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1,1,2,2-Tetrachloroethane (79-34-5)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Equivocal, Male, Rats
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  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • Positive, Male, Mice
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  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus study conclusions related to 1,1,2,2-Tetrachloroethane (79-34-5).
Micronucleus - Mice
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  • Male: Equivocal
    Female: Positive
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  • Male: Positive
    Female: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 1,1,2,2-Tetrachloroethane (79-34-5).
Mammalian Cell Mutagenicity
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  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 1,1,2,2-Tetrachloroethane (79-34-5).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 1,1,2,2-Tetrachloroethane (79-34-5).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1,1,2,2-Tetrachloroethane (79-34-5).
Bacterial Mutagenicity
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  • Negative
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  • Negative

Citation Information


NTP. 1,1,2,2-Tetrachloroethane (79-34-5). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2019-06-17. https://manticore.niehs.nih.gov/cebssearch/test_article/79-34-5

Publications


TR-027 Bioassay of 1,1,2,2-Tetrachloroethane for Possible Carcinogenicity (CASRN 79-34-5)
TOX-49 Toxicity Studies of 1,1,2,2-Tetrachloroethane Administered in Microcapsules in Feed to F344/N Rats and B6C3F1 Mice (CASRN 79-34-5)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C03554E) of 1,1,2,2-Tetrachloroethane (79-34-5) in F344/N Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C03554E) of 1,1,2,2-Tetrachloroethane (79-34-5) in B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,2,2-Tetrachloroethane (79-34-5) in Male Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,2,2-Tetrachloroethane (79-34-5) in Female Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,2,2-Tetrachloroethane (79-34-5) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,2,2-Tetrachloroethane (79-34-5) in Female B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 1,1,2,2-Tetrachloroethane (79-34-5) in Micronucleus Study A72450 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,1,2,2-Tetrachloroethane (79-34-5) in Micronucleus Study B72450 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,1,2,2-Tetrachloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 547949
Genetic Toxicity Evaluation of 1,1,2,2-Tetrachloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 866388