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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-000 (67-66-3)	67-66-3	Chloroform	Rats	Osborne Mendel	Male	Gavage	Kidney Tubular Cell	Positive	Positive	ADENOMA OR ADENOCARCINOMA COMBINED	Neoplastic Lesions
Yes	TR-006	139-13-9	Nitrilotriacetic acid (NTA)	Mice	B6C3F1	Female	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-006	139-13-9	Nitrilotriacetic acid (NTA)	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-006	139-13-9	Nitrilotriacetic acid (NTA)	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA OR ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Female	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA OR ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOCARCINOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-041	1897-45-6	Chlorothalonil	Rats	Osborne Mendel	Female	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
Yes	TR-041	1897-45-6	Chlorothalonil	Rats	Osborne Mendel	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
Yes	TR-076	126-72-7	tris(2,3-Dibromopropyl) phosphate	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA OR ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-076	126-72-7	tris(2,3-Dibromopropyl) phosphate	Rats	F344/N	Female	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
Yes	TR-076	126-72-7	tris(2,3-Dibromopropyl) phosphate	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA, ADENOMA OR ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-111	82-28-0	1-Amino-2-methylanthraquinone	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA OR ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-196	87-29-6	Cinnamyl anthranilate	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA OR ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-266	150-68-5	Monuron	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 7/50 OR ADENOCARCINOMA 0/50 1/50 8/50	Neoplastic Lesions
Yes	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 7/50 3/49 ADENOCARCINOMA 0/50 2/50 0/49 COMBINED 0/50 9/50 3/49	Neoplastic Lesions
Yes	TR-291	78-59-1	Isophorone	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/50 2/50 OR ADENOCARCINOMA 0/50 3/50 1/50	Neoplastic Lesions
Yes	TR-321	75-27-4	Bromodichloromethane	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 3/50; ADENOCARCINOMA 0/50 0/50 10/50; COMBINED 0/50, 1/50, 13/50	Neoplastic Lesions
Yes	TR-358	303-47-9	Ochratoxin A	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 1/50 5/50 OR CARCINOMA 0/50 0/51 1/50 3/50	Neoplastic Lesions
Yes	TR-341	67-20-9	Nitrofurantoin	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 1/50 2/50 OR CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 3/50	Neoplastic Lesions
Yes	TR-423	119-84-6	3,4-Dihydrocoumarin	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 1/48 0/47 2/50, STEP SECTIONS 1/50 0/48 3/47 5/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 4/50	Neoplastic Lesions
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 0/49 0/48 0/50 2/50 0/80	May Have Been Related
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50 3/48 1/49 0/73, STOP STUDY 4/48 1/50 3/49 1/50	Neoplastic Lesions
Yes	TR-358	303-47-9	Ochratoxin A	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 1/51 6/51 10/50 OR CARCINOMA 0/50 0/51 16/51 30/50	Neoplastic Lesions
Yes	TR-359	298-81-7	8-Methoxypsoralen	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 11/50 8/49 OR ADENOCARCINOMA 0/50 1/50 3/49	Neoplastic Lesions
Yes	TR-366	123-31-9	Hydroquinone	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	Adenoma 0/55 4/55 8/55	Neoplastic Lesions
Yes	TR-311	127-18-4	Tetrachloroethylene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/49 3/49 2/50 OR ADENOCARCINOMA 0/49 0/49 2/50 COMBINED 1/49 3/49 4/50	Neoplastic Lesions
Yes	TR-367	50-33-9	Phenylbutazone	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Some Evidence	Equivocal Evidence	ADENOMA (STEP SECTIONS) 0/50 3/50 1/50 OR CARCINOMA 0/50 1/50 0/50 COMBINED 0/50 4/50 1/50	May Have Been Related
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/50 4/50	Neoplastic Lesions
Yes	TR-361	67-72-1	Hexachloroethane	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/50 1/50	Neoplastic Lesions
Yes	TR-361	67-72-1	Hexachloroethane	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 2/50 3/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 7/50	Neoplastic Lesions
Yes	TR-369	98-85-1	alpha-Methylbenzyl alcohol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 1/50 5/50 OR ADENOCARCINOMA 0/50 1/50 0/50 COMBINED 0/50 2/50 5/50	Neoplastic Lesions
Yes	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 1/50 1/50 1/49 OR CARCINOMA 0/49 0/50 0/50 2/49	May Have Been Related
Yes	TR-407	2425-85-6	C.I. Pigment Red 3	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/50 0/50 6/50	Neoplastic Lesions
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 20/49 21/52	Neoplastic Lesions
Yes	TR-430	28407-37-6	C.I. Direct Blue 218	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/50 2/50 1/50 1/50 OR CARCINOMA 0/50 1/50 0/50 0/50 COMBINED 0/50 3/50 1/50 1/50	May Have Been Related
Yes	TR-323	756-79-6	Dimethyl methylphosphonate	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOCARCINOMA 0/50 2/50 3/49	Neoplastic Lesions
Yes	TR-401	137-09-7	2,4-Diaminophenol dihydrochloride	Mice	B6C3F1	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/48 3/50	Neoplastic Lesions
Yes	TR-370	271-89-6	Benzofuran	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOCARCINOMA 0/50 1/50 4/50	Neoplastic Lesions
Yes	TR-382	98-01-1	Furfural	Mice	B6C3F1	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/50 0/50 1/49 1/50 OR CARCINOMA 0/50 1/50 0/49 0/50 COMBINED 0/50 1/50 1/49 1/50	May Have Been Related
Yes	TR-409	117-39-5	Quercetin	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 0/50 0/50 0/50 3/50 (SINGLE AND STEP SECTIONS) ADENOMA 1/50 2/50 7/50 8/50 (SINGLE SECTIONS) ADENOCARCINOMA 0/50 0/50 0/50 1/50 (SINGLE AND STEP SECTIONS) OVERALL ADENOMA OR ADENOCARCINOMA 1/50 2/50 7/50 9/50	Neoplastic Lesions
Yes	TR-339	99-57-0	2-Amino-4-nitrophenol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 1/48 3/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 1/50 3/50 COMBINED 0/50 1/50 4/50	Neoplastic Lesions
Yes	TR-422	91-64-5	Coumarin	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 1/49 2/50 2/51 1/50, STEP SECTIONS 0/49 4/50 5/51 4/50	Neoplastic Lesions
Yes	TR-347	5989-27-5	D-Limonene	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 4/50 8/50 OR ADENOCARCINOMA 0/50 4/50 3/50	Neoplastic Lesions
Yes	TR-321	75-27-4	Bromodichloromethane	Mice	B6C3F1	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/49 2/50 6/50; ADENOCARCINOMA 0/49 0/50 4/50; COMBINED 1/49 2/50 9/50	Neoplastic Lesions
Yes	TR-321	75-27-4	Bromodichloromethane	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 6/50; ADENOCARCINOMA 0/50 0/50 9/50; COMBINED 0/50 1/50 15/50	Neoplastic Lesions
Yes	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 3/40 16/60 16/48 OR CARCINOMA 0/50 0/40 0/60 2/48	Neoplastic Lesions
Yes	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 5/50	Neoplastic Lesions
Yes	TR-424	120-32-1	o-Benzyl-p-chlorophenol	Mice	B6C3F1	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 2/50 2/50 2/50 OR CARCINOMA 0/50 0/50 2/50 1/50 COMBINED 0/50 2/50 4/50 3/50; (STEP SECTIONS) ADENOMA 0/50 1/50 2/50 3/50 OR CARCINOMA 0/50 0/50 1/50 0/50 COMBINED 0/50 1/50 3/50 3/50	Neoplastic Lesions
Yes	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 2/50 10/40 11/59 14/50 OR CARCINOMA 0/50 0/40 2/59 1/50	Neoplastic Lesions
Yes	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 5/50 24/50	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 3/50 2/49	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 1/49 1/50 3/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 2/49 3/50 9/50	Neoplastic Lesions
Yes	TR-475	109-99-9	Tetrahydrofuran	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 1/50 1/50 4/50 3/50 OR CARCINOMA 0/50 0/50 0/50 2/50 COMBINED 1/50 1/50 4/50 5/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/49 0/50 0/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/49 0/50 0/50 4/50	Neoplastic Lesions
Yes	TR-466	100-41-4	Ethylbenzene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 3/50 2/50 4/50 OR CARCINOMA 0/50 0/50 1/50 3/50 COMBINED 0/50 3/50 3/50 7/50; (SINGLE AND STEP SECTIONS) ADENOMA 3/50 5/50 7/50 20/50 OR CARCINOMA 0/50 0/50 1/50 3/50 COMBINED 3/50 5/50 8/50 21/50	Neoplastic Lesions
Yes	TR-319	106-46-7	1,4-Dichlorobenzene (p-dichlorobenzene)	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOCARCINOMA 1/50 3/50 7/50	Neoplastic Lesions
Yes	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Female	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 4/50 9/50 7/50 12/49; ADENOMA OR CARCINOMA 0/50 6/50 9/50 8/50 14/49	Neoplastic Lesions
Yes	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 1/50 3/50 9/50 5/50 3/50	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/51 0/53 1/51 3/55 1/59	May Have Been Related
Yes	TR-463	8003-22-3	D&C Yellow No. 11	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 0/50 0/51 0/51 2/54 OR CARCINOMA 0/50 0/51 1/51 0/54 COMBINED 0/50 0/51 1/51 2/54; (SINGLE AND STEP SECTIONS) ADENOMA 0/50 2/51 4/51 4/54 OR CARCINOMA 0/50 0/51 1/51 0/54 COMBINED 0/50 2/51 5/51 4/54	Neoplastic Lesions
Yes	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	SINGLE SECTIONS: ADENOMA 0/50 3/50 1/50 3/50 OR CARCINOMA 0/50 0/50 0/50 2/50 COMBINED 0/50 3/50 1/50 5/50; SINGLE AND STEP SECTIONS: ADENOMA 0/50 3/50 3/50 8/50 OR CARCINOMA 0/50 0/50 0/50 3/50 COMBINED 0/50 3/50 3/50 10/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 1/50 1/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 1/50 7/50 6/50 7/50 OR CARCINOMA 0/50 2/50 0/50 1/50 COMBINED 1/50 9/50 6/50 8/50	Neoplastic Lesions
Yes	TR-478	111-42-2	Diethanolamine	Mice	B6C3F1	Male	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 1/50 4/50 6/50 6/50 COMBINED 3/50 5/50 6/50 8/50; (SINGLE AND STEP SECTIONS) ADENOMA 1/50 6/50 8/50 7/50 COMBINED 3/50 7/50 8/50 9/50	Neoplastic Lesions
Yes	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA (STANDARD AND EXTENDED COMBINED) 4/50 6/50 17/50 13/50 20/50	Neoplastic Lesions
Yes	TR-542	98-82-8	Cumene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	renal tubule, adenoma or carcinoma (2/50, 5/50, 8/50, 7/50)	Neoplastic Lesions
Yes	TR-479	68603-42-9	Coconut oil acid diethanolamine condensate	Mice	B6C3F1	Male	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	adenoma 1/50, 1/50, 7/50; renal tubule adenoma or carcinoma 1/50, 1/50, 9/50	Neoplastic Lesions
Yes	TR-538	108-10-1	Methyl isobutyl ketone	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA (STANDARD EVALUATION - 0/50 0/50 2/50 3/50; STANDARD AND EXTENDED EVAULATION COMBINED - 2/50 3/50 3/50 10/50); CARCINOMA (STANDARD EVALUATION - 0/50 1/50 0/50 2/50); ADENOMA OR CARCINOMA (COMBINED) (STANDARD EVAULATION - 0/50 1/50 2/50 4/50; STANDARD AND EXTENDED EVALUATION - 2/50 4/50 3/50 11/50)	Neoplastic Lesions
