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Acrylamide (79-06-1)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • Clear Evidence, Female, Rats
  • Clear Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Clear Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Acrylamide (79-06-1).
Rodent Cytogenetics
CA SCE
  • View
    • Positive (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus Mice study conclusions related to Acrylamide (79-06-1).
Micronucleus - Mice
View
  • Female: Positive
View
  • Male: Positive
View
  • Male: Positive
View
  • Female: Negative
View
  • Male: Positive
An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Acrylamide (79-06-1).
Micronucleus - Rats
View
  • Male: Equivocal
View
  • Male: Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Acrylamide (79-06-1).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology In Vivo Alkaline Comet Assay Mice study conclusions related to Acrylamide (79-06-1).
In Vivo Alkaline Comet Assay - Mice
View
  • Male: Positive
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Acrylamide (79-06-1).
Drosophila Germ Cell Mutagenicity
SLRL RT
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Acrylamide (79-06-1).
Bacterial Mutagenicity
View
  • Weakly Positive
View
  • Negative

Citation Information


NTP. Acrylamide (79-06-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-575 Toxicology and Carcinogenesis Studies of Acrylamide (CASRN 79-06-1) in F344/N Rats and B6C3F1 Mice (Feed and Drinking Water Studies)
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Teratologic Evaluation of Acrylamide Administered to CD-1 Mice on Gestational Days 6 through 17
Teratologic Evaluation of Acrylamide Administered to Sprague-Dawley (CD) Rats on Gestational Days 6 through 20
Ghanayem BI, Witt KL, Kissling GE, Tice RR, Recio L. Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect. Mutat Res. 2005 Oct 15;578(1-2):284-97.
Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals. Mutat Res. 2008 Jan 8;649(1-2):101-13. Epub 2007 Aug 11.
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. X. Results of 70 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 208-227
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito


CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C20313) of Acrylamide (79-06-1) in F344/NCTR Rats Exposed via Dosed Water
3-Month Evaluation of the Toxicity (C20313B) of Acrylamide (79-06-1) in F344/NCTR Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C20313) of Acrylamide (79-06-1) in B6C3F1/NCTR Mice Exposed via Dosed Water
3-Month Evaluation of the Toxicity (C20313B) of Acrylamide (79-06-1) in B6C3F1/NCTR Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity (C20313) of Acrylamide (79-06-1) in F344/NCTR Rats Exposed via Dosed Water
Evaluation of the Chronic Toxicity and Carcinogenicity (C20313) of Acrylamide (79-06-1) in B6C3F1/NCTR Mice Exposed via Dosed Water

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Acrylamide (79-06-1) in DNA Damage Study G10949D in C57B1/6J Mice
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in Micronucleus Study A75648 in B6C3F1 Mice
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in Micronucleus Study A97370 in F344 Rats
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in Micronucleus Study F12535 in 129 Sv/Ev Mice
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in Micronucleus Study F75142 in 129 Sv/Ev Mice
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in Micronucleus Study F75648 in B6C3F1 Mice
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in Micronucleus Study F97370 in F344 Rats
Genetic Toxicity Evaluation of Acrylamide (79-06-1) in Micronucleus Study G10949 in C57BL/6 Mice
Genetic Toxicity Evaluation of Acrylamide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 440483
Summary Data
Genetic Toxicity Evaluation of Acrylamide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 965355
Summary Data

Other NTP Studies


ADME/TK Evaluation (S0008) of Acrylamide (79-06-1) in F344 Rats Exposed via Gavage Administration and Intravenous Injection Bile Study
Prenatal Developmental Toxicity Study (TER88048) of Acrylamide (79-06-1) in Sprague-Dawley Rats Exposed via Gavage
Prenatal Developmental Toxicity Study (TER89049) of Acrylamide (79-06-1) in Swiss CD-1 Mice Exposed via Gavage
Screen for Developmental Toxicity in Zebrafish- Study 1
Results