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Organ Sites with Neoplasia

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  • Organ: Large intestine
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-099 136-40-3 Phenazopyridine hydrochloride Rats Female Dosed-Feed Intestines (Large) Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-099 136-40-3 Phenazopyridine hydrochloride Rats Male Dosed-Feed Intestines (Large) Positive (ADENOCARCINOMA) Neoplastic Lesions
TR-047 139-65-1 4,4'-Thiodianiline Rats Male Dosed-Feed Intestines (Large) Positive ADENOCARCINOMA Neoplastic Lesions
TR-295 12001-29-5 Asbestos, chrysotile(IR) Rats Male Dosed-Feed Intestines (Large) Some Evidence ADENOMATOUS POLYP 0/85 9/250 2/100 Neoplastic Lesions
TR-321 75-27-4 Bromodichloromethane Rats Female Gavage Intestines (Large) Clear Evidence ADENOMATOUS POLYP 0/46 0/50 7/47; ADENOCARCINOMA 0/46 0/50 6/47 Neoplastic Lesions
TR-321 75-27-4 Bromodichloromethane Rats Male Gavage Intestines (Large) Clear Evidence ADENOMATOUS POLYP 0/50 3/50 33/50; ADENOCARCINOMA 0/50 11/50 38/50 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Male Dosed-Water Intestines (Large) Clear Evidence ADENOMATOUS POLYP 0/60 1/45 4/75 5/60 OR ADENOCARCINOMA 0/60 4/45 11/75 8/60 COMBINED 0/60 4/45 14/75 13/60 Neoplastic Lesions
TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats Female Dosed-Feed Intestines (Large) Clear Evidence ADENOMATOUS POLYP (ADENOMA) 0/50 28/40 53/60 43/49; CARCINOMA 0/50 2/40 21/60 8/49 Neoplastic Lesions
TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats Male Dosed-Feed Intestines (Large) Clear Evidence ADENOMATOUS POLYP (ADENOMA) 0/50 13/40 51/59 40/50; CARCINOMA 0/50 1/40 11/59 17/50 Neoplastic Lesions
TR-350 75-25-2 Tribromomethane Rats Female Gavage Intestines (Large) Clear Evidence ADENOMATOUS POLYP 0/48 1/50 6/49 OR ADENOCARCINOMA 0/48 0/50 2/49 COMBINED 0/48 1/50 8/49 Neoplastic Lesions
TR-350 75-25-2 Tribromomethane Rats Male Gavage Intestines (Large) Some Evidence ADENOMATOUS POLYP 0/50 0/50 2/50 OR ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Female Dosed-Water Intestines (Large) Clear Evidence ADENOMATOUS POLYP 0/60 0/45 1/75 2/60 OR ADENOCARCINOMA 0/60 1/45 0/75 1/60 COMBINED 0/60 1/45 1/75 3/60 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Female Dosed-Water Intestines (Large) Clear Evidence ADENOMATOUS POLYP 0/60 2/45 7/75 4/60 OR ADENOCARCINOMA 0/60 0/45 3/75 6/60 COMBINED 0/60 2/45 10/75 9/60 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Male Dosed-Water Intestines (Large) Clear Evidence ADENOMATOUS POLYP 0/60 0/45 7/75 10/60 OR ADENOCARCINOMA 0/60 0/45 3/75 15/60 COMBINED 0/60 0/45 10/75 23/75 Neoplastic Lesions
TR-397 2429-74-5 C.I. Direct blue 15 Rats Female Dosed-Water Intestines (Large) Clear Evidence ADENOMATOUS POLYP 0/50 0/35 3/65 1/50 Neoplastic Lesions
