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Organ Sites with Neoplasia

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  • Organ: Lung
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-590 1309-64-4 Antimony Trioxide Rats Male Inhalation Lung Some Evidence alveolar/bronchiolar adenoma (3/50, 4/50, 6/50, 8/50); alveolar/bronchiolar adenoma or carcinoma (3/50, 4/50, 8/50, 8/50) Neoplastic Lesions
TR-019 366-70-1 Procarbazine hydrochloride Mice Female Intraperitoneal Injection Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
TR-019 366-70-1 Procarbazine hydrochloride Mice Male Intraperitoneal Injection Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
TR-055 107-06-2 1,2-Dichloroethane Mice Female Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
TR-055 107-06-2 1,2-Dichloroethane Mice Male Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
TR-034 1582-09-8 Trifluralin Mice Female Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
TR-059 22966-79-6 Estradiol mustard Mice Male Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
TR-060 3546-10-9 Phenesterin Mice Female Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
TR-060 3546-10-9 Phenesterin Mice Male Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
TR-059 22966-79-6 Estradiol mustard Mice Female Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
TR-086 106-93-4 1,2-Dibromoethane Mice Female Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
TR-086 106-93-4 1,2-Dibromoethane Mice Male Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA) Neoplastic Lesions
TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Mice Female Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Mice Male Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
TR-118 602-87-9 5-Nitroacenaphthene Rats Female Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
TR-118 602-87-9 5-Nitroacenaphthene Rats Male Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
TR-115 95-06-7 Sulfallate Mice Male Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, CARCINOMA) Neoplastic Lesions
TR-143 2243-62-1 1,5-Naphthalenediamine Mice Female Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA) Neoplastic Lesions
TR-160 137-17-7 2,4,5-Trimethylaniline Rats Female Dosed-Feed Lung Positive (ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
TR-194 7446-34-6 Selenium sulfide Mice Female Gavage Lung Positive (ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA) Neoplastic Lesions
TR-210 106-93-4 1,2-Dibromoethane Mice Female Inhalation Lung Positive ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 7/49 13/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/49 5/49 37/50 Neoplastic Lesions
TR-210 106-93-4 1,2-Dibromoethane Mice Male Inhalation Lung Positive ALVEOLAR/BRONCHIOLAR ADENOMA 0/41 0/48 11/46; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/41 3/48 19/46 Neoplastic Lesions
TR-210 106-93-4 1,2-Dibromoethane Rats Female Inhalation Lung Positive ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/48 1/47 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/48 4/47 COMBINED 0/50 0/48 5/47 Neoplastic Lesions
TR-206 96-12-8 1,2-Dibromo-3-chloropropane Mice Female Inhalation Lung Positive ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 3/49 10/47; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/49 2/49 4/47 Neoplastic Lesions
TR-206 96-12-8 1,2-Dibromo-3-chloropropane Mice Male Inhalation Lung Positive ALVEOLAR/BRONCHIOLAR ADENOMA 0/41 1/40 6/45; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/41 2/40 1/45 Neoplastic Lesions
TR-239 108-60-1 bis(2-Chloro-1-methylethyl) ether Mice Female Gavage Lung Positive ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 4/50 8/50 Neoplastic Lesions
TR-239 108-60-1 bis(2-Chloro-1-methylethyl) ether Mice Male Gavage Lung Positive ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 13/50 11/50 Neoplastic Lesions
TR-269 542-75-6 1,3-Dichloropropene (Telone II) Mice Female Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 8/50 Neoplastic Lesions
TR-271 2784-94-3 HC blue 1 Rats Female Dosed-Feed Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/49 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/49 4/50 COMBINED 1/50 3/49 7/50 Neoplastic Lesions
TR-287 868-85-9 Dimethyl hydrogen phosphite Rats Male Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/50 5/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/50 20/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 5/50 Neoplastic Lesions
