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Organ Sites with Neoplasia

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  • Organ: Adrenal Medulla
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Publication No. CASRN Test Article Name Species Sex Route Organ Level of Evidence Tumor Type/Incidence Finding Type
TR-085 5131-60-2 4-Chloro-m-phenylenediamine Rats Male Dosed-Feed Adrenal Gland Medulla Positive PHEOCHROMOCYTOMA Neoplastic Lesions
TR-074 79-00-5 1,1,2-Trichloroethane Mice Female Gavage Adrenal Gland Medulla Positive PHEOCHROMOCYTOMA Neoplastic Lesions
TR-074 79-00-5 1,1,2-Trichloroethane Mice Male Gavage Adrenal Gland Medulla Positive PHEOCHROMOCYTOMA Neoplastic Lesions
TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Mice Male Dosed-Water Adrenal Gland Medulla Positive PHEOCHROMOCYTOMA 2/48 12/49 14/49 Neoplastic Lesions
TR-193 50-55-5 Reserpine Rats Male Dosed-Feed Adrenal Gland Medulla Positive PHEOCHROMOCYTOMA Neoplastic Lesions
TR-332 149-30-4 2-Mercaptobenzothiazole Rats Female Gavage Adrenal Gland Medulla Some Evidence PHEOCHROMOCYTOMA 1/50 5/50 6/50 Neoplastic Lesions
TR-332 149-30-4 2-Mercaptobenzothiazole Rats Male Gavage Adrenal Gland Medulla Some Evidence PHEOCHROMOCYTOMA 18/50 25/50 22/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/50 2/50 2/49 COMBINED 18/50 27/50 24/49 Neoplastic Lesions
TR-313 2385-85-5 Mirex Rats Male Dosed-Feed Adrenal Gland Medulla Clear Evidence PHEOCHROMOCYTOMA 8/51 7/52 13/52 11/52 18/51 19/51 Neoplastic Lesions
TR-285 569-61-9 C.I. Basic red 9 monohydrochloride Mice Female Dosed-Feed Adrenal Gland Medulla Clear Evidence PHEOCHROMOCYTOMA 1/48 7/47 7/45 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 1/45 COMBINED 1/48 8/47 8/45 Neoplastic Lesions
TR-349 87-86-5 Pentachlorophenol, Dowicide EC-7 Mice Female Dosed-Feed Adrenal Gland Medulla Clear Evidence PHEOCHROMOCYTOMA 0/35 2/49 2/46 38/49 Neoplastic Lesions
TR-349 87-86-5 Pentachlorophenol, Dowicide EC-7 Mice Male Dosed-Feed Adrenal Gland Medulla Clear Evidence PHEOCHROMOCYTOMA 0/34 4/48 21/48 44/49 OR MALIGNANT PHEOCHROMOCYTOMA 1/34 0/48 0/48 3/49 COMBINED 1/34 4/48 21/48 45/49 Neoplastic Lesions
TR-349 87-86-5 Pentachlorophenol, technical Mice Male Dosed-Feed Adrenal Gland Medulla Clear Evidence PHEOCHROMOCYTOMA 0/31 10/45 23/45 Neoplastic Lesions
TR-363 74-96-4 Bromoethane (ethyl bromide) Rats Male Inhalation Adrenal Gland Medulla Some Evidence PHEOCHROMOCYTOMA 8/48 23/47 17/50 21/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 2/50 0/49 COMBINED 8/48 23/47 18/50 21/49 Neoplastic Lesions
TR-402 110-00-9 Furan Mice Female Gavage Adrenal Gland Medulla Clear Evidence PHEOCHROMOCYTOMA 2/50 1/50 6/50 Neoplastic Lesions
TR-402 110-00-9 Furan Mice Male Gavage Adrenal Gland Medulla Clear Evidence PHEOCHROMOCYTOMA 1/49 6/50 10/50 Neoplastic Lesions
TR-407 2425-85-6 C.I. Pigment red 3 Rats Male Dosed-Feed Adrenal Gland Medulla Some Evidence PHEOCHROMOCYTOMA 24/50 32/50 37/50 36/50 Neoplastic Lesions
TR-414 1825-21-4 Pentachloroanisole Mice Male Gavage Adrenal Gland Medulla Some Evidence PHEOCHROMOCYTOMA 0/50 4/50 7/48 Neoplastic Lesions
TR-414 1825-21-4 Pentachloroanisole Rats Male Gavage Adrenal Gland Medulla Some Evidence PHEOCHROMOCYTOMA 12/50 17/50 23/50 15/48 OR MALIGNANT PHEOCHROMOCYTOMA 3/50 2/50 4/50 0/48 COMBINED 15/50 18/50 25/50 15/48 Neoplastic Lesions
TR-453 12035-72-2 Nickel subsulfide Rats Female Inhalation Adrenal Gland Medulla Clear Evidence PHEOCHROMOCYTOMA 2/53 7/53 36/53 Neoplastic Lesions
TR-453 12035-72-2 Nickel subsulfide Rats Male Inhalation Adrenal Gland Medulla Clear Evidence PHEOCHROMOCYTOMA 13/53 30/52 38/53 OR MALIGNANT PHEOCHROMOCYTOMA 0/53 2/52 10/53 COMBINED 14/53 30/52 38/53 Neoplastic Lesions
