Dimethyl hydrogen phosphite (868-85-9)

Study Results

Chronic Bioassay Level of Evidence

  • Clear Evidence, Male, Rats
  • Equivocal Evidence, Female, Rats
  • No Evidence, Male, Mice
  • No Evidence, Female, Mice

Genetic Toxicology

Rodent Cytogenetics
    • Positive (Nonstandard Protocol)
Micronucleus - Mice
  • Male: Positive;
Mammalian Cell Mutagenicity
  • Positive
Mammalian Cell Cytogenetics
    • Positive
    • Positive
Drosophila Germ Cell Mutagenicity
    • Negative
Bacterial Mutagenicity
  • Weakly Positive
  • Equivocal

Citation Information

NTP. Dimethyl hydrogen phosphite (868-85-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2018-02-23. https://manticore.niehs.nih.gov/cebssearch/test_article/868-85-9



Toxicology and Carcinogenesis Studies of Dimethyl Hydrogen Phosphite (CASRN 868-85-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)

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McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118

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Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193

Study Data

Toxicity and Carcinogenicity