5,5-Diphenylhydantoin (57-41-0)


Study Results


Chronic Bioassay Level of Evidence

Rats
  • Equivocal Evidence, Male, Rats
  • No Evidence, Female, Rats
Mice
  • Clear Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

Rodent Cytogenetics
CA SCE
    • Negative
    • Equivocal
Micronucleus - Mice
  • Male: Negative;
  • Male: Negative;
Mammalian Cell Mutagenicity
  • Negative
Mammalian Cell Cytogenetics
CA SCE
    • Negative
    • Positive
Drosophila Germ Cell Mutagenicity
SLRL
    • Negative
Bacterial Mutagenicity
  • Negative
  • Negative

Citation Information


NTP. 5,5-Diphenylhydantoin (57-41-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2017-11-24. https://manticore.niehs.nih.gov/cebssearch/test_article/57-41-0

Publications


TR-404

Toxicology and Carcinogenesis Studies of 5,5-Diphenylhydantoin (Phenytoin) (CASRN 57-41-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)
[Abstract]

Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142

Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702

Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data


Toxicity and Carcinogenicity