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5-Azacytidine (320-67-2)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Inadequate Study, Male, Rats
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  • Inadequate Study, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • Inadequate Study, Male, Mice
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  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus study conclusions related to 5-Azacytidine (320-67-2).
Micronucleus - Mice
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  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 5-Azacytidine (320-67-2).
Mammalian Cell Mutagenicity
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  • Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 5-Azacytidine (320-67-2).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 5-Azacytidine (320-67-2).
Bacterial Mutagenicity
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  • Positive
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  • Positive

Citation Information


NTP. 5-Azacytidine (320-67-2). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2018-10-19. https://manticore.niehs.nih.gov/cebssearch/test_article/320-67-2

Publications


TR-042 Bioassay of 5-Azacytidine for Possible Carcinogenicity (CASRN 320-67-2)
Zeiger, E., Anderson, B., Haworth, S., Lawlor, T., and Mortelman, K. Salmonella Mutagenicity Tests V. Results from the Testing of 311 Chemicals Environ. Molec. Mutagen. Vol. 19 (Suppl 21) (1992) 2-141

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity of 5-Azacytidine (320-67-2) in Male Sprague-Dawley Rats Exposed via Intraperitoneal Injection
Evaluation of the Chronic Toxicity and Carcinogenicity of 5-Azacytidine (320-67-2) in Female Sprague-Dawley Rats Exposed via Intraperitoneal Injection
Evaluation of the Chronic Toxicity and Carcinogenicity of 5-Azacytidine (320-67-2) in Male B6C3F1 Mice Exposed via Intraperitoneal Injection
Evaluation of the Chronic Toxicity and Carcinogenicity of 5-Azacytidine (320-67-2) in Female B6C3F1 Mice Exposed via Intraperitoneal Injection

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 5-Azacytidine (320-67-2) in Micronucleus Study A95392 in B6C3F1 Mice
Genetic Toxicity Evaluation of 5-Azacytidine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 440974
Genetic Toxicity Evaluation of 5-Azacytidine in Salmonella/E.coli Mutagenicity Test or Ames Test. Study A21960