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Organ Sites with Neoplasia

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  • Organ: Hematopoietic System
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-019 366-70-1 Procarbazine hydrochloride Mice Female Intraperitoneal Injection Hematopoietic System Positive (LYMPHOMA OR LEUKEMIA) Neoplastic Lesions
TR-019 366-70-1 Procarbazine hydrochloride Mice Male Intraperitoneal Injection Hematopoietic System Positive (LYMPHOMA OR LEUKEMIA) Neoplastic Lesions
TR-019 366-70-1 Procarbazine hydrochloride Rats Female Intraperitoneal Injection Hematopoietic System Positive (LYMPHOMA) Neoplastic Lesions
TR-019 366-70-1 Procarbazine hydrochloride Rats Male Intraperitoneal Injection Hematopoietic System Positive (LYMPHOMA OR LEUKEMIA) Neoplastic Lesions
TR-032 3778-73-2 Isophosphamide Mice Female Intraperitoneal Injection Hematopoietic System Positive (LYMPHOMA) Neoplastic Lesions
TR-039 303-34-4 Lasiocarpine Rats Female Dosed-Feed Hematopoietic System Positive Lymphoma/Leukemia Neoplastic Lesions
TR-042 320-67-2 5-Azacytidine Mice Female Intraperitoneal Injection Hematopoietic System Positive (LYMPHOMA OR GRANULOCYTIC SARCOMA) Neoplastic Lesions
TR-053 121-66-4 2-Amino-5-nitrothiazole Rats Male Dosed-Feed Hematopoietic System Positive (LYMPHOMA, LEUKEMIA) Neoplastic Lesions
TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (thio-tepa) Mice Female Intraperitoneal Injection Hematopoietic System Positive (LYMPHOMA, LEUKEMIA) Neoplastic Lesions
TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (thio-tepa) Mice Male Intraperitoneal Injection Hematopoietic System Positive (LYMPHOMA, LEUKEMIA) Neoplastic Lesions
TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (thio-tepa) Rats Male Intraperitoneal Injection Hematopoietic System Positive (LYMPHOMA OR LEUKEMIA) Neoplastic Lesions
TR-059 22966-79-6 Estradiol mustard Mice Female Gavage Hematopoietic System Positive (LYMPHOMA) Neoplastic Lesions
TR-059 22966-79-6 Estradiol mustard Mice Male Gavage Hematopoietic System Positive (LYMPHOMA OR LEUKEMIA) Neoplastic Lesions
TR-060 3546-10-9 Phenesterin Mice Female Gavage Hematopoietic System Positive (LYMPHOMA) Neoplastic Lesions
TR-060 3546-10-9 Phenesterin Mice Male Gavage Hematopoietic System Positive (LYMPHOMA) Neoplastic Lesions
TR-078 21416-87-5 ICRF-159 Mice Female Intraperitoneal Injection Hematopoietic System Positive (LYMPHOMA) Neoplastic Lesions
TR-128 91-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate Rats Female Dosed-Feed Hematopoietic System Positive (LYMPHOMA OR LEUKEMIA) Neoplastic Lesions
TR-128 91-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate Rats Male Dosed-Feed Hematopoietic System Positive (LYMPHOMA OR LEUKEMIA) Neoplastic Lesions
TR-134 128-66-5 C.I. Vat yellow 4 Mice Male Dosed-Feed Hematopoietic System Positive (LYMPHOMA) Neoplastic Lesions
TR-144 117-79-3 2-Aminoanthraquinone Mice Female Dosed-Feed Hematopoietic System Positive (LYMPHOMA) Neoplastic Lesions
TR-155 88-06-2 2,4,6-Trichlorophenol Rats Male Dosed-Feed Hematopoietic System Positive (LEUKEMIA) Neoplastic Lesions
