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Organ Sites with Neoplasia

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  • Organ: Kidney Tubular Cell
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-000 (67-66-3) 67-66-3 Chloroform Rats Male Gavage Kidney Tubular Cell Positive ADENOMA OR ADENOCARCINOMA COMBINED Neoplastic Lesions
TR-006 139-13-9 Nitrilotriacetic acid (NTA) Mice Female Dosed-Feed Kidney Tubular Cell Positive ADENOCARCINOMA Neoplastic Lesions
TR-006 139-13-9 Nitrilotriacetic acid (NTA) Mice Male Dosed-Feed Kidney Tubular Cell Positive ADENOCARCINOMA Neoplastic Lesions
TR-006 139-13-9 Nitrilotriacetic acid (NTA) Rats Male Dosed-Feed Kidney Tubular Cell Positive ADENOMA OR ADENOCARCINOMA Neoplastic Lesions
TR-006 18662-53-8 Nitrilotriacetic acid trisodium monohydrate Rats Female Dosed-Feed Kidney Tubular Cell Positive ADENOMA OR ADENOCARCINOMA Neoplastic Lesions
TR-006 18662-53-8 Nitrilotriacetic acid trisodium monohydrate Rats Male Dosed-Feed Kidney Tubular Cell Positive ADENOCARCINOMA OR CARCINOMA Neoplastic Lesions
TR-041 1897-45-6 Chlorothalonil Rats Female Dosed-Feed Kidney Tubular Cell Positive ADENOMA Neoplastic Lesions
TR-041 1897-45-6 Chlorothalonil Rats Male Dosed-Feed Kidney Tubular Cell Positive ADENOMA Neoplastic Lesions
TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Mice Male Dosed-Feed Kidney Tubular Cell Positive ADENOMA OR ADENOCARCINOMA Neoplastic Lesions
TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Rats Female Dosed-Feed Kidney Tubular Cell Positive ADENOMA Neoplastic Lesions
TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Rats Male Dosed-Feed Kidney Tubular Cell Positive ADENOMA, ADENOMA OR ADENOCARCINOMA Neoplastic Lesions
TR-111 82-28-0 1-Amino-2-methylanthraquinone Rats Male Dosed-Feed Kidney Tubular Cell Positive ADENOMA OR ADENOCARCINOMA Neoplastic Lesions
TR-266 150-68-5 Monuron Rats Male Dosed-Feed Kidney Tubular Cell Clear Evidence ADENOMA 0/50 2/50 7/50 OR ADENOCARCINOMA 0/50 1/50 8/50 Neoplastic Lesions
TR-196 87-29-6 Cinnamyl anthranilate Rats Male Dosed-Feed Kidney Tubular Cell Positive ADENOMA OR ADENOCARCINOMA Neoplastic Lesions
TR-291 78-59-1 Isophorone Rats Male Gavage Kidney Tubular Cell Some Evidence ADENOMA 0/50 0/50 2/50 OR ADENOCARCINOMA 0/50 3/50 1/50 Neoplastic Lesions
TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Rats Male Gavage Kidney Tubular Cell Clear Evidence ADENOMA 0/50 7/50 3/49 ADENOCARCINOMA 0/50 2/50 0/49 COMBINED 0/50 9/50 3/49 Neoplastic Lesions
TR-311 127-18-4 Tetrachloroethylene Rats Male Inhalation Kidney Tubular Cell Clear Evidence ADENOMA 1/49 3/49 2/50 OR ADENOCARCINOMA 0/49 0/49 2/50 COMBINED 1/49 3/49 4/50 Neoplastic Lesions
TR-319 106-46-7 1,4-Dichlorobenzene (p-dichlorobenzene) Rats Male Gavage Kidney Tubular Cell Clear Evidence ADENOCARCINOMA 1/50 3/50 7/50 Neoplastic Lesions
TR-321 75-27-4 Bromodichloromethane Mice Male Gavage Kidney Tubular Cell Clear Evidence ADENOMA 1/49 2/50 6/50; ADENOCARCINOMA 0/49 0/50 4/50; COMBINED 1/49 2/50 9/50 Neoplastic Lesions
