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Organ Sites with Neoplasia

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  • Organ: Liver
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-013 127-18-4 Tetrachloroethylene Mice Female Gavage Liver Positive (CARCINOMA) Neoplastic Lesions
TR-013 127-18-4 Tetrachloroethylene Mice Male Gavage Liver Positive (CARCINOMA) Neoplastic Lesions
TR-008 57-74-9 Chlordane (analytical grade) Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-008 57-74-9 Chlordane (analytical grade) Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-009 76-44-8 Heptachlor Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-009 76-44-8 Heptachlor Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-000 (143-50-0) 143-50-0 Chlordecone (kepone) Mice Female Dosed-Feed Liver Positive CARCINOMA; HYPERPLASIA Neoplastic Lesions
TR-000 (143-50-0) 143-50-0 Chlordecone (kepone) Mice Male Dosed-Feed Liver Positive CARCINOMA; HYPERPLASIA Neoplastic Lesions
TR-000 (143-50-0) 143-50-0 Chlordecone (kepone) Rats Female Dosed-Feed Liver Positive CARCINOMA; HYPERPLASIA Neoplastic Lesions
TR-000 (143-50-0) 143-50-0 Chlordecone (kepone) Rats Male Dosed-Feed Liver Positive CARCINOMA; HYPERPLASIA Neoplastic Lesions
TR-000 (67-66-3) 67-66-3 Chloroform Mice Female Gavage Liver Positive CARCINOMA Neoplastic Lesions
TR-000 (67-66-3) 67-66-3 Chloroform Mice Male Gavage Liver Positive CARCINOMA Neoplastic Lesions
TR-002 79-01-6 Trichloroethylene Mice Female Gavage Liver Positive (CARCINOMA) Neoplastic Lesions
TR-002 79-01-6 Trichloroethylene Mice Male Gavage Liver Positive (CARCINOMA) Neoplastic Lesions
TR-021 309-00-2 Aldrin Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-029 129-15-7 2-Methyl-1-nitroanthraquinone Rats Female Dosed-Feed Liver Positive (NEOPLASTIC NODULE OR CARCINOMA) Neoplastic Lesions
TR-029 129-15-7 2-Methyl-1-nitroanthraquinone Rats Male Dosed-Feed Liver Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
TR-025 133-90-4 Chloramben Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-026 1836-75-5 Nitrofen Mice Female Dosed-Feed Liver Positive HEPATOCELLULAR CARCINOMA Neoplastic Lesions
TR-026 1836-75-5 Nitrofen Mice Male Dosed-Feed Liver Positive HEPATOCELLULAR CARCINOMA Neoplastic Lesions
TR-027 79-34-5 1,1,2,2-Tetrachloroethane Mice Female Gavage Liver Positive (CARCINOMA) Neoplastic Lesions
TR-027 79-34-5 1,1,2,2-Tetrachloroethane Mice Male Gavage Liver Positive (CARCINOMA) Neoplastic Lesions
TR-047 139-65-1 4,4'-Thiodianiline Mice Female Dosed-Feed Liver Positive CARCINOMA Neoplastic Lesions
TR-047 139-65-1 4,4'-Thiodianiline Mice Male Dosed-Feed Liver Positive CARCINOMA Neoplastic Lesions
TR-047 139-65-1 4,4'-Thiodianiline Rats Male Dosed-Feed Liver Positive CARCINOMA Neoplastic Lesions
TR-033 961-11-5 Tetrachlorvinphos Mice Female Dosed-Feed Liver Positive (NEOPLASTIC NODULE) Neoplastic Lesions
TR-033 961-11-5 Tetrachlorvinphos Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-034 1582-09-8 Trifluralin Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-037 8001-35-2 Toxaphene Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-037 8001-35-2 Toxaphene Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-039 303-34-4 Lasiocarpine Rats Female Dosed-Feed Liver Positive Angiosarcoma, carcinoma, adenoma Neoplastic Lesions
TR-039 303-34-4 Lasiocarpine Rats Male Dosed-Feed Liver Positive Angiosarcoma, carcinoma, adenoma Neoplastic Lesions
TR-099 136-40-3 Phenazopyridine hydrochloride Mice Female Dosed-Feed Liver Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
TR-063 95-83-0 4-Chloro-o-phenylenediamine Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-063 95-83-0 4-Chloro-o-phenylenediamine Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-068 67-72-1 Hexachloroethane Mice Female Gavage Liver Positive (CARCINOMA) Neoplastic Lesions
TR-068 67-72-1 Hexachloroethane Mice Male Gavage Liver Positive (CARCINOMA) Neoplastic Lesions
TR-080 123-91-1 1,4-Dioxane Rats Female Dosed-Water Liver Positive (ADENOMA) Neoplastic Lesions
TR-090 115-32-2 Dicofol Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-085 5131-60-2 4-Chloro-m-phenylenediamine Mice Female Dosed-Feed Liver Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
TR-086 106-93-4 1,2-Dibromoethane Rats Female Gavage Liver Positive (CARCINOMA) Neoplastic Lesions
TR-074 79-00-5 1,1,2-Trichloroethane Mice Female Gavage Liver Positive (CARCINOMA) Neoplastic Lesions
TR-074 79-00-5 1,1,2-Trichloroethane Mice Male Gavage Liver Positive (CARCINOMA) Neoplastic Lesions
TR-075 510-15-6 Chlorobenzilate Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-075 510-15-6 Chlorobenzilate Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Mice Female Dosed-Feed Liver Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
TR-080 123-91-1 1,4-Dioxane Mice Female Dosed-Water Liver Positive (CARCINOMA) Neoplastic Lesions
TR-080 123-91-1 1,4-Dioxane Mice Male Dosed-Water Liver Positive (CARCINOMA) Neoplastic Lesions
TR-107 99-55-8 5-Nitro-o-toluidine Mice Female Dosed-Feed Liver Positive CARCINOMA Neoplastic Lesions
TR-107 99-55-8 5-Nitro-o-toluidine Mice Male Dosed-Feed Liver Positive CARCINOMA Neoplastic Lesions
TR-100 135-20-6 Cupferron Mice Female Dosed-Feed Liver Positive CARCINOMA Neoplastic Lesions
TR-100 135-20-6 Cupferron Rats Female Dosed-Feed Liver Positive CARCINOMA Neoplastic Lesions
TR-100 135-20-6 Cupferron Rats Male Dosed-Feed Liver Positive CARCINOMA Neoplastic Lesions
TR-092 122-66-7 Hydrazobenzene Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-092 122-66-7 Hydrazobenzene Rats Female Dosed-Feed Liver Positive (NEOPLASTIC NODULE) Neoplastic Lesions
TR-092 122-66-7 Hydrazobenzene Rats Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Rats Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-093 6109-97-3 3-Amino-9-ethylcarbazole HCl Rats Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-117 94-52-0 6-Nitrobenzimidazole Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-117 94-52-0 6-Nitrobenzimidazole Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-118 602-87-9 5-Nitroacenaphthene Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-124 120-62-7 Piperonyl sulfoxide Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-127 99-59-2 5-Nitro-o-anisidine Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-108 1937-37-7 C.I. Direct black 38 Rats Female Dosed-Feed Liver Positive Carcinoma, neoplastic nodules Neoplastic Lesions
TR-108 1937-37-7 C.I. Direct black 38 Rats Male Dosed-Feed Liver Positive Carcinoma, neoplastic nodules Neoplastic Lesions
TR-108 2602-46-2 C.I. Direct blue 6 Rats Female Dosed-Feed Liver Positive Carcinoma, neoplastic nodules Neoplastic Lesions
TR-108 2602-46-2 C.I. Direct blue 6 Rats Male Dosed-Feed Liver Positive Carcinoma, neoplastic nodules Neoplastic Lesions
TR-108 16071-86-6 C.I. Direct brown 95 Rats Female Dosed-Feed Liver Positive Carcinoma, neoplastic nodules Neoplastic Lesions
TR-111 82-28-0 1-Amino-2-methylanthraquinone Mice Female Dosed-Feed Liver Positive (NEOPLASTIC NODULE OR CARCINOMA) Neoplastic Lesions
