Vinylidene chloride (75-35-4)
DOI: https://doi.org/10.22427/NTP-DATA-DTXSID8021438
Study Results
Chronic Bioassay Level of Evidence
Rats | |
---|---|
View
|
Mice | |
---|---|
View
|
Genetic Toxicology
Micronucleus - Mice |
---|
View
|
Mammalian Cell Mutagenicity |
---|
View
|
Drosophila Germ Cell Mutagenicity |
---|
SLRL |
|
Bacterial Mutagenicity |
---|
View
|
Publications
TR-582
Toxicology and Carcinogenesis Studies of Vinylidene Chloride (CASRN 75-35-4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
McGregor, D., Brown, A.G., Cattanach, P., Edwards, I., McBride, D., Riach, C., Shepherd, W., and Caspary, W. Responses of the L5178Y mouse lymphoma forward mutation assay: V. Gases and vapors. Environ. Molec. Mutagen. Vol. 17 (1991) 122-129
Schantel A Hayes, Arun R Pandiri, Thai-vu T Ton , Hue-Hua L Hong , Natasha P Clayton, Keith R Shockley, Shyamal D Peddada, Kevin Gerrish, Michael Wyde, Robert C Sills, Mark J Hoenerhoff. Renal Cell Carcinomas in Vinylidene Chloride-exposed Male B6C3F1 Mice Are Characterized by Oxidative Stress and TP53 Pathway Dysregulation. Toxicol Pathol. 2016 Jan;44(1):71-87. PMID: 26682919
Foureman, P., Mason, J.M., Valencia, R., Zimmering, S. Chemical Mutagenesis Testing in Drosophila. IX. Results of 50 coded compounds tested for the National Toxicology Program. Environ. Molec. Mutagen. Vol. 23 (1994) 51-63
Study Data
Toxicity and Carcinogenicity Studies
2-Week Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in F344/N Rats via Whole Body Respiratory Exposure
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
2-Week Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in F344 Rats via Whole Body Respiratory Exposure. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Clinical Chemistry Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Clinical Chemistry Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
2-Week Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Pathology Tables
- E01 - Animal Removal Summary By Treatment Group
- E03 - Growth Curves
- E04 - Mean Body Weights And Survival Table
- E05 - Clinical Observations Summary
- E12 - Animal History
- P02 - Incidence Rates Of Neoplasms By Anatomic Site (a)
- P03 - Incidence Rates Of Non-Neoplastic Lesions By Anatomic Site(a)
- P04 - Neoplasms By Individual Animal
- P05 - Incidence Rates Of Neoplasms By Anatomic Site (Systemic Lesions Abridged) (a)
- P07 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P09 - Non-Neoplastic Lesions By Individual Animal
- P11 - Statistical Analysis of Survival Data
- P15 - Slide/Block Inventory
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged)
- P18 - Incidence Rates Of Non-neoplastic Lesions By Anatomic Site (a) With Average Severity Grades[b]
- P40 - Survival Curves
Individual Animal Data
- P14 - Female,Male Individual Animal Pathology Data
- Male Individual Animal Body Weight Data
- Male Individual Animal Organ Weight Data
- Male Individual Animal Pathology Data Non Neoplastic
- Male Individual Animal Survival Data
- Male Individual Clinical Observations
- Female Individual Animal Body Weight Data
- Female Individual Animal Organ Weight Data
- Female Individual Animal Pathology Data Non Neoplastic
- Female Individual Animal Survival Data
- Female Individual Clinical Observations
2-Week Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
3-Month Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in B6C3F1 Mice via Whole Body Respiratory Exposure. NTP Special Study
Pathology Tables
Individual Animal Data
- Male Individual Animal Hematology Data
- Male Individual Animal Organ Weight Data
- Female Individual Animal Hematology Data
- Female Individual Animal Organ Weight Data
Clinical Chemistry Reports
3-Month Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in F344/N Rats via Whole Body Respiratory Exposure
Study Tables
- E03 - Growth Curves (258 kB)
- E04 - Mean Body Weights and Survival Table (62 kB)
- E05 - Clinical Observations Summary (31 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (138 kB)
- P04 - Neoplasms by Individual Animal (895 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (89 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (976 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (65 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (96 kB)
- P40 - Survival Curves (232 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (37 kB)
- Female Individual Animal Non Neoplastic Pathology Data (63 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (37 kB)
- Male Individual Animal Non Neoplastic Pathology Data (79 kB)
- Male Individual Animal Organ Weight Data (19 kB)