TR-321 75-27-4 Bromodichloromethane Rats Female Gavage Kidney Tubular Cell Clear Evidence ADENOMA 0/50 1/50 6/50; ADENOCARCINOMA 0/50 0/50 9/50; COMBINED 0/50 1/50 15/50 Neoplastic Lesions
TR-321 75-27-4 Bromodichloromethane Rats Male Gavage Kidney Tubular Cell Clear Evidence ADENOMA 0/50 1/50 3/50; ADENOCARCINOMA 0/50 0/50 10/50; COMBINED 0/50, 1/50, 13/50 Neoplastic Lesions
TR-323 756-79-6 Dimethyl methylphosphonate Rats Male Gavage Kidney Tubular Cell Some Evidence ADENOCARCINOMA 0/50 2/50 3/49 Neoplastic Lesions
TR-374 556-52-5 Glycidol Rats Male Gavage Kidney Tubular Cell Clear Evidence ADENOMATOUS POLYP 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 1/50 3/50 COMBINED 0/50 1/50 4/50 Neoplastic Lesions
TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats Female Dosed-Feed Kidney Tubular Cell Clear Evidence ADENOMA 0/50 3/40 16/60 16/48 OR CARCINOMA 0/50 0/40 0/60 2/48 Neoplastic Lesions
TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats Male Dosed-Feed Kidney Tubular Cell Clear Evidence ADENOMA 2/50 10/40 11/59 14/50 OR CARCINOMA 0/50 0/40 2/59 1/50 Neoplastic Lesions
TR-339 99-57-0 2-Amino-4-nitrophenol Rats Male Gavage Kidney Tubular Cell Some Evidence ADENOMA 0/50 1/48 3/50 Neoplastic Lesions
TR-341 67-20-9 Nitrofurantoin Rats Male Dosed-Feed Kidney Tubular Cell Some Evidence ADENOMA 0/50 1/50 2/50 OR CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 3/50 Neoplastic Lesions
TR-347 5989-27-5 D-Limonene Rats Male Gavage Kidney Tubular Cell Clear Evidence ADENOMA 0/50 4/50 8/50 OR ADENOCARCINOMA 0/50 4/50 3/50 Neoplastic Lesions
TR-358 303-47-9 Ochratoxin A Rats Female Gavage Kidney Tubular Cell Clear Evidence ADENOMA 0/50 0/51 1/50 5/50 OR CARCINOMA 0/50 0/51 1/50 3/50 Neoplastic Lesions
TR-358 303-47-9 Ochratoxin A Rats Male Gavage Kidney Tubular Cell Clear Evidence ADENOMA 1/50 1/51 6/51 10/50 OR CARCINOMA 0/50 0/51 16/51 30/50 Neoplastic Lesions
TR-359 298-81-7 8-Methoxypsoralen Rats Male Gavage Kidney Tubular Cell Clear Evidence ADENOMA 1/50 11/50 8/49 OR ADENOCARCINOMA 0/50 1/50 3/49 Neoplastic Lesions
TR-361 67-72-1 Hexachloroethane Rats Male Gavage Kidney Tubular Cell Clear Evidence ADENOMA 0/50 0/50 1/50 Neoplastic Lesions
TR-361 67-72-1 Hexachloroethane Rats Male Gavage Kidney Tubular Cell Clear Evidence ADENOMA 1/50 2/50 3/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 7/50 Neoplastic Lesions
TR-366 123-31-9 Hydroquinone Rats Male Gavage Kidney Tubular Cell Some Evidence Adenoma 0/55 4/55 8/55 Neoplastic Lesions
TR-369 98-85-1 alpha-Methylbenzyl alcohol Rats Male Gavage Kidney Tubular Cell Some Evidence ADENOMA 0/50 1/50 5/50 OR ADENOCARCINOMA 0/50 1/50 0/50 COMBINED 0/50 2/50 5/50 Neoplastic Lesions
TR-370 271-89-6 Benzofuran Rats Female Gavage Kidney Tubular Cell Some Evidence ADENOCARCINOMA 0/50 1/50 4/50 Neoplastic Lesions
TR-391 115-96-8 tris(2-Chloroethyl) phosphate Rats Female Gavage Kidney Tubular Cell Clear Evidence ADENOMA 0/50 2/50 5/50 Neoplastic Lesions