TR-213 85-68-7 Butyl benzyl phthalate Rats Female Dosed-Feed Hematopoietic System Positive LEUKEMIA 7/49 7/49 18/50 Neoplastic Lesions
TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Mice Female Dosed-Water Hematopoietic System Positive LYMPHOMA 13/50 28/50 29/50 Neoplastic Lesions
TR-253 2835-39-4 Allyl isovalerate Mice Female Gavage Hematopoietic System Positive LYMPHOMA 11/50 11/50 18/50 Neoplastic Lesions
TR-253 2835-39-4 Allyl isovalerate Rats Male Gavage Hematopoietic System Positive LEUKEMIA 1/50 4/50 7/50 Neoplastic Lesions
TR-288 106-99-0 1,3-Butadiene Mice Female Inhalation Hematopoietic System Clear Evidence LYMPHOMA 1/50 10/49 10/49 Neoplastic Lesions
TR-288 106-99-0 1,3-Butadiene Mice Male Inhalation Hematopoietic System Clear Evidence LYMPHOMA 0/50 23/50 29/50 Neoplastic Lesions
TR-289 71-43-2 Benzene Mice Female Gavage Hematopoietic System Clear Evidence LYMPHOMA 15/49 25/45 26/50 22/49 Neoplastic Lesions
TR-289 71-43-2 Benzene Mice Male Gavage Hematopoietic System Clear Evidence LYMPHOMA 4/49 10/48 10/50 15/49 Neoplastic Lesions
TR-298 597-25-1 Dimethyl morpholinophosphoramidate Rats Female Gavage Hematopoietic System Some Evidence LEUKEMIA 9/50 13/50 12/49 18/50 Neoplastic Lesions
TR-298 597-25-1 Dimethyl morpholinophosphoramidate Rats Male Gavage Hematopoietic System Some Evidence LEUKEMIA 14/50 21/50 19/50 25/50 Neoplastic Lesions
TR-305 108171-27-3 Chlorinated paraffins: C23, 43% chlorine Mice Male Gavage Hematopoietic System Clear Evidence LYMPHOMA 6/50 12/50 16/50 Neoplastic Lesions
TR-326 75-21-8 Ethylene oxide Mice Female Inhalation Hematopoietic System Clear Evidence LYMPHOMA 9/49 6/48 22/49 Neoplastic Lesions
TR-332 149-30-4 2-Mercaptobenzothiazole Rats Male Gavage Hematopoietic System Some Evidence LEUKEMIA 7/50 16/50 3/50 Neoplastic Lesions
TR-311 127-18-4 Tetrachloroethylene Rats Female Inhalation Hematopoietic System Some Evidence LEUKEMIA 18/50 30/50 29/50 Neoplastic Lesions
TR-311 127-18-4 Tetrachloroethylene Rats Male Inhalation Hematopoietic System Clear Evidence LEUKEMIA 28/50 37/50 37/50 Neoplastic Lesions
TR-313 2385-85-5 Mirex Rats Female Dosed-Feed Hematopoietic System Clear Evidence LEUKEMIA 6/52 9/52 14/52 Neoplastic Lesions
TR-374 556-52-5 Glycidol Rats Female Gavage Hematopoietic System Clear Evidence LEUKEMIA 13/50 14/50 20/50 Neoplastic Lesions
TR-340 5634-39-9 Iodinated glycerol Rats Male Gavage Hematopoietic System Some Evidence LEUKEMIA 14/50 29/50 24/50 Neoplastic Lesions
TR-342 62-73-7 Dichlorvos Rats Male Gavage Hematopoietic System Some Evidence LEUKEMIA 11/50 20/50 21/50 Neoplastic Lesions
TR-366 123-31-9 Hydroquinone Rats Female Gavage Hematopoietic System Some Evidence Leukemia 9/55 15/55 22/55 Neoplastic Lesions
TR-397 2429-74-5 C.I. Direct blue 15 Rats Female Dosed-Water Hematopoietic System Clear Evidence MONONUCLEAR CELL LEUKEMIA 7/50 13/35 27/65 15/50 Neoplastic Lesions
TR-402 110-00-9 Furan Rats Female Gavage Hematopoietic System Clear Evidence MONONUCLEAR CELL LEUKEMIA 8/50 9/50 17/50 21/50 Neoplastic Lesions
TR-402 110-00-9 Furan Rats Male Gavage Hematopoietic System Clear Evidence MONONUCLEAR CELL LEUKEMIA 8/50 11/50 17/50 25/50 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats Male Dosed-Feed Hematopoietic System Clear Evidence MONONUCLEAR CELL LEUKEMIA 27/51 29/53 40/51 34/55 25/60 Neoplastic Lesions