TR-111 82-28-0 1-Amino-2-methylanthraquinone Rats Female Dosed-Feed Liver Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
TR-111 82-28-0 1-Amino-2-methylanthraquinone Rats Male Dosed-Feed Liver Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
TR-142 120-71-8 p-Cresidine Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-142 120-71-8 p-Cresidine Rats Male Dosed-Feed Liver Positive (NEOPLASTIC NODULE OR CARCINOMA) Neoplastic Lesions
TR-143 2243-62-1 1,5-Naphthalenediamine Mice Female Dosed-Feed Liver Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
TR-144 117-79-3 2-Aminoanthraquinone Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-144 117-79-3 2-Aminoanthraquinone Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-144 117-79-3 2-Aminoanthraquinone Rats Male Dosed-Feed Liver Positive (NEOPLASTIC NODULE OR CARCINOMA) Neoplastic Lesions
TR-146 139-94-6 Nithiazide Mice Male Dosed-Feed Liver Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
TR-131 72-55-9 p,p'-Dichlorodiphenyl dichloroethylene Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-131 72-55-9 p,p'-Dichlorodiphenyl dichloroethylene Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-133 1777-84-0 3-Nitro-p-acetophenetide Mice Male Dosed-Feed Liver Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
TR-160 137-17-7 2,4,5-Trimethylaniline Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-160 137-17-7 2,4,5-Trimethylaniline Rats Female Dosed-Feed Liver Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
TR-160 137-17-7 2,4,5-Trimethylaniline Rats Male Dosed-Feed Liver Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
TR-169 5307-14-2 2-Nitro-p-phenylenediamine Mice Female Dosed-Feed Liver Positive (ADENOMA) Neoplastic Lesions
TR-162 95-80-7 2,4-Diaminotoluene (2,4-toluene diamine) Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-162 95-80-7 2,4-Diaminotoluene (2,4-toluene diamine) Rats Female Dosed-Feed Liver Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
TR-162 95-80-7 2,4-Diaminotoluene (2,4-toluene diamine) Rats Male Dosed-Feed Liver Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
TR-153 636-21-5 o-Toluidine hydrochloride Mice Female Dosed-Feed Liver Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
TR-155 88-06-2 2,4,6-Trichlorophenol Mice Female Dosed-Feed Liver Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
TR-155 88-06-2 2,4,6-Trichlorophenol Mice Male Dosed-Feed Liver Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
TR-181 90-94-8 Michler's ketone Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-181 90-94-8 Michler's ketone Rats Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-181 90-94-8 Michler's ketone Rats Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-184 1836-75-5 Nitrofen Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-184 1836-75-5 Nitrofen Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-196 87-29-6 Cinnamyl anthranilate Mice Female Dosed-Feed Liver Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
TR-196 87-29-6 Cinnamyl anthranilate Mice Male Dosed-Feed Liver Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
TR-198 57653-85-7 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin Mice Female Gavage Liver Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
TR-198 57653-85-7 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin Mice Male Gavage Liver Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
TR-198 57653-85-7 1,2,3,6,7,8-Hexachlorodibenzo-p-dioxin Rats Female Gavage Liver Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
TR-186 101-61-1 4,4'-Methylenebis(N,N-dimethyl)benzenamine Mice Female Dosed-Feed Liver Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
TR-187 95-79-4 5-Chloro-o-toluidine Mice Female Dosed-Feed Liver Positive CARCINOMA Neoplastic Lesions
TR-187 95-79-4 5-Chloro-o-toluidine Mice Male Dosed-Feed Liver Positive CARCINOMA Neoplastic Lesions
TR-190 156-10-5 p-Nitrosodiphenylamine Mice Male Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-190 156-10-5 p-Nitrosodiphenylamine Rats Male Dosed-Feed Liver Positive (NEOPLASTIC NODULE OR CARCINOMA) Neoplastic Lesions
TR-194 7446-34-6 Selenium sulfide Mice Female Gavage Liver Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
TR-194 7446-34-6 Selenium sulfide Rats Female Gavage Liver Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
TR-194 7446-34-6 Selenium sulfide Rats Male Gavage Liver Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
TR-209 1746-01-6 2,3,7,8-Tetrachlorodibenzo-p-dioxin Mice Female Gavage Liver Positive CARCINOMA 1/73 2/50 2/48 6/47 Neoplastic Lesions
TR-209 1746-01-6 2,3,7,8-Tetrachlorodibenzo-p-dioxin Mice Male Gavage Liver Positive CARCINOMA 8/73 9/49 8/49 17/50 Neoplastic Lesions
TR-209 1746-01-6 2,3,7,8-Tetrachlorodibenzo-p-dioxin Rats Female Gavage Liver Positive NEOPLASTIC NODULE 5/75 1/49 3/50 12/49 Neoplastic Lesions
TR-212 103-23-1 Di(2-ethylhexyl)adipate Mice Female Dosed-Feed Liver Positive CARCINOMA 1/50 14/50 12/49 Neoplastic Lesions
TR-212 103-23-1 Di(2-ethylhexyl)adipate Mice Male Dosed-Feed Liver Positive ADENOMA 6/50 8/49 15/49 Neoplastic Lesions
TR-205 101-80-4 4,4'-Oxydianiline Mice Female Dosed-Feed Liver Positive (CARCINOMA) Neoplastic Lesions
TR-205 101-80-4 4,4'-Oxydianiline Mice Male Dosed-Feed Liver Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
TR-205 101-80-4 4,4'-Oxydianiline Rats Female Dosed-Feed Liver Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
TR-205 101-80-4 4,4'-Oxydianiline Rats Male Dosed-Feed Liver Positive (NEOPLASTIC NODULE, CARCINOMA) Neoplastic Lesions
TR-222 2832-40-8 C.I. Disperse yellow 3 Mice Female Dosed-Feed Liver Positive ADENOMA 0/50 6/50 12/50 Neoplastic Lesions
TR-222 2832-40-8 C.I. Disperse yellow 3 Rats Male Dosed-Feed Liver Positive NEOPLASTIC NODULE 1/49 15/50 10/50 Neoplastic Lesions
TR-235 17924-92-4 Zearalenone Mice Female Dosed-Feed Liver Positive ADENOMA 0/50 2/49 7/49 Neoplastic Lesions
TR-225 5160-02-1 D & C red no. 9 Rats Male Dosed-Feed Liver Positive NEOPLASTIC NODULE 0/50 6/50 7/49 Neoplastic Lesions
TR-226 842-07-9 C.I. Solvent yellow 14 Rats Female Dosed-Feed Liver Positive NEOPLASTIC NODULE 2/50 3/49 10/48 Neoplastic Lesions
TR-226 842-07-9 C.I. Solvent yellow 14 Rats Male Dosed-Feed Liver Positive NEOPLASTIC NODULE 5/50 10/50 30/50 Neoplastic Lesions
TR-232 76-01-7 Pentachloroethane Mice Female Gavage Liver Positive ADENOMA 2/46 8/42 19/45; CARCINOMA 1/46 28/42 13/45 Neoplastic Lesions
TR-232 76-01-7 Pentachloroethane Mice Male Gavage Liver Positive CARCINOMA 4/48 26/44 7/45 Neoplastic Lesions
TR-216 2432-99-7 11-Aminoundecanoic acid Rats Male Dosed-Feed Liver Positive NEOPLASTIC NODULE 1/50 9/50 8/50 Neoplastic Lesions
TR-217 117-81-7 Di(2-ethylhexyl) phthalate Mice Female Dosed-Feed Liver Positive CARCINOMA 0/50 7/50 17/50 Neoplastic Lesions
TR-217 117-81-7 Di(2-ethylhexyl) phthalate Mice Male Dosed-Feed Liver Positive CARCINOMA 9/50 14/48 19/50 Neoplastic Lesions
TR-217 117-81-7 Di(2-ethylhexyl) phthalate Rats Female Dosed-Feed Liver Positive CARCINOMA 0/50 2/49 8/50 Neoplastic Lesions
