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o-Toluidine (95-53-4)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID1026164

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to o-Toluidine (95-53-4).
Micronucleus - Rats
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  • Male: Positive
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to o-Toluidine (95-53-4).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to o-Toluidine (95-53-4).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to o-Toluidine (95-53-4).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to o-Toluidine (95-53-4).
Bacterial Mutagenicity
View
  • Positive

Citation Information

NTP. o-Toluidine (95-53-4). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426

Study Data

Protocol

Genetic Toxicology Studies

Genetic Toxicity Evaluation of o-Toluidine (95-53-4) in Micronucleus Study A10316 in F344 Rats
Summary and Individual Animal Data
Genetic Toxicity Evaluation of o-Toluidine (95-53-4) in Micronucleus Study A12130 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of o-Toluidine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 316866
Summary Data

Other NTP Studies

ADME/TK Evaluation (S0608) of o-Toluidine (95-53-4) in F344 Rats Exposed via Gavage
Data Summary

NTP Data Collections