TR-391 115-96-8 tris(2-Chloroethyl) phosphate Rats Male Gavage Kidney Tubular Cell Clear Evidence ADENOMA 1/50 5/50 24/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Female Topical Application Kidney Tubular Cell Clear Evidence ADENOMA 0/50 1/50 4/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Male Topical Application Kidney Tubular Cell Clear Evidence ADENOMA 0/50 0/50 4/50 Neoplastic Lesions
TR-401 137-09-7 2,4-Diaminophenol dihydrochloride Mice Male Gavage Kidney Tubular Cell Some Evidence ADENOMA 0/50 0/48 3/50 Neoplastic Lesions
TR-407 2425-85-6 C.I. Pigment red 3 Mice Male Dosed-Feed Kidney Tubular Cell Some Evidence ADENOMA 0/50 0/50 0/50 6/50 Neoplastic Lesions
TR-409 117-39-5 Quercetin Rats Male Dosed-Feed Kidney Tubular Cell Some Evidence (SINGLE SECTIONS) ADENOMA 0/50 0/50 0/50 3/50 (SINGLE AND STEP SECTIONS) ADENOMA 1/50 2/50 7/50 8/50 (SINGLE SECTIONS) ADENOCARCINOMA 0/50 0/50 0/50 1/50 (SINGLE AND STEP SECTIONS) OVERALL ADENOMA OR ADENOCARCINOMA 1/50 2/50 7/50 9/50 Neoplastic Lesions
TR-384 96-18-4 1,2,3-Trichloropropane Rats Male Gavage Kidney Tubular Cell Clear Evidence ADENOMA 0/50 2/50 20/49 21/52 Neoplastic Lesions
TR-466 100-41-4 Ethylbenzene Rats Female Inhalation Kidney Tubular Cell Some Evidence (SINGLE SECTIONS) ADENOMA 0/50 0/50 0/50 1/49 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 0/50 1/50 8/49 Neoplastic Lesions
TR-466 100-41-4 Ethylbenzene Rats Male Inhalation Kidney Tubular Cell Clear Evidence (SINGLE SECTIONS) ADENOMA 0/50 3/50 2/50 4/50 OR CARCINOMA 0/50 0/50 1/50 3/50 COMBINED 0/50 3/50 3/50 7/50; (SINGLE AND STEP SECTIONS) ADENOMA 3/50 5/50 7/50 20/50 OR CARCINOMA 0/50 0/50 1/50 3/50 COMBINED 3/50 5/50 8/50 21/50 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Mice Male Inhalation Kidney Tubular Cell Clear Evidence (SINGLE SECTIONS) ADENOMA 0/50 1/49 1/50 3/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 2/49 3/50 9/50 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Rats Female Inhalation Kidney Tubular Cell Clear Evidence (SINGLE SECTIONS) ADENOMA 0/49 0/50 0/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/49 0/50 0/50 4/50 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Rats Male Inhalation Kidney Tubular Cell Clear Evidence (SINGLE SECTIONS) ADENOMA 0/50 1/50 1/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 1/50 7/50 6/50 7/50 OR CARCINOMA 0/50 2/50 0/50 1/50 COMBINED 1/50 9/50 6/50 8/50 Neoplastic Lesions
TR-456 147-47-7 1,2-Dihydro-2,2,4-trimethylquinoline (monomer) Rats Male Topical Application Kidney Tubular Cell Some Evidence ADENOMA (SINGLE SECTIONS) 1/50 7/50 10/50 7/50 (STEP SECTIONS) 6/50 5/50 6/50 8/50 (COMBINED) 7/50 11/50 14/50 14/50; CARCINOMA (SINGLE SECTIONS) 0/50 1/50 0/50 0/50 (STEP SECTIONS) 0/50 1/50 0/50 0/50 (COMBINED) 0/50 1/50 0/50 0/50; ADENOMA OR CARCINOMA COMBINED (SINGLE SECTIONS) 1/50 8/50 10/50 7/50 (STEP SECTIONS) 6/50 6/50 6/50 8/50 (COMBINED) 7/50 12/50 14/50 14/50 Neoplastic Lesions
TR-463 8003-22-3 D & C yellow no. 11 Rats Male Dosed-Feed Kidney Tubular Cell Some Evidence (SINGLE SECTIONS) ADENOMA 0/50 0/51 0/51 2/54 OR CARCINOMA 0/50 0/51 1/51 0/54 COMBINED 0/50 0/51 1/51 2/54; (SINGLE AND STEP SECTIONS) ADENOMA 0/50 2/51 4/51 4/54 OR CARCINOMA 0/50 0/51 1/51 0/54 COMBINED 0/50 2/51 5/51 4/54 Neoplastic Lesions
