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Promethazine hydrochloride (58-33-3)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • No Evidence, Female, Rats
  • No Evidence, Male, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • No Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Promethazine hydrochloride (58-33-3).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to Promethazine hydrochloride (58-33-3).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Promethazine hydrochloride (58-33-3).
Bacterial Mutagenicity
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  • Negative
View
  • Negative

Citation Information


NTP. Promethazine hydrochloride (58-33-3). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2019-08-22. https://manticore.niehs.nih.gov/cebssearch/test_article/58-33-3

Publications


TR-425 Toxicology and Carcinogenesis Studies of Promethazine Hydrochloride (CASRN 58-33-3) in F344/N Rats and B6C3F1 Mice (Gavage Studies)
Mortelmans, K., Haworth, S., Lawlor, T., Speck, W., Tainer, B., and Zeiger, E. Salmonella mutagenicity tests. II. Results from the testing of 270 chemicals Environ. Mutagen. Vol. 8 (Suppl 7) (1986) 1-119
Yoon, J.S., Mason, J.M., Valencia, R., Woodruff, R.C., and Zimmering, S. Chemical mutagenesis testing in Drosophila: IV. Results of 45 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 349-367
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity (C60673B) of Promethazine Hydrochloride (58-33-3) in F344/N Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C60673B) of Promethazine Hydrochloride (58-33-3) in B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Promethazine Hydrochloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 488601
Genetic Toxicity Evaluation of Promethazine Hydrochloride in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 767991