Trichloroethylene (79-01-6)


Study Results


Chronic Bioassay Level of Evidence

Rats
  • Negative, Male, Rats
  • Inadequate Study, Male, Rats
  • Inadequate Study, Male, Rats
  • Inadequate Study, Male, Rats
  • Inadequate Study, Male, Rats
  • Inadequate Study, Male, Rats
  • Inadequate Study, Female, Rats
  • Negative, Female, Rats
  • Inadequate Study, Female, Rats
  • Inadequate Study, Female, Rats
  • Negative, Female, Rats
  • Inadequate Study, Female, Rats
Mice
  • Positive, Male, Mice
  • Positive, Male, Mice
  • Positive, Female, Mice
  • Positive, Female, Mice

Genetic Toxicology

Rodent Cytogenetics
CA SCE
    • Negative
    • Negative (Nonstandard Protocol)
Micronucleus - Mice
  • Male: Negative;
Mammalian Cell Mutagenicity
  • Positive
  • Positive
Mammalian Cell Cytogenetics
CA SCE
    • Negative
    • Positive
Drosophila Germ Cell Mutagenicity
SLRL
    • Equivocal
Bacterial Mutagenicity
  • Negative
  • Negative

Citation Information


NTP. Trichloroethylene (79-01-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2017-11-24. https://manticore.niehs.nih.gov/cebssearch/test_article/79-01-6

Publications


TR-273

Toxicology and Carcinogenesis Studies of Trichloroethylene (CASRN 79-01-6) in Four Strains of Rats (ACI, August, Marshall, Osborne-Mendel) (Gavage Studies)
[Abstract]

TR-243

Carcinogenesis Studies of Trichloroethylene (Without Epichlorohydrin) (CASRN 79-01-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
[Abstract]

TR-002

Carcinogenesis Bioassay of Trichloroethylene (CASRN 79-01-6)
[Abstract]

Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119

Shelby, M.D., Erexson, G.L., Hook, G.J., and Tice, R.R. Evaluation of a three-exposure mouse bone marrow micronucleus protocol: Results with 49 chemicals. Environ. Molec. Mutag. Vol. 21 (1993) 160-179

Myhr, B. and Caspary, W. Chemical mutagenesis at the TK locus in L5178Y mouse lymphoma cells. I. Results for 31 coded compounds in the National Toxicology Program. Environ. Molec. Mutagen. Vol. 18 (1991) 51-83

Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63

Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data


Toxicity and Carcinogenicity