Yes	TR-519	64742-88-7	Stoddard solvent (type lIC)	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Some Evidence	Equivocal Evidence	(STANDARD AND EXTENDED EVALUATION COMBINED) ADENOMA 3/50 2/50 3/50 7/50	May Have Been Related
Yes	TR-496	116355-83-0	Fumonisin B1	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	Adenoma 0/48 0/40 0/48 2/48 5/48 or Carcinoma 0/48 0/40 0/48 7/48 10/48 Combined 0/48 0/40 0/48 9/48 15/48	Neoplastic Lesions
Yes	TR-533	119-61-9	Benzophenone	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA (STANDARD EVALUATION) 1/50 1/50 2/50 4/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 2/50 2/50 7/50 8/50	Neoplastic Lesions
Yes	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	SINGLE SECTIONS: ADENOMA 0/50 0/50 6/50 3/50 OR CARCINOMA 1/50 0/50 2/50 0/50 COMBINED 1/50 0/50 6/50 3/50; SINGLE AND STEP SECTIONS: ADENOMA 2/50 4/50 9/50 13/50 OR CARCINOMA 1/50 1/50 2/50 0/50 COMBINED 3/50 5/50 9/50 13/50	Neoplastic Lesions
Yes	TR-465	77-09-8	Phenolphthalein	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 4/50 2/50 6/50 OR CARCINOMA 0/50 1/50 1/50 2/50 COMBINED 0/50 5/50 3/50 7/50; (SINGLE AND STEP SECTIONS) ADENOMA 1/50 10/50 15/50 15/50 OR CARCINOMA 0/50 1/50 2/50 2/50 COMBINED 1/50 10/50 16/50 16/50	Neoplastic Lesions
Yes	TR-470	110-86-1	Pyridine	Rats	F344/N	Male	Dosed-Water	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 1/50 0/48 2/50 6/49 COMBINED 1/50 1/48 2/50 6/49; (SINGLE AND STEP SECTIONS) ADENOMA 2/50 3/48 6/50 10/49 COMBINED 2/50 4/48 6/50 10/49	Neoplastic Lesions
Yes	TR-482	98-00-0	Furfuryl alcohol	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 0/50 0/49 049 2/50 OR CARCINOMA 0/50 0/49 0/49 2/50 COMBINED 0/50 0/49 0/49 4/50; (SINGLE AND STEP SECTIONS) ADENOMA 0/50 0/49 0/49 3/50 COMBINED 0/50 0/49 0/49 5/50	Neoplastic Lesions
Yes	TR-466	100-41-4	Ethylbenzene	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 0/50 0/50 0/50 1/49 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 0/50 1/50 8/49	Neoplastic Lesions
Yes	TR-470	110-86-1	Pyridine	Rats	Wistar	Male	Dosed-Water	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 1/50 0/48 2/50 6/49 COMBINED 1/50 1/48 2/50 6/49; (SINGLE AND STEP SECTIONS) ADENOMA 2/50 3/48 6/50 10/49 COMBINED 2/50 4/48 6/50 10/49	Neoplastic Lesions
Yes	TR-436	75-65-0	tert-Butyl alcohol	Rats	F344/N	Male	Dosed-Water	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 1/50 3/50 4/50 2/50 OR CARCINOMA 0/50 0/50 0/50 1/50 COMBINED 1/50 3/50 4/50 3/50; (SINGLE AND STEP SECTIONS) ADENOMA 8/50 11/50 19/50 13/50 OR CARCINOMA 0/50 2/50 1/50 1/50 COMBINED 8/50 13/50 19/50 13/50	Neoplastic Lesions
Yes	TR-513	91-17-8	Decalin	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 2/50 6/49 9/50 5/20 ADENOMA OR CARCINOMA 1/50 3/50 7/49 12/50 6/20	Neoplastic Lesions
Yes	TR-456	147-47-7	1,2-Dihydro-2,2,4-trimethylquinoline (monomer)	Rats	F344/N	Male	Topical Application	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA (SINGLE SECTIONS) 1/50 7/50 10/50 7/50 (STEP SECTIONS) 6/50 5/50 6/50 8/50 (COMBINED) 7/50 11/50 14/50 14/50; CARCINOMA (SINGLE SECTIONS) 0/50 1/50 0/50 0/50 (STEP SECTIONS) 0/50 1/50 0/50 0/50 (COMBINED) 0/50 1/50 0/50 0/50; ADENOMA OR CARCINOMA COMBINED (SINGLE SECTIONS) 1/50 8/50 10/50 7/50 (STEP SECTIONS) 6/50 6/50 6/50 8/50 (COMBINED) 7/50 12/50 14/50 14/50	Neoplastic Lesions
Yes	TR-486	78-79-5	Isoprene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTION) ADENOMA 0/50 2/50 2/50 6/50 (SINGLE AND STEP SECTION) ADENOMA 2/50 4/50 8/50 15/50	Neoplastic Lesions
Yes	TR-543	98-83-9	alpha-Methylstyrene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA (STANDARD EVALUATION) 0/50 0/50 1/50 0/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 2/50 5/50 ADENOMA OR CARCINOMA (STANDARD EVALUATION) 0/50 0/50 2/50 2/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 3/50 7/50	Neoplastic Lesions
Yes	TR-557	123-35-3	beta-Myrcene	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	Adenoma (standard evaluation) 0/50 4/50 8/50 (standard and extended evaluations) 0/50 12/50 13/50 adenoma or carcinoma (standard evaluation) 0/50 7/50 9/50 (standard and extended evaluations) 0/50 14/50 13/50	Neoplastic Lesions

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-111	82-28-0	1-Amino-2-methylanthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-111	82-28-0	1-Amino-2-methylanthraquinone	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA OR ADENOCARCINOMA	Neoplastic Lesions
No	TR-111	82-28-0	1-Amino-2-methylanthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(NEOPLASTIC NODULE OR CARCINOMA)	Neoplastic Lesions
No	TR-111	82-28-0	1-Amino-2-methylanthraquinone	Rats	F344/N	Female	Dosed-Feed	Liver	Positive	Positive	(NEOPLASTIC NODULE, CARCINOMA)	Neoplastic Lesions
No	TR-111	82-28-0	1-Amino-2-methylanthraquinone	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	(NEOPLASTIC NODULE, CARCINOMA)	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 16/50 27/50; SQUAMOUS CELL CARCINOMA 0/50 12/50 11/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 13/51 16/50; SQUAMOUS CELL CARCINOMA 0/50 12/51 13/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP (ADENOMA) 0/50 28/40 53/60 43/49; CARCINOMA 0/50 2/40 21/60 8/49	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP (ADENOMA) 0/50 13/40 51/59 40/50; CARCINOMA 0/50 1/40 11/59 17/50	Neoplastic Lesions
Yes	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 3/40 16/60 16/48 OR CARCINOMA 0/50 0/40 0/60 2/48	Neoplastic Lesions
Yes	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 2/50 10/40 11/59 14/50 OR CARCINOMA 0/50 0/40 2/59 1/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 6/50 45/50 49/50; CARCINOMA 0/50 23/50 27/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 10/50 38/51 39/50; CARCINOMA 9/50 18/51 21/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 28/40 47/60 29/48; CARCINOMA 0/50 12/40 57/60 45/48; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 11/60 13/48	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 20/40 40/59 34/50; CARCINOMA 1/50 12/40 55/59 46/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 6/59 2/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 17/50 13/49	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 26/51 24/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/50 2/40 7/60 9/46; TRANSITIONAL CELL CARCINOMA 0/50 0/40 8/60 16/46	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/50 1/38 2/58 8/50; TRANSITIONAL CELL CARCINOMA 0/50 0/38 1/58 4/50	Neoplastic Lesions
No	TR-456	147-47-7	1,2-Dihydro-2,2,4-trimethylquinoline (monomer)	Mice	Sencar	Female	Topical Application	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-456	147-47-7	1,2-Dihydro-2,2,4-trimethylquinoline (monomer)	Mice	B6C3F1	Female	Topical Application	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-456	147-47-7	1,2-Dihydro-2,2,4-trimethylquinoline (monomer)	Mice	Sencar	Male	Topical Application	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-456	147-47-7	1,2-Dihydro-2,2,4-trimethylquinoline (monomer)	Mice	B6C3F1	Male	Topical Application	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-456	147-47-7	1,2-Dihydro-2,2,4-trimethylquinoline (monomer)	Rats	F344/N	Male	Topical Application	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA (SINGLE SECTIONS) 1/50 7/50 10/50 7/50 (STEP SECTIONS) 6/50 5/50 6/50 8/50 (COMBINED) 7/50 11/50 14/50 14/50; CARCINOMA (SINGLE SECTIONS) 0/50 1/50 0/50 0/50 (STEP SECTIONS) 0/50 1/50 0/50 0/50 (COMBINED) 0/50 1/50 0/50 0/50; ADENOMA OR CARCINOMA COMBINED (SINGLE SECTIONS) 1/50 8/50 10/50 7/50 (STEP SECTIONS) 6/50 6/50 6/50 8/50 (COMBINED) 7/50 12/50 14/50 14/50	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/46 10/46 13/50 10/51 OR CARCINOMA 0/46 0/46 4/50 6/51 COMBINED 5/46 10/46 17/50 15/51	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 23/50 18/51 29/55; SQUAMOUS CELL CARCINOMA 0/50 46/50 49/51 49/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 3/52 28/51 22/54 33/56; SQUAMOUS CELL CARCINOMA 0/52 40/51 50/54 51/56	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 13/49 32/51 17/52; SQUAMOUS CELL CARCINOMA 0/50 3/49 9/51 4/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 29/50 33/49 38/52; SQUAMOUS CELL CARCINOMA 0/50 9/50 27/49 13/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/50 6/50 7/51 10/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/52 2/51 10/54 11/56	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Intestines (Large)	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/49 0/47 1/52 2/52	May Have Been Related
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Intestines (Large)	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/50 0/50 2/48 1/52	May Have Been Related
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 20/49 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 6/50 9/50 8/51 31/55 OR CARCINOMA 1/50 3/50 0/51 2/55 COMBINED 7/50 11/50 8/51 31/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 11/52 18/51 21/54 29/56; CARCINOMA 13/52 24/51 24/54 31/56	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 1/50 6/49 12/52 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Oral Cavity	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/52 0/51 0/54 2/56	May Have Been Related
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/50 0/50 1/51 5/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 5/49 10/52 18/52 ; SQUAMOUS CELL CARCINOMA 0/50 1/49 21/52 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 9/49 19/52; SQUAMOUS CELL CARCINOMA 1/50 0/50 11/49 25/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Pancreas Acinar Cell	Clear Evidence	Clear Evidence	ADENOMA 5/50 21/50 36/49 29/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 5/49 3/47 5/49 11/50 OR CARCINOMA 0/49 3/47 3/49 5/50 COMBINED 5/49 6/47 8/49 16/50	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/51 3/54; ADENOCARCINOMA 0/50 4/50 3/51 6/54; POLYP 0/50 2/50 1/51 6/54	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/60 1/59 0/60 4/60	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/60 0/60 0/59 3/60	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Brain	Clear Evidence	Clear Evidence	(STOP STUDY) GLIOMA 0/50 2/50 0/50 1/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 0/50 0/50 3/50 2/50 4/50 22/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 1/50 0/50 0/50 1/50 8/50 4/73, STOP STUDY 3/50 7/50 9/50 10/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 8/50 10/50 7/50 15/50 20/50 9/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 6/50 7/50 9/50 20/50 31/50 6/73, STOP STUDY 27/50 23/50 30/50 13/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 6/50 12/50 11/50 7/50 9/50 32/80; HISTIOCYTIC SARCOMA 3/50 2/50 7/50 4/50 7/50 4/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 4/50 2/50 4/50 6/50 2/50 51/73, STOP STUDY 8/50 22/50 8/50 33/50; HISTIOCYTIC SARCOMA 0/50 0/50 4/50 5/50 7/50 4/73, STOP STUDY 5/50 2/50 7/50 2/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Intestines (Small)	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50 1/50 2/50 0/73	May Have Been Related