TR-465 77-09-8 Phenolphthalein Rats Male Dosed-Feed Kidney Tubular Cell Clear Evidence (SINGLE SECTIONS) ADENOMA 0/50 4/50 2/50 6/50 OR CARCINOMA 0/50 1/50 1/50 2/50 COMBINED 0/50 5/50 3/50 7/50; (SINGLE AND STEP SECTIONS) ADENOMA 1/50 10/50 15/50 15/50 OR CARCINOMA 0/50 1/50 2/50 2/50 COMBINED 1/50 10/50 16/50 16/50 Neoplastic Lesions
TR-422 91-64-5 Coumarin Rats Male Gavage Kidney Tubular Cell Some Evidence ADENOMA 1/49 2/50 2/51 1/50, STEP SECTIONS 0/49 4/50 5/51 4/50 Neoplastic Lesions
TR-423 119-84-6 3,4-Dihydrocoumarin Rats Male Gavage Kidney Tubular Cell Some Evidence ADENOMA 0/50 1/48 0/47 2/50, STEP SECTIONS 1/50 0/48 3/47 5/50 Neoplastic Lesions
TR-424 120-32-1 o-Benzyl-p-chlorophenol Mice Male Gavage Kidney Tubular Cell Some Evidence ADENOMA 0/50 2/50 2/50 2/50 OR CARCINOMA 0/50 0/50 2/50 1/50 COMBINED 0/50 2/50 4/50 3/50; (STEP SECTIONS) ADENOMA 0/50 1/50 2/50 3/50 OR CARCINOMA 0/50 0/50 1/50 0/50 COMBINED 0/50 1/50 3/50 3/50 Neoplastic Lesions
TR-434 106-99-0 1,3-Butadiene Mice Male Inhalation Kidney Tubular Cell Clear Evidence ADENOMA 0/50 1/50 0/50 3/48 1/49 0/73, STOP STUDY 4/48 1/50 3/49 1/50 Neoplastic Lesions
TR-436 75-65-0 tert-Butyl alcohol Rats Male Dosed-Water Kidney Tubular Cell Some Evidence (SINGLE SECTIONS) ADENOMA 1/50 3/50 4/50 2/50 OR CARCINOMA 0/50 0/50 0/50 1/50 COMBINED 1/50 3/50 4/50 3/50; (SINGLE AND STEP SECTIONS) ADENOMA 8/50 11/50 19/50 13/50 OR CARCINOMA 0/50 2/50 1/50 1/50 COMBINED 8/50 13/50 19/50 13/50 Neoplastic Lesions
TR-450 116-14-3 Tetrafluoroethylene Rats Female Inhalation Kidney Tubular Cell Clear Evidence SINGLE SECTIONS: ADENOMA 0/50 3/50 1/50 3/50 OR CARCINOMA 0/50 0/50 0/50 2/50 COMBINED 0/50 3/50 1/50 5/50; SINGLE AND STEP SECTIONS: ADENOMA 0/50 3/50 3/50 8/50 OR CARCINOMA 0/50 0/50 0/50 3/50 COMBINED 0/50 3/50 3/50 10/50 Neoplastic Lesions
TR-450 116-14-3 Tetrafluoroethylene Rats Male Inhalation Kidney Tubular Cell Clear Evidence SINGLE SECTIONS: ADENOMA 0/50 0/50 6/50 3/50 OR CARCINOMA 1/50 0/50 2/50 0/50 COMBINED 1/50 0/50 6/50 3/50; SINGLE AND STEP SECTIONS: ADENOMA 2/50 4/50 9/50 13/50 OR CARCINOMA 1/50 1/50 2/50 0/50 COMBINED 3/50 5/50 9/50 13/50 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice Male Dosed-Feed Kidney Tubular Cell Clear Evidence ADENOMA 0/50 0/51 3/50 2/49 Neoplastic Lesions
TR-478 111-42-2 Diethanolamine Mice Male Topical Application Kidney Tubular Cell Clear Evidence (SINGLE SECTIONS) ADENOMA 1/50 4/50 6/50 6/50 COMBINED 3/50 5/50 6/50 8/50; (SINGLE AND STEP SECTIONS) ADENOMA 1/50 6/50 8/50 7/50 COMBINED 3/50 7/50 8/50 9/50 Neoplastic Lesions
TR-479 68603-42-9 Coconut oil acid diethanolamine condensate Mice Male Topical Application Kidney Tubular Cell Clear Evidence adenoma 1/50, 1/50, 7/50; renal tubule adenoma or carcinoma 1/50, 1/50, 9/50 Neoplastic Lesions
TR-482 98-00-0 Furfuryl alcohol Mice Male Inhalation Kidney Tubular Cell Some Evidence (SINGLE SECTIONS) ADENOMA 0/50 0/49 049 2/50 OR CARCINOMA 0/50 0/49 0/49 2/50 COMBINED 0/50 0/49 0/49 4/50; (SINGLE AND STEP SECTIONS) ADENOMA 0/50 0/49 0/49 3/50 COMBINED 0/50 0/49 0/49 5/50 Neoplastic Lesions