TR-237 630-20-6 1,1,1,2-Tetrachloroethane Mice Female Gavage Liver Positive ADENOMA 4/49 8/46 24/48 OR CARCINOMA 1/49 5/46 6/48 COMBINED 5/49 13/46 30/48 Neoplastic Lesions
TR-237 630-20-6 1,1,1,2-Tetrachloroethane Mice Male Gavage Liver Positive ADENOMA 6/48 14/46 21/50 Neoplastic Lesions
TR-217 117-81-7 Di(2-ethylhexyl) phthalate Rats Male Dosed-Feed Liver Positive NEOPLASTIC NODULE 2/50 5/49 7/49 OR CARCINOMA 1/50 1/49 5/49 COMBINED 3/50 6/49 12/49 Neoplastic Lesions
TR-219 609-20-1 2,6-Dichloro-p-phenylenediamine Mice Female Dosed-Feed Liver Positive ADENOMA 4/50 4/50 9/50 OR CARCINOMA 2/50 2/50 7/50 Neoplastic Lesions
TR-219 609-20-1 2,6-Dichloro-p-phenylenediamine Mice Male Dosed-Feed Liver Positive ADENOMA 4/50 7/50 15/50 Neoplastic Lesions
TR-244 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Mice Male Gavage Liver Positive CARCINOMA 12/25 8/27 8/24 12/25 15/23 21/22 Neoplastic Lesions
TR-244 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Rats Female Gavage Liver Positive NEOPLASTIC NODULE 0/20 2/21 0/21 2/11 5/19 8/20; CARCINOMA 0/20 0/21 0/21 0/11 3/19 7/20; CHOLANGIOCARCINOMA 0/20 0/21 0/21 0/11 0/19 7/20 Neoplastic Lesions
TR-244 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Rats Male Gavage Liver Positive NEOPLASTIC NODULE 0/33 0/39 1/40 4/31 4/33 1/31; CARCINOMA 0/33 2/39 0/40 1/31 7/33 7/31; CHOLANGIOCARCINOMA 0/33 0/39 0/40 0/31 0/33 2/31 Neoplastic Lesions
TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Mice Female Dosed-Water Liver Positive ADENOMA 3/50 9/50 12/50 Neoplastic Lesions
TR-251 26471-62-5 2,4- & 2,6-Toluene diisocyanate Rats Female Gavage Liver Positive NEOPLASTIC NODULE 3/50 8/50 8/48 Neoplastic Lesions
TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Mice Male Dosed-Water Liver Positive CARCINOMA 10/49 33/50 29/50 Neoplastic Lesions
TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Rats Male Dosed-Water Liver Positive NEOPLASTIC NODULE 1/50 12/50 25/50 Neoplastic Lesions
TR-250 140-11-4 Benzyl acetate Mice Female Gavage Liver Some Evidence ADENOMA 0/50 0/50 6/50 Neoplastic Lesions
TR-250 140-11-4 Benzyl acetate Mice Male Gavage Liver Some Evidence ADENOMA 0/50 5/49 13/50 Neoplastic Lesions
TR-251 26471-62-5 2,4- & 2,6-Toluene diisocyanate Mice Female Gavage Liver Positive ADENOMA 2/50 3/50 12/50 Neoplastic Lesions
TR-239 108-60-1 bis(2-Chloro-1-methylethyl) ether Mice Male Gavage Liver Positive CARCINOMA 5/50 13/50 17/50 Neoplastic Lesions
TR-243 79-01-6 Trichloroethylene Mice Female Gavage Liver Positive ADENOMA 2/48 8/49; CARCINOMA 2/48 13/49 Neoplastic Lesions
TR-243 79-01-6 Trichloroethylene Mice Male Gavage Liver Positive CARCINOMA 8/48 30/50 Neoplastic Lesions
TR-244 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Mice Female Gavage Liver Positive CARCINOMA 0/13 0/19 2/15 2/11 3/17 7/8 Neoplastic Lesions
TR-263 78-87-5 1,2-Dichloropropane (propylene dichloride) Mice Female Gavage Liver Some Evidence ADENOMA 1/50 5/50 5/50 Neoplastic Lesions
TR-263 78-87-5 1,2-Dichloropropane (propylene dichloride) Mice Male Gavage Liver Some Evidence ADENOMA 7/50 10/50 17/50 Neoplastic Lesions
TR-266 150-68-5 Monuron Rats Male Dosed-Feed Liver Clear Evidence NEOPLASTIC NODULE 1/50 6/49 7/50 OR CARCINOMA 0/50 1/49 3/50 COMBINED 1/50 6/49 9/50 Neoplastic Lesions
TR-269 542-75-6 1,3-Dichloropropene (Telone II) Rats Male Gavage Liver Clear Evidence NEOPLASTIC NODULE 1/52 6/52 7/52 Neoplastic Lesions
TR-271 2784-94-3 HC blue 1 Mice Female Dosed-Feed Liver Clear Evidence CARCINOMA 1/50 24/48 47/49 Neoplastic Lesions
TR-271 2784-94-3 HC blue 1 Mice Male Dosed-Feed Liver Clear Evidence CARCINOMA 11/50 20/50 30/50 Neoplastic Lesions
TR-274 78-42-2 tris(2-Ethylhexyl)phosphate Mice Female Gavage Liver Some Evidence CARCINOMA 0/48 4/50 7/50 Neoplastic Lesions
TR-282 124-48-1 Chlorodibromomethane Mice Female Gavage Liver Some Evidence ADENOMA 2/50 4/49 11/50 OR CARCINOMA 4/50 6/49 8/50 COMBINED 6/50 10/49 19/50 Neoplastic Lesions
TR-285 569-61-9 C.I. Basic red 9 monohydrochloride Mice Female Dosed-Feed Liver Clear Evidence CARCINOMA 3/49 19/50 37/49 Neoplastic Lesions
TR-285 569-61-9 C.I. Basic red 9 monohydrochloride Mice Male Dosed-Feed Liver Clear Evidence CARCINOMA 10/50 20/50 27/50 Neoplastic Lesions
TR-288 106-99-0 1,3-Butadiene Mice Female Inhalation Liver Clear Evidence ADENOMA 0/50 1/47 4/49 OR CARCINOMA 0/50 1/47 1/49 COMBINED 0/50 2/47 5/49 Neoplastic Lesions
TR-285 569-61-9 C.I. Basic red 9 monohydrochloride Rats Male Dosed-Feed Liver Clear Evidence CARCINOMA 0/50 2/50 8/50 Neoplastic Lesions
TR-366 123-31-9 Hydroquinone Mice Female Gavage Liver Some Evidence Adenoma 2/55 15/55 12/55; adenoma or carcinoma (combined) 3/55 16/55 13/55 Neoplastic Lesions
TR-367 50-33-9 Phenylbutazone Mice Male Gavage Liver Some Evidence ADENOMA 8/50 12/50 24/50 OR CARCINOMA 8/50 4/50 11/50 COMBINED 16/50 14/50 31/50 Neoplastic Lesions
TR-405 6459-94-5 C.I. Acid red 114 Rats Female Dosed-Water Liver Clear Evidence NEOPLASTIC NODULE 0/50 0/35 15/64 6/50, CARCINOMA 0/50 0/35 6/64 3/50, COMBINED 0/50 0/35 19/64 8/50 Neoplastic Lesions
TR-563 89-82-7 Pulegone Mice Male Gavage Liver Clear Evidence Hepatocellular: Adenoma 22/50 31/50 35/50 28/50 adenoma, carcinoma, or hepatoblastoma 29/50 37/50 42/50 36/50 Neoplastic Lesions
TR-538 108-10-1 Methyl isobutyl ketone Mice Male Inhalation Liver Some Evidence ADENOMA 17/50 25/50 23/50 34/50 ADENOMA OR CARCINOMA (COMBINED) 27/50 34/50 28/50 37/50 Neoplastic Lesions
TR-521 1746-01-6 TEF evaluation (TCDD) Rats Female Gavage Liver Clear Evidence ADENOMA 0/53 0/54 0/53 0/53 1/53 13/53 2/50 OR CHOLANGIOCARCINOMA 0/53 0/54 0/53 1/53 4/53 25/53 2/50 Neoplastic Lesions
TR-434 106-99-0 1,3-Butadiene Mice Male Inhalation Liver Clear Evidence ADENOMA OR CARCINOMA 21/50 23/50 30/50 25/48 33/48 5/72, STOP STUDY 27/49 19/49 19/50 11/50 Neoplastic Lesions
TR-520 57465-28-8 Toxic equivalency factor evaluation ((PCB 126) 3,3',4,4',5-pentachlorobiphenyl) Rats Female Gavage Liver Clear Evidence CHOLANGIOCARCINOMA 0/53 0/55 1/53 0/53 5/53 6/51 22/53 2/50 OR ADENOMA 1/53 2/55 1/53 0/53 2/53 4/51 7/53 0/50 OR HEPATOCHOLANGIOMA 0/53 0/55 0/53 0/53 0/53 0/51 3/53 0/50 Neoplastic Lesions
TR-457 599-79-1 Salicylazosulfapyridine Mice Female Gavage Liver Clear Evidence ADENOMA 12/50 28/50 25/50 28/49 OR CARCINOMA 2/50 10/50 10/50 9/49 COMBINED 14/50 32/50 28/50 29/49 Neoplastic Lesions
TR-457 599-79-1 Salicylazosulfapyridine Mice Male Gavage Liver Clear Evidence ADENOMA 13/50 32/50 28/50 42/50 OR CARCINOMA 13/50 15/50 23/50 8/50 COMBINED 24/50 38/50 38/50 44/50 Neoplastic Lesions
TR-457 599-79-1 Salicylazosulfapyridine Mice Male Gavage Liver Clear Evidence ADENOMA 13/50 32/50 28/50 42/50 OR CARCINOMA 13/50 15/50 23/50 8/50 COMBINED 24/50 38/50 38/50 44/50 Neoplastic Lesions
TR-466 100-41-4 Ethylbenzene Mice Female Inhalation Liver Some Evidence ADENOMA 6/50 9/50 12/50 16/50 OR CARCINOMA 7/50 4/50 3/50 12/50 COMBINED 13/50 12/50 15/50 25/50 Neoplastic Lesions
TR-470 110-86-1 Pyridine Mice Female Dosed-Water Liver Clear Evidence ADENOMA 37/49 39/50 43/50 34/50, CARCINOMA 13/49 23/50 33/50 41/50, HEPATOBLASTOMA 1/49 2/50 9/50 16/50 COMBINED 41/49, 42/50, 45/50, 44/50 Neoplastic Lesions
