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Trichloroethylene (79-01-6)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Inadequate Study, Male, Rats
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  • Inadequate Study, Male, Rats
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  • Inadequate Study, Male, Rats
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  • Negative, Male, Rats
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  • Inadequate Study, Male, Rats
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  • Inadequate Study, Male, Rats
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  • Negative, Female, Rats
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  • Inadequate Study, Female, Rats
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  • Negative, Female, Rats
View
  • Inadequate Study, Female, Rats
View
  • Inadequate Study, Female, Rats
View
  • Inadequate Study, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • Positive, Male, Mice
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  • Positive, Male, Mice
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  • Positive, Female, Mice
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  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Trichloroethylene (79-01-6).
Rodent Cytogenetics
CA SCE
  • View
    • Negative (Nonstandard Protocol)
An overview of Genetic Toxicology Micronucleus study conclusions related to Trichloroethylene (79-01-6).
Micronucleus - Mice
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  • Male: Negative;
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Trichloroethylene (79-01-6).
Mammalian Cell Mutagenicity
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  • Positive
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  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Trichloroethylene (79-01-6).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Trichloroethylene (79-01-6).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Trichloroethylene (79-01-6).
Bacterial Mutagenicity
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  • Negative
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  • Negative

Citation Information


NTP. Trichloroethylene (79-01-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2018-06-20. https://manticore.niehs.nih.gov/cebssearch/test_article/79-01-6

Publications


TR-002 Carcinogenesis Bioassay of Trichloroethylene (CASRN 79-01-6)
TR-243 Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CASRN 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
TR-273 Toxicology and Carcinogenesis Studies of Trichloroethylene (CASRN 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179
Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data


Toxicity and Carcinogenicity


Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Male ACI Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Female ACI Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Male F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Female F344 Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Female B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Male August Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Female August Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Male Marshall Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Female Marshall Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Male Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Male Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Female Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Female Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Trichloroethylene (79-01-6) in Female B6C3F1 Mice Exposed via Gavage