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Toxicity Estimates of the ToxCast Chemicals in C. elegans and Zebrafish

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Phase I and II C. elegans and zebrafish toxicity estimates. Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits. Windy A. Boyd , Marjolein V. Smith , Caroll A. Co , Jason R. Pirone , Julie R. Rice , Keith R. Shockley , and Jonathan H. Freedman. Published:01May2016. https://doi.org/10.1289/ehp.1409645.

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Chemical Name C.elegans: Mean response to 0.5 μM C.elegans: Mean response to 1.0 μM C.elegans: Mean response to 5.0 μM C.elegans: Mean response to 10 μM C.elegans: Mean response to 50 μM C.elegans: Mean response to 100 μM C.elegans: Mean response to 200 μM C.elegans: Lowest effective concentration (LEC) by size of nematode C.elegans: Estimated top asymptote (Hill function) C.elegans: Estimated slope (Hill function) C.elegans: Half-maximal activity concentration (AC50) (Hill function) Zebrafish: LECs based on Min. LEC of 18 morphological endpoints (Truong et al. 2014) C.elegans: Estimated bottom asymptote (Hill function) Zebrafish: LECs for mortality (Truong et al. 2014) Zebrafish: LECs based on Min. LEC of 17 sublethal endpoints (Truong et al. 2014) Zebrafish: Toxicity score from Padilla et al. 2012 (Phase I only) Zebrafish: 10% maximal activity concentration (AC10) from Padilla et al. 2012 (Phase I only) Zebrafish: 50% maximal activity concentration (AC50) from Padilla et al. 2012 (Phase I only) CASRN Chemical ID number