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 0/49 0/48 0/50 2/50 0/80	May Have Been Related
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50 3/48 1/49 0/73, STOP STUDY 4/48 1/50 3/49 1/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 15/49 14/49 15/50 19/50 16/50 2/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 21/50 23/50 30/50 25/48 33/48 5/72, STOP STUDY 27/49 19/49 19/50 11/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 4/50 15/50 19/50 24/50 25/50 22/78	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 21/50 23/50 19/50 31/49 35/50 3/73, STOP STUDY 36/50 28/50 32/50 17/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	ADENOACANTHOMA, ADENOCARCINOMA, OR MALIGNANT MIXED TUMOR 0/50 2/50 4/50 12/50 15/50 16/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Ovary	Clear Evidence	Clear Evidence	BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 1/49 0/49 1/48 9/50 8/50 6/79; ADENOMA OR BENIGN MIXED TUMOR 2/49 4/49 1/48 4/50 6/50 2/79	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Preputial Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 0/50 0/50 5/50 0/73, STOP STUDY 1/50 4/50 4/50 3/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Subcutaneous Tissue	Clear Evidence	Equivocal Evidence	NEUROFIBROSARCOMA OR SARCOMA 1/50 2/50 3/50 5/50 3/50 3/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/50 0/50 1/49 21/50 23/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/49 1/50 5/48 20/48 4/73, STOP STUDY 15/50 7/50 33/50 13/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 0/50 0/50 0/50 0/50 0/50 2/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	(STOP STUDY) CARCINOMA 1/50 0/50 2/50 2/50	May Have Been Related
No	TR-319	106-46-7	1,4-Dichlorobenzene (p-dichlorobenzene)	Mice	B6C3F1	Male	Gavage	Adrenal Gland Medulla	Clear Evidence	Equivocal Evidence	PHEOCHROMOCYTOMA 0/47 2/48 4/49	May Have Been Related
Yes	TR-319	106-46-7	1,4-Dichlorobenzene (p-dichlorobenzene)	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOCARCINOMA 1/50 3/50 7/50	Neoplastic Lesions
No	TR-319	106-46-7	1,4-Dichlorobenzene (p-dichlorobenzene)	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 10/50 6/48 21/50; CARCINOMA 5/50 5/48 19/50	Neoplastic Lesions
No	TR-319	106-46-7	1,4-Dichlorobenzene (p-dichlorobenzene)	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 5/50 13/49 16/50; CARCINOMA 14/50 11/49 32/50	Neoplastic Lesions
No	TR-339	99-57-0	2-Amino-4-nitrophenol	Mice	B6C3F1	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-339	99-57-0	2-Amino-4-nitrophenol	Mice	B6C3F1	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-339	99-57-0	2-Amino-4-nitrophenol	Rats	F344/N	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-339	99-57-0	2-Amino-4-nitrophenol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 1/48 3/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/51 1/53 10/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 1/51 5/55 0/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/52 1/50 5/51 3/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/51 2/50 2/49 OR SQUAMOUS CELL CARCINOMA 0/50 0/51 1/50 2/49 COMBINED 0/50 3/51 3/50 4/49	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 0/51 1/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/52 6/50 8/51 15/50 OR CARCINOMA 1/52 6/50 5/51 7/50 COMBINED 3/52 12/50 13/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 6/51 12/50 18/49 OR CARCINOMA 1/50 1/51 4/50 4/49 COMBINED 4/50 7/51 16/50 22/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 27/51 29/53 40/51 34/55 25/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 3/51 4/55 11/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Small)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 0/51 2/53 5/59	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/51 0/53 1/51 3/55 1/59	May Have Been Related
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 3/50 2/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/52 3/50 9/51 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/52 2/50 6/51 5/50 COMBINED 5/52 5/50 15/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 12/50 4/51 12/50 21/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 7/51 8/50 11/49 COMBINED 15/50 11/51 16/50 25/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/51 0/53 3/51 1/55 4/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 1/53 0/51 3/55 3/60 COMBINED 1/51 1/53 3/51 4/55 7/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/52 0/50 1/51 2/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 25/50 45/51 46/53 45/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 0/51 4/53 6/51 6/55 5/60 OR ADENOMA 0/51 0/53 1/51 1/55 0/60 COMBINED 0/51 4/53 7/51 7/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/51 3/53 8/51 9/55 26/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 2/51 4/53 5/52 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/53 1/52 COMBINED 2/50 3/51 5/53 6/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 4/53 8/51 10/55 12/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 1/51 0/55 2/60 COMBINED 0/51 4/53 9/51 10/55 13/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Pancreas Acinar Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/51 2/53 4/51 3/53 3/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Seminal Vesicle	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 0/51 0/55 1/59 OR CARCINOMA 0/51 0/53 0/51 0/55 1/59 COMBINED 0/51 0/53 0/51 0/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/51 0/53 2/51 5/55 11/60 OR KERATOACANTHOMA 3/51 5/53 11/51 16/55 10/60 OR TRICHOEPITHELIOMA 0/51 0/53 0/51 1/55 1/60 OR BASAL CELL ADENOMA 0/51 1/53 0/51 3/55 6/60 OR BASAL CELL CARCINOMA 0/51 0/53 2/51 2/55 0/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 0/51 0/55 1/60 COMBINED 4/51 6/53 14/51 24/55 21/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/52 1/50 4/51 11/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 2/51 8/53 11/51 15/55 7/60 OR FIBROSARCOMA 0/51 1/53 0/51 0/55 1/60 OR SARCOMA 0/51 0/53 2/51 3/55 2/60 COMBINED 2/51 9/53 13/51 16/55 10/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 2/53 3/52 OR CARCINOMA 0/50 0/51 0/53 1/52 COMBINED 0/50 0/51 2/53 4/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/51 1/53 2/51 2/55 7/59 OR CARCINOMA 0/51 1/53 4/51 1/55 2/59 COMBINED 0/51 2/53 6/51 3/55 9/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/51 0/53 1/51 2/55 1/59 OR TRANSITIONAL CELL CARCINOMA 0/51 0/53 0/51 1/55 1/59 COMBINED 0/51 0/53 1/51 3/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Vascular System (Unspecified)	Clear Evidence	Equivocal Evidence	HEMANGIOMA AND HEMANGIOSARCOMA 1/52 2/50 0/51 5/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 1/51 3/55 2/60 OR CARCINOMA 2/51 1/53 3/51 2/55 15/60 COMBINED 2/51 1/53 4/51 5/55 15/60	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 3/50 OR ADENOCARCINOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 6/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 9/50 38/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 19/50 33/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 12/49 17/50 OR SQUAMOUS CELL CARCINOMA 0/50 7/47 6/50 COMBINED 0/50 18/49 19/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 12/50 20/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/49 COMBINED 0/50 14/50 21/49	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 23/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 17/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 3/50 4/49; ADENOMATOUS POLYP 0/50 12/50 37/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 8/50 11/50; ADENOMATOUS POLYP 1/50 13/50 29/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 4/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 2/50 9/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 11/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULES 0/50 10/50 11/50 OR CARCINOMA 0/50 2/50 6/50 COMBINED 0/50 11/50 14/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULES 0/49 3/50 2/50 OR CARCINOMA 0/49 1/50 3/50 COMBINED 0/49 4/50 5/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 4/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 0/50 0/50 COMBINED 1/50 3/50 4/50	May Have Been Related
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 1/50 6/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 0/50 5/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	0/50 1/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Nasal Cavity	Clear Evidence	Clear Evidence	ADENOMA 0/50 44/50 49/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Nasal Cavity	Clear Evidence	Clear Evidence	ADENOMA 0/50 48/50 48/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 27/50 41/50 OR SQUAMOUS CELL CARCINOMA 0/50 15/50 27/50 COMBINED 0/50 39/50 49/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 40/50 33/50 OR SQUAMOUS CELL CARCINOMA 0/50 16/50 25/50 COMBINED 0/50 47/50 48/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 6/50; SEBACEOUS GLAND ADENOMA 0/50 3/50 2/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 3/50 11/50; SEBACEOUS GLAND ADENOMA 0/50 1/50 8/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA OR KERATOACANTHOMA 0/50 3/50 18/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 0/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 8/50 COMBINED 1/50 8/50 8/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA, OR KERATOACANTHOMA 0/50 20/50 31/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Vascular System (Spleen)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 0/50 3/50 OR HEMANGIOSARCOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 7/50 3/50 OR ADENOCARCINOMA 1/50 2/50 19/50 COMBINED 1/50 9/50 22/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 7/50 OR ADENOCARCINOMA 0/50 8/50 29/50 COMBINED 0/50 9/50 35/50	Neoplastic Lesions
Yes	TR-401	137-09-7	2,4-Diaminophenol dihydrochloride	Mice	B6C3F1	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/48 3/50	Neoplastic Lesions
No	TR-423	119-84-6	3,4-Dihydrocoumarin	Mice	B6C3F1	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-423	119-84-6	3,4-Dihydrocoumarin	Rats	F344/N	Male	Gavage	Kidney Transitional Cell	Some Evidence	Equivocal Evidence	CARCINOMA 0/50 0/48 0/47 2/50	May Have Been Related
Yes	TR-423	119-84-6	3,4-Dihydrocoumarin	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 1/48 0/47 2/50, STEP SECTIONS 1/50 0/48 3/47 5/50	Neoplastic Lesions
No	TR-423	119-84-6	3,4-Dihydrocoumarin	Mice	B6C3F1	Female	Gavage	Liver	Some Evidence	Some Evidence	ADENOMA 10/51 20/50 22/50 20/52 OR CARCINOMA 3/51 2/50 4/50 6/52 COMBINED 13/51 21/50 25/50 24/52	Neoplastic Lesions