TR-288 106-99-0 1,3-Butadiene Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 9/48 20/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 6/48 8/49 Neoplastic Lesions
TR-288 106-99-0 1,3-Butadiene Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 12/49 11/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/49 5/49 Neoplastic Lesions
TR-289 71-43-2 Benzene Mice Female Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 2/42 5/50 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 3/42 6/50 6/49 COMBINED 4/49 5/42 10/50 13/49 Neoplastic Lesions
TR-289 71-43-2 Benzene Mice Male Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 6/49 6/48 8/50 12/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 5/49 11/48 12/50 14/49 COMBINED 10/49 16/48 19/50 21/49 Neoplastic Lesions
TR-329 106-88-7 1,2-Epoxybutane Rats Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 1/50 1/49 OR ALVEOLAR/BRONCHIOLR CARCINOMA 0/50 1/50 4/49 COMBINED 0/50 2/50 5/49 Neoplastic Lesions
TR-405 6459-94-5 C.I. Acid red 114 Rats Female Dosed-Water Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/35 8/65 4/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 1/50 2/35 9/65 4/50 Neoplastic Lesions
TR-564 106-94-5 1-Bromopropane Mice Female Inhalation Lung Clear Evidence Alveolar/bronchiolar adenoma 1/50 6/50 4/50 10/50 alveolar/bronchiolar carcinoma 0/50 7/50 5/50 4/50 alveolar/bronchiolar adenoma or carcinoma 1/50 9/50 8/50 14/50 Neoplastic Lesions
TR-521 1746-01-6 TEF evaluation (TCDD) Rats Female Gavage Lung Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/54 0/53 0/52 0/53 9/52 0/50 Neoplastic Lesions
TR-434 106-99-0 1,3-Butadiene Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 21/50 23/50 19/50 31/49 35/50 3/73, STOP STUDY 36/50 28/50 32/50 17/50 Neoplastic Lesions
TR-448 542-56-3 Isobutyl nitrite Mice Female Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/51 14/51 7/50 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/51 2/51 2/50 2/50 COMBINED 6/51 15/51 9/50 19/50 Neoplastic Lesions
TR-448 542-56-3 Isobutyl nitrite Mice Male Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 12/50 13/49 17/53 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/49 4/53 COMBINED 8/50 16/50 16/49 19/53 Neoplastic Lesions
TR-448 542-56-3 Isobutyl nitrite Rats Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/46 2/45 2/46 10/46 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/46 1/45 0/46 1/46 COMBINED 0/46 3/45 2/46 11/46 Neoplastic Lesions
TR-466 100-41-4 Ethylbenzene Mice Male Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 9/50 10/50 16/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 1/50 5/50 3/50 COMBINED 7/50 10/50 15/50 19/50 Neoplastic Lesions
TR-499 22398-80-7 Indium phosphide Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 15/50 22/50 13/50 Neoplastic Lesions
TR-448 542-56-3 Isobutyl nitrite Rats Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/46 3/46 12/46 13/46 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/46 2/46 1/46 6/46 COMBINED 1/46 5/46 13/46 15/46 Neoplastic Lesions
TR-499 22398-80-7 Indium phosphide Rats Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADEMONA 0/50 7/50 5/50 19/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 3/50 1/50 11/50; COMBINED 1/50 10/50 6/50 26/50 Neoplastic Lesions
TR-499 22398-80-7 Indium phosphide Rats Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADEMONA 6/50 13/50 27/50 30/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 10/50 8/50 16/50; COMBINED 7/50 22/50 30/50 35/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 4/50 Neoplastic Lesions
TR-492 1303-00-0 Gallium arsenide Rats Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/50 2/50 7/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/50 2/50 3/50 COMBINED 0/50 0/50 4/50 9/50 Neoplastic Lesions
TR-522 30516-87-1 AZT transplacental carcinogenesis study Mice Male In Utero Lung Clear Evidence ALVEOLAR/BRONCHIOLAR CARCINOMA 5/50 11/50 6/50 11/37 8/32 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 14/50 20/50 13/50 18/37 18/32 Neoplastic Lesions
TR-507 1314-62-1 Vanadium pentoxide Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 17/50 23/50 19/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 23/50 18/50 22/50 COMBINED 1/50 32/50 35/50 32/50 Neoplastic Lesions
TR-485 434-07-1 Oxymetholone Rats Female Gavage Lung Clear Evidence ADEMONA 0/50 0/50 6/50 1/49 COMBINED 0/50 0/50 7/50 1/49 Neoplastic Lesions
