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Indole-3-carbinol (700-06-1)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • No Evidence, Male, Rats
  • Some Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • Clear Evidence, Male, Mice
  • No Evidence, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus study conclusions related to Indole-3-carbinol (700-06-1).
Micronucleus - Mice
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  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Micronucleus study conclusions related to Indole-3-carbinol (700-06-1).
Micronucleus - Rats
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  • Male: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Indole-3-carbinol (700-06-1).
Bacterial Mutagenicity
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  • Equivocal
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  • Positive
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  • Equivocal

Citation Information


NTP. Indole-3-carbinol (700-06-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2019-07-22. https://manticore.niehs.nih.gov/cebssearch/test_article/700-06-1

Publications


TR-584 Toxicology Studies of Indole-3-Carbinol (CASRN 700-06-1) in F344/N Rats and B6C3F1/N Mice and Toxicology and Carcinogenesis Studies of Indole-3-Carbinol in Harlan Sprague Dawley Rats and B6C3F1/N Mice (Gavage Studies)

Study Data


Toxicity and Carcinogenicity Studies


26-Week Evaluation of the Toxicity (C20010A) of Prevention 4 (Indole-3-carbinol) (700-06-1) in Tg.NK Mice Exposed via Dosed Feed
3-Month Evaluation of the Toxicity (C20006) of Indole-3-carbinol (700-06-1) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C20006) of Indole-3-carbinol (700-06-1) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C20006B) of Indole-3-carbinol (700-06-1) in Harlan Sprague-Dawley Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C20006B) of Indole-3-carbinol (700-06-1) in B6C3F1 Mice Exposed via Gavage
Special Evaluation of the Toxicity (C20006B) of Indole-3-carbinol (700-06-1) in Sprague-Dawley Rats Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Indole-3-carbinol (700-06-1) in Micronucleus Study A31749 in F344 Rats
Genetic Toxicity Evaluation of Indole-3-carbinol (700-06-1) in Micronucleus Study A94530 in B6C3F1 Mice
Genetic Toxicity Evaluation of Indole-3-carbinol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A34549
Genetic Toxicity Evaluation of Indole-3-carbinol in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A35905
Genetic Toxicity Evaluation of Prevention 4 (Indole-3-carbinol) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A51566