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1,1,1-Trichloroethane (71-55-6)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Inadequate Study, Male, Rats
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  • Inadequate Study, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • Inadequate Study, Male, Mice
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  • Inadequate Study, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus study conclusions related to 1,1,1-Trichloroethane (71-55-6).
Micronucleus - Mice
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  • Male: Equivocal
    Female: Negative
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  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 1,1,1-Trichloroethane (71-55-6).
Mammalian Cell Mutagenicity
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  • Equivocal
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  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 1,1,1-Trichloroethane (71-55-6).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 1,1,1-Trichloroethane (71-55-6).
Bacterial Mutagenicity
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  • Negative
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  • Negative
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  • Negative
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  • Negative

Citation Information


NTP. 1,1,1-Trichloroethane (71-55-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2019-07-22. https://manticore.niehs.nih.gov/cebssearch/test_article/71-55-6

Publications


TR-003 Bioassay of 1,1,1-Trichloroethane for Possible Carcinogenicity (CASRN 71-55-6)
TOX-41 Toxicity Studies of 1,1,1-Trichloroethane (CASRN 71-55-6)
Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Zeiger E, Anderson B, Haworth S, Lawlor T, Mortelmans K, Speck W. Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals. Environ Mutagen. 1987;9 Suppl 9:1-109.
Developmental Toxicity Evaluation of 1,1,1-Trichloroethane Administered in Drinking Water to CD Rats (Part II)
Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data


Toxicity and Carcinogenicity Studies


3-Month Evaluation of the Toxicity (C04626C) of 1,1,1-Trichloroethane (71-55-6) in F344 Rats Exposed via Microcapsules in Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C04626C) of 1,1,1-Trichloroethane (71-55-6) in B6C3F1 Mice Exposed via Microcapsules in Feed. NTP Special Study
3-Month Evaluation of the Toxicity (C04626) of 1,1,1-Trichloroethane (71-55-6) in F344/N Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C04626C) of 1,1,1-Trichloroethane (71-55-6) in F344/N Rats Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C04626C) of 1,1,1-Trichloroethane (71-55-6) in B6C3F1 Mice Exposed via Dosed Feed
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,1-Trichloroethane (71-55-6) in Male Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,1-Trichloroethane (71-55-6) in Female Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,1-Trichloroethane (71-55-6) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 1,1,1-Trichloroethane (71-55-6) in Female B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 1,1,1-Trichloroethane (71-55-6) in Micronucleus Study A09633 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane (71-55-6) in Micronucleus Study B09633 in B6C3F1 Mice
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 098436
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 677121
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 797607
Genetic Toxicity Evaluation of 1,1,1-Trichloroethane in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 844035

Other NTP Studies


Prenatal Developmental Toxicity Study (T0179) of 1,1,1-Trichloroethane (71-55-6) in Sprague-Dawley Rats Exposed via Dosed Water