TR-470 110-86-1 Pyridine Mice Male Dosed-Water Liver Clear Evidence ADENOMA 29/50 40/50 34/49 39/50, CARCINOMA 15/50 35/50 41/49 40/50, HEPATOBLASTOMA 2/50 18/50 22/49 15/50; COMBINED 38/50, 47/50, 46/49, 47/50 Neoplastic Lesions
TR-595 CELLPRADCDMA Cell Phone Radiation: CDMA Rats Male Whole Body Exposure Liver Clear Evidence hepatocellular adenoma or carcinoma (combined) (0/90, 2/90, 4/89, 1/88) May Have Been Related
TR-518 102-71-6 Triethanolamine Mice Female Topical Application Liver Some Evidence ADENOMA 9/50 18/50 20/50 33/50 COMBINED 12/50 23/50 24/50 34/50 Neoplastic Lesions
TR-405 6459-94-5 C.I. Acid red 114 Rats Male Dosed-Water Liver Clear Evidence NEOPLASTIC NODULE 2/50 1/35 10/65 15/50, CARCINOMA 0/50 1/35 6/65 7/50, COMBINED 2/50 2/35 15/65 20/50 Neoplastic Lesions
TR-407 2425-85-6 C.I. Pigment red 3 Rats Female Dosed-Feed Liver Some Evidence ADENOMA 0/50 0/50 1/50 10/50 Neoplastic Lesions
TR-510 51-79-6 Urethane Mice Male Dosed-Water Liver Clear Evidence HEMANGIOSARCOMA 1/46 2/47 5/46 13/44 ADENOMA 7/46 13/47 17/46 17/44 ADENOMA OR CARCINOMA 12/46 18/47 24/46 23/44 Neoplastic Lesions
TR-439 298-59-9 Methylphenidate hydrochloride Mice Female Dosed-Feed Liver Some Evidence HEPATOCELLULAR ADENOMA 6/49 10/48 10/49 28/50 CARCINOMA 5/49 3/48 2/49 6/50 COMBINED 9/49 11/48 11/49 30/50 Neoplastic Lesions
TR-439 298-59-9 Methylphenidate hydrochloride Mice Male Dosed-Feed Liver Some Evidence HEPATOCELLULAR ADENOMA 18/50 18/50 16/50 29/50 CARCINOMA 10/50 9/50 17/50 11/50 COMBINED 24/50 23/50 26/50 34/50; HEPATOBLASTOMA 0/50 1/50 1/50 5/50 Neoplastic Lesions
TR-450 116-14-3 Tetrafluoroethylene Mice Female Inhalation Liver Clear Evidence ADENOMA 15/48 17/48 20/47 15/47 OR CARCINOMA 4/48 28/48 22/47 20/47 COMBINED 17/48 33/48 29/47 28/47 Neoplastic Lesions
TR-450 116-14-3 Tetrafluoroethylene Mice Male Inhalation Liver Clear Evidence ADENOMA 17/48 17/48 12/48 20/48 OR CARCINOMA 11/48 20/48 33/48 26/48 COMBINED 26/48 34/48 39/48 35/48 Neoplastic Lesions
TR-430 28407-37-6 C.I. Direct blue 218 Mice Female Dosed-Feed Liver Clear Evidence ADENOMA 7/49 12/50 17/49 41/49; CARCINOMA 5/49 5/50 6/49 12/49 Neoplastic Lesions
TR-430 28407-37-6 C.I. Direct blue 218 Mice Male Dosed-Feed Liver Clear Evidence ADENOMA 16/50 19/50 17/50 40/50; CARCINOMA 7/50 3/50 8/50 17/50 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Mice Female Inhalation Liver Clear Evidence ADENOMA 17/50 19/49 11/50 16/50 OR CARCINOMA 4/50 11/49 14/50 19/50 COMBINED 20/50 26/49 20/50 30/50 Neoplastic Lesions
TR-475 109-99-9 Tetrahydrofuran Mice Female Inhalation Liver Clear Evidence ADENOMA 12/50 17/50 18/50 31/48 OR CARCINOMA 6/50 10/50 10/50 16/48 COMBINED 17/50 24/50 26/50 41/48 Neoplastic Lesions
TR-461 75-52-5 Nitromethane Mice Female Inhalation Liver Clear Evidence ADENOMA 14/50 25/50 17/50 35/50 OR CARCINOMA 10/50 14/50 8/50 12/50 COMBINED 19/50 34/50 22/50 40/50 Neoplastic Lesions
TR-494 84-65-1 Anthraquinone Mice Female Dosed-Feed Liver Clear Evidence ADENOMA 6/49 28/50 27/50 40/49 OR CARCINOMA 2/49 3/50 8/50 8/49 COMBINED 6/49 30/50 30/50 41/49 Neoplastic Lesions
TR-494 84-65-1 Anthraquinone Mice Male Dosed-Feed Liver Clear Evidence ADENOMA 21/50 32/50 38/50 41/49 OR CARCINOMA 8/50 13/50 17/50 21/49 OR HEPATOBLASTOMA 1/50 6/50 11/50 37/49 COMBINED 26/50 35/50 43/50 48/49 Neoplastic Lesions
TR-494 84-65-1 Anthraquinone Rats Female Dosed-Feed Liver Clear Evidence ADENOMA 0/50 2/50 6/50 4/50 3/50 Neoplastic Lesions
TR-503 302-17-0 Chloral hydrate Mice Male Gavage Liver Some Evidence ADEMONA OR CARCINOMA 16/48 25/48 23/47 22/48 (AD LIBITUM-FED GROUPS) Neoplastic Lesions
TR-503 302-17-0 Chloral hydrate Mice Male Gavage Liver Some Evidence CARCINOMA 2/48 5/58 4/48 8/48 (DIETARY-CONTROLLED GROUPS) Neoplastic Lesions
TR-504 88-72-2 o-Nitrotoluene Mice Female Dosed-Feed Liver Clear Evidence ADENOMA 7/60 5/59 19/59 29/60 CARCINOMA 2/60 4/59 6/59 16/60 COMBINED 9/60 9/59 24/59 39/60 Neoplastic Lesions
TR-485 434-07-1 Oxymetholone Rats Female Gavage Liver Clear Evidence ADENOMA 1/50 1/50 1/50 8/49 COMBINED 1/50 1/50 1/50 10/49 Neoplastic Lesions
TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Male Aquatic Liver Positive CHOLANGIOCARCINOMA 0/61 0/47 0/67 3/27 ADENOMA 3/61 8/47 17/67 9/27 CARCINOMA 0/61 1/47 0/67 7/27 ADENOMA OR CARCINOMA COMBINED 3/61 9/47 17/67 15/27 Neoplastic Lesions
TR-528 3296-90-0 Fish project 1 (2,2-bis(Bromomethyl)-1,3-propanediol) Fish Male Aquatic Liver Positive ADENOMA 1/27 0/21 1/31 3/29 ADENOMA OR CARCINOMA 1/27 0/21 1/31 4/29 Neoplastic Lesions
TR-528 3296-90-0 Fish project 1 (2,2-bis(Bromomethyl)-1,3-propanediol) Fish Male Aquatic Liver Positive ADENOMA 1/47 0/59 0/56 6/59 ADENOMA OR CARCINOMA 1/47 0/59 0/56 8/59 Neoplastic Lesions
TR-515 57018-52-7 Propylene glycol mono-t-butyl ether Mice Female Inhalation Liver Clear Evidence ADENOMA 14/49 8/50 10/50 37/49 CARCINOMA 4/49 8/50 7/50 10/49 COMBINED 18/49 14/50 16/50 41/49 HEPATOBLASTOMA 0/49 0/50 0/50 2/49 Neoplastic Lesions
TR-515 57018-52-7 Propylene glycol mono-t-butyl ether Mice Male Inhalation Liver Clear Evidence ADENOMA 18/50 23/49 26/50 36/50 CARCINOMA 9/50 8/49 13/50 11/50 COMBINED 25/50 26/49 33/50 41/50 HEPATOBLASTOMA 0/50 0/49 1/50 5/50 Neoplastic Lesions
TR-594 98-56-6 p-Chloro-a,a,a-trifluorotoluene Mice Male Inhalation Liver Clear Evidence hepatocellular carcinoma (8/50, 19/50, 16/50, 35/50); hepatoblastoma (1/50, 1/50, 1/50, 15/50) Neoplastic Lesions
TR-530 TEFBINARYMIX TEF evaluation (Binary mixture; PCB 126/PCB 153) Rats Female Gavage Liver Clear Evidence CHOLANGIOCARCINOMA 0/53 0/53 1/52 9/52 30/51 HEPATOCHOLANGIOMA 0/53 0/53 0/52 2/52 6/51 ADENOMA 0/53 0/53 3/52 5/52 27/51 Neoplastic Lesions
TR-516 693-98-1 2-Methylimidazole Mice Female Dosed-Feed Liver Some Evidence ADENOMA 3/50 4/49 6/49 10/50 Neoplastic Lesions
TR-516 693-98-1 2-Methylimidazole Mice Male Dosed-Feed Liver Some Evidence ADENOMA 7/50 14/50 13/50 18/50 CARCINOMA 4/50 8/50 14/50 6/50 COMBINED 10/50 22/50 22/50 22/50 Neoplastic Lesions
TR-528 3296-90-0 Fish project 1 (2,2-bis(Bromomethyl)-1,3-propanediol) Fish Male Aquatic Liver Positive ADENOMA 0/28 3/22 3/21 6/24 ADENOMA OR CARCINOMA 0/28 3/22 3/21 9/24 Neoplastic Lesions
TR-443 604-75-1 Oxazepam Mice Female Dosed-Feed Liver Clear Evidence (SWISS-WEBSTER) ADENOMA 0/60 22/59 47/59; CARCINOMA 1/60 1/59 11/59; (B6C3F1) ADENOMA 25/50 35/50 35/50 36/50; CARCINOMA 9/50 5/50 49/50 44/50; HEPATOBLASTOMA 0/50 1/50 8/50 8/50 Neoplastic Lesions
TR-531 TEFPCBMIX TEF Evaluation (PCB Mixture; PCB 126/PCB 118) Rats Female Gavage Liver Clear Evidence CHOLANGIOCARCINOMA 0/53 0/51 5/53 19/53 28/53 12/65 19/50 ADENOMA 2/53 1/51 0/53 4/53 17/53 5/65 1/50 CARCINOMA 0/53 0/51 0/53 0/53 1/53 0/65 0/50 Neoplastic Lesions
TR-420 396-01-0 Triamterene Mice Female Dosed-Feed Liver Some Evidence (FIRST STUDY) ADENOMA 10/50 22/50 23/50 36/60 OR CARCINOMA 4/50 4/50 3/50 8/60 COMBINED 13/50 26/50 25/50 37/60; (SECOND STUDY) ADENOMA 7/50 28/51 OR CARCINOMA 5/50 11/51 COMBINED 10/50 31/51 Neoplastic Lesions
