Polydimethylsiloxane (9016-00-6)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID9023833

Citation Information

NTP. Polydimethylsiloxane (9016-00-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

Immunotoxicity of Silicone in Female B6C3F1 Mice - 10 Day Exposure

[Abstract]

Immunotoxicity of Silicone in Female B6C3F1 Mice - 180-Day Exposure

[Abstract]

Study Data

Other NTP Studies

10-Day Immunotoxicity Evaluation (IMM89051, SIL-10-1-FL) of Polydimethylsiloxane (Silicone) (9016-00-6) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection

10-Day Immunotoxicity Evaluation (IMM89051, SIL-10-1-PU) of Polydimethylsiloxane (Silicone) (9016-00-6) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection

10-Day Immunotoxicity Evaluation (IMM89051, SIL-10-1-SC) of Polydimethylsiloxane (Silicone) (9016-00-6) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection

180-Day Immunotoxicity Evaluation (IMM89050, SIL-180-1-ELAS) of Polydimethylsiloxane (Silicone) (9016-00-6) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection

180-Day Immunotoxicity Evaluation (IMM89050, SIL-180-1-FL) of Polydimethylsiloxane (Silicone) (9016-00-6) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection

180-Day Immunotoxicity Evaluation (IMM89050, SIL-180-1-GEL) of Polydimethylsiloxane (Silicone) (9016-00-6) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection

180-Day Immunotoxicity Evaluation (IMM89050, SIL-180-1-PU) of Polydimethylsiloxane (Silicone) (9016-00-6) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection

180-Day Immunotoxicity Evaluation (IMM89050, SIL-180-1-SC) of Polydimethylsiloxane (Silicone) (9016-00-6) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection

180-Day Immunotoxicity Evaluation (IMM89050, SIL-180-2-GEL) of Polydimethylsiloxane (Silicone) (9016-00-6) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection

Data

3-Month Immunotoxicity Evaluation (IMM89050, SIL-90-1-GEL) of Polydimethylsiloxane (Silicone) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection

B6CF1 Mice Individual and Summary Data

Absolute Leukocyte Differentials (16 kB)
Body Weights (277 kB)
Bone Marrow Assay (DNA Synthesis) (11 kB)
Clinical Chemistry (15 kB)
Hematology (17 kB)
In Vitro Cytotoxic T Lymphocyte (CTL) Assay (27 kB)
Lymphocyte Proliferation (16 kB)
Macrophage Phagocytosis (11 kB)
Mixed Leukocyte Response (12 kB)
Natural Killer Activity (56 kB)
Organ Weights (24 kB)
Reticulocytes (10 kB)
Reticuloendothelial System (41 kB)
Serum Complement (C3) (10 kB)
Serum Complement (CH50) (units/ml) (10 kB)
Surface Markers (%) (48 kB)
Surface Markers (Absol) (46 kB)
T-Dependent AB Response Day 4 (24 kB)
T-Dependent AB Response Day 5 (16 kB)

Data

30-Day Immunotoxicity Evaluation (IMM89050, SIL-30-1-GEL) of Polydimethylsiloxane (Silicone) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection

B6CF1 Mice Individual and Summary Data

Absolute Leukocyte Differentials (16 kB)
Body Weights (277 kB)
Bone Marrow Assay (DNA Synthesis) (11 kB)
Clinical Chemistry (15 kB)
Hematology (17 kB)
In Vitro Cytotoxic T Lymphocyte (CTL) Assay (27 kB)
Lymphocyte Proliferation (16 kB)
Macrophage Phagocytosis (11 kB)
Mixed Leukocyte Response (12 kB)
Natural Killer Activity (56 kB)
Organ Weights (24 kB)
Reticulocytes (10 kB)
Reticuloendothelial System (41 kB)
Serum Complement (C3) (10 kB)
Serum Complement (CH50) (units/ml) (10 kB)
Surface Markers (%) (48 kB)
Surface Markers (Absol) (46 kB)
T-Dependent AB Response Day 4 (24 kB)
T-Dependent AB Response Day 5 (16 kB)

Data

60-Day Immunotoxicity Evaluation (IMM89050, SIL-60-1-GEL) of Polydimethylsiloxane (Silicone) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection

B6CF1 Mice Individual and Summary Data

Absolute Leukocyte Differentials (16 kB)
Body Weights (277 kB)
Bone Marrow Assay (DNA Synthesis) (11 kB)
Clinical Chemistry (15 kB)
Hematology (17 kB)
In Vitro Cytotoxic T Lymphocyte (CTL) Assay (27 kB)
Lymphocyte Proliferation (16 kB)
Macrophage Phagocytosis (11 kB)
Mixed Leukocyte Response (12 kB)
Natural Killer Activity (56 kB)
Organ Weights (24 kB)
Reticulocytes (10 kB)
Reticuloendothelial System (41 kB)
Serum Complement (C3) (10 kB)
Serum Complement (CH50) (units/ml) (10 kB)
Surface Markers (%) (48 kB)
Surface Markers (Absol) (46 kB)
T-Dependent AB Response Day 4 (24 kB)
T-Dependent AB Response Day 5 (16 kB)