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Organ Sites with Neoplasia

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  • Organ: Clitoral Gland
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-084 39156-41-7 2,4-Diaminoanisole sulfate Rats Female Dosed-Feed Clitoral Gland Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
TR-118 602-87-9 5-Nitroacenaphthene Rats Female Dosed-Feed Clitoral Gland Positive (CARCINOMA) Neoplastic Lesions
TR-127 99-59-2 5-Nitro-o-anisidine Rats Female Dosed-Feed Clitoral Gland Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
TR-143 2243-62-1 1,5-Naphthalenediamine Rats Female Dosed-Feed Clitoral Gland Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
TR-374 556-52-5 Glycidol Rats Female Gavage Clitoral Gland Clear Evidence ADENOMA 3/50 7/50 7/50, ADENOCARCINOMA 0/50 1/50 0/50, OR CARCINOMA 2/50 1/50 5/50 COMBINED 5/50 9/50 12/50 Neoplastic Lesions
TR-368 389-08-2 Nalidixic acid Rats Female Dosed-Feed Clitoral Gland Clear Evidence ADENOMA 4/46 10/46 11/47, PAPILLOMA 0/46 1/46 0/47, OR CARCINOMA 1/46 4/46 5/47 COMBINED 5/46 15/46 16/47 Neoplastic Lesions
TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats Female Dosed-Water Clitoral Gland Clear Evidence ADENOMA 5/58 15/44 13/74 16/55; CARCINOMA 2/58 17/44 41/74 30/55 Neoplastic Lesions
TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats Female Dosed-Water Clitoral Gland Clear Evidence ADENOMA 0/60 9/45 32/75 17/59 OR CARCINOMA 0/60 5/45 11/75 18/59 COMBINED 0/60 14/45 42/75 32/59 Neoplastic Lesions
TR-397 2429-74-5 C.I. Direct blue 15 Rats Female Dosed-Water Clitoral Gland Clear Evidence ADENOMA 5/50 5/31 12/64 12/50, CARCINOMA 2/50 6/31 12/64 15/50, COMBINED 7/50 11/31 24/64 27/50 Neoplastic Lesions
TR-400 96-13-9 2,3-Dibromo-1-propanol Rats Female Topical Application Clitoral Gland Clear Evidence ADENOMA 0/50 1/50 3/50 OR ADENOCARCINOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 6/50 Neoplastic Lesions
TR-405 6459-94-5 C.I. Acid red 114 Rats Female Dosed-Water Clitoral Gland Clear Evidence ADENOMA 7/48 10/32 10/62 10/50, CARCINOMA 4/48 9/32 19/62 15/50, COMBINED 11/48 17/32 28/62 23/50 Neoplastic Lesions
TR-384 96-18-4 1,2,3-Trichloropropane Rats Female Gavage Clitoral Gland Clear Evidence ADENOMA 5/46 10/46 13/50 10/51 OR CARCINOMA 0/46 0/46 4/50 6/51 COMBINED 5/46 10/46 17/50 15/51 Neoplastic Lesions
TR-442 62-23-7 p-Nitrobenzoic acid Rats Female Dosed-Feed Clitoral Gland Some Evidence ADENOMA 4/50 12/49 10/49 12/50 OR CARCINOMA 1/50 2/49 5/49 4/50 COMBINED 4/50 14/49 15/49 15/50 Neoplastic Lesions
TR-498 99-99-0 p-Nitrotoluene Rats Female Dosed-Feed Clitoral Gland Some Evidence ADENOMA OR CARCINOMA 8/50 12/50 20/50 8/49 Neoplastic Lesions
TR-588 5694-00-8 Glycidamide Rats Female Dosed-Water Clitoral Gland Clear Evidence carcinoma 4/48 6/48 7/48 11/48 14/47 Neoplastic Lesions
TR-575 79-06-1 Acrylamide Rats Female Dosed-Water Clitoral Gland Clear Evidence carcinoma 1/4 6/48 12/47 3/48 8/47 Neoplastic Lesions