TR-420 396-01-0 Triamterene Mice Male Dosed-Feed Liver Some Evidence (FIRST STUDY) ADENOMA 17/50 22/50 19/50 20/60 OR CARCINOMA 5/50 7/50 3/50 13/60 COMBINED 20/50 26/50 19/50 29/60; (SECOND STUDY) ADENOMA 21/50 36/50 OR CARCINOMA 9/50 11/50 COMBINED 25/50 38/50 Neoplastic Lesions
TR-434 106-99-0 1,3-Butadiene Mice Female Inhalation Liver Clear Evidence ADENOMA OR CARCINOMA 15/49 14/49 15/50 19/50 16/50 2/80 Neoplastic Lesions
TR-559 31508-00-6 TEF evaluation (PCB 118) Rats Female Gavage Liver Clear Evidence Cholangiocarcinoma 0/52 0/51 0/52 0/52 3/52 36/49 29/49 adenoma 0/52 1/51 1/52 4/52 12/52 24/49 1/49 hepatocholangioma 0/52 0/51 0/52 0/52 0/52 4/49 0/49 Neoplastic Lesions
TR-594 98-56-6 p-Chloro-a,a,a-trifluorotoluene Mice Female Inhalation Liver Clear Evidence hepatocellular adenoma (12/50, 14/50, 24/50, 34/50); hepatocellular carcinoma (7/50, 8/50, 12/50, 34/50); hepatoblastoma (0/50, 0/50, 1/50, 8/50) Neoplastic Lesions
TR-496 116355-83-0 Fumonisin B1 Mice Female Dosed-Feed Liver Clear Evidence ADENOMA 5/47 3/48 1/48 16/47 31/45 OR CARCINOMA 0/47 0/48 0/48 10/47 9/45 COMBINED 5/47 3/48 1/48 19/47 39/45 Neoplastic Lesions
TR-533 119-61-9 Benzophenone Mice Male Dosed-Feed Liver Some Evidence ADENOMA 11/50 15/50 23/50 23/50 ADENOMA, CARCINOMA, OR HEPATOBLASTOMA 18/50 20/50 25/50 29/50 Neoplastic Lesions
TR-491 93-15-2 Methyleugenol Mice Female Gavage Liver Clear Evidence ADENOMA 20/50 48/50 46/49 41/50 OR CARCINOMA 7/50 37/50 47/49 47/50 COMBINED 25/50 50/50 49/49 49/50; HEPATOBLASTOMA 0/50 6/50 11/49 15/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/50 0/50 2/50 Neoplastic Lesions
TR-491 93-15-2 Methyleugenol Mice Male Gavage Liver Clear Evidence ADENOMA 26/49 43/50 38/50 39/50 CARCINOMA 10/49 20/50 19/50 9/50 COMBINED 31/49 47/50 46/50 40/50; HEPATOBLASTOMA 0/49 0/50 1/50 3/50 Neoplastic Lesions
TR-512 37319-17-8 Elmiron (sodium pentosanpolysulfate) Mice Female Gavage Liver Some Evidence HEMANGIOSARCOMA 1/50 1/49 1/50 4/49; ADENOMA 7/50 5/49 4/50 15/49; HEPATOCELLULAR ADENOMA OR CARCINOMA 10/50 8/49 9/50 18/49 Neoplastic Lesions
TR-512 37319-17-8 Elmiron (sodium pentosanpolysulfate) Mice Male Gavage Liver Some Evidence HEMANGIOSARCOMA 2/50 0/50 4/50 9/50 Neoplastic Lesions
TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Female Aquatic Liver Positive CHOLANGIOCARCINOMA 0/95 29/93 53/94 41/67 ADENOMA 1/95 1/93 5/94 8/67 CARCINOMA 1/95 1/93 2/94 5/67 ADENOMA OR CARCINOMA 2/95 2/93 7/94 13/67 HEPATOCHOLANGIOCARCINOMA 0/95 0/93 4/94 7/67 Neoplastic Lesions
TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Female Aquatic Liver Positive CHOLANGIOCARCINOMA 1/57 15/44 31/49 21/31 ADENOMA 4/57 2/44 2/49 1/31 CARCINOMA 0/57 2/44 1/49 4/31 ADENOMA OR CARCINOMA 4/57 4/44 2/49 5/31 HEPATOCHOLANGIOCARCINOMA 0/57 0/44 0/49 1/31 Neoplastic Lesions
TR-443 604-75-1 Oxazepam Mice Male Dosed-Feed Liver Clear Evidence (SWISS-WEBSTER) ADENOMA 1/60 35/60 50/60; CARCINOMA 0/60 5/60 19/60; (B6C3F1) ADENOMA 17/49 18/50 34/50 32/50; CARCINOMA 9/49 5/50 45/50 50/50; HEPATOBLASTOMA 0/49 2/50 21/50 13/50 Neoplastic Lesions
TR-560 63-05-8 Androstenedione Mice Female Gavage Liver Clear Evidence Adenoma 14/50 16/50 18/50 28/50 carcinoma 5/50 13/50 15/50 15/50 adenoma or carcinoma 17/50 23/50 27/50 32/50 Neoplastic Lesions
TR-560 63-05-8 Androstenedione Mice Male Gavage Liver Clear Evidence Hepatocellular adenoma, multiple 16/50 27/50 23/50 34/50 hepatocellular adenoma (includes multiples) 32/50 38/50 29/50 43/50 hepatocellular carcinoma multiple 7/50 12/50 10/50 17/50 hepatocellular adenoma or hepatocellular carcinoma (combined includes multiples) 41/50 47/50 42/50 48/50 hepatoblastoma 3/50 8/50 7/50 8/50 hepatocellular adenoma, carcinoma, or hepatoblastoma (combined) 41/50 47/50 43/50 48/50 Neoplastic Lesions
TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Female Aquatic Liver Positive CHOLANGIOMA 0/64 3/64 4/47 2/33 CHOLANGIOCARCINOMA 0/64 0/64 0/47 6/33 ADENOMA OR CARCINOMA 5/64 4/64 4/47 8/33 Neoplastic Lesions
TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Female Aquatic Liver Positive CHOLANGIOMA 2/31 2/31 0/31 2/27 CHOLANGIOCARCINOMA 0/31 0/31 0/31 5/27 ADENOMA OR CARCINOMA 2/31 1/31 2/31 3/27 Neoplastic Lesions
TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Male Aquatic Liver Positive CHOLANGIOMA 0/42 0/47 3/33 1/46 CHOLANGIOCARCINOMA 0/42 19/47 16/33 26/46 ADENOMA 0/42 1/47 0/33 0/46 ADENOMA OR CARCINOMA 0/42 2/47 0/33 1/46 Neoplastic Lesions
TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Male Aquatic Liver Positive CHOLANGIOMA 0/95 6/94 2/65 1/78 CHOLANGIOCARCINOMA 0/95 32/94 43/65 45/78 ADENOMA OR CARCINOMA 0/95 2/94 1/65 6/78 HEPATOCHOLANGIOCARCINOMA 0/95 0/94 2/65 6/78 Neoplastic Lesions
TR-528 96-18-4 Fish project 1 (1,2,3-Trichloropropane) Fish Male Aquatic Liver Positive CHOLANGIOCARCINOMA 0/32 0/19 0/26 1/19 ADENOMA 3/32 4/19 5/26 7/19 CARCINOMA 0/32 0/19 1/26 4/19 ADENOMA OR CARCINOMA COMBINED 3/32 4/19 5/26 10/19 Neoplastic Lesions
TR-422 91-64-5 Coumarin Mice Female Gavage Liver Clear Evidence ADENOMA 8/50 26/49 29/51 12/50 Neoplastic Lesions
TR-423 119-84-6 3,4-Dihydrocoumarin Mice Female Gavage Liver Some Evidence ADENOMA 10/51 20/50 22/50 20/52 OR CARCINOMA 3/51 2/50 4/50 6/52 COMBINED 13/51 21/50 25/50 24/52 Neoplastic Lesions
TR-463 8003-22-3 D & C yellow no. 11 Rats Female Dosed-Feed Liver Some Evidence ADENOMA 0/50 2/51 5/50 4/51 OR CARCINOMA 0/50 0/51 0/50 1/51 COMBINED 0/50 2/51 5/50 5/51 Neoplastic Lesions
TR-463 8003-22-3 D & C yellow no. 11 Rats Male Dosed-Feed Liver Some Evidence ADENOMA 1/50 2/51 1/51 7/54 Neoplastic Lesions
TR-504 88-72-2 o-Nitrotoluene Rats Male Dosed-Feed Liver Clear Evidence ADENOMA 2/60 3/60 3/60 7/60 3/60 4/60 ADENOMA OR CARCINOMA 3/60 3/60 3/60 8/60 3/60 6/60 CHOLANGIOCARCINOMA 0/60 0/60 0/60 0/60 0/60 3/60 HEPATOCHOLANGIOCARCINOMA 0/60 1/60 0/60 1/60 0/60 0/60 Neoplastic Lesions
TR-561 119-64-2 Tetralin Rats Female Inhalation Liver Some Evidence Adenoma 0/50 0/50 0/50 3/50 adenoma or carcinoma 0/50 0/50 1/50 4/50 Neoplastic Lesions
TR-562 GOLDENSEALRT Goldenseal root powder Mice Male Dosed-Feed Liver Some Evidence Hepatoblastoma 1/50 2/50 1/5 6/50 multiple adenoma 3/50 5/50 11/50 18/50 Neoplastic Lesions
TR-562 GOLDENSEALRT Goldenseal root powder Rats Female Dosed-Feed Liver Clear Evidence Adenoma: 0/50 0/50 1/50 8/50 Neoplastic Lesions
TR-562 GOLDENSEALRT Goldenseal root powder Rats Male Dosed-Feed Liver Clear Evidence Adenoma: 1/50 1/50 2/50 10/50 adenoma or carcinoma 1/50 1/50 2/50 11/50 Neoplastic Lesions
TR-457 599-79-1 Salicylazosulfapyridine Mice Female Gavage Liver Clear Evidence ADENOMA 12/50 28/50 25/50 28/49 OR CARCINOMA 2/50 10/50 10/50 9/49 COMBINED 14/50 32/50 28/50 29/49 Neoplastic Lesions
TR-499 22398-80-7 Indium phosphide Mice Female Inhalation Liver Clear Evidence ADENOMA 12/50 14/50 18/50 14/50; CARCINOMA 6/50 17/50 8/50 10/50; COMBINED 18/50 28/50 24/50 23/50 Neoplastic Lesions
TR-499 22398-80-7 Indium phosphide Mice Male Inhalation Liver Clear Evidence ADENOMA 17/50 24/50 23/50 32/50; CARCINOMA 11/50 22/50 23/50 16/50; COMBINED 26/50 40/50 37/50 39/50 Neoplastic Lesions