TR-397 2429-74-5 C.I. Direct blue 15 Rats Male Dosed-Water Intestines (Large) Clear Evidence NEOPLASMS 0/50 1/35 6/65 8/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Female Topical Application Intestines (Large) Clear Evidence ADENOCARCINOMA 0/50 3/50 4/49; ADENOMATOUS POLYP 0/50 12/50 37/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Male Topical Application Intestines (Large) Clear Evidence ADENOCARCINOMA 0/50 8/50 11/50; ADENOMATOUS POLYP 1/50 13/50 29/50 Neoplastic Lesions
TR-405 6459-94-5 C.I. Acid red 114 Rats Female Dosed-Water Intestines (Large) Clear Evidence NEOPLASMS 0/50 1/35 0/65 3/50 Neoplastic Lesions
TR-416 91-23-6 o-Nitroanisole Rats Female Dosed-Feed Intestines (Large) Clear Evidence (STOP STUDY) ADENOMATOUS POLYP 0/60 8/60 18/60, CARCINOMA 0/60 0/60 2/60 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Male Dosed-Feed Intestines (Large) Clear Evidence ADENOMA OR CARCINOMA 0/51 0/53 3/51 4/55 11/59 Neoplastic Lesions
TR-416 91-23-6 o-Nitroanisole Rats Male Dosed-Feed Intestines (Large) Clear Evidence (STOP STUDY) ADENOMATOUS POLYP 0/60 26/60 30/60, CARCINOMA 0/60 0/60 5/60 Neoplastic Lesions
TR-504 88-72-2 o-Nitrotoluene Mice Female Dosed-Feed Intestines (Large) Clear Evidence (CECUM) CARCINOMA 0/60 1/60 4/60 3/60 Neoplastic Lesions
TR-504 88-72-2 o-Nitrotoluene Mice Male Dosed-Feed Intestines (Large) Clear Evidence (CECUM) CARCINOMA 0/60 12/60 9/60 0/60 Neoplastic Lesions
TR-564 106-94-5 1-Bromopropane Rats Female Inhalation Intestines (Large) Clear Evidence Adenoma 0/50 1/50 2/50 5/50 Neoplastic Lesions
TR-564 106-94-5 1-Bromopropane Rats Male Inhalation Intestines (Large) Some Evidence Adenoma 0/50 0/50 2/50 1/50 Neoplastic Lesions
TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Rats Female Dosed-Water Intestines (Large) Clear Evidence Adenoma 0/50 0/50 3/50 7/50 Neoplastic Lesions
TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Rats Male Dosed-Water Intestines (Large) Clear Evidence Adenoma 0/50 2/50 0/50 4/50 Neoplastic Lesions
TR-587 79-94-7 Tetrabromobisphenol A Mice Male Gavage Intestines (Large) Some Evidence (cecum or colon) adenoma or carcinoma 0/50 0/50 3/50 May Have Been Related
TR-577 ALOEVLEAFEXT Aloe vera whole leaf extract (native) Rats Female Dosed-Water Intestines (Large) Clear Evidence Proximal colon adenoma 0/43 0/45 4/42 5/39; proximal colon carcinoma 0/43 0/45 2/42 4/39; cecum adenoma 0/47 0/48 1/47 6/48; ascending colon adenoma 0/47 0/48 1/46 5/46; all sections, adenoma 0/48, 0/48 6/48 13/48; carcinoma 0/48 0/48 3/48 4/48; adenoma and carcinoma combined 0/48 0/48 8/48 15/48 Neoplastic Lesions
TR-577 ALOEVLEAFEXT Aloe vera whole leaf extract (native) Rats Male Dosed-Water Intestines (Large) Clear Evidence Proximal colon adenoma 0/44 0/44 7/46 10/41; proximal colon carcinoma 0/44 0/44 4/46 4/41; cecum adenoma 0/46 0/45 8/48 8/48; cecum carcinoma 0/46 0/45 1/48 2/48; ascending colon adenoma 0/47 0/47 19/48 8/46; ascending colon carcinoma 0/47 0/47 4/48 8/46; transverse colon adenoma 0/47 0/47 6/47 3/47; transverse colon carcinoma 0/47 0/47 1/47 1/47; adenoma 0/47, 0/48 26/48 23/48; carcinoma 0/47 0/48 10/48 14/48; all sections, adenoma and carcinoma combined 0/47 0/48 28/48 31/48 Neoplastic Lesions