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4-Chloro-o-phenylenediamine (95-83-0)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Positive, Male, Rats
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  • Positive, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • Positive, Male, Mice
View
  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 4-Chloro-o-phenylenediamine (95-83-0).
Rodent Cytogenetics
CA SCE
  • View
    • Positive (Nonstandard Protocol)
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus study conclusions related to 4-Chloro-o-phenylenediamine (95-83-0).
Micronucleus - Mice
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  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 4-Chloro-o-phenylenediamine (95-83-0).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 4-Chloro-o-phenylenediamine (95-83-0).
Bacterial Mutagenicity
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  • Positive

Citation Information


NTP. 4-Chloro-o-phenylenediamine (95-83-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2019-12-14. https://manticore.niehs.nih.gov/cebssearch/test_article/95-83-0

Publications


TR-063 Bioassay of 4-Chloro-o-phenylenediamine for Possible Carcinogenicity (CASRN 95-83-0)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelmans, K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals Environ. Molec. Mutagen. Vol. 11 (Suppl 12) (1988) 1-158
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1985) Reproducibility of microbial mutagenicity assays. II. Testing of carcinogens and noncarcinogens in Salmonella typhimurium and Escerichia coli. Environ. Mutagen. 7 (Suppl 5): 1-248.
Loveday, K.S., Anderson, B.E., Resnick, M.A., and Zeiger, E. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro V: Results with 46 chemicals Environ. Molec. Mutagen. Vol. 16 (1990) 272-303

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Chloro-o-phenylenediamine (95-83-0) in Male F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Chloro-o-phenylenediamine (95-83-0) in Female F344 Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Chloro-o-phenylenediamine (95-83-0) in Male B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 4-Chloro-o-phenylenediamine (95-83-0) in Female B6C3F1 Mice Exposed via Dosed Feed

Other NTP Studies


2-Week Immunotoxicity Evaluation (IMM86001) of Toluenes (2-4-Diaminotoluene, p-Nitrotoluene, 4-Chloro-o-Phenylenediamine) (TOLUENES) in Female B6C3F1 Mice Exposed via Gavage