TR-537 631-64-1 Water disinfection byproducts (Dibromoacetic acid) Mice Female Dosed-Water Liver Clear Evidence ADENOMA 19/49 26/50 32/50 35/49 CARCINOMA 3/49 3/50 12/50 8/49 COMBINED 22/49 28/50 37/50 37/49 Neoplastic Lesions
TR-537 631-64-1 Water disinfection byproducts (Dibromoacetic acid) Mice Male Dosed-Water Liver Clear Evidence ADENOMA 18/49 37/50 37/50 42/50 CARCINOMA 14/49 9/50 19/50 26/50 COMBINED 28/49 41/50 42/50 47/50 HEPATOBLASTOMA 0/49 4/50 6/50 18/50 Neoplastic Lesions
TR-538 108-10-1 Methyl isobutyl ketone Mice Female Inhalation Liver Some Evidence ADENOMA 13/50 15/50 20/50 23/50 ADENOMA OR CARCINOMA (COMBINED) 17/50 17/50 22/50 27/50 Neoplastic Lesions
TR-563 89-82-7 Pulegone Mice Female Gavage Liver Clear Evidence Hepatocellular: Adenoma 13/49 15/50 13/50 27/50 adenoma, carcinoma or hepatoblastoma 17/49 15/50 15/50 33/50 Neoplastic Lesions
TR-491 93-15-2 Methyleugenol Rats Female Gavage Liver Clear Evidence ADENOMA 1/50 8/50 11/49 33/49 43/50 OR CARCINOMA 0/50 0/50 4/49 8/49 22/50 COMBINED 1/50 8/50 14/49 34/49 43/50; HEPATOCHOLANGIOMA 0/50 0/50 0/49 0/49 8/50 OR HEPATOCHOLANGIOCARCINOMA 0/50 0/50 0/49 3/49 9/50 COMBINED 0/50 0/50 0/49 3/49 17/50 Neoplastic Lesions
TR-491 93-15-2 Methyleugenol Rats Male Gavage Liver Clear Evidence ADENOMA 5/50 12/50 23/50 38/50 32/50 OR CARCINOMA 2/50 3/50 14/50 25/50 36/50 COMBINED 7/50 14/50 28/50 43/50 45/50; HEPATOCHOLANGIOMA 0/50 0/50 0/50 1/50 6/50 OR HEPATOCHOLANGIOCARCINOMA 0/50 0/50 1/50 1/50 7/50 COMBINED 0/50 0/50 1/50 2/50 13/50 Neoplastic Lesions
TR-525 57117-31-4 TEF evaluation (PECDF (Pentachlorodibenzofuran)) Rats Female Gavage Liver Some Evidence ADENOMA 1/53 0/53 1/53 0/52 2/53 4/53 1/50 OR CHOLANGIOCARCINOMA 0/53 0/53 0/53 1/52 1/53 2/53 0/50 Neoplastic Lesions
TR-526 TEFDIOXINMIX TEF evaluation (Dioxin mixture) Rats Female Gavage Liver Clear Evidence ADENOMA 0/53 1/53 1/53 1/53 11/51 OR CHOLANGIOCARCINOMA 0/53 0/53 2/53 7/53 9/51 Neoplastic Lesions
TR-527 129-73-7 Leucomalachite green Mice Female Dosed-Feed Liver Some Evidence ADENOMA OR CARCINOMA 3/47 6/48 6/47 11/47 Neoplastic Lesions
TR-349 87-86-5 Pentachlorophenol, technical Mice Male Dosed-Feed Liver Clear Evidence ADENOMA 5/32 20/47 33/48 OR CARCINOMA 2/32 10/47 12/48 COMBINED 7/32 26/47 37/48 Neoplastic Lesions
TR-510 51-79-6 Urethane Mice Female Dosed-Water Liver Clear Evidence HEMANGIOSARCOMA 0/48 0/47 1/47 7/47 ADENOMA 5/48 10/47 19/47 18/47 ADENOMA OR CARCINOMA 5/48 11/47 20/47 19/47 Neoplastic Lesions
TR-416 91-23-6 o-Nitroanisole Mice Female Dosed-Feed Liver Some Evidence ADENOMA 14/50 2/50 36/50 18/50 Neoplastic Lesions
TR-416 91-23-6 o-Nitroanisole Mice Male Dosed-Feed Liver Clear Evidence ADENOMA 14/50 26/50 41/50 29/50; CARCINOMA 7/50 12/50 11/50 7/50; HEPATOBLASTOMA 0/50 3/50 17/50 9/50 Neoplastic Lesions
TR-374 556-52-5 Glycidol Mice Male Gavage Liver Clear Evidence ADENOMA 18/50 16/50 30/50 OR CARCINOMA 10/50 17/50 8/50 COMBINED 24/50 31/50 35/50 Neoplastic Lesions
TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Mice Female Gavage Liver Clear Evidence ADENOMA 0/50 18/50 22/50 OR CARCINOMA 3/50 4/50 9/50 COMBINED 3/50 22/50 28/50 Neoplastic Lesions
TR-351 20265-96-7 p-Chloroaniline hydrochloride Mice Male Gavage Liver Some Evidence ADENOMA 9/50 15/49 10/50 44/50 OR CARCINOMA 3/50 7/49 11/50 17/50 COMBINED 11/50 21/49 20/50 21/50 Neoplastic Lesions
TR-397 2429-74-5 C.I. Direct blue 15 Rats Male Dosed-Water Liver Clear Evidence NEOPLASTIC NODULE 0/50 6/35 8/65 7/50, CARCINOMA 0/50 0/35 1/65 4/50, COMBINED 0/50 6/35 9/65 11/50 Neoplastic Lesions
TR-402 110-00-9 Furan Mice Male Gavage Liver Clear Evidence ADENOMA 20/50 33/50 42/50, CARCINOMA 7/50 32/50 34/50, COMBINED 26/50 44/50 50/50 Neoplastic Lesions
TR-402 110-00-9 Furan Rats Female Gavage Liver Clear Evidence ADENOMA 0/50 2/50 4/50 7/50, CARCINOMA 0/50 0/50 0/50 1/50, COMBINED 0/50 2/50 4/50 8/50; CHOLANGIOCARCINOMA 0/50 49/50 50/50 48/50 Neoplastic Lesions
TR-402 110-00-9 Furan Rats Male Gavage Liver Clear Evidence ADENOMA 1/50 4/50 18/50 27/50, CARCINOMA 0/50 1/50 6/50 18/50, COMBINED 1/50 5/50 22/50 35/50; CHOLANGIOCARCINOMA 0/50 43/50 48/50 49/50 Neoplastic Lesions
TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Mice Male Gavage Liver Clear Evidence ADENOMA 11/50 20/50 29/50 OR CARCINOMA 11/50 15/50 17/50 COMBINED 2/50 34/50 38/50 Neoplastic Lesions
TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Rats Female Gavage Liver Clear Evidence NEOPLASTIC NODULE 0/50 4/50 7/50; CARCINOMA 0/50 1/50 1/50 Neoplastic Lesions
TR-398 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Mice Female Dosed-Feed Liver Clear Evidence ADENOMA 4/50 39/50 46/48; CARCINOMA 1/50 22/50 35/48 Neoplastic Lesions
TR-398 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Mice Male Dosed-Feed Liver Clear Evidence ADENOMA 9/50 48/49 42/50; CARCINOMA 8/50 30/49 36/50 Neoplastic Lesions
TR-398 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Rats Female Dosed-Feed Liver Clear Evidence ADENOMA 0/50 10/50 38/50 OR CARCINOMA 0/50 2/50 4/50 COMBINED 0/50 12/50 39/50 Neoplastic Lesions
TR-398 67774-32-7 Polybrominated biphenyl mixture (Firemaster FF-1) Rats Male Dosed-Feed Liver Clear Evidence ADENOMA 1/50 10/49 38/50 OR CARCINOMA 0/50 2/49 19/50 COMBINED 1/50 12/49 41/50 Neoplastic Lesions
TR-382 98-01-1 Furfural Mice Female Gavage Liver Some Evidence ADENOMA 1/50 3/50 5/50 8/50 Neoplastic Lesions
TR-328 598-55-0 Methyl carbamate Rats Female Gavage Liver Clear Evidence NEOPLASTIC NODULE 0/50 0/50 5/49; CARCINOMA 0/50 0/50 1/50 Neoplastic Lesions
TR-328 598-55-0 Methyl carbamate Rats Male Gavage Liver Clear Evidence NEOPLASTIC NODULE 3/50 0/50 3/49; CARCINOMA 1/50 0/50 4/49 Neoplastic Lesions
TR-319 106-46-7 1,4-Dichlorobenzene (p-dichlorobenzene) Mice Female Gavage Liver Clear Evidence ADENOMA 10/50 6/48 21/50; CARCINOMA 5/50 5/48 19/50 Neoplastic Lesions
TR-319 106-46-7 1,4-Dichlorobenzene (p-dichlorobenzene) Mice Male Gavage Liver Clear Evidence ADENOMA 5/50 13/49 16/50; CARCINOMA 14/50 11/49 32/50 Neoplastic Lesions
TR-388 96-45-7 Ethylene thiourea (ETU) Mice Female Dosed-Feed Liver Clear Evidence ADENOMA 9/50 2/50 33/50; CARCINOMA 2/50 29/50 47/50 Neoplastic Lesions
TR-370 271-89-6 Benzofuran Mice Female Gavage Liver Clear Evidence ADENOMA 1/50 22/48 21/47; HEPATOBLASTOMA 0/50 1/48 2/47; ADENOMA, HEPATOBLASTOMA, OR CARCINOMA 3/50 3/48 1/47 COMBINED 4/50 25/48 22/47 Neoplastic Lesions
TR-370 271-89-6 Benzofuran Mice Male Gavage Liver Clear Evidence ADENOMA 4/49 24/39 34/48; HEPATOBLASTOMA 0/49 3/39 18/48; ADENOMA, HEPATOBLASTOMA, OR CARCINOMA 9/49 8/39 9/48 COMBINED 12/49 31/39 40/48 Neoplastic Lesions
TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Rats Male Gavage Liver Clear Evidence NEOPLASTIC NODULE 0/50 10/50 16/48; CARCINOMA 0/50 3/50 2/48 Neoplastic Lesions
TR-309 1163-19-5 Decabromodiphenyl oxide Rats Female Dosed-Feed Liver Some Evidence NEOPLASTIC NODULE 1/50 3/49 9/50 Neoplastic Lesions
TR-309 1163-19-5 Decabromodiphenyl oxide Rats Male Dosed-Feed Liver Some Evidence NEOPLASTIC NODULE 1/50 7/50 15/49 Neoplastic Lesions