No	TR-359	298-81-7	8-Methoxypsoralen	Rats	F344/N	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-359	298-81-7	8-Methoxypsoralen	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 11/50 8/49 OR ADENOCARCINOMA 0/50 1/50 3/49	Neoplastic Lesions
No	TR-359	298-81-7	8-Methoxypsoralen	Rats	F344/N	Male	Gavage	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 9/50 9/49	May Have Been Related
No	TR-359	298-81-7	8-Methoxypsoralen	Rats	F344/N	Male	Gavage	Subcutaneous Tissue	Clear Evidence	Equivocal Evidence	FIBROMA 1/50 5/50 7/49	May Have Been Related
No	TR-359	298-81-7	8-Methoxypsoralen	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 7/50 4/49	Neoplastic Lesions
No	TR-369	98-85-1	alpha-Methylbenzyl alcohol	Mice	B6C3F1	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-369	98-85-1	alpha-Methylbenzyl alcohol	Mice	B6C3F1	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-369	98-85-1	alpha-Methylbenzyl alcohol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 1/50 5/50 OR ADENOCARCINOMA 0/50 1/50 0/50 COMBINED 0/50 2/50 5/50	Neoplastic Lesions
No	TR-543	98-83-9	alpha-Methylstyrene	Rats	F344/N	Male	Inhalation	Hematopoietic System	Some Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 26/50 32/50 29/50 38/50	May Have Been Related
Yes	TR-543	98-83-9	alpha-Methylstyrene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA (STANDARD EVALUATION) 0/50 0/50 1/50 0/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 2/50 5/50 ADENOMA OR CARCINOMA (STANDARD EVALUATION) 0/50 0/50 2/50 2/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 3/50 7/50	Neoplastic Lesions
No	TR-543	98-83-9	alpha-Methylstyrene	Mice	B6C3F1/N	Male	Inhalation	Liver	Equivocal Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 28/50 36/50 33/50 37/50	May Have Been Related
No	TR-543	98-83-9	alpha-Methylstyrene	Mice	B6C3F1/N	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 10/50 20/50 21/50 23/50 CARCINOMA 3/50 9/50 6/50 18/50 ADENOMA OR CARCINOMA 13/50 26/50 24/50 33/50	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Male	Dosed-Feed	Kidney Transitional Cell	Some Evidence	Some Evidence	PAPILLOMA 0/50 0/50 2/50 0/50 1/50	Neoplastic Lesions
Yes	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Female	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 4/50 9/50 7/50 12/49; ADENOMA OR CARCINOMA 0/50 6/50 9/50 8/50 14/49	Neoplastic Lesions
Yes	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 1/50 3/50 9/50 5/50 3/50	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Male	Dosed-Feed	Liver	Some Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 1/50 3/50 4/50 5/50 3/50	May Have Been Related
No	TR-494	84-65-1	Anthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 6/49 28/50 27/50 40/49 OR CARCINOMA 2/49 3/50 8/50 8/49 COMBINED 6/49 30/50 30/50 41/49	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 21/50 32/50 38/50 41/49 OR CARCINOMA 8/50 13/50 17/50 21/49 OR HEPATOBLASTOMA 1/50 6/50 11/50 37/49 COMBINED 26/50 35/50 43/50 48/49	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 6/50 4/50 3/50	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/45 1/48 2/48 2/48 OR CARCINOMA 0/45 0/48 0/48 2/48 COMBINED 1/45 1/48 2/48 4/48	May Have Been Related
No	TR-494	84-65-1	Anthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/50 0/50 2/49 2/46	May Have Been Related
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL EPITHELIAL PAPILLOMA OR CARCINOMA 0/49 0/49 0/49 1/50 2/49	Neoplastic Lesions
No	TR-494	84-65-1	Anthraquinone	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Some Evidence	Some Evidence	TRANSITIONAL EPITHELIAL PAPILLOMA 0/50 1/50 3/50 7/50 3/49	Neoplastic Lesions
No	TR-370	271-89-6	Benzofuran	Mice	B6C3F1	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 COMBINED 2/50 9/50 5/50	Neoplastic Lesions
No	TR-370	271-89-6	Benzofuran	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/49 7/39 10/48 OR SQUAMOUS CELL CARCINOMA 0/49 4/39 3/48 COMBINED 2/49 11/39 13/48	Neoplastic Lesions
Yes	TR-370	271-89-6	Benzofuran	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOCARCINOMA 0/50 1/50 4/50	Neoplastic Lesions
No	TR-370	271-89-6	Benzofuran	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 22/48 21/47; HEPATOBLASTOMA 0/50 1/48 2/47; ADENOMA, HEPATOBLASTOMA, OR CARCINOMA 3/50 3/48 1/47 COMBINED 4/50 25/48 22/47	Neoplastic Lesions
No	TR-370	271-89-6	Benzofuran	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 4/49 24/39 34/48; HEPATOBLASTOMA 0/49 3/39 18/48; ADENOMA, HEPATOBLASTOMA, OR CARCINOMA 9/49 8/39 9/48 COMBINED 12/49 31/39 40/48	Neoplastic Lesions
No	TR-370	271-89-6	Benzofuran	Mice	B6C3F1	Female	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 5/48 13/47 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/48 3/47 COMBINED 2/50 9/48 14/47	Neoplastic Lesions
No	TR-370	271-89-6	Benzofuran	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 7/39 15/48 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/49 3/39 5/48 COMBINED 10/49 9/39 19/48	Neoplastic Lesions
No	TR-533	119-61-9	Benzophenone	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Some Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 27/50 41/50 39/50 24/50	May Have Been Related
No	TR-533	119-61-9	Benzophenone	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Equivocal Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 19/50 25/50 30/50 29/50; HISTIOCYTIC SARCOMA 0/50 0/50 1/50 2/50	Neoplastic Lesions
No	TR-533	119-61-9	Benzophenone	Mice	B6C3F1/N	Female	Dosed-Feed	Hematopoietic System	Some Evidence	Some Evidence	HISTIOCYTIC SARCOMA: 0/50 0/50 5/50 3/50	Neoplastic Lesions
Yes	TR-533	119-61-9	Benzophenone	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA (STANDARD EVALUATION) 1/50 1/50 2/50 4/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 2/50 2/50 7/50 8/50	Neoplastic Lesions
No	TR-533	119-61-9	Benzophenone	Mice	B6C3F1/N	Female	Dosed-Feed	Liver	Some Evidence	Equivocal Evidence	ADENOMA 5/50 4/50 10/50 8/50	May Have Been Related
No	TR-533	119-61-9	Benzophenone	Mice	B6C3F1/N	Male	Dosed-Feed	Liver	Some Evidence	Some Evidence	ADENOMA 11/50 15/50 23/50 23/50 ADENOMA, CARCINOMA, OR HEPATOBLASTOMA 18/50 20/50 25/50 29/50	Neoplastic Lesions
No	TR-557	123-35-3	beta-Myrcene	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Equivocal Evidence	Equivocal Evidence	Adenoma (standard evaluation) 0/50 1/50 0/50 2/50 extended evaluation 0/50 1/50 1/50 2/50 standard and extended evaluations 0/50 2/50 1/50 3/50	May Have Been Related
Yes	TR-557	123-35-3	beta-Myrcene	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	Adenoma (standard evaluation) 0/50 4/50 8/50 (standard and extended evaluations) 0/50 12/50 13/50 adenoma or carcinoma (standard evaluation) 0/50 7/50 9/50 (standard and extended evaluations) 0/50 14/50 13/50	Neoplastic Lesions
No	TR-557	123-35-3	beta-Myrcene	Mice	B6C3F1/N	Female	Gavage	Liver	Equivocal Evidence	Equivocal Evidence	Adenoma 6/50 13/50 6/50 carcinoma 1/50 7/50 2/50 adenoma or carcinoma 7/50 18/50 8/50	May Have Been Related
No	TR-557	123-35-3	beta-Myrcene	Mice	B6C3F1/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	Adenoma 26/50 41/50 43/50 carcinoma 14/50 20/50 28/50 adenoma or carcinoma 33/50 44/50 48/50 hepatoblastoma 4/50 6/50 11/50 adenoma, carcinoma, or hepatoblastoma 34/50 45/50 48/50	Neoplastic Lesions
No	TR-321	75-27-4	Bromodichloromethane	Rats	F344/N	Female	Gavage	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/46 0/50 7/47; ADENOCARCINOMA 0/46 0/50 6/47	Neoplastic Lesions
No	TR-321	75-27-4	Bromodichloromethane	Rats	F344/N	Male	Gavage	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 3/50 33/50; ADENOCARCINOMA 0/50 11/50 38/50	Neoplastic Lesions
Yes	TR-321	75-27-4	Bromodichloromethane	Mice	B6C3F1	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/49 2/50 6/50; ADENOCARCINOMA 0/49 0/50 4/50; COMBINED 1/49 2/50 9/50	Neoplastic Lesions
Yes	TR-321	75-27-4	Bromodichloromethane	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 6/50; ADENOCARCINOMA 0/50 0/50 9/50; COMBINED 0/50 1/50 15/50	Neoplastic Lesions
Yes	TR-321	75-27-4	Bromodichloromethane	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 3/50; ADENOCARCINOMA 0/50 0/50 10/50; COMBINED 0/50, 1/50, 13/50	Neoplastic Lesions
No	TR-321	75-27-4	Bromodichloromethane	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 13/48 23/50; CARCINOMA 2/50 5/48 10/50	Neoplastic Lesions
No	TR-430	28407-37-6	C.I. Direct Blue 218	Rats	F344/N	Male	Dosed-Feed	Forestomach	Some Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 1/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 0/50	May Have Been Related
No	TR-430	28407-37-6	C.I. Direct Blue 218	Mice	B6C3F1	Male	Dosed-Feed	Intestines (Small)	Clear Evidence	Equivocal Evidence	CARCINOMA 1/50 0/50 0/50 3/50	May Have Been Related
Yes	TR-430	28407-37-6	C.I. Direct Blue 218	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/50 2/50 1/50 1/50 OR CARCINOMA 0/50 1/50 0/50 0/50 COMBINED 0/50 3/50 1/50 1/50	May Have Been Related
No	TR-430	28407-37-6	C.I. Direct Blue 218	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 7/49 12/50 17/49 41/49; CARCINOMA 5/49 5/50 6/49 12/49	Neoplastic Lesions
No	TR-430	28407-37-6	C.I. Direct Blue 218	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 16/50 19/50 17/50 40/50; CARCINOMA 7/50 3/50 8/50 17/50	Neoplastic Lesions
No	TR-430	28407-37-6	C.I. Direct Blue 218	Rats	F344/N	Male	Dosed-Feed	Oral Cavity	Some Evidence	Some Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 0/50 5/51; SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 1/51; BASOSQUAMOUS TUMOR BENIGN 0/50 0/50 0/50 1/51	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Male	Dosed-Feed	Adrenal Gland Medulla	Some Evidence	Some Evidence	PHEOCHROMOCYTOMA 24/50 32/50 37/50 36/50	Neoplastic Lesions
Yes	TR-407	2425-85-6	C.I. Pigment Red 3	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/50 0/50 6/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Female	Dosed-Feed	Liver	Some Evidence	Some Evidence	ADENOMA 0/50 0/50 1/50 10/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Male	Dosed-Feed	Skin	Some Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 2/50 6/50	May Have Been Related
No	TR-407	2425-85-6	C.I. Pigment Red 3	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/49 1/50 5/50	Neoplastic Lesions
No	TR-407	2425-85-6	C.I. Pigment Red 3	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Some Evidence	Equivocal Evidence	CARCINOMA 0/50 0/50 2/50 3/50	May Have Been Related
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Male	Gavage	Hematopoietic System	Clear Evidence	Equivocal Evidence	LEUKEMIA 7/50 12/50 14/50	May Have Been Related