TR-465 77-09-8 Phenolphthalein Mice Female Dosed-Feed Hematopoietic System Clear Evidence HISTIOCYTIC SARCOMA 0/50 2/50 7/50 7/50; LYMPHOMA 15/50 28/50 33/5 25/50; LYMPHOMA (THYMIC ORIGIN) 1/50 9/50 10/50 7/50 Neoplastic Lesions
TR-465 77-09-8 Phenolphthalein Mice Male Dosed-Feed Hematopoietic System Clear Evidence HISTIOCYTIC SARCOMA 1/50 3/50 11/50 12/49; LYMPHOMA (THYMIC ORIGIN) 0/50 4/50 7/50 2/49 Neoplastic Lesions
TR-416 91-23-6 o-Nitroanisole Rats Female Dosed-Feed Hematopoietic System Clear Evidence MONONUCLEAR CELL LEUKEMIA 14/50 11/50 14/50 26/50 Neoplastic Lesions
TR-416 91-23-6 o-Nitroanisole Rats Male Dosed-Feed Hematopoietic System Clear Evidence MONONUCLEAR CELL LEUKEMIA 26/50 25/50 42/50 34/50 Neoplastic Lesions
TR-434 106-99-0 1,3-Butadiene Mice Female Inhalation Hematopoietic System Clear Evidence LYMPHOMA 6/50 12/50 11/50 7/50 9/50 32/80; HISTIOCYTIC SARCOMA 3/50 2/50 7/50 4/50 7/50 4/80 Neoplastic Lesions
TR-434 106-99-0 1,3-Butadiene Mice Male Inhalation Hematopoietic System Clear Evidence LYMPHOMA 4/50 2/50 4/50 6/50 2/50 51/73, STOP STUDY 8/50 22/50 8/50 33/50; HISTIOCYTIC SARCOMA 0/50 0/50 4/50 5/50 7/50 4/73, STOP STUDY 5/50 2/50 7/50 2/50 Neoplastic Lesions
TR-450 116-14-3 Tetrafluoroethylene Mice Female Inhalation Hematopoietic System Clear Evidence HISTIOCYTIC SARCOMA 1/48 21/48 19/47 18/48 Neoplastic Lesions
TR-450 116-14-3 Tetrafluoroethylene Mice Male Inhalation Hematopoietic System Clear Evidence HISTIOCYTIC SARCOMA 0/48 12/48 7/48 7/48 Neoplastic Lesions
TR-450 116-14-3 Tetrafluoroethylene Rats Female Inhalation Hematopoietic System Clear Evidence MONONUCLEAR CELL LEUKEMIA: 16/50 31/50 23/50 36/50 Neoplastic Lesions
TR-492 1303-00-0 Gallium arsenide Rats Female Inhalation Hematopoietic System Clear Evidence MONONUCLEAR CELL LEUKEMIA 22/50 21/50 18/50 33/50 Neoplastic Lesions
TR-504 88-72-2 o-Nitrotoluene Mice Female Dosed-Feed Hematopoietic System Clear Evidence HEMANGIOSARCOMA 0/60 2/60 3/60 50/60 Neoplastic Lesions
TR-504 88-72-2 o-Nitrotoluene Mice Male Dosed-Feed Hematopoietic System Clear Evidence HEMANGIOSARCOMA 4/60 17/60 55/60 60/60 Neoplastic Lesions
TR-508 23246-96-0 Riddelliine Rats Female Gavage Hematopoietic System Clear Evidence MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 12/50 8/50 13/50 18/50 18/50 14/50 Neoplastic Lesions
TR-508 23246-96-0 Riddelliine Rats Male Gavage Hematopoietic System Clear Evidence Hematopoietic System: MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 2/50 9/50 Neoplastic Lesions
TR-533 119-61-9 Benzophenone Mice Female Dosed-Feed Hematopoietic System Some Evidence HISTIOCYTIC SARCOMA: 0/50 0/50 5/50 3/50 Neoplastic Lesions
TR-537 631-64-1 Water disinfection byproducts (Dibromoacetic acid) Rats Female Dosed-Water Hematopoietic System Some Evidence MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 11/50 13/50 16/50 22/50 Neoplastic Lesions
TR-537 631-64-1 Water disinfection byproducts (Dibromoacetic acid) Rats Male Dosed-Water Hematopoietic System Some Evidence MALIGNANT MESOTHELIOMA (ALL ORGANS) 3/50 1/50 0/50 10/50 Neoplastic Lesions