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3'-Azido-3'-deoxythymidine (30516-87-1)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Mice studies.
Mice
View
  • Clear Evidence, Female, Mice
  • Equivocal Evidence, Male, Mice

Genetic Toxicology

An overview of Genetic Toxicology Micronucleus Mice study conclusions related to 3'-Azido-3'-deoxythymidine (30516-87-1).
Micronucleus - Mice
View
  • Male: Positive
View
  • Male: Positive
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 3'-Azido-3'-deoxythymidine (30516-87-1).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 3'-Azido-3'-deoxythymidine (30516-87-1).
Bacterial Mutagenicity
View
  • Positive
View
  • Weakly Positive

Citation Information


NTP. 3'-Azido-3'-deoxythymidine (30516-87-1). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2020-09-18. https://manticore.niehs.nih.gov/cebssearch/test_article/30516-87-1

Publications


TR-469 Toxicology and Carcinogenesis Studies of AZT (CASRN 30516-87-1) and AZT/ a-Interferon A/D B6C3F1 Mice (Gavage Studies)
TR-522 Toxicology and Carcinogenesis Studies of Transplacental AZT (CASRN 30516-87-1) in Swiss (CD-1®) Mice (in utero Studies)
Phillips, M.D., Nascimbeni, B., Tice, R.R., and Shelby, M.D. Induction of MN in Mouse BM cells: An evaluation of nucleoside analogues used in the treatment of Aids. Environ. Molec. Mutag. Vol. 18 (1991) 168-183
GMM-14 Toxicology and Carcinogenicity Studies of 3´-Azido-3´-Deoxythymidine (AZT) (CAS No. 30516-87-1) in Genetically Modified C3B6.129F1-Trp53tm1Brd N12 Haploinsufficient Mice (In Utero and Postnatal Gavage Study)

Study Data


Toxicity and Carcinogenicity Studies


18-33 Day Evaluation of the Toxicity (C89006) of Interferon AD + 3'-Azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB) in B6C3F1 Mice Exposed via Subcutaneous Injection
18-33 Day Evaluation of the Toxicity (C89007) of 3'-Azido-3'-deoxythymidine/2',3'-Dideoxycytidine (AZTDDCCOMB) in B6C3F1 Mice Exposed via Gavage
3-Month Evaluation of the Toxicity (C98002) of AZT + Nitazoxanide (AIDS Initiative) (AZT+NITAZOX) in B6C3F1 Mice Exposed via Gavage. NTP Special Study
26-39 Week Evaluation of the Toxicity (C20310C) of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in C3B6F1-+/Trp53(tm1Brd) Mice Exposed via Gavage
26-39 Week Evaluation of the Toxicity (C20310C) of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in C3B6F1-+/Trp53(tm1Brd) Mice Exposed via Gavage
3-Month Evaluation of the Toxicity (C88072) of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in F344/N Rats Exposed via Gavage
3-Month Evaluation of the Toxicity (C88072) of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in B6C3F1 Mice Exposed via Gavage
19-Month (with Perinatal Exposure) Evaluation of the Toxicity (C99022) of AZT transplacental carcinogenesis study (30516-87-1) in SWISS Mice via In-Utero Exposure
Evaluation of the Chronic Toxicity and Carcinogenicity (C88072) of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C89006) of Interferon AD + 3'-Azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB) in B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C89006) of Interferon AD + 3'-Azido-3'-deoxythymidine (AIDS Initiative) (INTAZTCOMB) in B6C3F1 Mice Exposed via Gavage

Genetic Toxicology Studies


Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in Micronucleus Study 912603 in B6C3F1 Mice
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AIDS) (30516-87-1) in Micronucleus Study A88072 in B6C3F1 Mice
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AIDS) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study 860655
Summary Data
Genetic Toxicity Evaluation of 3'-Azido-3'-deoxythymidine (AIDS) in Salmonella/E.coli Mutagenicity Test or Ames Test. Study G88195
Summary Data

Other NTP Studies


28-Day Immunotoxicity Evaluation (IMM96013) of AZT + Pyrimethamine Combination (Aids) (AZT/PYRIMETH) in B6C3F1 Mice via Gavage
Toxicokinetic Evaluation (S0305) of 3'-Azido-3'-deoxythymidine and Methadone Hydrochloride (AZTMETHCOMB) in B6C3F1 and CD-1 Mice Exposed via Intravenous Injection or Gavage
Data - Methadone Hydrochloride (HCl)
Data - 3'-Azido-3'-deoxythymidine (AZT), AZT + Methadone HCl, and Methadone Hydrochloride (HCl)
Data - 3'-Azido-3'-deoxythymidine (AZT)
Toxicokinetic Evaluation (S0553) of 3'-Azido-3'-deoxythymidine + Rifampicin (AZTRIFAMPIN) in B6C3F1 Mice Exposed via Intravenous Injection or Gavage
Data - 3'-Azido-3'-deoxythymidine and 3'-Azido-3'-deoxythymidine + Rifampicin
Data - 3'-Azido-3'-deoxythymidine + Rifampicin
Data - 3'-Azido-3'-deoxythymidine
Toxicokinetic Evaluation (S0609) of 3'-Azido-3'-deoxythymidine (30516-87-1) and 3'-Azido-3'-deoxythymidine + Trimethoprim and Sulfamethoxazole (AZTTMPSMX) in B6C3F1 Mice Exposed via Intravenous Injection or Gavage
Data - AZT + TMP/SMX (Mixture) Combination
Data - 3'-Azido-3'-deoxythymidine and AZT + TMP/SMX (Mixture) Combination
Data - 3'-Azido-3'-deoxythymidine (AZT)
Toxicokinetic Evaluation (S0610) of 3'-Azido-3'-deoxythymidine (30516-87-1) and 3'-Azido-3'-deoxythymidine + Trimethoprim and Sulfamethoxazole (AZTTMPSMX) in B6C3F1 Mice Exposed via Gavage
Data
Toxicokinetic Evaluation (S0643) of 3'-Azido-3'-deoxythymidine and 3'-Azido-3'-deoxythymidine + Multiple Administrations of Rifampicin (AZTRIFAMPIN) in B6C3F1 Mice Exposed via Gavage or Gavage and Intravenous Injection
Data - 3'-Azido-3'-deoxythymidine (AZT) + Rifampicin
Data - 3'-Azido-3'-deoxythymidine (AZT)
3'-Azido-3'-deoxythymidine and 3'-Azido-3'-deoxythymidine + Rifampicin
Transplacental Pharmacokinetic Evaluation (S0874) of 3'-Azido-3'-Deoxythymidine (30516-87-1) in CD-1 Mice Exposed via Intravenous Injection and Dosed Water
Data