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Pentachlorophenol (87-86-5)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • Some Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice
View
  • Clear Evidence, Male, Mice
  • Some Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Pentachlorophenol (87-86-5).
Micronucleus - Mice
View
  • Male: Negative
An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Pentachlorophenol (87-86-5).
Micronucleus - Rats
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Pentachlorophenol (87-86-5).
Mammalian Cell Cytogenetics
CA SCE
  • View
    • Weakly Positive
  • View
    • Weakly Positive
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Pentachlorophenol (87-86-5).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. Pentachlorophenol (87-86-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2020-07-11. https://manticore.niehs.nih.gov/cebssearch/test_article/87-86-5

Publications


TR-349 Toxicology and Carcinogenesis Studies of Two Pentachlorophenol Technical-Grade Mixtures (CASRN 87-86-5) in B6C3F1 Mice (Feed Studies)
TR-483 Toxicology and Carcinogenesis Studies of Pentachlorophenol (CASRN 87-86-5) in F344/N Rats (Feed Studies)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data


Toxicity and Carcinogenicity Studies


18-33 Day Evaluation of the Toxicity (C89002) of Pentachlorophenol, Purified (87-86-5) in F344/N Rats Exposed via Dosed Feed
26-Week Evaluation of the Toxicity (C89002B) of Transgenic LECM (Pentachlorophenol) (87-86-5) in P53(C57BL/6) Mice Exposed via Dosed Feed
26-Week Evaluation of the Toxicity (C89002C) of Transgenic LECM (Pentachlorophenol) (87-86-5) in Tg.AC Mice Exposed via Topical Application
Evaluation of the Chronic Toxicity and Carcinogenicity (C89002) of Pentachlorophenol, Purified (87-86-5) in F344/N Rats Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C55378) of Pentachlorophenol, Technical (87-86-5) in B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C55389) of Pentachlorophenol, Dowicide EC-7 (87-86-5) in B6C3F1 Mice Exposed via Dosed Feed

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Pentachlorophenol, Dowicide EC-7 (87-86-5) in Micronucleus Study A54434 in B6C3F1 Mice
Genetic Toxicity Evaluation of Pentachlorophenol, Dowicide EC-7 (87-86-5) in Micronucleus Study A84354 in F344 Rats
Genetic Toxicity Evaluation of Pentachlorophenol, Technical in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 771899
Summary Data

Other NTP Studies


Toxicokinetic Evaluation (S0328) of Pentachlorophenol (87-86-5) in F344/N Rats Exposed via Dosed Feed, Intravenous Injection or Gavage
Data
Toxicokinetic Evaluation (S0579) of Pentachlorophenol (87-86-5) in F344/N Rats Exposed via Dosed Feed
Data