TR-465 77-09-8 Phenolphthalein Rats Female Dosed-Feed Adrenal Gland Medulla Some Evidence PHEOCHROMOCYTOMA 3/50 11/50 9/50 2/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/50 1/50 1/50 0/50 COMBINED 3/50 12/50 10/50 2/49 Neoplastic Lesions
TR-421 14807-96-6 Talc Rats Female Inhalation Adrenal Gland Medulla Clear Evidence PHEOCHROMOCYTOMA 13/48 14/47 18/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 10/49 COMBINED 13/48 14/47 23/49 Neoplastic Lesions
TR-421 14807-96-6 Talc Rats Male Inhalation Adrenal Gland Medulla Some Evidence PHEOCHROMOCYTOMA 25/49 30/48 36/47 OR MALIGNANT PHEOCHROMOCYTOMA 3/49 3/48 7/47 COMBINED 26/49 32/48 37/47 Neoplastic Lesions
TR-451 1313-99-1 Nickel (II) oxide Rats Female Inhalation Adrenal Gland Medulla Some Evidence PHEOCHROMOCYTOMA 4/51 7/52 6/53 18/53 Neoplastic Lesions
TR-451 1313-99-1 Nickel (II) oxide Rats Male Inhalation Adrenal Gland Medulla Some Evidence PHEOCHROMOCYTOMA 27/54 24/52 26/53 32/52 OR MALIGNANT PHEOCHROMOCYTOMA 0/54 0/52 1/53 6/52 COMBINED 27/54 24/52 27/53 35/52 Neoplastic Lesions
TR-465 77-09-8 Phenolphthalein Rats Male Dosed-Feed Adrenal Gland Medulla Clear Evidence PHEOCHROMOCYTOMA 17/50 34/50 34/50 34/50 Neoplastic Lesions
TR-492 1303-00-0 Gallium arsenide Rats Female Inhalation Adrenal Gland Medulla Clear Evidence BENIGN PHEOCHROMOCYTOMA 4/50 5/49 6/50 13/49 Neoplastic Lesions
TR-499 22398-80-7 Indium phosphide Rats Female Inhalation Adrenal Gland Medulla Clear Evidence BENIGN PHEOCHROMOCYTOMA 2/50 6/48 2/50 9/49 Neoplastic Lesions
TR-499 22398-80-7 Indium phosphide Rats Male Inhalation Adrenal Gland Medulla Clear Evidence BENIGN PHEOCHROMOCYTOMA 10/50 22/50 16/49 23/50 BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 10/50 26/50 18/49 24/50 Neoplastic Lesions
TR-513 91-17-8 Decalin Rats Male Inhalation Adrenal Gland Medulla Clear Evidence BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 8/49 9/49 13/49 16/49 8/20 Neoplastic Lesions
TR-471 10026-24-1 Cobalt sulfate heptahydrate Rats Female Inhalation Adrenal Gland Medulla Clear Evidence BENIGN PHEOCHROMOCYTOMA 2/48 1/49 3/50 8/48, MALIGNANT PHEOCHROMOCYTOMA 0/48 0/49 1/50 1/48 OR COMPLEX PHEOCHROMOCYTOMA 0/48 0/49 0/50 1/48 COMBINED 2/48 1/49 4/50 10/48 Neoplastic Lesions
TR-519 64742-88-7 Stoddard solvent (type lIC) Rats Male Inhalation Adrenal Gland Medulla Some Evidence BENIGN PHEOCHROMOCYTOMA 5/50 9/50 13/50 17/50 BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 6/50 9/50 13/50 19/50 Neoplastic Lesions
TR-595 CELLPRADGSM Cell Phone Radiation: GSM Rats Male Whole Body Exposure Adrenal Gland Medulla Clear Evidence benign, malignant, or complex pheochromocytoma (11/88, 24/90, 28/89, 14/87) Neoplastic Lesions
TR-590 1309-64-4 Antimony Trioxide Rats Male Inhalation Adrenal Gland Medulla Some Evidence benign pheochromocytoma (1/49, 0/50, 2/49, 7/50) Neoplastic Lesions
TR-590 1309-64-4 Antimony Trioxide Rats Female Inhalation Adrenal Gland Medulla Some Evidence benign pheochromocytoma (0/49, 2/49, 2/49, 6/50); benign or malignant pheochromocytoma (0/49, 2/49, 2/49, 7/50) Neoplastic Lesions
TR-594 98-56-6 p-Chloro-a,a,a-trifluorotoluene Rats Female Inhalation Adrenal Gland Medulla Some Evidence benign pheochromocytoma (0/49, 3/50, 4/50, 6/50) Neoplastic Lesions
TR-581 7440-48-4 Cobalt Rats Male Inhalation Adrenal Gland Medulla Clear Evidence benign pheochromocytoma 15/50 23/50 37/50 34/50 malignant pheochromocytoma 2/50 2/50 9/50 16/50 benign or malignant pheochromocytoma 17/50 23/50 38/50 41/50 Neoplastic Lesions
TR-581 7440-48-4 Cobalt Rats Female Inhalation Adrenal Gland Medulla Clear Evidence benign pheochromocytoma 6/50 12/50 22/50 36/50 malignant pheochromocytoma 0/50 2/50 3/50 11/50 benign or malignant pheochromocytoma 6/50 13/50 23/50 40/50 Neoplastic Lesions