Yes	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 7/50 3/49 ADENOCARCINOMA 0/50 2/50 0/49 COMBINED 0/50 9/50 3/49	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 18/50 22/50 OR CARCINOMA 3/50 4/50 9/50 COMBINED 3/50 22/50 28/50	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 11/50 20/50 29/50 OR CARCINOMA 11/50 15/50 17/50 COMBINED 2/50 34/50 38/50	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Female	Gavage	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 4/50 7/50; CARCINOMA 0/50 1/50 1/50	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 10/50 16/48; CARCINOMA 0/50 3/50 2/48	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Mice	B6C3F1	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 8/50 12/49 18/49 OR CARCINOMA 0/50 0/49 2/49 COMBINED 8/50 12/49 15/49	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 6/50 3/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 6/50 6/50	Neoplastic Lesions
No	TR-000 (67-66-3)	67-66-3	Chloroform	Rats	Osborne Mendel	Female	Gavage	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-000 (67-66-3)	67-66-3	Chloroform	Rats	Osborne Mendel	Male	Gavage	Kidney Tubular Cell	Positive	Positive	ADENOMA OR ADENOCARCINOMA COMBINED	Neoplastic Lesions
No	TR-000 (67-66-3)	67-66-3	Chloroform	Mice	B6C3F1	Female	Gavage	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-000 (67-66-3)	67-66-3	Chloroform	Mice	B6C3F1	Male	Gavage	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	Squamous Cell Papilloma 0/50 0/50 0/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 0/50 2/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/50 3/50 3/50 8/50 OR CARCINOMA 1/50 2/50 0/50 1/50 COMBINED 2/50 5/50 3/50 9/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/50 5/50 8/50 10/50 OR CARCINOMA 0/50 0/50 2/50 2/50 COMBINED 2/50 5/50 10/50 12/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 1/49 1/50 3/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 2/49 3/50 9/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/49 0/50 0/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/49 0/50 0/50 4/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 1/50 1/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 1/50 7/50 6/50 7/50 OR CARCINOMA 0/50 2/50 0/50 1/50 COMBINED 1/50 9/50 6/50 8/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 17/50 19/49 11/50 16/50 OR CARCINOMA 4/50 11/49 14/50 19/50 COMBINED 20/50 26/49 20/50 30/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Lung	Clear Evidence	Equivocal Evidence	Alveolar/Bronchiolar Adenoma 1/49 0/50 0/50 3/50	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 2/50 16/49 29/50 26/50 or Alveolar/Bronchiolar Carcinoma 2/50 14/49 16/50 28/50 Combined 4/50 28/49 34/50 42/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 8/50 18/50 22/50 28/50 or Alveolar/Bronchiolar Carcinoma 6/50 12/50 23/50 28/50 Combined 13/50 28/50 36/50 43/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 2/50 0/50 3/49 3/50 or Alveolar/Bronchiolar Carcinoma 0/50 2/50 1/49 4/50 Combined 2/50 2/50 4/49 6/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	CARCINOMA 3/50 4/50 7/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 24/49 32/50 36/50 36/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	SARCOMA 0/50 4/50 8/50 3/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/49 2/50 2/50 7/50 OR SQUAMOUS CELL CARCINOMA 0/49 1/50 3/50 4/50 COMBINED 1/49 3/50 5/50 11/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 4/50 10/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 2/50 COMBINED 0/50 2/50 5/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/50 11/50 11/50 18/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/49 1/50 0/50 3/50 OR CARCINOMA 0/49 0/50 1/50 2/50 COMBINED 1/49 1/50 1/50 5/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/49 4/50 OR CARCINOMA 0/50 0/50 2/49 1/50 COMBINED 0/50 2/50 4/49 5/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Urinary Bladder	Clear Evidence	Equivocal Evidence	TRANSITIONAL EPITHELIUM CARCINOMA 0/49 0/50 0/50 2/50	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Urinary Bladder	Clear Evidence	Equivocal Evidence	TRANSITIONAL EPITHELIUM PAPILLOMA 0/50 0/50 0/50 1/49 OR CARCINOMA 0/50 0/50 1/50 0/49	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Vascular System (Unspecified)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 0/50 2/50 3/50 OR HEMANGIOSARCOMA 4/50 6/50 17/50 5/50 COMBINED 4/50 6/50 18/50 8/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Vascular System (Unspecified)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 1/50 2/50 2/50 OR HEMANGIOSARCOMA 3/50 13/50 22/50 19/50 COMBINED 3/50 14/50 23/50 21/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 0/50 3/50	Neoplastic Lesions
No	TR-041	1897-45-6	Chlorothalonil	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-041	1897-45-6	Chlorothalonil	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-041	1897-45-6	Chlorothalonil	Rats	Osborne Mendel	Female	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
Yes	TR-041	1897-45-6	Chlorothalonil	Rats	Osborne Mendel	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
No	TR-196	87-29-6	Cinnamyl anthranilate	Rats	F344/N	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-196	87-29-6	Cinnamyl anthranilate	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA OR ADENOCARCINOMA	Neoplastic Lesions
No	TR-196	87-29-6	Cinnamyl anthranilate	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(ADENOMA, CARCINOMA)	Neoplastic Lesions
No	TR-196	87-29-6	Cinnamyl anthranilate	Mice	B6C3F1	Male	Dosed-Feed	Liver	Positive	Positive	(ADENOMA, CARCINOMA)	Neoplastic Lesions
No	TR-196	87-29-6	Cinnamyl anthranilate	Rats	F344/N	Male	Dosed-Feed	Pancreas Acinar Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-479	68603-42-9	Coconut oil acid diethanolamine condensate	Rats	F344/N	Female	Topical Application	Kidney Tubular Cell	Equivocal Evidence	Equivocal Evidence	adenoma or carcinoma (standard evaluation 0/50, 2/50, 0/50; standard and extended evaluations combined 0/50, 4/50, 1/50)	May Have Been Related
Yes	TR-479	68603-42-9	Coconut oil acid diethanolamine condensate	Mice	B6C3F1	Male	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	adenoma 1/50, 1/50, 7/50; renal tubule adenoma or carcinoma 1/50, 1/50, 9/50	Neoplastic Lesions
No	TR-479	68603-42-9	Coconut oil acid diethanolamine condensate	Mice	B6C3F1	Female	Topical Application	Liver	Clear Evidence	Clear Evidence	adenoma 32/50, 44/50, 43/50; hepatocellular carcinoma 3/50, 21/50, 32/50; hepatocellular adenoma, carcinoma, or hepatoblastoma 33/50, 46/50, 48/50	Neoplastic Lesions
No	TR-479	68603-42-9	Coconut oil acid diethanolamine condensate	Mice	B6C3F1	Male	Topical Application	Liver	Clear Evidence	Clear Evidence	adenoma 22/50, 35/50, 45/50; hepatoblastoma 1/50, 1/50, 10/50; hepatocellular adenoma, carcinoma, or hepatoblastoma 29/50, 39/50, 49/50	Neoplastic Lesions
No	TR-422	91-64-5	Coumarin	Mice	B6C3F1	Female	Gavage	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 1/52 5/50 2/51 2/51	May Have Been Related
No	TR-422	91-64-5	Coumarin	Mice	B6C3F1	Male	Gavage	Forestomach	Some Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 2/50 8/50 2/50 0/51	May Have Been Related
No	TR-422	91-64-5	Coumarin	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Equivocal Evidence	Equivocal Evidence	ADENOMA 0/49 0/50 0/50 2/49, STEP SECTIONS 0/49 0/50 1/50 1/49	Neoplastic Lesions
Yes	TR-422	91-64-5	Coumarin	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 1/49 2/50 2/51 1/50, STEP SECTIONS 0/49 4/50 5/51 4/50	Neoplastic Lesions
No	TR-422	91-64-5	Coumarin	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 8/50 26/49 29/51 12/50	Neoplastic Lesions
No	TR-422	91-64-5	Coumarin	Mice	B6C3F1	Female	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 2/51 5/49 7/49 20/51 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 0/49 0/49 7/51 COMBINED 2/51 5/49 7/49 27/51	Neoplastic Lesions
No	TR-422	91-64-5	Coumarin	Mice	B6C3F1	Male	Gavage	Lung	Some Evidence	Some Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 14/50 8/50 14/50 24/51 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 1/50 2/50 1/51 COMBINED 14/50 9/50 15/50 25/51	Neoplastic Lesions
Yes	TR-542	98-82-8	Cumene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	renal tubule, adenoma or carcinoma (2/50, 5/50, 8/50, 7/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	adenoma (18/50, 23/50, 27/50, 29/50); adenoma or carcinoma (25/50, 26/50, 29/50, 36/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma (1/50, 26/50, 36/50, 38/50); alveolar/bronchiolar carcinoma (3/50, 16/50, 20/50, 34/50); alveolar/bronchiolar adenoma or carcinoma (4/50, 31/50, 42/50, 46/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma (13/50, 31/50, 31/50, 29/50); alveolar/bronchiolar carcinoma (9/50, 19/50, 32/50, 33/50); alveolar/bronchiolar adenoma or carcinoma (19/50, 38/50, 42/50, 43/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Rats	F344/N	Male	Inhalation	Nasal Cavity	Clear Evidence	Clear Evidence	respiratory epithelium, adenoma (0/50, 7/50, 18/49, 10/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Rats	F344/N	Female	Inhalation	Nasal Cavity	Some Evidence	Some Evidence	respiratory epithelium, adenoma (0/50, 5/48, 4/50, 3/50)	Neoplastic Lesions
No	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Male	Inhalation	Spleen	Clear Evidence	Equivocal Evidence	hemangioscaroma	May Have Been Related
No	TR-542	98-82-8	Cumene	Rats	F344/N	Male	Inhalation	Testis	Clear Evidence	Equivocal Evidence	interstitial cell adenoma	May Have Been Related
No	TR-542	98-82-8	Cumene	Mice	B6C3F1/N	Male	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	adenoma	May Have Been Related
No	TR-347	5989-27-5	D-Limonene	Mice	B6C3F1	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-347	5989-27-5	D-Limonene	Mice	B6C3F1	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-347	5989-27-5	D-Limonene	Rats	F344/N	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-347	5989-27-5	D-Limonene	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 4/50 8/50 OR ADENOCARCINOMA 0/50 4/50 3/50	Neoplastic Lesions
Yes	TR-463	8003-22-3	D&C Yellow No. 11	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 0/50 0/51 0/51 2/54 OR CARCINOMA 0/50 0/51 1/51 0/54 COMBINED 0/50 0/51 1/51 2/54; (SINGLE AND STEP SECTIONS) ADENOMA 0/50 2/51 4/51 4/54 OR CARCINOMA 0/50 0/51 1/51 0/54 COMBINED 0/50 2/51 5/51 4/54	Neoplastic Lesions
No	TR-463	8003-22-3	D&C Yellow No. 11	Rats	F344/N	Female	Dosed-Feed	Liver	Some Evidence	Some Evidence	ADENOMA 0/50 2/51 5/50 4/51 OR CARCINOMA 0/50 0/51 0/50 1/51 COMBINED 0/50 2/51 5/50 5/51	Neoplastic Lesions
No	TR-463	8003-22-3	D&C Yellow No. 11	Rats	F344/N	Male	Dosed-Feed	Liver	Some Evidence	Some Evidence	ADENOMA 1/50 2/51 1/51 7/54	Neoplastic Lesions
No	TR-463	8003-22-3	D&C Yellow No. 11	Rats	F344/N	Female	Dosed-Feed	Oral Cavity	Some Evidence	Equivocal Evidence	SQUAMOUS CELL CARCINOMA 0/50 0/51 0/50 1/51	May Have Been Related
No	TR-463	8003-22-3	D&C Yellow No. 11	Rats	F344/N	Male	Dosed-Feed	Oral Cavity	Some Evidence	Some Evidence	SQUAMOUS CELL PAPILLOMA 1/50 1/51 2/51 4/54 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/51 1/54 COMBINED 1/50 2/51 3/51 5/54	Neoplastic Lesions
