-64-4 Antimony Trioxide Rats Female Inhalation Lung Some Evidence cystic keratinizing epithelioma or squamous cell carcinoma (0/50, 0/50, 0/50, 3/50) May Have Been Related
Yes TR-594 98-56-6 p-Chloro-a,a,a-trifluorotoluene Rats Male Inhalation Lung Some Evidence alveolar/bronchiolar adenoma or carcinoma (0/50, 2/50, 0/50, 3/50) May Have Been Related
Yes TR-575 79-06-1 Acrylamide Mice Female Dosed-Water Lung Clear Evidence alveolar/bronchiolar adenoma 1/47 4/47 6/48 11/45 19/45 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Mice Male Dosed-Water Lung Clear Evidence alveolar/bronchiolar adenoma 5/47 6/46 13/47 10/45 19/48 alveolar/bronchiolar adenoma or carcinoma 6/47 6/46 14/47 10/45 20/48 Neoplastic Lesions
Yes TR-579 99-97-8 N,N-Dimethyl-p-toluidine Mice Female Gavage Lung Clear Evidence alveolar/bronchiolar adenoma 2/50, 4/50, 8/50, 12/50; alveolar/bronchiolar adenoma or carcinoma 2/50, 5/50, 9/50, 13/50 Neoplastic Lesions
Yes TR-581 7440-48-4 Cobalt Rats Male Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma 2/50 10/50 10/50 14/50 alveolar/bronchiolar carcinoma 0/50 16/50 34/50 36/50 alveolar/bronchiolar adenoma or carcinoma 2/50 25/50 39/50 44/50 Neoplastic Lesions
Yes TR-581 7440-48-4 Cobalt Rats Female Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma 2/50 7/50 9/50 13/50 alveolar/bronchiolar carcinoma 0/50 9/50 17/50 30/50 alveolar/bronchiolar adenoma or carcinoma 2/50 15/50 20/50 38/50 cystic keratinizing epithelioma 0/50 4/50 1/50 2/50 Neoplastic Lesions
Yes TR-581 7440-48-4 Cobalt Mice Male Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma 7/50 11/49 15/50 3/50 alveolar/bronchiolar carcinoma 11/50 38/49 42/50 46/50 alveolar/bronchiolar adenoma or carcinoma 16/50 41/49 43/50 47/50 Neoplastic Lesions