TR-510 51-79-6 Urethane Mice Male Dosed-Water Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 17/48 22/47 34/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 1/48 9/47 9/48 COMBINED 5/48 18/48 29/47 37/48 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Mice Female Inhalation Lung Clear Evidence Alveolar/Bronchiolar Adenoma 2/50 16/49 29/50 26/50 or Alveolar/Bronchiolar Carcinoma 2/50 14/49 16/50 28/50 Combined 4/50 28/49 34/50 42/50 Neoplastic Lesions
TR-471 10026-24-1 Cobalt sulfate heptahydrate Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 6/50 9/50 10/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 1/50 4/50 9/50 COMBINED 4/50 7/50 13/50 18/50 Neoplastic Lesions
TR-471 10026-24-1 Cobalt sulfate heptahydrate Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 9/50 12/50 13/50 18/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 4/50 5/50 7/50 11/50 COMBINED 11/50 14/50 19/50 28/50 Neoplastic Lesions
TR-471 10026-24-1 Cobalt sulfate heptahydrate Rats Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 1/49 10/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/49 6/50 6/50 COMBINED 0/50 3/49 16/50 16/50 Neoplastic Lesions
TR-471 10026-24-1 Cobalt sulfate heptahydrate Rats Male Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 4/50 1/48 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/50 3/48 1/50 COMBINED 1/50 4/50 4/48 7/50 Neoplastic Lesions
TR-590 1309-64-4 Antimony Trioxide Mice Female Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma (1/50, 10/50, 19/50, 8/50); alveolar/bronchiolar carcinoma (2/50, 14/50, 11/50, 11/50); alveolar/bronchiolar adenoma or carcinoma (3/50, 22/50, 27/50, 18/50) Neoplastic Lesions
TR-590 1309-64-4 Antimony Trioxide Rats Female Inhalation Lung Some Evidence cystic keratinizing epithelioma or squamous cell carcinoma (0/50, 0/50, 0/50, 3/50) May Have Been Related
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Male Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/51 0/53 3/51 1/55 4/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 1/53 0/51 3/55 3/60 COMBINED 1/51 1/53 3/51 4/55 7/60 Neoplastic Lesions
TR-440 10028-15-6 Ozone Mice Female Inhalation Lung Some Evidence (2 YR. STUDY) ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 5/50 5/49 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 2/50 5/49 8/50 COMBINED 6/50 7/50 9/49 16/50 Neoplastic Lesions
TR-440 10028-15-6 Ozone Mice Female Inhalation Lung Some Evidence (LIFETIME STUDY) ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 3/49 11/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 5/49 2/50 COMBINED 6/50 8/49 12/50 Neoplastic Lesions
TR-530 TEFBINARYMIX TEF evaluation (Binary mixture; PCB 126/PCB 153) Rats Female Gavage Lung Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/53 0/52 1/53 11/52 Neoplastic Lesions
TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Male Gavage Lung Clear Evidence Cystic keratinizing epithelioma 0/50 14/50 31/50 37/50 Neoplastic Lesions
TR-421 14807-96-6 Talc Rats Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 0/48 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/48 5/50 COMBINED 1/50 0/48 13/50 Neoplastic Lesions
TR-461 75-52-5 Nitromethane Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 3/50 2/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 3/50 5/50 3/50 COMBINED 3/50 6/50 6/50 12/50 Neoplastic Lesions
TR-461 75-52-5 Nitromethane Mice Male Inhalation Lung Clear Evidence ALVEOLAR ADENOMA 11/50 10/50 9/50 12/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 3/50 3/50 11/50 COMBINED 13/50 13/50 12/50 20/50 Neoplastic Lesions
TR-462 1313-27-5 Molybdenum trioxide Mice Female Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 4/50 8/49 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 2/50 0/49 6/50 COMBINED 3/50 6/50 8/49 15/49 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Mice Male Inhalation Lung Clear Evidence Alveolar/Bronchiolar Adenoma 8/50 18/50 22/50 28/50 or Alveolar/Bronchiolar Carcinoma 6/50 12/50 23/50 28/50 Combined 13/50 28/50 36/50 43/50 Neoplastic Lesions
TR-594 98-56-6 p-Chloro-a,a,a-trifluorotoluene Rats Male Inhalation Lung Some Evidence alveolar/bronchiolar adenoma or carcinoma (0/50, 2/50, 0/50, 3/50) May Have Been Related
TR-591 TRIMVX Metal Working Fluids: TRIM® VX Mice Male Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma or carcinoma 14/50 14/50 11/49 23/50 Neoplastic Lesions
