Dimethyl hydrogen phosphite (868-85-9)


Study Results


Chronic Bioassay Level of Evidence

Rats
  • Clear Evidence, Male, Rats
  • Equivocal Evidence, Female, Rats
Mice
  • No Evidence, Male, Mice
  • No Evidence, Female, Mice

Genetic Toxicology

Rodent Cytogenetics
CA
    • Positive (Nonstandard Protocol)
Micronucleus - Mice
  • Male: Positive;
Mammalian Cell Mutagenicity
  • Positive
Mammalian Cell Cytogenetics
CA SCE
    • Positive
    • Positive
Drosophila Germ Cell Mutagenicity
SLRL
    • Negative
Bacterial Mutagenicity
  • Weakly Positive
  • Equivocal

Citation Information


NTP. Dimethyl hydrogen phosphite (868-85-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2018-02-23. https://manticore.niehs.nih.gov/cebssearch/test_article/868-85-9

Publications


TR-287

Toxicology and Carcinogenesis Studies of Dimethyl Hydrogen Phosphite (CASRN 868-85-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
[Abstract]

Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119

Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179

McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118

Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702

Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193

Study Data


Toxicity and Carcinogenicity