TR-352 924-42-5 N-Methylolacrylamide Mice Female Gavage Liver Clear Evidence ADENOMA 3/50 4/50 17/49 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Mice Male Topical Application Liver Clear Evidence ADENOMA 1/50 2/50 9/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 11/50 Neoplastic Lesions
TR-404 57-41-0 5,5-Diphenylhydantoin (phenytoin) Mice Female Dosed-Feed Liver Clear Evidence ADENOMA 5/48 13/49 22/50, HEPATOBLASTOMA OR CARCINOMA 0/48 1/49 12/50, COMBINED 5/48 14/49 30/50 Neoplastic Lesions
TR-382 98-01-1 Furfural Mice Male Gavage Liver Clear Evidence ADENOMA 9/50 13/50 11/49 19/50; CARCINOMA 7/50 12/50 6/49 21/50 Neoplastic Lesions
TR-382 98-01-1 Furfural Rats Male Gavage Liver Some Evidence CHOLANGIOCARCINOMA 0/50 0/50 2/50 Neoplastic Lesions
TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Mice Female Dosed-Feed Liver Clear Evidence ADENOMA 6/50 45/50 49/50; CARCINOMA 0/50 23/50 27/50 Neoplastic Lesions
TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Mice Male Dosed-Feed Liver Clear Evidence ADENOMA 10/50 38/51 39/50; CARCINOMA 9/50 18/51 21/50 Neoplastic Lesions
TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats Female Dosed-Feed Liver Clear Evidence ADENOMA 0/50 28/40 47/60 29/48; CARCINOMA 0/50 12/40 57/60 45/48; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 11/60 13/48 Neoplastic Lesions
TR-321 75-27-4 Bromodichloromethane Mice Female Gavage Liver Clear Evidence ADENOMA 1/50 13/48 23/50; CARCINOMA 2/50 5/48 10/50 Neoplastic Lesions
TR-476 125-33-7 Primidone (primaclone) Mice Female Dosed-Feed Liver Clear Evidence ADENOMA 15/50 42/50 45/49 47/50, CARCINOMA 3/50 11/50 19/49 38/50 OR HEPATOBLASTOMA 1/50 4/50 4/49 4/50 COMBINED 16/50 42/50 46/49 50/50 Neoplastic Lesions
TR-476 125-33-7 Primidone (primaclone) Mice Male Dosed-Feed Liver Clear Evidence ADENOMA 22/50 41/50 39/50 32/50, CARCINOMA 12/50 31/50 35/50 38/50 OR HEPATOBLASTOMA 0/50 17/50 26/50 7/50 COMBINED 31/50 49/50 49/50 46/50 Neoplastic Lesions
TR-388 96-45-7 Ethylene thiourea (ETU) Mice Male Dosed-Feed Liver Clear Evidence ADENOMA 11/49 16/50 9/50; CARCINOMA 13/49 19/50 45/50 Neoplastic Lesions
TR-352 924-42-5 N-Methylolacrylamide Mice Male Gavage Liver Clear Evidence ADENOMA 8/50 4/50 19/50 OR CARCINOMA 6/50 13/50 12/50 COMBINED 12/50 17/50 26/50 Neoplastic Lesions
TR-508 23246-96-0 Riddelliine Mice Male Gavage Liver Clear Evidence HEMANGIOSARCOMA 2/50 1/50 0/50 2/50 31/50 Neoplastic Lesions
TR-508 23246-96-0 Riddelliine Rats Female Gavage Liver Clear Evidence HEMANGIOSARCOMA 0/50 0/50 0/50 0/50 3/50 38/50; ADENOMA 1/50 0/50 0/50 0/50 1/50 7/50 Neoplastic Lesions
TR-508 23246-96-0 Riddelliine Rats Male Gavage Liver Clear Evidence HEMANGIOSARCOMA 0/50 43/50; ADENOMA 0/50 4/50 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Female Dosed-Water Liver Clear Evidence NEOPLASTIC NODULE 0/60 1/44 0/75 2/60 OR CARCINOMA 0/60 0/44 0/75 1/60 COMBINED 0/60 1/44 0/75 3/60 Neoplastic Lesions
TR-311 127-18-4 Tetrachloroethylene Mice Female Inhalation Liver Clear Evidence CARCINOMA 1/48 13/50 36/50 Neoplastic Lesions
TR-311 127-18-4 Tetrachloroethylene Mice Male Inhalation Liver Clear Evidence ADENOMA 11/49 8/49 18/50; CARCINOMA 7/49 25/49 26/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Female Topical Application Liver Clear Evidence NEOPLASTIC NODULES 0/50 10/50 11/50 OR CARCINOMA 0/50 2/50 6/50 COMBINED 0/50 11/50 14/50 Neoplastic Lesions
TR-450 116-14-3 Tetrafluoroethylene Rats Female Inhalation Liver Clear Evidence ADENOMA 0/50 4/50 5/50 6/50 OR CARCINOMA 0/50 4/50 9/50 2/50 COMBINED 0/50 7/50 12/50 8/50 Neoplastic Lesions
TR-304 115-28-6 Chlorendic acid Mice Male Dosed-Feed Liver Clear Evidence ADENOMA 5/50 9/49 10/50; CARCINOMA 9/50 17/49 20/50 Neoplastic Lesions
TR-304 115-28-6 Chlorendic acid Rats Female Dosed-Feed Liver Clear Evidence NEOPLASTIC NODULE 1/50 3/49 11/50; CARCINOMA 0/50 3/49 5/50 Neoplastic Lesions
TR-304 115-28-6 Chlorendic acid Rats Male Dosed-Feed Liver Clear Evidence NEOPLASTIC NODULE 2/50 21/50 23/50 Neoplastic Lesions
TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats Male Dosed-Feed Liver Clear Evidence ADENOMA 1/50 20/40 40/59 34/50; CARCINOMA 1/50 12/40 55/59 46/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 6/59 2/50 Neoplastic Lesions
TR-450 116-14-3 Tetrafluoroethylene Rats Male Inhalation Liver Clear Evidence ADENOMA 3/50 6/50 8/50 5/50 OR CARCINOMA 1/50 1/50 10/50 3/50 COMBINED 4/50 7/50 15/50 8/50 Neoplastic Lesions
TR-478 111-42-2 Diethanolamine Mice Female Topical Application Liver Clear Evidence ADENOMA 32/50 50/50 48/50 48/50 OR CARCINOMA 5/50 19/50 38/50 42/50 Neoplastic Lesions
TR-349 87-86-5 Pentachlorophenol, Dowicide EC-7 Mice Female Dosed-Feed Liver Clear Evidence ADENOMA 1/34 3/50 6/49 30/48 OR CARCINOMA 0/34 1/50 0/49 1/48 COMBINED 1/34 4/50 6/49 31/48 Neoplastic Lesions
TR-395 57-66-9 Probenecid Mice Female Gavage Liver Some Evidence ADENOMA 3/48 2/49 14/49, CARCINOMA 2/48 2/49 3/49, COMBINED 5/48 3/49 16/49 Neoplastic Lesions
TR-384 96-18-4 1,2,3-Trichloropropane Mice Female Gavage Liver Clear Evidence ADENOMA 6/50 9/50 8/51 31/55 OR CARCINOMA 1/50 3/50 0/51 2/55 COMBINED 7/50 11/50 8/51 31/55 Neoplastic Lesions
TR-478 111-42-2 Diethanolamine Mice Male Topical Application Liver Clear Evidence ADENOMA 31/50 42/50 49/50 45/50, CARCINOMA 12/50 17/50 33/50 34/50 OR HEPATOBLASTOMA 0/50 2/50 8/50 5/50 Neoplastic Lesions
TR-479 68603-42-9 Coconut oil acid diethanolamine condensate Mice Female Topical Application Liver Clear Evidence adenoma 32/50, 44/50, 43/50; hepatocellular carcinoma 3/50, 21/50, 32/50; hepatocellular adenoma, carcinoma, or hepatoblastoma 33/50, 46/50, 48/50 Neoplastic Lesions
TR-479 68603-42-9 Coconut oil acid diethanolamine condensate Mice Male Topical Application Liver Clear Evidence adenoma 22/50, 35/50, 45/50; hepatoblastoma 1/50, 1/50, 10/50; hepatocellular adenoma, carcinoma, or hepatoblastoma 29/50, 39/50, 49/50 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Female Dosed-Water Liver Clear Evidence NEOPLASTIC NODULE 0/60 0/45 7/74 3/60 OR CARCINOMA 0/60 0/45 1/74 1/60 COMBINED 0/60 0/45 7/74 4/60 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Male Dosed-Water Liver Clear Evidence NEOPLASTIC NODULE 0/60 3/45 7/74 6/60; NEOPLASTIC NODULE OR CARCINOMA 1/60 1/45 0/74 2/60 COMBINED 1/60 4/45 7/74 8/60 Neoplastic Lesions
TR-306 75-09-2 Methylene chloride Mice Female Inhalation Liver Clear Evidence ADENOMA 2/50 6/48 22/48 OR CARCINOMA 1/50 11/48 32/48 COMBINED 3/50 16/48 40/48 Neoplastic Lesions
TR-313 2385-85-5 Mirex Rats Female Dosed-Feed Liver Clear Evidence NEOPLASTIC NODULE 2/52 23/52 30/52 Neoplastic Lesions
TR-313 2385-85-5 Mirex Rats Male Dosed-Feed Liver Clear Evidence NEOPLASTIC NODULE 3/52 5/52 5/52 14/52 15/52 26/52 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Male Topical Application Liver Clear Evidence NEOPLASTIC NODULES 0/49 3/50 2/50 OR CARCINOMA 0/49 1/50 3/50 COMBINED 0/49 4/50 5/50 Neoplastic Lesions
TR-306 75-09-2 Methylene chloride Mice Male Inhalation Liver Clear Evidence ADENOMA 10/50 14/49 14/49 OR CARCINOMA 13/50 15/49 26/49 COMBINED 22/50 24/49 33/49 Neoplastic Lesions