- Male Individual Animal Survival Data (11 kB)
3-Month Evaluation of the Toxicity (C20303) of Vinylidene Chloride (75-35-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Study Tables
- E03 - Growth Curves (255 kB)
- E04 - Mean Body Weights and Survival Table (118 kB)
- E05 - Clinical Observations Summary (29 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (198 kB)
- P04 - Neoplasms by Individual Animal (2 mB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (102 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (1 mB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (175 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (163 kB)
- P40 - Survival Curves (245 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (36 kB)
- Female Individual Animal Clinical Observations (2 kB)
- Female Individual Animal Non Neoplastic Pathology Data (102 kB)
- Female Individual Animal Organ Weight Data (19 kB)
- Female Individual Animal Survival Data (11 kB)
- Male Individual Animal Body Weight Data (30 kB)
- Male Individual Animal Clinical Observations (2 kB)
- Male Individual Animal Non Neoplastic Pathology Data (40 kB)
- Male Individual Animal Organ Weight Data (17 kB)
- Male Individual Animal Survival Data (10 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20303) of Vinylidene Chloride (75-35-4) in F344/N Rats via Whole Body Respiratory Exposure
Study Tables
- E03 - Growth Curves (65 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E05 - Clinical Observations Summary (24 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (55 kB)
- P04 - Neoplasms by Individual Animal (806 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (52 kB)
- P08 - Statistical Analysis of Primary Tumors (278 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (797 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (395 kB)
- P11 - Statistical Analysis of Survival Data (28 kB)
- P14 - Individual Animal Pathology Data (2 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (652 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (57 kB)
- P40 - Survival Curves (67 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (379 kB)
- Female Individual Animal Clinical Observations (322 kB)
- Female Individual Animal Neoplastic Pathology Data (348 kB)
- Female Individual Animal Non Neoplastic Pathology Data (757 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (410 kB)
- Male Individual Animal Clinical Observations (170 kB)
- Male Individual Animal Neoplastic Pathology Data (452 kB)
- Male Individual Animal Non Neoplastic Pathology Data (768 kB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (33 kB)
Evaluation of the Chronic Toxicity and Carcinogenicity (C20303) of Vinylidene Chloride (75-35-4) in B6C3F1 Mice via Whole Body Respiratory Exposure
Study Tables
- E03 - Growth Curves (71 kB)
- E04 - Mean Body Weights and Survival Table (24 kB)
- E05 - Clinical Observations Summary (20 kB)
- P03 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site (54 kB)
- P04 - Neoplasms by Individual Animal (727 kB)
- P05 - Incidence Rates of Neoplasms by Anatomic Sites (Systemic Lesions Abridged) (50 kB)
- P08 - Statistical Analysis of Primary Tumors (213 kB)
- P09 - Non-Neoplastic Lesions by Individual Animal (802 kB)
- P10 - Statistical Analysis of Non-Neoplastic Lesions (360 kB)
- P11 - Statistical Analysis of Survival Data (24 kB)
- P14 - Individual Animal Pathology Data (1 mB)
- P17 - Neoplasms By Individual Animal (Systemic Lesions Abridged) (665 kB)
- P18 - Incidence Rates of Non-Neoplastic Lesions by Anatomic Site with Average Severity Grades (56 kB)
- P40 - Survival Curves (65 kB)
Individual Animal Data
- Female Individual Animal Body Weight Data (409 kB)
- Female Individual Animal Clinical Observations (82 kB)
- Female Individual Animal Neoplastic Pathology Data (238 kB)
- Female Individual Animal Non Neoplastic Pathology Data (538 kB)
- Female Individual Animal Organ Weight Data (57 kB)
- Female Individual Animal Survival Data (34 kB)
- Male Individual Animal Body Weight Data (393 kB)
- Male Individual Animal Clinical Observations (91 kB)
- Male Individual Animal Neoplastic Pathology Data (197 kB)
- Male Individual Animal Non Neoplastic Pathology Data (483 kB)
- Male Individual Animal Organ Weight Data (57 kB)
- Male Individual Animal Survival Data (33 kB)
Genetic Toxicology Studies
Genetic Toxicity Evaluation of Vinylidene Chloride (75-35-4) in Micronucleus Study A71539 in B6C3F1 Mice
Summary and Individual Animal Data
Genetic Toxicity Evaluation of Vinylidene Chloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 121030
Summary Data
- G06 - Ames Summary Data (167 KB)