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Dimethyl hydrogen phosphite (868-85-9)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Clear Evidence, Male, Rats
View
  • Equivocal Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Male, Mice
View
  • No Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Dimethyl hydrogen phosphite (868-85-9).
Rodent Cytogenetics
CA
  • View
    • Positive (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus study conclusions related to Dimethyl hydrogen phosphite (868-85-9).
Micronucleus - Mice
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Dimethyl hydrogen phosphite (868-85-9).
Mammalian Cell Mutagenicity
View
  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Dimethyl hydrogen phosphite (868-85-9).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Dimethyl hydrogen phosphite (868-85-9).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Dimethyl hydrogen phosphite (868-85-9).
Bacterial Mutagenicity
View
  • Weakly Positive
View
  • Equivocal

Citation Information


NTP. Dimethyl hydrogen phosphite (868-85-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2018-11-20. https://manticore.niehs.nih.gov/cebssearch/test_article/868-85-9

Publications


TR-287 Toxicology and Carcinogenesis Studies of Dimethyl Hydrogen Phosphite (CASRN 868-85-9) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
McGregor, D.B., Brown, A., Cattanach, P., Edwards, I., McBride, D., and Caspary, W.J. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay to coded chemicals. II. 18 coded chemicals. Environ. Molec. Mutagen. Vol. 11 (1988) 91-118
Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
Gulati, D., Witt, K., Anderson, B., Zeiger, E.,and Shelby, M. Chromosome aberration and sister chromatid exchange test in Chinese hamster ovary cells in vitro III: Results with 27 chemicals Environ. Molec. Mutagen. Vol. 13 (1989) 133-193

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of Dimethyl Hydrogen Phosphite (868-85-9) in Male F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Dimethyl Hydrogen Phosphite (868-85-9) in Female F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Dimethyl Hydrogen Phosphite (868-85-9) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Dimethyl Hydrogen Phosphite (868-85-9) in Female B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Dimethyl Hydrogen Phosphite (868-85-9) in Micronucleus Study 224367 in B6C3F1 Mice
Genetic Toxicity Evaluation of Dimethyl Hydrogen Phosphite in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 772334
Genetic Toxicity Evaluation of Dimethyl Hydrogen Phosphite in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 940869