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NTP Data Collections Guided Search

There are numerous datasets from the National Toxicology Program (NTP). They vary in size and content consisting of both small datasets with simple formats and large datasets with complex disparate formats. The NTP Data Collections Guided Search allows public users as well as NTP scientists to access them through new guided search options. The search results are displayed as simple filterable tables and available for download.

Name Group Description
The ICCVAM Acute Systemic Toxicity Reference List NICEATM

The ICCVAM in vitro basal cytotoxicity assays proposed for setting starting doses for in vivo acute oral toxicity studies.

Please download whole dataset from FTP

The NICEATM Estrogen Receptor Uterotrophic Assay Data NICEATM

The dataset provides data on the effects of chemicals on the Estrogen Receptor (ER) from uterotrophic assays.

Please download whole dataset from FTP

The ICCVAM Skin Sensitization (Murine LLNA) Reference List NICEATM

The dataset provides a list of recommended reference substances for validation of In Vitro Murine Local Lymph Node Assay (LLNA) for skin sensitization.

Please download whole dataset from FTP

Ames Conclusions NTP

Conclusions from Ames studies for each strain, activation condition, etc.

Please download whole dataset from FTP

Bioassay Genetox Conclusion Dataset NTP

Treatment-related findings including bioassay genetox conclusions from chronic bioassay level of evidence, bacterial mutagenicity, micronucleus, Tox21 and comet assay. Note: Large searches may take a long time.

Please download whole dataset from FTP.

List of Chemicals with Threshold Limit Values Primarily Based on Sensory Irritation* NON_NTP

Inhalation Threshold Limit Values (TLVs) for 112 chemicals listed in the 2015, American Conference of Governmental Industrial Hygienists (ACGIH) booklet entitled "TLVs and BEIs Based on the Documentation of the Threshold Limit Values for Chemical Substances and Physical Agents & Biological Exposure Indices".

Please download whole dataset from FTP

Hallmark Gene Sets Annotations NTP

Annotation of Hallmark Gene Sets using NextBio platform to identify correlations between Hallmark Gene Sets and gene expression studies focusing on liver, heart and kidney tissue in rodents and humans. Additionally, correlations to gene expression studies in other tissues in rodents are described herein.

Please download whole dataset from FTP

Microarray Dataset NTP

Toxicogenomic studies consisting of microarrays to evaluate the biological response to a toxicological challenge at the genome level.

Please download whole dataset from FTP

Drosophila Germ Cell Mutagenicity NTP

Conclusions from Drosophila germ cell mutagenicity studies.

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Mammalian Cell Cytogenetics NTP

Conclusions from mammalian cell cytogenetics studies for CHO-W-B1 hamsters.

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Mammalian Cell Mutagenicity NTP

Conclusions from mammalian cell mutagenics studies for each activation condition.

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Rodent Cytogenetics NTP

Conclusions from rodent cytogenetics studies for B6C3F1 mice.

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In Vivo Micronucleus NTP

Study and trial conclusions from in vivo micronucleus assays for each strain and tissue, etc.

Please download whole dataset from FTP

Benchmark Dose Analysis for Neoplastic and Non-neoplastic Lesions NTP

Benchmark Dose (BMD) analysis for all public neoplastic and non-neoplastic lesion incidence data with best fit models.

Please download whole dataset from FTP

Update of the 1993 database of Schaper for RD50 and corresponding TLV values* NON_NTP

Inhalation Threshold Limit Values (TLVs) for 103 chemicals originally listed in Schaper, M. (1993), Development of a database for sensory irritants and its use in establishing occupational exposure limits, Am. Ind. Hyg. Assoc. J. 54: 488-544; doi: 10.1080/15298669391355017, were updated in 2015. Data resulting from this update are included in this data table.

Please download whole dataset from FTP

The ICCVAM Androgen Receptor Agonist Reference List NICEATM

The dataset provides a list of recommended reference substances for evaluation or validation of In Vitro Androgen Receptor (AR) agonism assays.

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Toxicity Estimates of the ToxCast Chemicals in C. elegans and Zebrafish NTP

Phase I and II C. elegans and zebrafish toxicity estimates. Developmental Effects of the ToxCast™ Phase I and Phase II Chemicals in Caenorhabditis elegans and Corresponding Responses in Zebrafish, Rats, and Rabbits. Windy A. Boyd , Marjolein V. Smith , Caroll A. Co , Jason R. Pirone , Julie R. Rice , Keith R. Shockley , and Jonathan H. Freedman. Published:01May2016. https://doi.org/10.1289/ehp.1409645.

Please download whole dataset from FTP

Evaluation of Androgen Receptor Agonists Dataset NTP

Evaluation of androgen assay results using a curated Hershberger database. Kleinstreuer NC, Browne P, Chang X, Judson R, Casey W, Ceger P, Deisenroth C, Baker N, Markey K, Thomas RS. Published: 25 May 2018. https://doi.org/10.1016/j.reprotox.2018.08.017. Performance data from applying the ToxCast/Tox 21 androgen receptor model, based on 11 high throughput assays, to 39 reference chemicals.

Please download whole dataset from FTP

Evaluation of Androgen Receptor Antagonists NTP

Evaluation of androgen assay results using a curated Hershberger database. Kleinstreuer NC, Browne P, Chang X, Judson R, Casey W, Ceger P, Deisenroth C, Baker N, Markey K, Thomas RS. Published: 25 May 2018. https://doi.org/10.1016/j.reprotox.2018.08.017. Performance data from applying the ToxCast/Tox 21 androgen receptor model, based on 11 high throughput assays, to 39 reference chemicals.

Please download whole dataset from FTP

Tox21 Androgen Receptor Assays and Androgen Receptor Pathway Model Dataset NTP

Evaluation of androgen assay results using a curated Hershberger database. Kleinstreuer NC, Browne P, Chang X, Judson R, Casey W, Ceger P, Deisenroth C, Baker N, Markey K, Thomas RS. Published: 25 May 2018. https://doi.org/10.1016/j.reprotox.2018.08.017. Performance data from applying the ToxCast/Tox 21 androgen receptor model, based on 11 high throughput assays, to 39 reference chemicals.

Please download whole dataset from FTP

Comet Assay Conclusions NTP

Conclusions from comet assays for each strain, organ, etc.

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In Vitro Micronucleus NTP

Study and trial conclusions from micronucleus assays for each cell type and activation condition, etc.

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Tox21 Phase 2 Purity Tox21

The purity data is for the NTP Tox21 Phase 2 chemicals provided to NCATS for the Tox21 Phase 2 program. These data results from the analysis of neat chemicals, prior to the preparation of the DMSO solutions sent to NCATS and should not be equated with NCATS QC Day 0 or QC Day 4 data.

Key for the purity flags in the MRI 1-page reports

Please download whole dataset from FTP

Statistically Analyzed NTP Pathology Lesions NTP

This dataset contains lesions found in studies where each dose group had two or more of the lesion.  Lesions with a statistically significant difference (p<0.05) in incidence between the exposed and control animals are flagged.

Please download whole dataset from FTP