No	TR-513	91-17-8	Decalin	Rats	F344/N	Female	Inhalation	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-513	91-17-8	Decalin	Rats	F344/N	Male	Inhalation	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 8/49 9/49 13/49 16/49 8/20	Neoplastic Lesions
Yes	TR-513	91-17-8	Decalin	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 2/50 6/49 9/50 5/20 ADENOMA OR CARCINOMA 1/50 3/50 7/49 12/50 6/20	Neoplastic Lesions
No	TR-513	91-17-8	Decalin	Mice	B6C3F1	Female	Inhalation	Liver	Equivocal Evidence	Equivocal Evidence	ADENOMA 7/49 13/50 8/50 17/50 CARCINOMA 4/49 16/50 6/50 5/50 COMBINED 11/49 27/50 14/50 20/50	May Have Been Related
No	TR-513	91-17-8	Decalin	Mice	B6C3F1	Female	Inhalation	Uterus/Cervix	Equivocal Evidence	Equivocal Evidence	STROMAL POLYP 0/49 0/50 2/50 3/50 STROMAL POLYP OR STROMAL SARCOMA 0/49 0/50 2/50 4/50	May Have Been Related
Yes	TR-478	111-42-2	Diethanolamine	Mice	B6C3F1	Male	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 1/50 4/50 6/50 6/50 COMBINED 3/50 5/50 6/50 8/50; (SINGLE AND STEP SECTIONS) ADENOMA 1/50 6/50 8/50 7/50 COMBINED 3/50 7/50 8/50 9/50	Neoplastic Lesions
No	TR-478	111-42-2	Diethanolamine	Mice	B6C3F1	Female	Topical Application	Liver	Clear Evidence	Clear Evidence	ADENOMA 32/50 50/50 48/50 48/50 OR CARCINOMA 5/50 19/50 38/50 42/50	Neoplastic Lesions
No	TR-478	111-42-2	Diethanolamine	Mice	B6C3F1	Male	Topical Application	Liver	Clear Evidence	Clear Evidence	ADENOMA 31/50 42/50 49/50 45/50, CARCINOMA 12/50 17/50 33/50 34/50 OR HEPATOBLASTOMA 0/50 2/50 8/50 5/50	Neoplastic Lesions
No	TR-323	756-79-6	Dimethyl methylphosphonate	Mice	B6C3F1	Male	Gavage	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-323	756-79-6	Dimethyl methylphosphonate	Mice	B6C3F1	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-323	756-79-6	Dimethyl methylphosphonate	Rats	F344/N	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-323	756-79-6	Dimethyl methylphosphonate	Rats	F344/N	Male	Gavage	Hematopoietic System	Some Evidence	Equivocal Evidence	LEUKEMIA 10/50 11/50 17/50	May Have Been Related
No	TR-323	756-79-6	Dimethyl methylphosphonate	Rats	F344/N	Male	Gavage	Kidney Transitional Cell	Some Evidence	Some Evidence	PAPILLOMA 0/50 7/50 3/49	Neoplastic Lesions
Yes	TR-323	756-79-6	Dimethyl methylphosphonate	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOCARCINOMA 0/50 2/50 3/49	Neoplastic Lesions
Yes	TR-466	100-41-4	Ethylbenzene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 3/50 2/50 4/50 OR CARCINOMA 0/50 0/50 1/50 3/50 COMBINED 0/50 3/50 3/50 7/50; (SINGLE AND STEP SECTIONS) ADENOMA 3/50 5/50 7/50 20/50 OR CARCINOMA 0/50 0/50 1/50 3/50 COMBINED 3/50 5/50 8/50 21/50	Neoplastic Lesions
Yes	TR-466	100-41-4	Ethylbenzene	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 0/50 0/50 0/50 1/49 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 0/50 1/50 8/49	Neoplastic Lesions
No	TR-466	100-41-4	Ethylbenzene	Mice	B6C3F1	Female	Inhalation	Liver	Some Evidence	Some Evidence	ADENOMA 6/50 9/50 12/50 16/50 OR CARCINOMA 7/50 4/50 3/50 12/50 COMBINED 13/50 12/50 15/50 25/50	Neoplastic Lesions
No	TR-466	100-41-4	Ethylbenzene	Mice	B6C3F1	Male	Inhalation	Lung	Some Evidence	Some Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 9/50 10/50 16/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 1/50 5/50 3/50 COMBINED 7/50 10/50 15/50 19/50	Neoplastic Lesions
No	TR-466	100-41-4	Ethylbenzene	Rats	F344/N	Male	Inhalation	Testis	Clear Evidence	Clear Evidence	ADENOMA 36/50 33/50 40/50 44/50	Neoplastic Lesions
No	TR-496	116355-83-0	Fumonisin B1	Rats	F344/N	Female	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-496	116355-83-0	Fumonisin B1	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	Adenoma 0/48 0/40 0/48 2/48 5/48 or Carcinoma 0/48 0/40 0/48 7/48 10/48 Combined 0/48 0/40 0/48 9/48 15/48	Neoplastic Lesions
No	TR-496	116355-83-0	Fumonisin B1	Mice	MV	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	Adenoma 5/47 3/48 1/48 16/47 31/45 or Carcinoma 0/47 0/48 0/48 10/47 9/45 Combined 5/47 3/48 1/48 19/47 39/45	Neoplastic Lesions
No	TR-382	98-01-1	Furfural	Rats	F344/N	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-382	98-01-1	Furfural	Mice	B6C3F1	Female	Gavage	Forestomach	Some Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 1/50 0/50 1/50 6/50	May Have Been Related
Yes	TR-382	98-01-1	Furfural	Mice	B6C3F1	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/50 0/50 1/49 1/50 OR CARCINOMA 0/50 1/50 0/49 0/50 COMBINED 0/50 1/50 1/49 1/50	May Have Been Related
No	TR-382	98-01-1	Furfural	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 9/50 13/50 11/49 19/50; CARCINOMA 7/50 12/50 6/49 21/50	Neoplastic Lesions
No	TR-382	98-01-1	Furfural	Mice	B6C3F1	Female	Gavage	Liver	Some Evidence	Some Evidence	ADENOMA 1/50 3/50 5/50 8/50	Neoplastic Lesions
No	TR-382	98-01-1	Furfural	Rats	F344/N	Male	Gavage	Liver	Some Evidence	Some Evidence	CHOLANGIOCARCINOMA 0/50 0/50 2/50	Neoplastic Lesions
No	TR-482	98-00-0	Furfuryl alcohol	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Equivocal Evidence	Equivocal Evidence	ADENOMA (SINGLE AND STEP SECTIONS) COMBINED 0/50 1/49 2/49 2/50	May Have Been Related
Yes	TR-482	98-00-0	Furfuryl alcohol	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 0/50 0/49 049 2/50 OR CARCINOMA 0/50 0/49 0/49 2/50 COMBINED 0/50 0/49 0/49 4/50; (SINGLE AND STEP SECTIONS) ADENOMA 0/50 0/49 0/49 3/50 COMBINED 0/50 0/49 0/49 5/50	Neoplastic Lesions
No	TR-482	98-00-0	Furfuryl alcohol	Rats	F344/N	Female	Inhalation	Nasal Cavity	Equivocal Evidence	Equivocal Evidence	RESPIRATORY EPITHELIUM ADENOMA 0/49 0/50 0/48 1/49; LATERAL WALL ADENOMA 0/49 0/50 1/48 0/49	May Have Been Related
No	TR-482	98-00-0	Furfuryl alcohol	Rats	F344/N	Male	Inhalation	Nasal Cavity	Some Evidence	Some Evidence	ADENOMA, CARCINOMA, OR SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 4/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 5/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 7/50 7/50, ADENOCARCINOMA 0/50 1/50 0/50, OR CARCINOMA 2/50 1/50 5/50 COMBINED 5/50 9/50 12/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Epididymis	Clear Evidence	Equivocal Evidence	SARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 9/50 OR SQUAMOUS CELL CARCINOMA 1/50 0/50 1/50 COMBINED 1/50 2/50 10/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 8/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 4/50 11/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 1/50 1/50 2/50 COMBINED 1/50 2/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Glandular Stomach	Clear Evidence	Equivocal Evidence	FIBROSARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 4/50 10/50 16/50 OR ADENOCARCINOMA 0/50 1/50 1/50 COMBINED 4/50 11/50 17/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 7/50 10/50 16/50 OR ADENOCARCINOMA 1/50 2/50 7/50 COMBINED 8/50 12/50 22/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LEUKEMIA 13/50 14/50 20/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 1/50 3/50 COMBINED 0/50 1/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 18/50 16/50 30/50 OR CARCINOMA 10/50 17/50 8/50 COMBINED 24/50 31/50 35/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 6/50 6/50 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/50 5/50 14/50 COMBINED 13/50 11/50 21/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50, FIBROADENOMA 1/50 0/50 0/50, OR ADENOCARCINOMA 1/50 5/50 15/50 COMBINED 2/50 6/50 15/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 14/50 32/50 29/50; ADENOCARCINOMA 1/50 11/50 16/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 3/50 8/50 7/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 3/50 34/50 39/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 6/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 1/50 3/50 7/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 1/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 2/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SEBACEOUS GLAND ADENOMA 0/50 0/50 1/50, BASAL CELL CARCINOMA 0/50 4/50 2/50, OR SEBACEOUS GLAND ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 5/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/50 1/50 6/50 OR FIBROSARCOMA 0/50 2/50 3/50 COMBINED 0/50 3/50 9/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/49 OR CARCINOMA 0/50 0/50 3/49 COMBINED 0/50 1/50 3/49	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/50 OR CARCINOMA 1/50 2/50 5/50 COMBINED 1/50 4/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Urinary Bladder	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Uterus/Cervix	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 3/50 2/50 COMBINED 0/50 3/50 3/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 3/50 6/50	Neoplastic Lesions
No	TR-361	67-72-1	Hexachloroethane	Rats	F344/N	Male	Gavage	Adrenal Gland Medulla	Clear Evidence	Equivocal Evidence	PHEOCHROMOCYTOMA 15/50 28/45 21/49	May Have Been Related
Yes	TR-361	67-72-1	Hexachloroethane	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 2/50 3/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 7/50	Neoplastic Lesions
Yes	TR-361	67-72-1	Hexachloroethane	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/50 1/50	Neoplastic Lesions
No	TR-366	123-31-9	Hydroquinone	Rats	F344/N	Female	Gavage	Hematopoietic System	Some Evidence	Some Evidence	Leukemia 9/55 15/55 22/55	Neoplastic Lesions
Yes	TR-366	123-31-9	Hydroquinone	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	Adenoma 0/55 4/55 8/55	Neoplastic Lesions
No	TR-366	123-31-9	Hydroquinone	Mice	B6C3F1	Female	Gavage	Liver	Some Evidence	Some Evidence	Adenoma 2/55 15/55 12/55; adenoma or carcinoma (combined) 3/55 16/55 13/55	Neoplastic Lesions
No	TR-291	78-59-1	Isophorone	Mice	B6C3F1	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-291	78-59-1	Isophorone	Rats	F344/N	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-291	78-59-1	Isophorone	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Equivocal Evidence	Equivocal Evidence	LYMPHOMA 8/48 18/50 5/50	Neoplastic Lesions
Yes	TR-291	78-59-1	Isophorone	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 0/50 2/50 OR ADENOCARCINOMA 0/50 3/50 1/50	Neoplastic Lesions
No	TR-291	78-59-1	Isophorone	Mice	B6C3F1	Male	Gavage	Liver	Equivocal Evidence	Equivocal Evidence	ADENOMA 6/48 7/50 13/50 OR CARCINOMA 14/48 13/50 22/50 COMBINED 18/48 18/50 29/50	Neoplastic Lesions
No	TR-291	78-59-1	Isophorone	Rats	F344/N	Male	Gavage	Preputial Gland	Some Evidence	Some Evidence	CARCINOMA 0/50 0/50 5/50	Neoplastic Lesions
No	TR-291	78-59-1	Isophorone	Mice	B6C3F1	Male	Gavage	Subcutaneous Tissue	Equivocal Evidence	Equivocal Evidence	FIBROMA 0/48 2/50 3/50; FIBROSARCOMA 3/48 4/50 10/50; NEUROFIBROSARCOMA 1/48 0/50 0/50; SARCOMA 0/48 0/50 1/50	Neoplastic Lesions