TR-349 87-86-5 Pentachlorophenol, Dowicide EC-7 Mice Male Dosed-Feed Liver Clear Evidence ADENOMA 5/35 13/48 17/48 32/49 OR CARCINOMA 1/35 7/48 7/48 9/49 COMBINED 6/35 19/48 21/48 34/49 Neoplastic Lesions
TR-349 87-86-5 Pentachlorophenol, technical Mice Female Dosed-Feed Liver Some Evidence ADENOMA 3/33 8/49 8/50 OR CARCINOMA 0/33 1/49 1/50 COMBINED 3/33 9/49 9/50 Neoplastic Lesions
TR-397 2429-74-5 C.I. Direct blue 15 Rats Female Dosed-Water Liver Clear Evidence NEOPLASTIC NODULE 0/50 0/35 2/65 4/50, CARCINOMA 0/50 0/35 0/65 1/50, COMBINED 0/50 0/35 2/65 5/50 Neoplastic Lesions
TR-402 110-00-9 Furan Mice Female Gavage Liver Clear Evidence ADENOMA 5/50 31/50 48/50, CARCINOMA 2/50 7/50 27/50, COMBINED 7/50 34/50 50/50 Neoplastic Lesions
TR-384 96-18-4 1,2,3-Trichloropropane Mice Male Gavage Liver Clear Evidence ADENOMA 11/52 18/51 21/54 29/56; CARCINOMA 13/52 24/51 24/54 31/56 Neoplastic Lesions
TR-480 120-40-1 Lauric acid diethanolamine condensate Mice Female Topical Application Liver Some Evidence ADENOMA 23/50 32/49 29/50 ADENOMA OR CARCINOMA COMBINED 28/50 40/49 36/50 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Male Dosed-Water Liver Clear Evidence NEOPLASTIC NODULE 0/60 0/45 29/75 26/60 OR CARCINOMA 0/60 0/45 12/75 12/60 COMBINED 0/60 0/45 35/75 33/60 Neoplastic Lesions
TR-576 15625-89-5 Trimethylolpropane triacrylate Mice Female Topical Application Liver Some Evidence hepatoblastoma 0/50, 4/50, 0/50, 3/50; hepatocholangiocarcinoma 0/50, 0/50, 1/50, 2/50 Neoplastic Lesions
TR-554 67-47-0 5-(Hydroxymethyl)-2-furfural Mice Female Gavage Liver Some Evidence Adenoma 14/50 26/49 26/50 6/50 Neoplastic Lesions
TR-541 75-12-7 Formamide Mice Male Gavage Liver Clear Evidence hemangiosarcoma (1/50, 5/50, 7/50, 8/50) Neoplastic Lesions
TR-542 98-82-8 Cumene Mice Female Inhalation Liver Clear Evidence adenoma (18/50, 23/50, 27/50, 29/50); adenoma or carcinoma (25/50, 26/50, 29/50, 36/50) Neoplastic Lesions
TR-578 90045-36-6 Ginkgo biloba extract Mice Female Gavage Liver Clear Evidence hepatocellular adenoma 17/50, 37/50, 41/50, 48/50; hepatocellular carcinoma 9/50, 10/50, 15/50, 44/50; hepatoblastoma 1/50, 1/50, 8/50, 11/50 Neoplastic Lesions
TR-578 90045-36-6 Ginkgo biloba extract Mice Male Gavage Liver Clear Evidence hepatocellular carcinoma 22/50, 31/50, 41/50, 47/50; hepatoblastoma 3/50, 28/50, 36/50, 38/50 Neoplastic Lesions
TR-557 123-35-3 beta-Myrcene Mice Male Gavage Liver Clear Evidence Adenoma 26/50 41/50 43/50 carcinoma 14/50 20/50 28/50 adenoma or carcinoma 33/50 44/50 48/50 hepatoblastoma 4/50 6/50 11/50 adenoma, carcinoma, or hepatoblastoma 34/50 45/50 48/50 Neoplastic Lesions
TR-543 98-83-9 alpha-Methylstyrene Mice Female Inhalation Liver Clear Evidence ADENOMA 10/50 20/50 21/50 23/50 CARCINOMA 3/50 9/50 6/50 18/50 ADENOMA OR CARCINOMA 13/50 26/50 24/50 33/50 Neoplastic Lesions
TR-579 99-97-8 N,N-Dimethyl-p-toluidine Mice Female Gavage Liver Clear Evidence hepatocellular adenoma 17/50, 19/50, 37/50, 44/50; hepatocellular carcinoma 6/50, 13/50, 18/50, 31/50; hepatoblastoma 0/50, 1/50, 0/50, 4/50 Neoplastic Lesions
TR-579 99-97-8 N,N-Dimethyl-p-toluidine Mice Male Gavage Liver Clear Evidence hepatocellular adenoma, multiple 17/50, 19/50, 27/50, 26/50; hepatocellular carcinoma 22/50, 25/50, 30/50, 36/50; hepatoblastoma 1/50, 5/50, 10/50, 8/50 Neoplastic Lesions
TR-579 99-97-8 N,N-Dimethyl-p-toluidine Rats Female Gavage Liver Clear Evidence hepatocellular carcinoma 0/50, 0/50, 0/50, 4/49; hepatocellular adenoma or carcinoma 0/50, 1/50, 1/50, 7/49 Neoplastic Lesions
TR-579 99-97-8 N,N-Dimethyl-p-toluidine Rats Male Gavage Liver Clear Evidence hepatocellular carcinoma 0/50, 0/50, 1/50, 6/50; hepatocellular adenoma or carcinoma 0/50, 0/50, 2/50, 6/50 Neoplastic Lesions
TR-571 9000-38-8 Kava kava extract Mice Female Gavage Liver Clear Evidence Hepatocellular carcinoma 3/50 13/50 8/50 8/50 hepatocellular adenoma or carcinoma 10/50 21/50 20/50 13/50 Neoplastic Lesions
TR-571 9000-38-8 Kava kava extract Mice Male Gavage Liver Clear Evidence Hepatoblastoma 0/50 4/50 9/50 12/50 Neoplastic Lesions
TR-587 79-94-7 Tetrabromobisphenol A Mice Male Gavage Liver Some Evidence hepatoblastoma 2/50 11/50 8/50 Neoplastic Lesions
TR-580 108-99-6 beta-Picoline Mice Female Dosed-Water Liver Clear Evidence hepatocellular carcinoma 11/49 20/50 26/50 23/50 hepatoblastoma 1/49 3/50 4/50 4/50 Neoplastic Lesions
TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Female Gavage Liver Clear Evidence Cholangiocarcinoma 1/50 1/50 1/49 3/49 Neoplastic Lesions
TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Male Gavage Liver Clear Evidence Cholangiocarcinoma 0/50 4/50 4/50 6/50 Neoplastic Lesions
TR-589 32534-81-9 Pentabromodiphenyl Oxide (Technical) (DE 71) Rats Male Gavage Liver Clear Evidence hepatocellular adenoma or carcinoma 3/49 2/50 4/50 9/50; hepatocholangioma, hepatocellular adenoma, or hepatocellular carcinoma 3/49 2/50 4/50 11/50 Neoplastic Lesions
TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Mice Female Dosed-Water Liver Clear Evidence Adenoma 27/50 48/50 44/50 46/50 carcinoma 14/50 23/50 26/50 20/50 adenoma or carcinoma 31/50 49/50 46/50 46/50 Neoplastic Lesions
TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Mice Male Dosed-Water Liver Clear Evidence Adenoma 27/50 40/50 40/50 31/50 carcinoma 19/50 25/50 36/50 45/50 adenoma or carcinoma 34/50 44/50 49/50 49/50 hepatoblastoma 4/50 11/50 28/50 34/50 Neoplastic Lesions
TR-589 32534-81-9 Pentabromodiphenyl Oxide (Technical) (DE 71) Rats Female Gavage Liver Clear Evidence cholangiocarcinoma 0/50 0/49 0/50 2/47 hepatocholangioma 0/50 0/49 0/50 8/47 hepatocellular adenoma 3/50 2/49 8/50 16/47 hepatocellular carcinoma 0/50 0/49 1/50 6/47 hepatocellular adenoma or carcinoma 3/50 2/49 8/50 17/47) hepatocholangioma, hepatocellular adenoma, or hepatocellular carcinoma 3/50 2/49 8/50 21/47 Neoplastic Lesions
TR-589 32534-81-9 Pentabromodiphenyl Oxide (Technical) (DE 71) Mice Male Gavage Liver Clear Evidence hepatocellular adenoma 23/50 35/50 49/50 40/50 hepatocellular carcinoma 18/50 15/50 30/50 45/50 hepatocellular adenoma or carcinoma 31/50 40/50 49/50 47/50 hepatoblastoma 1/50 1/50 16/50 5/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 31/50 40/50 49/50 47/50 Neoplastic Lesions
TR-589 32534-81-9 Pentabromodiphenyl Oxide (Technical) (DE 71) Mice Female Gavage Liver Clear Evidence hepatocellular adenoma 5/50 7/49 32/50 46/49 hepatocellular carcinoma 4/50 2/49 6/50 27/49 hepatocellular adenoma or carcinoma 8/50 8/49 33/50 47/49 Neoplastic Lesions
TR-528 3296-90-0 Fish project 1 (2,2-bis(Bromomethyl)-1,3-propanediol) Fish Male Aquatic Liver Positive ADENOMA 3/61 4/50 4/41 8/38 ADENOMA OR CARCINOMA 4/61 6/50 6/41 10/38 Neoplastic Lesions
TR-575 79-06-1 Acrylamide Rats Female Dosed-Water Liver Clear Evidence adenoma 0/48 0/48 1/48 1/48 3/48 Neoplastic Lesions
TR-551 97-54-1 Isoeugenol Mice Male Gavage Liver Clear Evidence Adenoma 24/50 35/50 37/50 33/50 carcinoma 8/50 18/50 19/50 18/50 adenoma or carcinoma 28/50 43/50 43/50 43/50 Neoplastic Lesions