TR-591 TRIMVX Metal Working Fluids: TRIM® VX Mice Female Inhalation Lung Clear Evidence alveolar/bronchiolar carcinoma 5/50 3/50 6/50 14/50 alveolar/bronchiolar adenoma or carcinoma 9/50 8/50 8/50 20/50 Neoplastic Lesions
TR-462 1313-27-5 Molybdenum trioxide Mice Male Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 9/50 14/50 10/49 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 16/50 14/49 10/50 COMBINED 11/50 27/50 21/49 18/50 Neoplastic Lesions
TR-531 TEFPCBMIX TEF Evaluation (PCB Mixture; PCB 126/PCB 118) Rats Female Gavage Lung Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/51 0/53 20/53 49/53 41/66 12/50 Neoplastic Lesions
TR-559 31508-00-6 TEF evaluation (PCB 118) Rats Female Gavage Lung Clear Evidence Cystic keratinizing epithelioma 0/51 0/52 0/52 0/52 0/52 20/50 0/50 Neoplastic Lesions
TR-434 106-99-0 1,3-Butadiene Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 4/50 15/50 19/50 24/50 25/50 22/78 Neoplastic Lesions
TR-535 822-36-6 4-Methylimidazole Mice Female Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 8/50 16/50 8/50 ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 0/50 2/50 7/50 COMBINED 3/50 8/50 17/50 14/50 Neoplastic Lesions
TR-422 91-64-5 Coumarin Mice Female Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/51 5/49 7/49 20/51 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 0/49 0/49 7/51 COMBINED 2/51 5/49 7/49 27/51 Neoplastic Lesions
TR-422 91-64-5 Coumarin Mice Male Gavage Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 14/50 8/50 14/50 24/51 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 1/50 2/50 1/51 COMBINED 14/50 9/50 15/50 25/51 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Rats Male Inhalation Lung Clear Evidence Alveolar/Bronchiolar Adenoma 2/50 0/50 3/49 3/50 or Alveolar/Bronchiolar Carcinoma 0/50 2/50 1/49 4/50 Combined 2/50 2/50 4/49 6/50 Neoplastic Lesions
TR-504 88-72-2 o-Nitrotoluene Rats Male Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 5/60 1/60 2/60 3/60 8/60 OR ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 2/60 5/60 1/60 2/60 3/60 11/60 Neoplastic Lesions
TR-535 822-36-6 4-Methylimidazole Mice Male Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 4/50 4/50 8/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA (COMBINED) 9/50 13/50 16/50 22/50 Neoplastic Lesions
TR-453 12035-72-2 Nickel subsulfide Rats Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/53 5/53 5/53 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 3/53 6/53 OR SQUAMOUS CELL CARCINOMA 0/53 1/53 0/53 COMBINED 2/53 6/53 9/53 Neoplastic Lesions
TR-453 12035-72-2 Nickel subsulfide Rats Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/53 3/53 6/53; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 3/53 6/53; ALVEOLAR/BRONCHIOLAR ADENOMA OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 6/53 11/53 Neoplastic Lesions
TR-499 22398-80-7 Indium phosphide Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADEMONA 3/50 6/50 10/50 7/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/50 7/50; COMBINED 4/50 11/50 15/50 14/50 Neoplastic Lesions
TR-537 631-64-1 Water disinfection byproducts (Dibromoacetic acid) Mice Male Dosed-Water Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 7/49 5/50 17/50 12/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 12/49 12/50 22/50 17/50 Neoplastic Lesions
TR-520 57465-28-8 Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) Rats Female Gavage Lung Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/55 0/53 0/53 1/53 11/51 35/51 0/50 OR SQUAMOUS CELL CARCINOMA 0/53 0/55 0/53 0/53 0/53 1/51 2/51 0/50 Neoplastic Lesions
TR-526 TEFDIOXINMIX TEF evaluation (Dioxin mixture) Rats Female Gavage Lung Clear Evidence CYSTIC KERATINIZING EPITHELIOMA 0/53 0/53 0/53 2/53 20/53 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice Female Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/52 3/50 9/51 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/52 2/50 6/51 5/50 COMBINED 5/52 5/50 15/51 19/50 Neoplastic Lesions
TR-386 509-14-8 Tetranitromethane Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 19/50 41/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 11/50 45/50 Neoplastic Lesions
TR-386 509-14-8 Tetranitromethane Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 17/50 34/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 16/50 46/50 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice Male Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 12/50 4/51 12/50 21/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 7/51 8/50 11/49 COMBINED 15/50 11/51 16/50 25/49 Neoplastic Lesions