No	TR-486	78-79-5	Isoprene	Rats	F344/N	Female	Inhalation	Brain	Some Evidence	Equivocal Evidence	ASTROCYTOMA 0/50 0/50 1/50 0/50, GLIOMA 0/50 0/50 0/50 1/50, MEDULOBLASTOMA 0/50 0/50 0/50 1/50, MENINGEAL GRANULAR CELL TUMOR 0/50 1/50 0/50 1/50, MENINGEAL SARCOMA 0/50 1/50 0/50 1/50	May Have Been Related
Yes	TR-486	78-79-5	Isoprene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTION) ADENOMA 0/50 2/50 2/50 6/50 (SINGLE AND STEP SECTION) ADENOMA 2/50 4/50 8/50 15/50	Neoplastic Lesions
No	TR-486	78-79-5	Isoprene	Rats	F344/N	Male	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 2/50 4/50 6/50 21/50 FIBROADENOMA OR CARCINOMA COMBINED 2/50 5/50 7/50 21/50	Neoplastic Lesions
No	TR-486	78-79-5	Isoprene	Rats	F344/N	Female	Inhalation	Mammary Gland	Some Evidence	Some Evidence	FIBROADENOMA 19/50 35/50 32/50 32/50 MULTIPLE FIBROADENOMA 7/50 12/50 19/50 17/50	Neoplastic Lesions
No	TR-486	78-79-5	Isoprene	Rats	F344/N	Male	Inhalation	Testis	Clear Evidence	Clear Evidence	ADENOMA 33/50 37/50 44/50 48/50	Neoplastic Lesions
No	TR-538	108-10-1	Methyl isobutyl ketone	Rats	F344/N	Male	Inhalation	Hematopoietic System	Some Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 25/50 26/50 32/50 35/50	May Have Been Related
No	TR-538	108-10-1	Methyl isobutyl ketone	Rats	F344/N	Female	Inhalation	Kidney Mesenchymal Cell	Equivocal Evidence	Equivocal Evidence	TUMOR MALIGNANT 0/50 0/50 0/50 2/50	Neoplastic Lesions
Yes	TR-538	108-10-1	Methyl isobutyl ketone	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA (STANDARD EVALUATION - 0/50 0/50 2/50 3/50; STANDARD AND EXTENDED EVAULATION COMBINED - 2/50 3/50 3/50 10/50); CARCINOMA (STANDARD EVALUATION - 0/50 1/50 0/50 2/50); ADENOMA OR CARCINOMA (COMBINED) (STANDARD EVAULATION - 0/50 1/50 2/50 4/50; STANDARD AND EXTENDED EVALUATION - 2/50 4/50 3/50 11/50)	Neoplastic Lesions
No	TR-538	108-10-1	Methyl isobutyl ketone	Mice	B6C3F1	Female	Inhalation	Liver	Some Evidence	Some Evidence	ADENOMA 13/50 15/50 20/50 23/50 ADENOMA OR CARCINOMA (COMBINED) 17/50 17/50 22/50 27/50	Neoplastic Lesions
No	TR-538	108-10-1	Methyl isobutyl ketone	Mice	B6C3F1	Male	Inhalation	Liver	Some Evidence	Some Evidence	ADENOMA 17/50 25/50 23/50 34/50 ADENOMA OR CARCINOMA (COMBINED) 27/50 34/50 28/50 37/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 0/50 0/50 1/50 3/50	May Have Been Related
No	TR-491	93-15-2	Methyleugenol	Mice	B6C3F1	Male	Gavage	Glandular Stomach	Clear Evidence	Clear Evidence	MALIGNANT NEUROENDOCRINE TUMOR 0/49 0/48 0/49 2/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Female	Gavage	Glandular Stomach	Clear Evidence	Clear Evidence	BENIGN NEUROENDOCRINE TUMOR 0/50 0/50 13/50 9/50 5/50 OR MALIGNANT NEUROENDOCRINE TUMOR 0/50 1/50 12/50 26/50 36/50 COMBINED 0/50 1/50 25/50 34/50 41/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Glandular Stomach	Clear Evidence	Clear Evidence	BENIGN NEUROENDOCRINE TUMOR 1/50 0/50 0/50 3/50 2/50 OR MALIGNANT NEURENDOCRINE TUMOR 0/50 0/50 0/50 4/50 2/50 COMBINED 1/50 0/50 0/50 7/50 4/50	Neoplastic Lesions
Yes	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA (STANDARD AND EXTENDED COMBINED) 4/50 6/50 17/50 13/50 20/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 20/50 48/50 46/49 41/50 OR CARCINOMA 7/50 37/50 47/49 47/50 COMBINED 25/50 50/50 49/49 49/50; HEPATOBLASTOMA 0/50 6/50 11/49 15/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/50 0/50 2/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 26/49 43/50 38/50 39/50 CARCINOMA 10/49 20/50 19/50 9/50 COMBINED 31/49 47/50 46/50 40/50; HEPATOBLASTOMA 0/49 0/50 1/50 3/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 8/50 11/49 33/49 43/50 OR CARCINOMA 0/50 0/50 4/49 8/49 22/50 COMBINED 1/50 8/50 14/49 34/49 43/50; HEPATOCHOLANGIOMA 0/50 0/50 0/49 0/49 8/50 OR HEPATOCHOLANGIOCARCINOMA 0/50 0/50 0/49 3/49 9/50 COMBINED 0/50 0/50 0/49 3/49 17/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 5/50 12/50 23/50 38/50 32/50 OR CARCINOMA 2/50 3/50 14/50 25/50 36/50 COMBINED 7/50 14/50 28/50 43/50 45/50; HEPATOCHOLANGIOMA 0/50 0/50 0/50 1/50 6/50 OR HEPATOCHOLANGIOCARCINOMA 0/50 0/50 1/50 1/50 7/50 COMBINED 0/50 0/50 1/50 2/50 13/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 5/50 5/50 15/50 13/50 6/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 1/50 3/50 5/50 12/50 5/50	Neoplastic Lesions
No	TR-491	93-15-2	Methyleugenol	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	FIBROMA 1/50 9/50 8/50 5/50 4/50 OR FIBROMA OR FIBROSARCOMA 1/50 12/50 8/50 8/50 4/50	Neoplastic Lesions
No	TR-266	150-68-5	Monuron	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-266	150-68-5	Monuron	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-266	150-68-5	Monuron	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 7/50 OR ADENOCARCINOMA 0/50 1/50 8/50	Neoplastic Lesions
No	TR-266	150-68-5	Monuron	Rats	F344/N	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 1/50 6/49 7/50 OR CARCINOMA 0/50 1/49 3/50 COMBINED 1/50 6/49 9/50	Neoplastic Lesions
Yes	TR-006	139-13-9	Nitrilotriacetic acid (NTA)	Mice	B6C3F1	Female	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-006	139-13-9	Nitrilotriacetic acid (NTA)	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-006	139-13-9	Nitrilotriacetic acid (NTA)	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA OR ADENOCARCINOMA	Neoplastic Lesions
No	TR-006	139-13-9	Nitrilotriacetic acid (NTA)	Rats	F344/N	Male	Dosed-Feed	Ureter	Positive	Positive	(ADENOMA OR PAPILLOMA)	Neoplastic Lesions
No	TR-006	139-13-9	Nitrilotriacetic acid (NTA)	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Male	Dosed-Feed	Kidney Transitional Cell	Equivocal Evidence	Equivocal	PAPILLOMA	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Male	Dosed-Feed	Kidney Transitional Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Equivocal Evidence	Equivocal	ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Female	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA OR ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOCARCINOMA OR CARCINOMA	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Female	Dosed-Feed	Ureter	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Male	Dosed-Feed	Ureter	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Equivocal Evidence	Equivocal	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-006	18662-53-8	Nitrilotriacetic acid trisodium monohydrate	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Positive	Positive	(TRANSITIONAL CELL CARCINOMA)	Neoplastic Lesions
No	TR-341	67-20-9	Nitrofurantoin	Rats	F344/N	Female	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-341	67-20-9	Nitrofurantoin	Rats	F344/N	Male	Dosed-Feed	Bone	Some Evidence	Equivocal Evidence	OSTEOSARCOMA 0/50 1/50 2/50	May Have Been Related
Yes	TR-341	67-20-9	Nitrofurantoin	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 1/50 2/50 OR CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 3/50	Neoplastic Lesions
No	TR-341	67-20-9	Nitrofurantoin	Mice	B6C3F1	Female	Dosed-Feed	Ovary	Clear Evidence	Clear Evidence	TUBULAR CELL ADENOMA 0/50 0/50 5/50; BENIGN MIXED TUMORS 0/50 0/50 4/50; GRANULOSA CELL TUMOR 0/50 3/50 2/50	Neoplastic Lesions
No	TR-341	67-20-9	Nitrofurantoin	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Some Evidence	Equivocal Evidence	FIBROMA 0/50 5/50 4/50; FIBROSARCOMA 1/50 2/50 1/50	May Have Been Related
No	TR-424	120-32-1	o-Benzyl-p-chlorophenol	Rats	F344/N	Female	Gavage	Kidney Transitional Cell	Equivocal Evidence	Equivocal Evidence	CARCINOMA 0/50 0/50 1/51 1/50	Neoplastic Lesions
Yes	TR-424	120-32-1	o-Benzyl-p-chlorophenol	Mice	B6C3F1	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 0/50 2/50 2/50 2/50 OR CARCINOMA 0/50 0/50 2/50 1/50 COMBINED 0/50 2/50 4/50 3/50; (STEP SECTIONS) ADENOMA 0/50 1/50 2/50 3/50 OR CARCINOMA 0/50 0/50 1/50 0/50 COMBINED 0/50 1/50 3/50 3/50	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 0/50 1/50	May Have Been Related
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA O/50 0/50 1/50 1/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 1/50	May Have Been Related
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 14/50 11/50 14/50 26/50	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 26/50 25/50 42/50 34/50	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(STOP STUDY) ADENOMATOUS POLYP 0/60 8/60 18/60, CARCINOMA 0/60 0/60 2/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(STOP STUDY) ADENOMATOUS POLYP 0/60 26/60 30/60, CARCINOMA 0/60 0/60 5/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Kidney Transitional Cell	Clear Evidence	Clear Evidence	(STOP STUDY) PAPILLOMA 0/60 0/60 1/60 OR CARCINOMA 0/60 0/60 1/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Kidney Transitional Cell	Clear Evidence	Clear Evidence	PAPILLOMA (STOP STUDY) 0/60 0/60 4/60 OR CARCINOMA 0/60 1/60 8/60	Neoplastic Lesions
Yes	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 1/50 1/50 1/49 OR CARCINOMA 0/49 0/50 0/50 2/49	May Have Been Related
No	TR-416	91-23-6	o-Nitroanisole	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 14/50 26/50 41/50 29/50; CARCINOMA 7/50 12/50 11/50 7/50; HEPATOBLASTOMA 0/50 3/50 17/50 9/50	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Mice	B6C3F1	Female	Dosed-Feed	Liver	Some Evidence	Some Evidence	ADENOMA 14/50 2/50 36/50 18/50	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	(STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/58 2/59 1/60, TRANSITIONAL CELL CARCINOMA 0/58 28/59 48/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	(STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/59 9/59 1/60, TRANSITIONAL CELL CARCINOMA 0/59 27/59 50/60, SQUAMOUS CELL PAPILLOMA 0/59 0/59 4/60, SQUAMOUS CELL CARCINOMA 0/59 0/59 6/60, SARCOMA 0/59 2/59 9/60	Neoplastic Lesions
Yes	TR-358	303-47-9	Ochratoxin A	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 1/50 5/50 OR CARCINOMA 0/50 0/51 1/50 3/50	Neoplastic Lesions
Yes	TR-358	303-47-9	Ochratoxin A	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 1/51 6/51 10/50 OR CARCINOMA 0/50 0/51 16/51 30/50	Neoplastic Lesions
No	TR-358	303-47-9	Ochratoxin A	Rats	F344/N	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 17/50 23/51 22/50 28/50	Neoplastic Lesions
No	TR-465	77-09-8	Phenolphthalein	Rats	F344/N	Male	Dosed-Feed	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	PHEOCHROMOCYTOMA 17/50 34/50 34/50 34/50	Neoplastic Lesions
No	TR-465	77-09-8	Phenolphthalein	Rats	F344/N	Female	Dosed-Feed	Adrenal Gland Medulla	Some Evidence	Some Evidence	PHEOCHROMOCYTOMA 3/50 11/50 9/50 2/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/50 1/50 1/50 0/50 COMBINED 3/50 12/50 10/50 2/49	Neoplastic Lesions
No	TR-465	77-09-8	Phenolphthalein	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 0/50 2/50 7/50 7/50; LYMPHOMA 15/50 28/50 33/5 25/50; LYMPHOMA (THYMIC ORIGIN) 1/50 9/50 10/50 7/50	Neoplastic Lesions
No	TR-465	77-09-8	Phenolphthalein	Mice	B6C3F1	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 1/50 3/50 11/50 12/49; LYMPHOMA (THYMIC ORIGIN) 0/50 4/50 7/50 2/49	Neoplastic Lesions
