2,2',4,4',5-Pentabromodiphenyl ether (60348-60-9)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID9030048

Study Results

Genetic Toxicology

An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2,2',4,4',5-Pentabromodiphenyl ether (60348-60-9).
Bacterial Mutagenicity
View Negative

Citation Information

NTP. 2,2',4,4',5-Pentabromodiphenyl ether (60348-60-9). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications

Ryan KR, Sirenko O, Parham F, Hsieh JH, Cromwell EF, Tice RR, Behl M. Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity. Neurotoxicology. 2016 Mar;53:271-281. doi: 10.1016/j.neuro.2016.02.003. Epub 2016 Feb 4. PMID: 26854185

Behl M, Rice JR, Smith MV, Co CA, Bridge MF, Hsieh JH, Freedman JH, Boyd WA. Editor's Highlight: Comparative Toxicity of Organophosphate Flame Retardants and Polybrominated Diphenyl Ethers to Caenorhabditis elegans. Toxicol Sci. 2016 Dec;154(2):241-252. doi: 10.1093/toxsci/kfw162. Epub 2016 Aug 26. PMID: 27566445

Sirenko O, Grimm FA, Ryan KR, Iwata Y, Chiu WA, Parham F, Wignall JA, Anson B, Cromwell EF, Behl M, Rusyn I, Tice RR. In vitro cardiotoxicity assessment of environmental chemicals using an organotypic human induced pluripotent stem cell-derived model. Toxicol Appl Pharmacol. 2017 May 1;322:60-74. doi: 10.1016/j.taap.2017.02.020. Epub 2017 Mar 1. PMID: 28259702

Nyffeler J, Dolde X, Krebs A, Pinto-Gil K, Pastor M, Behl M, Waldmann T, Leist M. Combination of multiple neural crest migration assays to identify environmental toxicants from a proof-of-concept chemical library. Arch Toxicol. 2017 Nov;91(11):3613-3632. doi: 10.1007/s00204-017-1977-y. Epub 2017 May 5. PMID: 28477266

Sirenko O, Parham F, Dea S, Sodhi N, Biesmans S, Mora-Castilla S, Ryan K, Behl M, Chandy G, Crittenden C, Vargas-Hurlston S, Guicherit O, Gordon R, Zanella F, Carromeu C. Functional and Mechanistic Neurotoxicity Profiling Using Human iPSC-Derived Neural 3D Cultures. Toxicol Sci. 2019 Jan 1;167(1):58-76. doi: 10.1093/toxsci/kfy218. PMID: 30169818

Quevedo C, Behl M, Ryan K, Paules RS, Alday A, Muriana A, Alzualde A. Detection and Prioritization of Developmentally Neurotoxic and/or Neurotoxic Compounds Using Zebrafish. Toxicol Sci. 2019 Mar 1;168(1):225-240. doi: 10.1093/toxsci/kfy291. PMID: 30521027

Zhang S, Ireland D, Sipes NS, Behl M, Collins ES. Screening for neurotoxic potential of 15 flame retardants using freshwater planarians. Neurotoxicol Teratol. 2019 May-Jun;73:54-66. doi: 10.1016/j.ntt.2019.03.003. Epub 2019 Mar 31. PMID: 30943442

Klose J, Pahl M, Bartmann K, Bendt F, Blum J, Dolde X, Förster N, Holzer AK, Hübenthal U, Keßel HE, Koch K, Masjosthusmann S, Schneider S, Stürzl LC, Woeste S, Rossi A, Covaci A, Behl M, Leist M, Tigges J, Fritsche E. Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery. Cell Biol Toxicol. 2022 Oct;38(5):781-807. doi: 10.1007/s10565-021-09603-2. Epub 2021 May 10. PMID: 33969458

Developmental Exposure to Low Concentrations of Two Brominated Flame Retardants, BDE-47 and BDE-99, Causes Life-Long Behavioral Alterations in Zebrafish Lilah Glazer, Corinne N. Wells, Meghan Drastal, Kathryn-Ann Odamah, Richard E. Galat, Mamta Behl, Edward D. Levin.
Neurotoxicology (2017). DOI: https://doi.org/10.1016/j.neuro.2017.09.007 PMID: 28935585

Study Data

Protocol

Genetic Toxicology Studies

Data

Genetic Toxicity Evaluation of 2,2',4,4',5-Pentabromodiphenyl Ether in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A93319

Summary Data

G06 - Ames Summary Data (61 KB)

Other NTP Studies