TR-386 509-14-8 Tetranitromethane Rats Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 6/50 3/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 19/50 50/50 COMBINED 0/50 22/50 50/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 12/50; MALIGNANT MIXED TUMORS 0/50 0/50 1/50; SARCOMA 0/50 0/50 1/50 Neoplastic Lesions
TR-386 509-14-8 Tetranitromethane Rats Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 13/50 11/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 1/50 19/50, COMBINED 0/50 26/50 46/50; SQUAMOUS CELL CARCINOMA 1/50 1/50 19/50; SARCOMA 0/50 0/50 1/50 Neoplastic Lesions
TR-374 556-52-5 Glycidol Mice Male Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 6/50 6/50 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/50 5/50 14/50 COMBINED 13/50 11/50 21/50 Neoplastic Lesions
TR-370 271-89-6 Benzofuran Mice Female Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 5/48 13/47 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/48 3/47 COMBINED 2/50 9/48 14/47 Neoplastic Lesions
TR-370 271-89-6 Benzofuran Mice Male Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 7/39 15/48 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/49 3/39 5/48 COMBINED 10/49 9/39 19/48 Neoplastic Lesions
TR-352 924-42-5 N-Methylolacrylamide Mice Female Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 4/50 7/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 5/50 7/49 COMBINED 6/50 8/50 13/49 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Mice Male Topical Application Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 1/50 6/50 Neoplastic Lesions
TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Mice Female Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 17/50 13/49 Neoplastic Lesions
TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Mice Male Dosed-Feed Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 26/51 24/50 Neoplastic Lesions
TR-507 1314-62-1 Vanadium pentoxide Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 13/50 16/50 26/50 15/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 12/50 29/50 30/50 35/50 COMBINED 22/50 42/50 43/50 43/50 Neoplastic Lesions
TR-352 924-42-5 N-Methylolacrylamide Mice Male Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 6/50 11/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/49 4/50 10/50 COMBINED 5/49 10/50 18/50 Neoplastic Lesions
TR-507 1314-62-1 Vanadium pentoxide Rats Male Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 8/49 5/48 6/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 3/49 1/48 3/50 COMBINED 4/50 10/49 6/48 9/50 Neoplastic Lesions
TR-508 23246-96-0 Riddelliine Mice Female Gavage Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/50 COMBINED 2/50 13/50 Neoplastic Lesions
TR-410 91-20-3 Naphthalene Mice Female Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 5/68 2/64 28/134 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Female Dosed-Water Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 1/45 3/74 3/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 0/74 1/60 COMBINED 1/60 1/45 3/74 4/60 Neoplastic Lesions
TR-451 1313-99-1 Nickel (II) oxide Rats Female Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/53 0/53 1/53 4/54 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/53 0/53 5/53 1/54 COMBINED 1/53 0/53 6/53 5/54 Neoplastic Lesions
TR-451 1313-99-1 Nickel (II) oxide Rats Male Inhalation Lung Some Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 0/54 1/53 3/53 2/52 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/54 0/53 3/53 2/52 OR SQUAMOUS CELL CARCINOMA 1/54 0/53 0/53 0/52 COMBINED 1/54 1/53 6/53 4/52 Neoplastic Lesions
TR-306 75-09-2 Methylene chloride Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 23/48 28/48; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 13/48 29/48 Neoplastic Lesions
TR-306 75-09-2 Methylene chloride Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 19/50 24/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 10/50 28/50 Neoplastic Lesions
TR-326 75-21-8 Ethylene oxide Mice Female Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 2/49 4/48 17/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 1/48 7/49 Neoplastic Lesions
TR-326 75-21-8 Ethylene oxide Mice Male Inhalation Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 11/50 11/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 10/50 16/50 Neoplastic Lesions
