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alpha/beta Thujone mixture (76231-76-0)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
View
  • No Evidence, Female, Rats
  • Some Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
View
  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to alpha/beta Thujone mixture (76231-76-0).
Micronucleus - Mice
View
  • Male: Negative
    Female: Positive
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to alpha/beta Thujone mixture (76231-76-0).
Bacterial Mutagenicity
View
  • Negative

Citation Information


NTP. alpha/beta Thujone mixture (76231-76-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2020-07-11. https://manticore.niehs.nih.gov/cebssearch/test_article/76231-76-0

Publications


TR-570 Toxicology and Carcinogenesis Studies of ?,?-Thujone (CASRN 76231-76-0) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito


CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005

Study Data


Toxicity and Carcinogenicity Studies


2-Week Evaluation of the Toxicity (C99037) of alpha/beta Thujone Mixture (76231-76-0) in F344/N Rats Exposed via Gavage
2-Week Evaluation of the Toxicity (C99037) of alpha/beta Thujone Mixture (76231-76-0) in F344/N Rats Exposed via Gavage
2-Week Evaluation of the Toxicity (C99037) of alpha/beta Thujone Mixture (76231-76-0) in F344 Rats Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C99037B) of alpha/beta Thujone Mixture (76231-76-0) in F344 Rats Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C99037B) of alpha/beta Thujone Mixture (76231-76-0) in F344 Rats Exposed via Gavage. NTP Special Study
2-Week Evaluation of the Toxicity (C99037) of alpha/beta Thujone Mixture (76231-76-0) in B6C3F1 Mice Exposed via Gavage
2-Week Evaluation of the Toxicity (C99037) of alpha/beta Thujone Mixture (76231-76-0) in B6C3F1 Mice Exposed via Gavage
2-Week Evaluation of the Toxicity (C99037) of alpha/beta Thujone Mixture (76231-76-0) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C99037B) of alpha/beta Thujone Mixture (76231-76-0) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
3-Month Evaluation of the Toxicity (C99037B) of alpha/beta Thujone Mixture (76231-76-0) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C99037B) of alpha/beta Thujone Mixture (76231-76-0) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C99037B) of alpha/beta Thujone Mixture (76231-76-0) in F344/N Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C99037B) of alpha/beta Thujone Mixture (76231-76-0) in B6C3F1 Mice Exposed via Gavage
Special Evaluation of the Toxicity (C99037B) of alpha/beta Thujone Mixture (76231-76-0) in F344/N Rats Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of alpha/beta Thujone Mixture (76231-76-0) in Micronucleus Study A26162 in B6C3F1 Mice
Genetic Toxicity Evaluation of alpha/beta Thujone Mixture in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A36495
Summary Data

Other NTP Studies


Toxicokinetic Evaluation (C99037B) of Alpha Thujone (546-80-5) and Thujone Mixture (76231-76-0) in F344/N Rats and B6C3F1 Mice Exposed via Gavage or Intravenous Injection
Data - alpha/beta-Thujone Mixture
Data - alpha-Thujone and alpha/beta-Thujone Mixture
Data - alpha-Thujone