Yes	TR-465	77-09-8	Phenolphthalein	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 4/50 2/50 6/50 OR CARCINOMA 0/50 1/50 1/50 2/50 COMBINED 0/50 5/50 3/50 7/50; (SINGLE AND STEP SECTIONS) ADENOMA 1/50 10/50 15/50 15/50 OR CARCINOMA 0/50 1/50 2/50 2/50 COMBINED 1/50 10/50 16/50 16/50	Neoplastic Lesions
No	TR-465	77-09-8	Phenolphthalein	Mice	B6C3F1	Female	Dosed-Feed	Ovary	Clear Evidence	Clear Evidence	BENIGN SEX-CORD STROMAL TUMOR 0/50 7/49 6/50 5/50	Neoplastic Lesions
No	TR-367	50-33-9	Phenylbutazone	Mice	B6C3F1	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-367	50-33-9	Phenylbutazone	Rats	F344/N	Female	Gavage	Kidney Transitional Cell	Some Evidence	Some Evidence	CARCINOMA 0/50 0/50 2/50	Neoplastic Lesions
Yes	TR-367	50-33-9	Phenylbutazone	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Some Evidence	Equivocal Evidence	ADENOMA (STEP SECTIONS) 0/50 3/50 1/50 OR CARCINOMA 0/50 1/50 0/50 COMBINED 0/50 4/50 1/50	May Have Been Related
No	TR-367	50-33-9	Phenylbutazone	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Equivocal Evidence	Equivocal Evidence	ADENOMA 0/50 0/49 3/50 OR CARCINOMA 0/50 1/49 0/50 COMBINED 0/50 1/49 3/50	Neoplastic Lesions
No	TR-367	50-33-9	Phenylbutazone	Mice	B6C3F1	Male	Gavage	Liver	Some Evidence	Some Evidence	ADENOMA 8/50 12/50 24/50 OR CARCINOMA 8/50 4/50 11/50 COMBINED 16/50 14/50 31/50	Neoplastic Lesions
No	TR-470	110-86-1	Pyridine	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Equivocal Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 12/50 16/50 22/50 23/50	May Have Been Related
Yes	TR-470	110-86-1	Pyridine	Rats	F344/N	Male	Dosed-Water	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 1/50 0/48 2/50 6/49 COMBINED 1/50 1/48 2/50 6/49; (SINGLE AND STEP SECTIONS) ADENOMA 2/50 3/48 6/50 10/49 COMBINED 2/50 4/48 6/50 10/49	Neoplastic Lesions
Yes	TR-470	110-86-1	Pyridine	Rats	Wistar	Male	Dosed-Water	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 1/50 0/48 2/50 6/49 COMBINED 1/50 1/48 2/50 6/49; (SINGLE AND STEP SECTIONS) ADENOMA 2/50 3/48 6/50 10/49 COMBINED 2/50 4/48 6/50 10/49	Neoplastic Lesions
No	TR-470	110-86-1	Pyridine	Mice	B6C3F1	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	ADENOMA 37/49 39/50 43/50 34/50, CARCINOMA 13/49 23/50 33/50 41/50, HEPATOBLASTOMA 1/49 2/50 9/50 16/50 COMBINED 41/49, 42/50, 45/50, 44/50	Neoplastic Lesions
No	TR-470	110-86-1	Pyridine	Mice	B6C3F1	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	ADENOMA 29/50 40/50 34/49 39/50, CARCINOMA 15/50 35/50 41/49 40/50, HEPATOBLASTOMA 2/50 18/50 22/49 15/50; COMBINED 38/50, 47/50, 46/49, 47/50	Neoplastic Lesions
No	TR-470	110-86-1	Pyridine	Rats	Wistar	Male	Dosed-Water	Testis	Equivocal Evidence	Equivocal Evidence	INTERSTITIAL CELL ADEMONA 5/50 6/49 4/49 12/50	Neoplastic Lesions
No	TR-409	117-39-5	Quercetin	Rats	F344/N	Female	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-409	117-39-5	Quercetin	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 0/50 0/50 0/50 3/50 (SINGLE AND STEP SECTIONS) ADENOMA 1/50 2/50 7/50 8/50 (SINGLE SECTIONS) ADENOCARCINOMA 0/50 0/50 0/50 1/50 (SINGLE AND STEP SECTIONS) OVERALL ADENOMA OR ADENOCARCINOMA 1/50 2/50 7/50 9/50	Neoplastic Lesions
No	TR-519	64742-88-7	Stoddard solvent (type lIC)	Mice	B6C3F1	Male	Inhalation	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-519	64742-88-7	Stoddard solvent (type lIC)	Rats	F344/N	Female	Inhalation	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-519	64742-88-7	Stoddard solvent (type lIC)	Rats	F344/N	Male	Inhalation	Adrenal Gland Medulla	Some Evidence	Some Evidence	BENIGN PHEOCHROMOCYTOMA 5/50 9/50 13/50 17/50 BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 6/50 9/50 13/50 19/50	Neoplastic Lesions
Yes	TR-519	64742-88-7	Stoddard solvent (type lIC)	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Some Evidence	Equivocal Evidence	(STANDARD AND EXTENDED EVALUATION COMBINED) ADENOMA 3/50 2/50 3/50 7/50	May Have Been Related
No	TR-519	64742-88-7	Stoddard solvent (type lIC)	Mice	B6C3F1	Female	Inhalation	Liver	Equivocal Evidence	Equivocal Evidence	ADENOMA 9/50 12/50 15/50 18/50	May Have Been Related
Yes	TR-436	75-65-0	tert-Butyl alcohol	Rats	F344/N	Male	Dosed-Water	Kidney Tubular Cell	Some Evidence	Some Evidence	(SINGLE SECTIONS) ADENOMA 1/50 3/50 4/50 2/50 OR CARCINOMA 0/50 0/50 0/50 1/50 COMBINED 1/50 3/50 4/50 3/50; (SINGLE AND STEP SECTIONS) ADENOMA 8/50 11/50 19/50 13/50 OR CARCINOMA 0/50 2/50 1/50 1/50 COMBINED 8/50 13/50 19/50 13/50	Neoplastic Lesions
No	TR-436	75-65-0	tert-Butyl alcohol	Mice	B6C3F1	Male	Dosed-Water	Thyroid Gland Follicular Cell	Equivocal Evidence	Equivocal Evidence	ADENOMA 1/60 0/59 4/59 1/57 OR CARCINOMA 0/60 0/59 0/59 1/57 COMBINED 1/60 0/59 4/59 2/57	Neoplastic Lesions
No	TR-436	75-65-0	tert-Butyl alcohol	Mice	B6C3F1	Female	Dosed-Water	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	ADENOMA 2/58 3/60 2/59 9/59	Neoplastic Lesions
No	TR-311	127-18-4	Tetrachloroethylene	Rats	F344/N	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LEUKEMIA 28/50 37/50 37/50	Neoplastic Lesions
No	TR-311	127-18-4	Tetrachloroethylene	Rats	F344/N	Female	Inhalation	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 18/50 30/50 29/50	Neoplastic Lesions
Yes	TR-311	127-18-4	Tetrachloroethylene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/49 3/49 2/50 OR ADENOCARCINOMA 0/49 0/49 2/50 COMBINED 1/49 3/49 4/50	Neoplastic Lesions
No	TR-311	127-18-4	Tetrachloroethylene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	CARCINOMA 1/48 13/50 36/50	Neoplastic Lesions
No	TR-311	127-18-4	Tetrachloroethylene	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 11/49 8/49 18/50; CARCINOMA 7/49 25/49 26/50	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA: 34/50 43/50 38/50 31/50	May Have Been Related
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 1/48 21/48 19/47 18/48	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 0/48 12/48 7/48 7/48	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA: 16/50 31/50 23/50 36/50	Neoplastic Lesions
Yes	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	SINGLE SECTIONS: ADENOMA 0/50 3/50 1/50 3/50 OR CARCINOMA 0/50 0/50 0/50 2/50 COMBINED 0/50 3/50 1/50 5/50; SINGLE AND STEP SECTIONS: ADENOMA 0/50 3/50 3/50 8/50 OR CARCINOMA 0/50 0/50 0/50 3/50 COMBINED 0/50 3/50 3/50 10/50	Neoplastic Lesions
Yes	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	SINGLE SECTIONS: ADENOMA 0/50 0/50 6/50 3/50 OR CARCINOMA 1/50 0/50 2/50 0/50 COMBINED 1/50 0/50 6/50 3/50; SINGLE AND STEP SECTIONS: ADENOMA 2/50 4/50 9/50 13/50 OR CARCINOMA 1/50 1/50 2/50 0/50 COMBINED 3/50 5/50 9/50 13/50	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 15/48 17/48 20/47 15/47 OR CARCINOMA 4/48 28/48 22/47 20/47 COMBINED 17/48 33/48 29/47 28/47	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 17/48 17/48 12/48 20/48 OR CARCINOMA 11/48 20/48 33/48 26/48 COMBINED 26/48 34/48 39/48 35/48	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 4/50 5/50 6/50 OR CARCINOMA 0/50 4/50 9/50 2/50 COMBINED 0/50 7/50 12/50 8/50	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 3/50 6/50 8/50 5/50 OR CARCINOMA 1/50 1/50 10/50 3/50 COMBINED 4/50 7/50 15/50 8/50	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Testis	Clear Evidence	Equivocal Evidence	INTERSTITIAL CELL ADENOMA 39/50 40/50 48/50 47/50	May Have Been Related
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Female	Inhalation	Vascular System (Liver)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/48 5/48 2/47 1/47 OR HEMANGIOSARCOMA 0/48 27/48 27/47 34/47 COMBINED 0/48 31/48 28/47 35/47	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Male	Inhalation	Vascular System (Liver)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/48 10/48 5/48 2/48 OR HEMANGIOSARCOMA 0/48 21/48 27/48 37/48 COMBINED 0/48 26/48 30/48 38/48	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Female	Inhalation	Vascular System (Liver)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/50 5/50 1/50	Neoplastic Lesions
No	TR-475	109-99-9	Tetrahydrofuran	Mice	B6C3F1	Male	Inhalation	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-475	109-99-9	Tetrahydrofuran	Rats	F344/N	Female	Inhalation	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-475	109-99-9	Tetrahydrofuran	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA 1/50 1/50 4/50 3/50 OR CARCINOMA 0/50 0/50 0/50 2/50 COMBINED 1/50 1/50 4/50 5/50	Neoplastic Lesions
No	TR-475	109-99-9	Tetrahydrofuran	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 12/50 17/50 18/50 31/48 OR CARCINOMA 6/50 10/50 10/50 16/48 COMBINED 17/50 24/50 26/50 41/48	Neoplastic Lesions
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Mice	B6C3F1	Female	Gavage	Harderian Gland	Equivocal Evidence	Equivocal Evidence	ADENOMA 3/50 7/50 7/50 OR CARCINOMA 0/50 1/50 0/50 COMBINED 3/50 8/50 7/50	Neoplastic Lesions
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 14/50 16/50 20/50	May Have Been Related
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Male	Gavage	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 5/50 14/50 13/50	May Have Been Related
Yes	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 5/50	Neoplastic Lesions
Yes	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 5/50 24/50	Neoplastic Lesions
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Mice	B6C3F1	Male	Gavage	Kidney Tubular Cell	Equivocal Evidence	Equivocal Evidence	ADENOMA 1/50 1/50 3/50	Neoplastic Lesions
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/50 1/50 1/50 OR CARCINOMA 0/50 2/50 3/50 COMBINED 1/50 3/50 4/50	May Have Been Related
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/50 2/48 3/50 OR CARCINOMA 0/50 0/48 2/50 COMBINED 1/50 2/48 5/50	May Have Been Related
No	TR-076	126-72-7	tris(2,3-Dibromopropyl) phosphate	Mice	B6C3F1	Female	Dosed-Feed	Forestomach	Positive	Positive	(SQUAMOUS CELL PAPILLOMA, SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-076	126-72-7	tris(2,3-Dibromopropyl) phosphate	Mice	B6C3F1	Male	Dosed-Feed	Forestomach	Positive	Positive	(SQUAMOUS CELL PAPILLOMA, SQUAMOUS CELL PAPILLOMA OR CARCINOMA)	Neoplastic Lesions
Yes	TR-076	126-72-7	tris(2,3-Dibromopropyl) phosphate	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA OR ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-076	126-72-7	tris(2,3-Dibromopropyl) phosphate	Rats	F344/N	Female	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
Yes	TR-076	126-72-7	tris(2,3-Dibromopropyl) phosphate	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Positive	Positive	ADENOMA, ADENOMA OR ADENOCARCINOMA	Neoplastic Lesions
No	TR-076	126-72-7	tris(2,3-Dibromopropyl) phosphate	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(ADENOMA, CARCINOMA)	Neoplastic Lesions
No	TR-076	126-72-7	tris(2,3-Dibromopropyl) phosphate	Mice	B6C3F1	Female	Dosed-Feed	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-076	126-72-7	tris(2,3-Dibromopropyl) phosphate	Mice	B6C3F1	Male	Dosed-Feed	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA)	Neoplastic Lesions