TR-510 51-79-6 Urethane Mice Female Dosed-Water Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 6/48 17/48 29/47 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 4/48 13/48 19/47 COMBINED 6/48 8/48 28/48 39/47 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Male Dosed-Water Lung Clear Evidence ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 0/45 7/75 6/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 1/75 0/60 COMBINED 1/60 0/45 8/75 6/60 Neoplastic Lesions
TR-581 7440-48-4 Cobalt Rats Male Inhalation Lung Clear Evidence cystic keratinizing epithelioma 0/50 1/50 0/50 1/50 May Have Been Related
TR-581 7440-48-4 Cobalt Mice Female Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma 3/49 9/50 8/50 10/50 alveolar/bronchiolar carcinoma 5/49 25/50 38/50 43/50 alveolar/bronchiolar adenoma or carcinoma 8/49 30/50 41/50 45/50 May Have Been Related
TR-590 1309-64-4 Antimony Trioxide Rats Female Inhalation Lung Some Evidence alveolar/bronchiolar adenoma (0/50, 2/50, 6/50, 5/50) Neoplastic Lesions
TR-542 98-82-8 Cumene Mice Female Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma (1/50, 26/50, 36/50, 38/50); alveolar/bronchiolar carcinoma (3/50, 16/50, 20/50, 34/50); alveolar/bronchiolar adenoma or carcinoma (4/50, 31/50, 42/50, 46/50) Neoplastic Lesions
TR-542 98-82-8 Cumene Mice Male Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma (13/50, 31/50, 31/50, 29/50); alveolar/bronchiolar carcinoma (9/50, 19/50, 32/50, 33/50); alveolar/bronchiolar adenoma or carcinoma (19/50, 38/50, 42/50, 43/50) Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Mice Male Dosed-Water Lung Clear Evidence alveolar/bronchiolar adenoma 0/47 7/46 7/47 13/47 17/47 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Mice Female Dosed-Water Lung Clear Evidence alveolar/bronchiolar adenoma 3/46 5/48 3/47 7/47 9/44 Neoplastic Lesions
TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Mice Female Gavage Lung Clear Evidence Alveolar/bronchiolar adenoma or carcinoma 0/49 2/50 1/50 4/50 alveolar/bronchiolar adenoma or carcinoma 3/49 8/50 5/50 10/50 cystic keratinizing epithelioma 0/49 0/50 0/50 2/50 Neoplastic Lesions
TR-579 99-97-8 N,N-Dimethyl-p-toluidine Mice Female Gavage Lung Clear Evidence alveolar/bronchiolar adenoma 2/50, 4/50, 8/50, 12/50; alveolar/bronchiolar adenoma or carcinoma 2/50, 5/50, 9/50, 13/50 Neoplastic Lesions
TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Mice Male Gavage Lung Clear Evidence Alveolar/bronchiolar adenoma 5/50 16/50 12/49 6/50 alveolar/bronchiolar adenoma or carcinoma 7/50 17/50 15/49 6/50 Neoplastic Lesions
TR-580 108-99-6 beta-Picoline Rats Female Dosed-Water Lung Some Evidence alveolar/bronchiolar adenoma 0/50 3/50 2/50 5/50 alveolar/bronchiolar adenoma or carcinoma 0/50 4/50 2/50 5/50 Neoplastic Lesions
TR-580 108-99-6 beta-Picoline Mice Female Dosed-Water Lung Clear Evidence alveolar/bronchiolar adenoma 5/50 6/50 4/49 11/50 carcinoma 7/50 8/50 10/49 13/50 alveolar/bronchiolar adenoma or carcinoma 11/50 13/50 13/49 21/50 Neoplastic Lesions
TR-575 79-06-1 Acrylamide Mice Female Dosed-Water Lung Clear Evidence alveolar/bronchiolar adenoma 1/47 4/47 6/48 11/45 19/45 Neoplastic Lesions
TR-575 79-06-1 Acrylamide Mice Male Dosed-Water Lung Clear Evidence alveolar/bronchiolar adenoma 5/47 6/46 13/47 10/45 19/48 alveolar/bronchiolar adenoma or carcinoma 6/47 6/46 14/47 10/45 20/48 Neoplastic Lesions
TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Female Gavage Lung Clear Evidence Cystic keratinizing epithelioma 0/50 6/50 26/49 39/49 Neoplastic Lesions
TR-590 1309-64-4 Antimony Trioxide Mice Male Inhalation Lung Clear Evidence alveolar/bronchiolar carcinoma (4/50, 18/50, 20/50, 27/50) Neoplastic Lesions
TR-581 7440-48-4 Cobalt Rats Male Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma 2/50 10/50 10/50 14/50 alveolar/bronchiolar carcinoma 0/50 16/50 34/50 36/50 alveolar/bronchiolar adenoma or carcinoma 2/50 25/50 39/50 44/50 Neoplastic Lesions
TR-581 7440-48-4 Cobalt Rats Female Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma 2/50 7/50 9/50 13/50 alveolar/bronchiolar carcinoma 0/50 9/50 17/50 30/50 alveolar/bronchiolar adenoma or carcinoma 2/50 15/50 20/50 38/50 cystic keratinizing epithelioma 0/50 4/50 1/50 2/50 Neoplastic Lesions
TR-581 7440-48-4 Cobalt Mice Male Inhalation Lung Clear Evidence alveolar/bronchiolar adenoma 7/50 11/49 15/50 3/50 alveolar/bronchiolar carcinoma 11/50 38/49 42/50 46/50 alveolar/bronchiolar adenoma or carcinoma 16/50 41/49 43/50 47/50 Neoplastic Lesions