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2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6)


Study Results


Chronic Bioassay Level of Evidence

An overview of chronic evidence from Rats studies.
Rats
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  • Positive, Male, Rats
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  • Clear Evidence, Female, Rats
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  • Positive, Female, Rats
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  • Clear Evidence, Female, Rats
An overview of chronic evidence from Mice studies.
Mice
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  • Equivocal, Male, Mice
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  • Positive, Male, Mice
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  • Positive, Female, Mice
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  • Positive, Female, Mice

Genetic Toxicology

An overview of Genetic Toxicology Rodent Cytogenetics study conclusions related to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6).
Rodent Cytogenetics
CA SCE
  • View
    • Not a Valid Test
An overview of Genetic Toxicology Mammalian Cell Mutagenicity study conclusions related to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6).
Mammalian Cell Mutagenicity
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  • Negative
An overview of Genetic Toxicology Mammalian Cell Cytogenetics study conclusions related to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6).
Mammalian Cell Cytogenetics
CA SCE
An overview of Genetic Toxicology Drosophila Germ Cell Mutagenicity study conclusions related to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6).
Drosophila Germ Cell Mutagenicity
SLRL
An overview of Genetic Toxicology Bacterial Mutagenicity study conclusions related to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6).
Bacterial Mutagenicity
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  • Negative

Citation Information


NTP. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed 2019-09-22. https://manticore.niehs.nih.gov/cebssearch/test_article/1746-01-6

Publications


TR-201 Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Swiss-Webster Mice (Dermal Study)
TR-209 Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (CASRN 1746-01-6) in Osborne-Mendel Rats and B6C3F1 Mice (Gavage Study)
TR-521 Toxicology and Carcinogenesis Studies of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) (CASRN 1746-01-6) in Female Harlan Sprague-Dawley Rats (Gavage Studies)
Mortelmans, K., Haworth, S., Speck, W., and Zeiger, E. Mutagenicity testing of Agent Orange components and related chemicals Toxicology and Applied Pharmacology Vol. 75 (1984) 137-146
McGregor, D., Brown, A., Howgate, S., McBride, D., Riach, C., and Caspary, W. Responses of the L5178Y tk+/tk- mouse lymphoma cell forward mutation assay. IV: 27 coded chemicals. Environ. Molec. Mutagen. Vol. 17 (1991) 196-219
Zimmering, S., Mason, J.M., Valencia, R., and Woodruff, R.C. Chemical mutagenesis testing in Drosophila. II. Results of 20 coded compounds tested for the National Toxicology Program. Environ. Mutagen. Vol. 7 (1985) 87-100
Galloway, S., Armstrong, M., Reuben, C., Colman, S., Brown, B., Cannon, C., Bloom, A., Nakamura, F., Ahmed, M., Duk, S., Rimpo, J., Margolin, B., Resnick, M., Anderson, B., and Zeiger, E. Chromosome aberration and sister chromatid exchanges in Chinese hamster ovary cells: Evaluations of 108 chemicals. Environ. Molec. Mutagen. Vol. 10 (Suppl 10) (1987) 1-176

Study Data


Toxicity and Carcinogenicity Studies


Evaluation of the Chronic Toxicity and Carcinogenicity (C96007B) of TEF (Dioxin Mixture) (TEFDIOXINMIX) in Harlan Sprague-Dawley Rats Exposed via Gavage. NTP Special Study
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6) in Male Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6) in Female Osborne-Mendel Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C96007G) of TEF (TCDD) (1746-01-6) in Sprague-Dawley Rats Exposed via Gavage. NTP Special Study
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6) in Male B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6) in Female B6C3F1 Mice Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6) in Male Swiss-Webster Mice Exposed via Topical Application
Evaluation of the Chronic Toxicity and Carcinogenicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (1746-01-6) in Female Swiss-Webster Mice Exposed via Topical Application
Evaluation of the Chronic Toxicity and Carcinogenicity (C96007B) of TEF (Dioxin Mixture) (TEFDIOXINMIX) in Harlan Sprague-Dawley Rats Exposed via Gavage
Evaluation of the Chronic Toxicity and Carcinogenicity (C96007G) of TEF (TCDD) (1746-01-6) in Harlan Sprague-Dawley Rats Exposed via Gavage

Other NTP Studies


Toxicokinetic Evaluation (S0621) of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (1746-01-6) in Sprague-Dawley Rats Exposed via Gavage
Data