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Perfluorooctanoic acid (335-67-1)

DOI: https://doi.org/10.22427/NTP-DATA-DTXSID8031865


Study Results


Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Rats study conclusions related to Perfluorooctanoic acid (335-67-1).
Micronucleus - Rats
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  • Male: Positive
    Female: Negative
An overview of Genetic Toxicology In Vivo Alkaline Comet Assay Rats study conclusions related to Perfluorooctanoic acid (335-67-1).
In Vivo Alkaline Comet Assay - Rats
View
  • Male: Negative
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to Perfluorooctanoic acid (335-67-1).
Bacterial Mutagenicity
View
  • Equivocal

Citation Information


NTP. Perfluorooctanoic acid (335-67-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP).

Publications


TR-598 Toxicology and Carcinogenesis Studies of Perfluorooctanoic Acid Administered in Feed to Sprague Dawley (Hsd:Sprague Dawley SD) Rats
TOX-97 NTP Report on the Toxicity Studies of Perfluorinated Compounds: Carboxylates Administered via Oral Gavage in Hsd: Sprague Dawley SD Rats
Repeat 5-day in vivo genomic dose response studies Fred Parham, Michele R Balik-Meisner, William M Gwinn, Matthew D Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, Bruce Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R Shah, Deepak Mav, Dhiral P Phadke, Georgia Roberts, Michael J DeVito, Scott S Auerbach

DOI: https://doi.org/10.22427/NTP-DATA-002-00099-0001-000-1

BioProject ID: PRJNA926950
Latent, sex-specific metabolic health effects in CD-1 mouse offspring exposed to PFOA or HFPO-DA (GenX) during gestation Harlie A. Cope, Bevin E. Blake, Charlotte Love, James McCord, Susan A. Elmore, Janice B. Harvey, Vesna A. Chappell, Suzanne E. Fenton
Science Direct (2021) https://doi.org/10.1016/j.emcon.2021.10.004 PMID: 35097227
DOI: https://doi.org/10.22427/NTP-DATA-002-02657-0013-0000-6
Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX) Bevin E. Blake, Harlie A. Cope, Samantha M. Hall, Robert D. Keys, Beth W. Mahler, James McCord, Brittany Scott, Heather M. Stapleton, Mark J. Strynar, Susan A. Elmore, Suzanne E. Fenton
Environmental Health Perspectives(2020) DOI: https://doi.org/10.1289/EHP6233 PMID: 32074459 PMCID: PMC7064328
DOI: https://doi.org/10.22427/NTP-DATA-021-00006-0001-0000-0
Exposure to Select PFAS and PFAS Mixtures Alters Response to Platinum-Based Chemotherapy in Endometrial Cancer Cell Lines Brittany P. Rickard, Marta Overchuk, Justin Tulino, Xianming Tan, Frances S. Ligler, Victoria L. Bae-Jump, Suzanne E. Fenton, and Imran Rizvi

DOI: https://doi.org/10.22427/NTP-DATA-500-009-001-000-5
Select Per- and Polyfluoroalkyl Substances (PFAS) Induce Resistance to Carboplatin in Ovarian Cancer Cell Lines Brittany P. Rickard, Xianming Tan, Suzanne E. Fenton, and Imran Rizvi
International Journal of Molecular Sciences (2022), 23(9), 5176; DOI: https://doi.org/10.3390/ijms23095176

DOI: https://doi.org/10.22427/NTP-DATA-025-00001-0002-000-0
Evaluation of 5-Day In Vivo Rat Liver and Kidney with High-Throughput Transcriptomics for Estimating Benchmark Doses of Apical Outcomes William M. Gwinn, Scott S. Auerbach, Fred Parham, Matthew D. Stout, Suramya Waidyanatha, Esra Mutlu, Brad Collins, Richard S Paules, B. Alex Merrick, Stephen Ferguson, Sreenivasa Ramaiahgari, John R. Bucher, Barney Sparrow, Heather Toy, Jenni Gorospe, Nick Machesky, Ruchir R. Shah, Michele R. Balik-Meisner, Deepak Mav, Dhiral P. Phadke, Georgia Roberts, Michael J. DeVito


CEBS DOI: https://doi.org/10.22427/NTP-DATA-002-00058-0002-0000-7
GEO No.: GSE147072: https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE147072
BioProject No.: PRJNA612884: https://www.ncbi.nlm.nih.gov/bioproject/?term=PRJNA612884
SRA No.: SRP253005: https://www.ncbi.nlm.nih.gov/sra?term=SRP253005

Study Data


Toxicity and Carcinogenicity Studies


28-Day Evaluation of the Toxicity (C91070B) of Perfluorooctanoic Acid (PFOA) (335-67-1) in Harlan Sprague-Dawley Rats Exposed via Gavage
Study Tables
Individual Animal Data
5-day study (C91070C) of perfluorooctanoic acid (335-67-1) delivered via Gavage in HSD Rat
Evaluation of the Chronic Toxicity and Carcinogenicity (C20614) of Perfluorooctanoic Acid (335-67-1) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
Interim (16 Week) of Chronic Study One (C20614) – Male and Female Rats
Chronic Study One (C20614) - Male and Female Rats
Chronic Individual Animal Data of Study One (C20614) - Male and Female Rats
Evaluation of the Chronic Toxicity and Carcinogenicity (C20614B) of Perfluorooctanoic Acid (335-67-1) in Harlan Sprague-Dawley Rats Exposed via Dosed Feed
Interim (16 Week) of Chronic Study Two (C20614B) – Male Rats
Chronic Study Two (C20614B) – Male Rats
Chronic Individual Animal Data of Study Two (C20614B) - Male Rats

Genetic Toxicology Studies


Genetic Toxicity Evaluation of Perfluorooctanoic Acid (335-67-1) in DNA Damage Study G91070B in Sprague-Dawley Rats
Genetic Toxicity Evaluation of Perfluorooctanoic Acid (335-67-1) in Micronucleus Study G91070 in Harlan Sprague-Dawley Rats
Genetic Toxicity Evaluation of Perfluorooctanoic Acid in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A98283
Summary Data

Other NTP Studies


Evaluation (500-009-001-000-5) of the Effect of PFAS and PFAS Mixtures (335-67-1, 375-85-9, 2706-90-3) on Endometrial Cancer Cell Lines response to Platinum Based Chemotherapy
Supplemental Materials
Figures
Toxicokinetic Evaluation (C20614) of Perfluorooctanoic Acid (335-67-1) in Harlan Sprague-Dawley Rats Exposed via Gavage or Intravenous Injection
Data
Toxicokinetic Evaluation (K10075) of Perfluorooctanoic Acid (DTXSID8031865) in Rat