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Dicyclohexylcarbodiimide (538-75-0)


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Micronucleus study conclusions related to Dicyclohexylcarbodiimide (538-75-0).
Micronucleus - Rats
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  • Male: Negative
An overview of Genetic Toxicology Micronucleus study conclusions related to Dicyclohexylcarbodiimide (538-75-0).
Micronucleus - Mice
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  • Male: Weakly Positive
    Female: Weakly Positive
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Dicyclohexylcarbodiimide (538-75-0).
Bacterial Mutagenicity
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  • Negative

Citation Information


NTP. Dicyclohexylcarbodiimide (538-75-0). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2019-06-17. https://manticore.niehs.nih.gov/cebssearch/test_article/538-75-0

Publications


Witt, K.L., Tice, R.R., Shelby, M.D., Chhabra, R.S., and Zeiger, E. Induction of Micronucleated Erythrocytes in Rodents by Diisopropylcarbodiimide and Dicyclohexylcarbodiimide: Dependence on Exposure Protocol. Environ. Molec. Mutag. Vol. 33 (1999) 65-74
GMM-09 Toxicology Studies of Dicyclohexylcarbodiimide (CASRN 538-75-0) in F344/N Rats, B6C3F1 Mice, and Genetically Modified (FVB Tg.AC Hemizygous) Mice and Carcinogenicity Study of Dicyclohexylcarbodiimide in Genetically Modified [B6.129-Trp53tm1Brd (N5) Haploinsufficient] Mice (Dermal Studies)

Study Data


Toxicity and Carcinogenicity Studies


150-Day Evaluation of the Toxicity (C93021B) of Dicyclohexylcarbodiimide (538-75-0) in Tg.AC Mice Exposed via Topical Application
150-Day Evaluation of the Toxicity (C93021B) of Dicyclohexylcarbodiimide (538-75-0) in Tg.AC (FVB/N) Mice Exposed via Topical Application. NTP Special Study
2-Week Evaluation of the Toxicity (C93021) of Dicyclohexylcarbodiimide (538-75-0) in F344/N Rats Exposed via Topical Application
3-Month Evaluation of the Toxicity (C93021) of Dicyclohexylcarbodiimide (538-75-0) in F344 Rats Exposed via Topical Application. NTP Special Study
2-Week Evaluation of the Toxicity (C93021) of Dicyclohexylcarbodiimide (538-75-0) in B6C3F1 Mice Exposed via Topical Application
3-Month Evaluation of the Toxicity (C93021) of Dicyclohexylcarbodiimide (538-75-0) in B6C3F1 Mice Exposed via Topical Application. NTP Special Study
26-Week Evaluation of the Toxicity (C93021C) of Dicyclohexylcarbodiimide (538-75-0) in P53(C57BL/6) Mice Exposed via Topical Application
3-Month Evaluation of the Toxicity (C93021) of Dicyclohexylcarbodiimide (538-75-0) in F344/N Rats Exposed via Topical Application
3-Month Evaluation of the Toxicity (C93021) of Dicyclohexylcarbodiimide (538-75-0) in B6C3F1 Mice Exposed via Topical Application

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Dicyclohexylcarbodiimide (538-75-0) in Micronucleus Study A45449 in F344 Rats
Genetic Toxicity Evaluation of Dicyclohexylcarbodiimide (538-75-0) in Micronucleus Study A63966 in B6C3F1 Mice
Genetic Toxicity Evaluation of Dicyclohexylcarbodiimide in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A46724