TR-486 78-79-5 Isoprene Rats Male Inhalation Kidney Tubular Cell Clear Evidence (SINGLE SECTION) ADENOMA 0/50 2/50 2/50 6/50 (SINGLE AND STEP SECTION) ADENOMA 2/50 4/50 8/50 15/50 Neoplastic Lesions
TR-491 93-15-2 Methyleugenol Rats Male Gavage Kidney Tubular Cell Clear Evidence ADENOMA (STANDARD AND EXTENDED COMBINED) 4/50 6/50 17/50 13/50 20/50 Neoplastic Lesions
TR-494 84-65-1 Anthraquinone Rats Female Dosed-Feed Kidney Tubular Cell Clear Evidence ADENOMA 0/50 4/50 9/50 7/50 12/49; ADENOMA OR CARCINOMA 0/50 6/50 9/50 8/50 14/49 Neoplastic Lesions
TR-494 84-65-1 Anthraquinone Rats Male Dosed-Feed Kidney Tubular Cell Some Evidence ADENOMA 1/50 3/50 9/50 5/50 3/50 Neoplastic Lesions
TR-496 116355-83-0 Fumonisin B1 Rats Male Dosed-Feed Kidney Tubular Cell Clear Evidence ADENOMA 0/48 0/40 0/48 2/48 5/48 OR CARCINOMA 0/48 0/40 0/48 7/48 10/48 COMBINED 0/48 0/40 0/48 9/48 15/48 Neoplastic Lesions
TR-513 91-17-8 Decalin Rats Male Inhalation Kidney Tubular Cell Clear Evidence ADENOMA 1/50 2/50 6/49 9/50 5/20 ADENOMA OR CARCINOMA 1/50 3/50 7/49 12/50 6/20 Neoplastic Lesions
TR-470 110-86-1 Pyridine Rats Male Dosed-Water Kidney Tubular Cell Some Evidence (SINGLE SECTIONS) ADENOMA 1/50 0/48 2/50 6/49 COMBINED 1/50 1/48 2/50 6/49; (SINGLE AND STEP SECTIONS) ADENOMA 2/50 3/48 6/50 10/49 COMBINED 2/50 4/48 6/50 10/49 Neoplastic Lesions
TR-475 109-99-9 Tetrahydrofuran Rats Male Inhalation Kidney Tubular Cell Some Evidence ADENOMA 1/50 1/50 4/50 3/50 OR CARCINOMA 0/50 0/50 0/50 2/50 COMBINED 1/50 1/50 4/50 5/50 Neoplastic Lesions
TR-557 123-35-3 beta-Myrcene Rats Male Gavage Kidney Tubular Cell Clear Evidence Adenoma (standard evaluation) 0/50 4/50 8/50 (standard and extended evaluations) 0/50 12/50 13/50 adenoma or carcinoma (standard evaluation) 0/50 7/50 9/50 (standard and extended evaluations) 0/50 14/50 13/50 Neoplastic Lesions
TR-533 119-61-9 Benzophenone Rats Male Dosed-Feed Kidney Tubular Cell Some Evidence ADENOMA (STANDARD EVALUATION) 1/50 1/50 2/50 4/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 2/50 2/50 7/50 8/50 Neoplastic Lesions
TR-538 108-10-1 Methyl isobutyl ketone Rats Male Inhalation Kidney Tubular Cell Some Evidence ADENOMA (STANDARD EVALUATION - 0/50 0/50 2/50 3/50; STANDARD AND EXTENDED EVAULATION COMBINED - 2/50 3/50 3/50 10/50); CARCINOMA (STANDARD EVALUATION - 0/50 1/50 0/50 2/50); ADENOMA OR CARCINOMA (COMBINED) (STANDARD EVAULATION - 0/50 1/50 2/50 4/50; STANDARD AND EXTENDED EVALUATION - 2/50 4/50 3/50 11/50) Neoplastic Lesions
TR-542 98-82-8 Cumene Rats Male Inhalation Kidney Tubular Cell Clear Evidence renal tubule, adenoma or carcinoma (2/50, 5/50, 8/50, 7/50) Neoplastic Lesions
TR-543 98-83-9 alpha-Methylstyrene Rats Male Inhalation Kidney Tubular Cell Some Evidence ADENOMA (STANDARD EVALUATION) 0/50 0/50 1/50 0/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 2/50 5/50 ADENOMA OR CARCINOMA (STANDARD EVALUATION) 0/50 0/50 2/50 2/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 3/50 7/50 Neoplastic Lesions