5,5-Diphenylhydantoin (57-41-0)

Study Results

Chronic Bioassay Level of Evidence

  • Equivocal Evidence, Male, Rats
  • No Evidence, Female, Rats
  • Clear Evidence, Female, Mice
  • No Evidence, Male, Mice

Genetic Toxicology

Rodent Cytogenetics
    • Negative
    • Equivocal
Micronucleus - Mice
  • Male: Negative;
  • Male: Negative;
Mammalian Cell Mutagenicity
  • Negative
Mammalian Cell Cytogenetics
    • Negative
    • Positive
Drosophila Germ Cell Mutagenicity
    • Negative
Bacterial Mutagenicity
  • Negative
  • Negative

Citation Information

NTP. 5,5-Diphenylhydantoin (57-41-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2018-02-23. https://manticore.niehs.nih.gov/cebssearch/test_article/57-41-0



Toxicology and Carcinogenesis Studies of 5,5-Diphenylhydantoin (Phenytoin) (CASRN 57-41-0) in F344/N Rats and B6C3F1 Mice (Feed Studies)

Haworth, S., Lawlor, T., Mortelmans, K., Speck, W., and Zeiger, E. Salmonella mutagenicity test results for 250 chemicals Environ. Mutagen. Vol. 5 (Suppl 1) (1983) 3-142

Woodruff, R.C., Mason, J.M., Valencia, R., and Zimmering, S. Chemical mutagenesis testing in Drosophila: V. Results of 53 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 677-702

Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data

Toxicity and Carcinogenicity