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Cyclophosphamide monohydrate (6055-19-2)


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Micronucleus study conclusions related to Cyclophosphamide monohydrate (6055-19-2).
Micronucleus - Rats
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  • Male: Positive
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  • Male: Positive
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  • Male: Positive
An overview of Genetic Toxicology Micronucleus study conclusions related to Cyclophosphamide monohydrate (6055-19-2).
Micronucleus - Mice
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  • Male: Positive
    Female: Positive
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  • Male: Positive
    Female: Positive
View
  • Male: Positive
    Female: Positive
View
  • Male: Positive
    Female: Weakly Positive
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Cyclophosphamide monohydrate (6055-19-2).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Cyclophosphamide monohydrate (6055-19-2).
Drosophila Germ Cell Mutagenicity
SLRL RT
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Cyclophosphamide monohydrate (6055-19-2).
Bacterial Mutagenicity
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  • Positive
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  • Positive

Citation Information


NTP. Cyclophosphamide monohydrate (6055-19-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2019-07-22. https://manticore.niehs.nih.gov/cebssearch/test_article/6055-19-2

Publications


Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142
Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367

Study Data


Toxicity and Carcinogenicity Studies


26-Week Evaluation of the Toxicity (C97011A) of Cyclophosphide Monohydrate (6055-19-2) in FVB/N Mice Exposed via Topical Application. NTP Special Study
26-Week Evaluation of the Toxicity (C97011A) of Transgenic Model (Cyclophosphamide Monohydrate) (6055-19-2) in FVB/N Mice Exposed via Topical Application
26-Week Evaluation of the Toxicity (C97011B) of Cyclophosphide Monohydrate (6055-19-2) in FVB/N Mice Exposed via Gavage. NTP Special Study
26-Week Evaluation of the Toxicity (C97011B) of Transgenic Model (Cyclophosphamide Monohydrate) (6055-19-2) in FVB/N Mice Exposed via Gavage
26-Week Evaluation of the Toxicity (C97011A) of Transgenic Model (Cyclophosphamide Monohydrate) (6055-19-2) in Tg.AC (FVB/N) Mice Exposed via Topical Application. NTP Special Study
26-Week Evaluation of the Toxicity (C97011B) of Cyclophosphide Monohydrate (6055-19-2) in Tg.AC (FVB/N) Mice Exposed via Gavage. NTP Special Study

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Cyclophosphamide Monohydrate (6055-19-2) in Micronucleus Study A17052 in B6C3F1 Mice
Genetic Toxicity Evaluation of Cyclophosphamide Monohydrate (6055-19-2) in Micronucleus Study A25833 in F344 Rats
Genetic Toxicity Evaluation of Cyclophosphamide Monohydrate (6055-19-2) in Micronucleus Study A57498 in B6C3F1 Mice
Genetic Toxicity Evaluation of Cyclophosphamide Monohydrate (6055-19-2) in Micronucleus Study A91782 in B6C3F1 Mice
Genetic Toxicity Evaluation of Cyclophosphamide Monohydrate (6055-19-2) in Micronucleus Study A95722 in B6C3F1 Mice
Genetic Toxicity Evaluation of Cyclophosphamide Monohydrate (6055-19-2) in Micronucleus Study F25833 in F344 Rats
Genetic Toxicity Evaluation of Cyclophosphamide Monohydrate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 101998
Genetic Toxicity Evaluation of Cyclophosphamide Monohydrate in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 122836
Genetic Toxicity Evaluation of Transgenic Model (Cyclophosphamide Monohydrate) (6055-19-2) in Micronucleus Study G10351 in Wistar Han Rats