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Chloroform (67-66-3)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Positive, Male, Rats
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  • Negative, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • Positive, Male, Mice
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  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to Chloroform (67-66-3).
Rodent Cytogenetics
CA SCE
An overview of Genetic Toxicology Micronucleus study conclusions related to Chloroform (67-66-3).
Micronucleus - Mice
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  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Chloroform (67-66-3).
Mammalian Cell Mutagenicity
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  • Positive
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  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Chloroform (67-66-3).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Chloroform (67-66-3).
Bacterial Mutagenicity
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  • Negative

Citation Information


NTP. Chloroform (67-66-3). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2019-07-22. https://manticore.niehs.nih.gov/cebssearch/test_article/67-66-3

Publications


TR-000 (67-66-3) Report on the Carcinogenesis Bioassay of Chloroform (CASRN 67-66-3)
Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of Chloroform (67-66-3) in Male Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Chloroform (67-66-3) in Female Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Chloroform (67-66-3) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of Chloroform (67-66-3) in Female B6C3F1 Mice Exposed via Gavage

Other NTP Studies


28-Day Immunotoxicity Evaluation (IMM98002) of Water Disinfection Byproducts (Chloroform) (67-66-3) in B6C3F1 Mice via Dosed Water