Share This:

Organ Sites with Neoplasia

View results
  • Organ: Harderian Gland
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-100 135-20-6 Cupferron Mice Female Dosed-Feed Harderian Gland Positive ADENOMA Neoplastic Lesions
TR-205 101-80-4 4,4'-Oxydianiline Mice Female Dosed-Feed Harderian Gland Positive (ADENOMA) Neoplastic Lesions
TR-205 101-80-4 4,4'-Oxydianiline Mice Male Dosed-Feed Harderian Gland Positive (ADENOMA) Neoplastic Lesions
TR-289 71-43-2 Benzene Mice Male Gavage Harderian Gland Clear Evidence ADENOMA 0/49 9/46 13/49 11/48 Neoplastic Lesions
TR-326 75-21-8 Ethylene oxide Mice Female Inhalation Harderian Gland Clear Evidence CYSTADENOMA 1/46 6/46 8/47 Neoplastic Lesions
TR-326 75-21-8 Ethylene oxide Mice Male Inhalation Harderian Gland Clear Evidence CYSTADENOMA 1/43 9/44 8/42 Neoplastic Lesions
TR-374 556-52-5 Glycidol Mice Female Gavage Harderian Gland Clear Evidence ADENOMA 4/50 10/50 16/50 OR ADENOCARCINOMA 0/50 1/50 1/50 COMBINED 4/50 11/50 17/50 Neoplastic Lesions
TR-374 556-52-5 Glycidol Mice Male Gavage Harderian Gland Clear Evidence ADENOMA 7/50 10/50 16/50 OR ADENOCARCINOMA 1/50 2/50 7/50 COMBINED 8/50 12/50 22/50 Neoplastic Lesions
TR-384 96-18-4 1,2,3-Trichloropropane Mice Female Gavage Harderian Gland Clear Evidence ADENOMA 2/50 6/50 7/51 10/55 Neoplastic Lesions
TR-384 96-18-4 1,2,3-Trichloropropane Mice Male Gavage Harderian Gland Clear Evidence ADENOMA 1/52 2/51 10/54 11/56 Neoplastic Lesions
TR-340 5634-39-9 Iodinated glycerol Mice Female Gavage Harderian Gland Some Evidence ADENOMA 6/50 8/40 13/50 OR CARCINOMA 0/50 0/40 1/50 COMBINED 6/50 8/40 14/50 Neoplastic Lesions
TR-352 924-42-5 N-Methylolacrylamide Mice Female Gavage Harderian Gland Clear Evidence ADENOMA 5/47 8/45 20/48 Neoplastic Lesions
TR-352 924-42-5 N-Methylolacrylamide Mice Male Gavage Harderian Gland Clear Evidence ADENOMA 1/48 14/49 29/50 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Mice Female Inhalation Harderian Gland Clear Evidence ADENOMA 1/50 3/50 3/50 8/50 OR CARCINOMA 1/50 2/50 0/50 1/50 COMBINED 2/50 5/50 3/50 9/50 Neoplastic Lesions
TR-467 126-99-8 Chloroprene Mice Male Inhalation Harderian Gland Clear Evidence ADENOMA 2/50 5/50 8/50 10/50 OR CARCINOMA 0/50 0/50 2/50 2/50 COMBINED 2/50 5/50 10/50 12/50 Neoplastic Lesions
TR-461 75-52-5 Nitromethane Mice Female Inhalation Harderian Gland Clear Evidence ADENOMA 5/50 7/50 16/50 19/50 OR CARCINOMA 1/50 2/50 4/50 3/50 COMBINED 6/50 9/50 20/50 21/50 Neoplastic Lesions
TR-461 75-52-5 Nitromethane Mice Male Inhalation Harderian Gland Clear Evidence ADENOMA 9/50 10/50 19/50 32/50 OR CARCINOMA 1/50 1/50 6/50 5/50 COMBINED 10/50 11/50 25/50 37/50 Neoplastic Lesions
TR-434 106-99-0 1,3-Butadiene Mice Female Inhalation Harderian Gland Clear Evidence ADENOMA OR CARCINOMA 8/50 10/50 7/50 15/50 20/50 9/80 Neoplastic Lesions
TR-434 106-99-0 1,3-Butadiene Mice Male Inhalation Harderian Gland Clear Evidence ADENOMA OR CARCINOMA 6/50 7/50 9/50 20/50 31/50 6/73, STOP STUDY 27/50 23/50 30/50 13/50 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice Female Dosed-Feed Harderian Gland Clear Evidence ADENOMA 2/52 6/50 8/51 15/50 OR CARCINOMA 1/52 6/50 5/51 7/50 COMBINED 3/52 12/50 13/51 19/50 Neoplastic Lesions
TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice Male Dosed-Feed Harderian Gland Clear Evidence ADENOMA 3/50 6/51 12/50 18/49 OR CARCINOMA 1/50 1/51 4/50 4/49 COMBINED 4/50 7/51 16/50 22/49 Neoplastic Lesions
TR-506 107-13-1 Acrylonitrile Mice Female Gavage Harderian Gland Clear Evidence ADENOMA 10/50 10/50 25/50 23/50 ADENOMA OR CARCINOMA 11/50 10/50 26/50 25/50 Neoplastic Lesions
TR-506 107-13-1 Acrylonitrile Mice Male Gavage Harderian Gland Clear Evidence ADENOMA 5/50 16/50 24/50 27/50 ADENOMA OR CARCINOMA 6/50 16/50 27/50 30/50 Neoplastic Lesions
TR-510 51-79-6 Urethane Mice Female Dosed-Water Harderian Gland Clear Evidence ADENOMA 3/48 10/48 8/48 21/48 CARCINOMA 0/48 1/48 11/48 11/48 COMBINED 3/48 11/48 19/48 30/48 Neoplastic Lesions
TR-510 51-79-6 Urethane Mice Male Dosed-Water Harderian Gland Clear Evidence ADENOMA 3/47 11/47 25/47 28/47 CARCINOMA 0/47 1/47 7/47 16/47 COMBINED 3/47 12/47 30/47 38/47 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Mice Male Dosed-Water Harderian Gland Clear Evidence adenoma 3/47 17/47 23/47 32/46 42/47 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Mice Female Dosed-Water Harderian Gland Clear Evidence adenoma 2/45 19/47 20/47 24/46 40/46 Neoplastic Lesions
TR-594 98-56-6 p-Chloro-a,a,a-trifluorotoluene Mice Female Inhalation Harderian Gland Clear Evidence adenoma (2/50, 6/50, 6/50, 8/50); adenoma or adenocarcinoma (2/50, 6/50, 9/50, 8/50) Neoplastic Lesions
TR-575 79-06-1 Acrylamide Mice Female Dosed-Water Harderian Gland Clear Evidence adenoma 0/45 8/44 20/48 32/47 31/43 Neoplastic Lesions
TR-575 79-06-1 Acrylamide Mice Male Dosed-Water Harderian Gland Clear Evidence adenoma 2/46 13/46 27/47 36/47 39/47 adenocarcinoma 0/46 0/46 0/47 1/47 1/47 adenoma or adenocarcinoma 2/46 13/46 27/47 37/47 39/47 Neoplastic Lesions