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Diethylstilbestrol (56-53-1)


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Micronucleus study conclusions related to Diethylstilbestrol (56-53-1).
Micronucleus - Mice
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  • Female: Negative
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  • Female: Positive
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  • Male: Negative
    Female: Negative
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  • Female: Positive
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  • Male: Negative
    Female: Negative
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  • Male: Negative
    Female: Negative
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  • Male: Negative
    Female: Negative
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to Diethylstilbestrol (56-53-1).
Mammalian Cell Mutagenicity
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  • Positive
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  • Positive
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  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to Diethylstilbestrol (56-53-1).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Diethylstilbestrol (56-53-1).
Bacterial Mutagenicity
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  • Negative

Citation Information


NTP. Diethylstilbestrol (56-53-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2018-09-19. https://manticore.niehs.nih.gov/cebssearch/test_article/56-53-1

Publications


Zeiger, E., and Haworth, S. Tests with a preincubation modification of the Salmonella/microsome assay. In Evaluation of Short-Term Tests for Carcinogens Elsevier/North Holland 187-199
Dunkel, V., Zeiger, E., Brusick, D., McCoy, E., McGregor, D., Mortelmans, K., Rosenkranz, H., and Simmon, V. (1984) Reproducibility of microbial mutagenicity assays. I. Tests with Salmonella typhimurium and Escherichia coli using a standardized protocol. Environ. Mutagen. 6 (Suppl. 2): 1-251.
Final Report on the Developmental Toxicity of Diethylstilbestrol in Swiss (CD-1) Mice
Final Report on the Developmental Toxicity of Diethylstilbestrol in Swiss (CD-1) Mice
Myhr, B., Bower, L., and Caspary, W. Assays for the induction of gene mutations at the thymine kinase locus in L1578Y mouse lymphoma cells in culture. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland Vol. (1985) 555-568
Myhr, B.C., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for sixty-three coded chemicals tested at Litton Bionetics, Inc. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 103-194
Mitchell, A.D., Rudd, C.J., and Caspary, W.J. Evaluation of the L5178Y mouse lymphoma cell mutagenesis assay: Intralaboratory results for 63 coded chemicals tested at SRI International. Environ. Molec. Mutagen. Vol. 12 (Suppl 13) (1988) 37-102
Gulati, D., Sabharwal, P., and Shelby, M. Tests for the induction of chromosomal aberrations and sister chromatid exchanges in cultured Chinese hamster ovary (CHO) cells. In Evaluation of Short-Term Tests for Carcinogens, Elsevier/North Holland 413-426

Study Data


Toxicity and Carcinogenicity Studies


26-Week Evaluation of the Toxicity (C97011G) of Transgenic Model (DES) (56-53-1) in FVB/N Mice Exposed via Topical Application. NTP Special Study
26-Week Evaluation of the Toxicity (C97011H) of Transgenic Model (DES) (56-53-1) in FVB/N Mice Exposed via Gavage. NTP Special Study
2-Week Evaluation of the Toxicity (C97011H) of Transgenic Model (DES) (56-53-1) in FVB/N Mice Exposed via Gavage
26-Week Evaluation of the Toxicity (C97011G) of Transgenic Model (DES) (56-53-1) in FVB/N Mice Exposed via Topical Application
26-Week Evaluation of the Toxicity (C97011H) of Transgenic Model (DES) (56-53-1) in FVB/N Mice Exposed via Gavage
26-Week Evaluation of the Toxicity (C97011G) of Transgenic Model (DES) (56-53-1) in Tg.AC (FVB/N) Mice Exposed via Topical Application. NTP Special Study
26-Week Evaluation of the Toxicity (C97011H) of Transgenic Model (DES) (56-53-1) in Tg.AC (FVB/N) Mice Exposed via Gavage. NTP Special Study